Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 153


Horizontal transfer of a pathway for coumarate catabolism unexpectedly inhibits purine nucleotide biosynthesis.

Close DM, Cooper CJ, Wang X, Chirania P, Gupta M, Ossyra JR, Giannone RJ, Engle N, Tschaplinski TJ, Smith JC, Hedstrom L, Parks JM, Michener JK.

Mol Microbiol. 2019 Sep 18. doi: 10.1111/mmi.14393. [Epub ahead of print]


Oxanosine Monophosphate Is a Covalent Inhibitor of Inosine 5'-Monophosphate Dehydrogenase.

Yu R, Kim Y, Maltseva N, Braunstein P, Joachimiak A, Hedstrom L.

Chem Res Toxicol. 2019 Mar 18;32(3):456-466. doi: 10.1021/acs.chemrestox.8b00342. Epub 2019 Feb 25.


Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.

Long MJC, Lawson AP, Baggio R, Qian Y, Rozhansky L, Fasci D, El Oualid F, Weerapana E, Hedstrom L.

Bioorg Med Chem Lett. 2019 Jan 15;29(2):204-211. doi: 10.1016/j.bmcl.2018.11.055. Epub 2018 Nov 28.


A call to arms: Unifying the fight against resistance.

Kaushansky A, Hedstrom L, Goldman A, Singh J, Yang PL, Rathod PK, Cynamon M, Wodarz D, Mahadevan D, Tomaras A, Navia MA, Schiffer CA.

Sci Signal. 2018 Oct 23;11(553). pii: eaav0442. doi: 10.1126/scisignal.aav0442.


Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L.

J Med Chem. 2018 Jun 14;61(11):4739-4756. doi: 10.1021/acs.jmedchem.7b01839. Epub 2018 May 30.


Sabellastarte magnifica Carboxypeptidase Inhibitor: The first Kunitz inhibitor simultaneously interacting with carboxypeptidases and serine proteases.

Reytor González ML, Alonso-Del-Rivero Antigua M, Hedstrom L, Kuzmič P, Pires JR.

Biochimie. 2018 Jul;150:37-47. doi: 10.1016/j.biochi.2018.04.024. Epub 2018 May 3.


Dynamic Characteristics of Guanosine-5'-monophosphate Reductase Complexes Revealed by High-Resolution 31P Field-Cycling NMR Relaxometry.

Rosenberg MM, Redfield AG, Roberts MF, Hedstrom L.

Biochemistry. 2018 Jun 5;57(22):3146-3154. doi: 10.1021/acs.biochem.8b00142. Epub 2018 Mar 26.


The outcome of two-step blood pressure screening in dental healthcare.

Andersson H, Hedström L, Bergman S, Bergh H.

Scand J Public Health. 2018 Aug;46(6):623-629. doi: 10.1177/1403494818759840. Epub 2018 Mar 1.


Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.

Lawson AP, Bak DW, Shannon DA, Long MJC, Vijaykumar T, Yu R, Oualid FE, Weerapana E, Hedstrom L.

Oncotarget. 2017 Apr 20;8(31):51296-51316. doi: 10.18632/oncotarget.17261. eCollection 2017 Aug 1.


Expression and Purification of Active Recombinant Human Alpha-1 Antitrypsin (AAT) from Escherichia coli.

Krishnan B, Hedstrom L, Hebert DN, Gierasch LM, Gershenson A.

Methods Mol Biol. 2017;1639:195-209. doi: 10.1007/978-1-4939-7163-3_19.


Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis.

Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, Mann BJ, Hedstrom L.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00939-17. doi: 10.1128/AAC.00939-17. Print 2017 Oct.


Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin-Like Protein (Pup) between Substrates.

Zhang S, Burns-Huang KE, Janssen GV, Li H, Ovaa H, Hedstrom L, Darwin KH.

MBio. 2017 Feb 21;8(1). pii: e00122-17. doi: 10.1128/mBio.00122-17.


The Bare Essentials of Antibiotic Target Validation.

Hedstrom L.

ACS Infect Dis. 2017 Jan 13;3(1):2-4. doi: 10.1021/acsinfecdis.6b00185. Epub 2016 Nov 9.


Substrate and Cofactor Dynamics on Guanosine Monophosphate Reductase Probed by High Resolution Field Cycling 31P NMR Relaxometry.

Rosenberg MM, Redfield AG, Roberts MF, Hedstrom L.

