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Items: 1 to 50 of 155

1.

Protective effect of in-feed specific IgM towards Yersinia ruckeri in rainbow trout.

Chettri JK, Al-Jubury A, Hansen MB, Lihme A, Dalsgaard I, Buchmann K, Heegaard PMH.

Fish Shellfish Immunol. 2019 Aug 9. pii: S1050-4648(19)30824-1. doi: 10.1016/j.fsi.2019.08.024. [Epub ahead of print]

PMID:
31404633
2.

The Effect of Inactivated Mycobacterium Paratuberculosis Vaccine on the Response to a Heterologous Bacterial Challenge in Pigs.

Jensen KJ, Hansen MS, Heegaard PMH, Benn CS, Jungersen G.

Front Immunol. 2019 Jul 5;10:1557. doi: 10.3389/fimmu.2019.01557. eCollection 2019.

3.

Low concentration of serum immunoglobulin G is associated with pre-weaning diarrhea in young mink kits (Neovison vison).

Mathiesen R, Chriél M, Struve T, Heegaard PMH.

Acta Vet Scand. 2019 Jun 10;61(1):26. doi: 10.1186/s13028-019-0461-5.

4.

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.

Astrup LB, Skovgaard K, Rasmussen RS, Iburg TM, Agerholm JS, Aalbæk B, Jensen HE, Nielsen OL, Johansen FF, Heegaard PMH, Leifsson PS.

Neurol Res. 2019 May;41(5):399-412. doi: 10.1080/01616412.2019.1573455. Epub 2019 Feb 1.

PMID:
30707086
5.

AU Content in the MicroRNA Sequence Influences its Stability after Heat Treatment.

López AG, Brogaard L, Heegaard PMH, Cirera S, Skovgaard K.

Microrna. 2019;8(3):216-222. doi: 10.2174/2211536608666190131102252.

PMID:
30706831
6.

Animal Models for Influenza A Virus Infection Incorporating the Involvement of Innate Host Defenses: Enhanced Translational Value of the Porcine Model.

Starbæk SMR, Brogaard L, Dawson HD, Smith AD, Heegaard PMH, Larsen LE, Jungersen G, Skovgaard K.

ILAR J. 2018 Nov 22. doi: 10.1093/ilar/ily009. [Epub ahead of print]

PMID:
30476076
7.

Experimental anal infection of rainbow trout with Flavobacterium psychrophilum: A novel challenge model.

Chettri JK, Al-Jubury A, Dalsgaard I, Heegaard PMH, Buchmann K.

J Fish Dis. 2018 Dec;41(12):1917-1919. doi: 10.1111/jfd.12888. Epub 2018 Sep 11. No abstract available.

PMID:
30203498
8.

Mink (Neovison vison) kits with pre-weaning diarrhea have elevated serum amyloid A levels and intestinal pathomorphological similarities with New Neonatal Porcine Diarrhea Syndrome.

Mathiesen R, Birch JM, Chriél M, Jensen HE, Agger JF, Heegaard PMH, Struve T.

Acta Vet Scand. 2018 Aug 15;60(1):48. doi: 10.1186/s13028-018-0403-7.

9.

Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs.

Shim J, Poulsen CB, Hagensen MK, Larsen T, Heegaard PMH, Christoffersen C, Bolund L, Schmidt M, Liu Y, Li J, Li R, Callesen H, Bentzon JF, Sørensen CB.

JACC Basic Transl Sci. 2017 Oct 30;2(5):591-600. doi: 10.1016/j.jacbts.2017.06.004. eCollection 2017 Oct.

10.

The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production.

van Dijk A, Hedegaard CJ, Haagsman HP, Heegaard PMH.

Vet Res. 2018 Jul 31;49(1):68. doi: 10.1186/s13567-018-0558-2. Review.

11.

Quantitative immunoassay for mink immunoglobulin in serum and milk.

Mathiesen R, Chriél M, Struve T, Heegaard PMH.

Acta Vet Scand. 2018 Jun 18;60(1):36. doi: 10.1186/s13028-018-0391-7.

12.

IFN-λ and microRNAs are important modulators of the pulmonary innate immune response against influenza A (H1N2) infection in pigs.

Brogaard L, Larsen LE, Heegaard PMH, Anthon C, Gorodkin J, Dürrwald R, Skovgaard K.

PLoS One. 2018 Apr 20;13(4):e0194765. doi: 10.1371/journal.pone.0194765. eCollection 2018.

13.

Efficacy and safety of simultaneous vaccination with two modified live virus vaccines against porcine reproductive and respiratory syndrome virus types 1 and 2 in pigs.

Kristensen CS, Kvisgaard LK, Pawlowski M, Holmgaard Carlsen S, Hjulsager CK, Heegaard PMH, Bøtner A, Stadejek T, Haugegaard S, Larsen LE.

Vaccine. 2018 Jan 4;36(2):227-236. doi: 10.1016/j.vaccine.2017.11.059. Epub 2017 Nov 27.

14.

Genetic and biological characterization of a Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) causing significant clinical disease in the field.

Kvisgaard LK, Larsen LE, Hjulsager CK, Bøtner A, Rathkjen PH, Heegaard PMH, Bisgaard NP, Nielsen J, Hansen MS.

Vet Microbiol. 2017 Nov;211:74-83. doi: 10.1016/j.vetmic.2017.10.001. Epub 2017 Oct 3. Erratum in: Vet Microbiol. 2018 Jan;213:143-149.

15.

Loss of prion protein induces a primed state of type I interferon-responsive genes.

Malachin G, Reiten MR, Salvesen Ø, Aanes H, Kamstra JH, Skovgaard K, Heegaard PMH, Ersdal C, Espenes A, Tranulis MA, Bakkebø MK.

PLoS One. 2017 Jun 26;12(6):e0179881. doi: 10.1371/journal.pone.0179881. eCollection 2017.

16.

Pathogenicity of three genetically diverse strains of PRRSV Type 1 in specific pathogen free pigs.

Stadejek T, Larsen LE, Podgórska K, Bøtner A, Botti S, Dolka I, Fabisiak M, Heegaard PMH, Hjulsager CK, Huć T, Kvisgaard LK, Sapierzyński R, Nielsen J.

Vet Microbiol. 2017 Sep;209:13-19. doi: 10.1016/j.vetmic.2017.05.011. Epub 2017 May 16.

PMID:
28554869
17.

The effect of color type on early wound healing in farmed mink (Neovison vison).

Jespersen A, Jensen HE, Agger JF, Heegaard PMH, Damborg P, Aalbæk B, Hammer AS.

BMC Vet Res. 2017 May 22;13(1):135. doi: 10.1186/s12917-017-1052-1.

18.

Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea.

Hedegaard CJ, Lauridsen C, Heegaard PMH.

Vet Immunol Immunopathol. 2017 Apr;186:9-14. doi: 10.1016/j.vetimm.2017.02.001. Epub 2017 Feb 4.

PMID:
28413052
19.

Increased Intestinal Inflammation and Digestive Dysfunction in Preterm Pigs with Severe Necrotizing Enterocolitis.

Støy ACF, Heegaard PMH, Skovgaard K, Bering SB, Bjerre M, Sangild PT.

Neonatology. 2017;111(4):289-296. doi: 10.1159/000452614. Epub 2016 Dec 24.

PMID:
28013313
20.

Novel porcine model of implant-associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response.

Jensen LK, Koch J, Dich-Jorgensen K, Aalbaek B, Petersen A, Fuursted K, Bjarnsholt T, Kragh KN, Tøtterup M, Bue M, Hanberg P, Søballe K, Heegaard PMH, Jensen HE.

J Orthop Res. 2017 Oct;35(10):2211-2221. doi: 10.1002/jor.23505. Epub 2017 Jan 15.

21.

Delayed development of systemic immunity in preterm pigs as a model for preterm infants.

Nguyen DN, Jiang P, Frøkiær H, Heegaard PM, Thymann T, Sangild PT.

Sci Rep. 2016 Nov 10;6:36816. doi: 10.1038/srep36816.

22.

Activation of innate immune genes in caprine blood leukocytes after systemic endotoxin challenge.

Salvesen Ø, Reiten MR, Heegaard PM, Tranulis MA, Espenes A, Skovgaard K, Ersdal C.

BMC Vet Res. 2016 Oct 28;12(1):241.

23.

High-fat but not sucrose intake is essential for induction of dyslipidemia and non-alcoholic steatohepatitis in guinea pigs.

Ipsen DH, Tveden-Nyborg P, Rolin B, Rakipovski G, Beck M, Mortensen LW, Færk L, Heegaard PM, Møller P, Lykkesfeldt J.

Nutr Metab (Lond). 2016 Aug 9;13:51. doi: 10.1186/s12986-016-0110-1. eCollection 2016.

24.

Milk diets influence doxorubicin-induced intestinal toxicity in piglets.

Shen RL, Pontoppidan PE, Rathe M, Jiang P, Hansen CF, Buddington RK, Heegaard PM, Müller K, Sangild PT.

Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G324-33. doi: 10.1152/ajpgi.00373.2015. Epub 2016 Jul 21.

25.