J Biol Chem. 2016 Oct 28;291(44):22988-22998. Epub 2016 Sep 9.


Boc3Arg-Linked Ligands Induce Degradation by Localizing Target Proteins to the 20S Proteasome.

Shi Y, Long MJ, Rosenberg MM, Li S, Kobjack A, Lessans P, Coffey RT, Hedstrom L.

ACS Chem Biol. 2016 Dec 16;11(12):3328-3337. Epub 2016 Oct 18.


Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.

Wei Y, Kuzmič P, Yu R, Modi G, Hedstrom L.

Biochemistry. 2016 Sep 20;55(37):5279-88. doi: 10.1021/acs.biochem.6b00265. Epub 2016 Sep 2.


Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling.

Coffey RT, Shi Y, Long MJ, Marr MT 2nd, Hedstrom L.

J Biol Chem. 2016 Mar 4;291(10):5221-33. doi: 10.1074/jbc.M115.691584. Epub 2016 Jan 6.


Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.

Lawson AP, Long MJC, Coffey RT, Qian Y, Weerapana E, El Oualid F, Hedstrom L.

Cancer Res. 2015 Dec 1;75(23):5130-5142. doi: 10.1158/0008-5472.CAN-15-1544. Epub 2015 Nov 5.


Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.

Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A.

PLoS One. 2015 Oct 6;10(10):e0138976. doi: 10.1371/journal.pone.0138976. eCollection 2015.


Cryptosporidium: a first step toward tractability.

Hedstrom L.

Trends Parasitol. 2015 Sep;31(9):401-2. doi: 10.1016/ Epub 2015 Aug 21.


Is there a connection between sublingual varices and hypertension?

Hedström L, Albrektsson M, Bergh H.

BMC Oral Health. 2015 Jul 11;15:78. doi: 10.1186/s12903-015-0054-2.


Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity.

Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):531-8. doi: 10.1107/S2053230X15000187. Epub 2015 Apr 21.


A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.

Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A.

J Biol Chem. 2015 Feb 27;290(9):5893-911. doi: 10.1074/jbc.M114.619767. Epub 2015 Jan 8.


Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors.

Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.

J Med Chem. 2014 Dec 26;57(24):10544-50. doi: 10.1021/jm501527z. Epub 2014 Dec 4.


A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

Checkley W, White AC Jr, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, Fayer R, Griffiths JK, Guerrant RL, Hedstrom L, Huston CD, Kotloff KL, Kang G, Mead JR, Miller M, Petri WA Jr, Priest JW, Roos DS, Striepen B, Thompson RC, Ward HD, Van Voorhis WA, Xiao L, Zhu G, Houpt ER.

Lancet Infect Dis. 2015 Jan;15(1):85-94. doi: 10.1016/S1473-3099(14)70772-8. Epub 2014 Sep 29. Review.


Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.

Kuang Y, Long MJ, Zhou J, Shi J, Gao Y, Xu C, Hedstrom L, Xu B.

J Biol Chem. 2014 Oct 17;289(42):29208-18. doi: 10.1074/jbc.M114.600288. Epub 2014 Aug 25.


Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents.

Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L.

ACS Med Chem Lett. 2014 Jun 10;5(8):846-50. doi: 10.1021/ml500203p. eCollection 2014 Aug 14. Erratum in: ACS Med Chem Lett. 2014 Oct 9;5(10):1174.


Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial.

Albrektson M, Hedström L, Bergh H.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 May;117(5):590-594. doi: 10.1016/j.oooo.2014.01.228. Epub 2014 Feb 6.


Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo.

Wang J, Han X, Wong CC, Cheng H, Aslanian A, Xu T, Leavis P, Roder H, Hedstrom L, Yates JR 3rd, Kashina A.

Chem Biol. 2014 Mar 20;21(3):331-7. doi: 10.1016/j.chembiol.2013.12.017. Epub 2014 Feb 13.


Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis.

Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L.

Antimicrob Agents Chemother. 2014;58(3):1603-14. doi: 10.1128/AAC.02075-13. Epub 2013 Dec 23.


Actionable knowledge and strategic decision making for bio- and agroterrorism threats: building a collaborative early warning culture.

Mårtensson PÅ, Hedström L, Sundelius B, Skiby JE, Elbers A, Knutsson R.

Biosecur Bioterror. 2013 Sep;11 Suppl 1:S46-54. doi: 10.1089/bsp.2013.0039.


Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD.

J Med Chem. 2013 May 23;56(10):4028-43. doi: 10.1021/jm400241j. Epub 2013 May 13.


Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.

Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):1004-7. doi: 10.1016/j.bmcl.2012.12.037. Epub 2012 Dec 27.


Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.

Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD.

J Med Chem. 2012 Sep 13;55(17):7759-71. doi: 10.1021/jm3007917. Epub 2012 Sep 5.


Mushroom tyrosinase oxidizes tyrosine-rich sequences to allow selective protein functionalization.

Long MJ, Hedstrom L.

Chembiochem. 2012 Aug 13;13(12):1818-25. doi: 10.1002/cbic.201100792. Epub 2012 Jul 17.


Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules.

Gao Y, Long MJ, Shi J, Hedstrom L, Xu B.

Chem Commun (Camb). 2012 Aug 28;48(67):8404-6. doi: 10.1039/c2cc33631f. Epub 2012 Jul 17.


Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, Hedstrom L, Joachimiak A.

Biochemistry. 2012 Aug 7;51(31):6148-63. Epub 2012 Jul 25.


Inhibitor mediated protein degradation.

Long MJ, Gollapalli DR, Hedstrom L.

Chem Biol. 2012 May 25;19(5):629-37. doi: 10.1016/j.chembiol.2012.04.008.


The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.

Hedstrom L.

Crit Rev Biochem Mol Biol. 2012 May-Jun;47(3):250-63. doi: 10.3109/10409238.2012.656843. Epub 2012 Feb 15. Review.


Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH.

Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1985-8. doi: 10.1016/j.bmcl.2012.01.029. Epub 2012 Jan 24.


Multivalent glycocluster design through directed evolution.

MacPherson IS, Temme JS, Habeshian S, Felczak K, Pankiewicz K, Hedstrom L, Krauss IJ.

Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11238-42. No abstract available.


Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa.

McGrew DA, Hedstrom L.

Adv Exp Med Biol. 2012;723:539-45. doi: 10.1007/978-1-4614-0631-0_68. Review.


Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.

Patton GC, Stenmark P, Gollapalli DR, Sevastik R, Kursula P, Flodin S, Schuler H, Swales CT, Eklund H, Himo F, Nordlund P, Hedstrom L.

Nat Chem Biol. 2011 Oct 30;7(12):950-8. doi: 10.1038/nchembio.693.


Kinetically controlled drug resistance: how Penicillium brevicompactum survives mycophenolic acid.

Sun XE, Hansen BG, Hedstrom L.

J Biol Chem. 2011 Nov 25;286(47):40595-600. doi: 10.1074/jbc.M111.305235. Epub 2011 Oct 6.


Adaptive evolution of drug targets in producer and non-producer organisms.

Hansen BG, Sun XE, Genee HJ, Kaas CS, Nielsen JB, Mortensen UH, Frisvad JC, Hedstrom L.

Biochem J. 2012 Jan 1;441(1):219-26. doi: 10.1042/BJ20111278.


Allosteric activation via kinetic control: potassium accelerates a conformational change in IMP dehydrogenase.

Riera TV, Zheng L, Josephine HR, Min D, Yang W, Hedstrom L.

Biochemistry. 2011 Oct 4;50(39):8508-18. doi: 10.1021/bi200785s. Epub 2011 Sep 9.


Cell compatible trimethoprim-decorated iron oxide nanoparticles bind dihydrofolate reductase for magnetically modulating focal adhesion of mammalian cells.

Long MJ, Pan Y, Lin HC, Hedstrom L, Xu B.

J Am Chem Soc. 2011 Jul 6;133(26):10006-9. doi: 10.1021/ja202767g. Epub 2011 Jun 14.


The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors.

Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR.

Curr Med Chem. 2011;18(13):1909-18. Review.


Specific biotinylation of IMP dehydrogenase.

Hoefler BC, Gollapalli DR, Hedstrom L.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1363-5. doi: 10.1016/j.bmcl.2011.01.042. Epub 2011 Jan 14.


The Cys319 loop modulates the transition between dehydrogenase and hydrolase conformations in inosine 5'-monophosphate dehydrogenase.

Josephine HR, Ravichandran KR, Hedstrom L.

Biochemistry. 2010 Dec 21;49(50):10674-81. doi: 10.1021/bi101590c. Epub 2010 Nov 23.

Supplemental Content

Loading ...
Support Center