Characterization and differentiation of equine experimental local and early systemic inflammation by expression responses of inflammation-related genes in peripheral blood leukocytes.

Vinther AM, Heegaard PM, Skovgaard K, Buhl R, Andreassen SM, Andersen PH.

BMC Vet Res. 2016 Jun 1;12:83. doi: 10.1186/s12917-016-0706-8.

26.

Hepatic expression of inflammatory genes and microRNAs in pigs with high "cholesteryl ester transfer protein" (CETP) activity.

Cirera S, Tørsleff BC, Ritz C, Fredholm M, Heegaard PM, Skovgaard K.

Mamm Genome. 2016 Oct;27(9-10):503-10. doi: 10.1007/s00335-016-9649-4. Epub 2016 May 30.

PMID:
27240589
27.

Passive immunisation, an old idea revisited: Basic principles and application to modern animal production systems.

Hedegaard CJ, Heegaard PM.

Vet Immunol Immunopathol. 2016 Jun;174:50-63. doi: 10.1016/j.vetimm.2016.04.007. Epub 2016 Apr 26. Review.

PMID:
27185263
28.

Doxorubicin-Induced Gut Toxicity in Piglets Fed Bovine Milk and Colostrum.

Shen RL, Rathe M, Jiang P, Pontoppidan PE, Heegaard PM, Müller K, Sangild PT.

J Pediatr Gastroenterol Nutr. 2016 Dec;63(6):698-707.

PMID:
27027906
29.

Late regulation of immune genes and microRNAs in circulating leukocytes in a pig model of influenza A (H1N2) infection.

Brogaard L, Heegaard PM, Larsen LE, Mortensen S, Schlegel M, Dürrwald R, Skovgaard K.

Sci Rep. 2016 Feb 19;6:21812. doi: 10.1038/srep21812.

30.

Modelling severe Staphylococcus aureus sepsis in conscious pigs: are implications for animal welfare justified?

Olsen HG, Kjelgaard-Hansen M, Tveden-Nyborg P, Birck MM, Hammelev KP, Vegge A, Aalbæk B, Leifsson PS, Jensen HE, Iburg T, Heegaard PM, Nielsen OL.

BMC Res Notes. 2016 Feb 16;9:99. doi: 10.1186/s13104-016-1888-7.

31.

Natural Pig Plasma Immunoglobulins Have Anti-Bacterial Effects: Potential for Use as Feed Supplement for Treatment of Intestinal Infections in Pigs.

Hedegaard CJ, Strube ML, Hansen MB, Lindved BK, Lihme A, Boye M, Heegaard PM.

PLoS One. 2016 Jan 29;11(1):e0147373. doi: 10.1371/journal.pone.0147373. eCollection 2016.

32.

Spray Dried, Pasteurised Bovine Colostrum Protects Against Gut Dysfunction and Inflammation in Preterm Pigs.

Sty AC, Sangild PT, Skovgaard K, Thymann T, Bjerre M, Chatterton DE, Purup S, Boye M, Heegaard PM.

J Pediatr Gastroenterol Nutr. 2016 Aug;63(2):280-7. doi: 10.1097/MPG.0000000000001056.

PMID:
26756878
33.

Circulating Extracellular microRNA in Systemic Autoimmunity.

Heegaard NHH, Carlsen AL, Skovgaard K, Heegaard PMH.

Exp Suppl. 2015;106:171-195. doi: 10.1007/978-3-0348-0955-9_8.

PMID:
26608204
34.

Novel Adjuvants and Immunomodulators for Veterinary Vaccines.

Heegaard PM, Fang Y, Jungersen G.

Methods Mol Biol. 2016;1349:63-82. doi: 10.1007/978-1-4939-3008-1_5.

PMID:
26458830
35.

Prion-Specific Antibodies Produced in Wild-Type Mice.

Heegaard PM, Bergström AL, Andersen HG, Cordes H.

Methods Mol Biol. 2015;1348:285-301. doi: 10.1007/978-1-4939-2999-3_25.

PMID:
26424281
36.

Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals.

Ludvigsen TP, Kirk RK, Christoffersen BØ, Pedersen HD, Martinussen T, Kildegaard J, Heegaard PM, Lykkesfeldt J, Olsen LH.

J Transl Med. 2015 Sep 22;13:312. doi: 10.1186/s12967-015-0670-2.

37.

Non-invasive assessment of in-vitro embryo quality to improve transfer success.

Rødgaard T, Heegaard PM, Callesen H.

Reprod Biomed Online. 2015 Nov;31(5):585-92. doi: 10.1016/j.rbmo.2015.08.003. Epub 2015 Aug 12. Review.

38.

Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs.

Christoffersen BØ, Jensen SJ, Ludvigsen TP, Nilsson SK, Grossi AB, Heegaard PM.

Comp Med. 2015 Aug;65(4):333-41.

39.

Necrotizing Enterocolitis in Preterm Pigs Is Associated with Increased Density of Intestinal Mucosa-Associated Bacteria Including Clostridium perfringens.

Støy AC, Mølbak L, Delègue CL, Thymann T, Sangild PT, Heegaard PM, Manurung S, Skovgaard K.

Neonatology. 2015;108(3):188-95. doi: 10.1159/000431280. Epub 2015 Aug 7.

PMID:
26278554
40.

Dynamic expression of leukocyte innate immune genes in whole blood from horses with lipopolysaccharide-induced acute systemic inflammation.

Vinther AM, Skovgaard K, Heegaard PM, Andersen PH.

BMC Vet Res. 2015 Jun 16;11:134. doi: 10.1186/s12917-015-0450-5.

41.

Concurrent host-pathogen gene expression in the lungs of pigs challenged with Actinobacillus pleuropneumoniae.

Brogaard L, Klitgaard K, Heegaard PM, Hansen MS, Jensen TK, Skovgaard K.

BMC Genomics. 2015 May 28;16:417. doi: 10.1186/s12864-015-1557-6.

42.

Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes.

Lindegaard KK, Jorgensen NB, Just R, Heegaard PM, Madsbad S.

Diabetol Metab Syndr. 2015 Feb 24;7:12. doi: 10.1186/s13098-015-0012-9. eCollection 2015.

43.

Lipidated α-peptide/β-peptoid hybrids with potent anti-inflammatory activity.

Skovbakke SL, Larsen CJ, Heegaard PM, Moesby L, Franzyk H.

J Med Chem. 2015 Jan 22;58(2):801-13. doi: 10.1021/jm501341h. Epub 2014 Dec 29.

PMID:
25489798
44.

Intestinal colonization of broiler chickens by Campylobacter spp. in an experimental infection study.

Bahrndorff S, Garcia AB, Vigre H, Nauta M, Heegaard PM, Madsen M, Hoorfar J, Hald B.

Epidemiol Infect. 2015 Aug;143(11):2381-9. doi: 10.1017/S0950268814003239. Epub 2014 Dec 4.

PMID:
25471550
45.

The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2.

Skovbakke SL, Heegaard PM, Larsen CJ, Franzyk H, Forsman H, Dahlgren C.

Biochem Pharmacol. 2015 Jan 15;93(2):182-95. doi: 10.1016/j.bcp.2014.11.004. Epub 2014 Nov 14.

PMID:
25462815
46.

Vaccination of pigs with attenuated Lawsonia intracellularis induced acute phase protein responses and primed cell-mediated immunity without reduction in bacterial shedding after challenge.

Riber U, Heegaard PM, Cordes H, Ståhl M, Jensen TK, Jungersen G.

Vaccine. 2015 Jan 1;33(1):156-62. doi: 10.1016/j.vaccine.2014.10.084. Epub 2014 Nov 11.

47.

Urea and thiourea modified polypropyleneimine dendrimers clear intracellular α-synuclein aggregates in a human cell line.

Laumann K, Boas U, Larsen HM, Heegaard PM, Bergström AL.

Biomacromolecules. 2015 Jan 12;16(1):116-24. doi: 10.1021/bm501244m. Epub 2014 Dec 1.

PMID:
25418683
48.

Melatonin does not affect oxidative/inflammatory biomarkers in a closed-chest porcine model of acute myocardial infarction.

Halladin NL, Ekeløf S, Jensen SE, Aarøe J, Kjærgaard B, Heegaard PM, Lykkesfeldt J, Rosenberg J, Gögenur I.

In Vivo. 2014 Jul-Aug;28(4):483-8.

PMID:
24982213
49.

Seroprevalence of Lawsonia intracellularis antibodies in intensive pig farms in China.

Wu Z, Ling Y, Tian D, Pan Q, Heegaard PM, He C.

BMC Vet Res. 2014 Apr 28;10:100. doi: 10.1186/1746-6148-10-100.

50.

Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs.

Boonen HC, Moesgaard SG, Birck MM, Christoffersen BO, Cirera S, Heegaard PM, Højbøge TR, Jensen LJ, Mortensen A, Olsen LH, Sheykhzade M, Tang J, Lykkesfeldt J.

Pflugers Arch. 2014 Dec;466(12):2167-76. doi: 10.1007/s00424-014-1486-2. Epub 2014 Mar 5.

PMID:
24590510

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