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The Imperative to Vaccinate.

Hedrick SM.

J Pediatr. 2018 Oct;201:259-263. doi: 10.1016/j.jpeds.2018.06.041. Epub 2018 Jul 25. No abstract available.


Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1.

Utzschneider DT, Delpoux A, Wieland D, Huang X, Lai CY, Hofmann M, Thimme R, Hedrick SM.

Cell Rep. 2018 Mar 27;22(13):3454-3467. doi: 10.1016/j.celrep.2018.03.020.


The Effects of Dendritic Cell Hypersensitivity on Persistent Viral Infection.

Tsau JS, Huang X, Lai CY, Hedrick SM.

J Immunol. 2018 Feb 15;200(4):1335-1346. doi: 10.4049/jimmunol.1601870. Epub 2018 Jan 8.


Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.

Delpoux A, Michelini RH, Verma S, Lai CY, Omilusik KD, Utzschneider DT, Redwood AJ, Goldrath AW, Benedict CA, Hedrick SM.

J Exp Med. 2018 Feb 5;215(2):575-594. doi: 10.1084/jem.20170697. Epub 2017 Dec 27.


FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity.

Delpoux A, Lai CY, Hedrick SM, Doedens AL.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):E8865-E8874. doi: 10.1073/pnas.1618916114. Epub 2017 Oct 2.


Understanding Immunity through the Lens of Disease Ecology.

Hedrick SM.

Trends Immunol. 2017 Dec;38(12):888-903. doi: 10.1016/ Epub 2017 Sep 4. Review.


A rheostat tuning thymic selection.

Morris GP, Hedrick SM.

Nat Immunol. 2017 Jun 20;18(7):713-714. doi: 10.1038/ni.3778. No abstract available.


Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes.

Stienne C, Michieletto MF, Benamar M, Carrié N, Bernard I, Nguyen XH, Lippi Y, Duguet F, Liblau RS, Hedrick SM, Saoudi A, Dejean AS.

Immunity. 2016 Oct 18;45(4):774-787. doi: 10.1016/j.immuni.2016.09.010. Epub 2016 Oct 11.


Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK.

Elife. 2016 Jul 4;5. pii: e10134. doi: 10.7554/eLife.10134.


Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs.

Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C.

Neuron. 2016 May 4;90(3):535-50. doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21.


Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.

Mah IK, Soloff R, Hedrick SM, Mariani FV.

Stem Cell Reports. 2015 Nov 10;5(5):866-880. doi: 10.1016/j.stemcr.2015.09.021. Epub 2015 Oct 30.


Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis.

Kang H, Corr M, Mansson R, Welinder E, Hedrick SM, Stone EL.

PLoS One. 2015 May 13;10(5):e0126728. doi: 10.1371/journal.pone.0126728. eCollection 2015.


ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM.

Immunity. 2015 Feb 17;42(2):239-251. doi: 10.1016/j.immuni.2015.01.017.


Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Immunity. 2014 Dec 18;41(6):934-46. doi: 10.1016/j.immuni.2014.10.021. Epub 2014 Nov 28.


Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.

Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16466-71. doi: 10.1073/pnas.1419337111. Epub 2014 Oct 31.


Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.

Cuda CM, Misharin AV, Gierut AK, Saber R, Haines GK 3rd, Hutcheson J, Hedrick SM, Mohan C, Budinger GS, Stehlik C, Perlman H.

J Immunol. 2014 Jun 15;192(12):5548-60. doi: 10.4049/jimmunol.1400122. Epub 2014 May 7.


Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process.

Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V.

PLoS One. 2014 Feb 19;9(2):e89274. doi: 10.1371/journal.pone.0089274. eCollection 2014.


Differentiation of CD8 memory T cells depends on Foxo1.

Hess Michelini R, Doedens AL, Goldrath AW, Hedrick SM.

J Exp Med. 2013 Jun 3;210(6):1189-200. doi: 10.1084/jem.20130392. Epub 2013 May 27.


Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies.

Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A.

Integr Biol (Camb). 2013 Jan;5(1):195-203. doi: 10.1039/c2ib20109g.


FOXO transcription factors throughout T cell biology.

Hedrick SM, Hess Michelini R, Doedens AL, Goldrath AW, Stone EL.

Nat Rev Immunol. 2012 Sep;12(9):649-61. doi: 10.1038/nri3278. Review.


Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody.

Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ.

Adv Mater. 2012 Aug 2;24(29):3981-7. doi: 10.1002/adma.201200776. Epub 2012 Jun 12.


Polar opposites: Erk direction of CD4 T cell subsets.

Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick SM.

J Immunol. 2012 Jul 15;189(2):721-31. doi: 10.4049/jimmunol.1103015. Epub 2012 Jun 6.


Positive selection in the thymus: an enigma wrapped in a mystery.

Hedrick SM.

J Immunol. 2012 Mar 1;188(5):2043-5. doi: 10.4049/jimmunol.1200077. Review. No abstract available.


Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C.

Nature. 2011 Sep 14;477(7364):335-9. doi: 10.1038/nature10400.


Mechanisms of necroptosis in T cells.

Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM.

J Exp Med. 2011 Apr 11;208(4):633-41. doi: 10.1084/jem.20110251. Epub 2011 Mar 14.


Foxo transcription factors control regulatory T cell development and function.

Kerdiles YM, Stone EL, Beisner DR, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM.

Immunity. 2010 Dec 14;33(6):890-904. doi: 10.1016/j.immuni.2010.12.002. Erratum in: Immunity. 2011 Jan 28;34(1):135. Beisner, Daniel L [corrected to Beisner, Daniel R].


Highly specialized role of Forkhead box O transcription factors in the immune system.

Dejean AS, Hedrick SM, Kerdiles YM.

Antioxid Redox Signal. 2011 Feb 15;14(4):663-74. doi: 10.1089/ars.2010.3414. Epub 2010 Dec 13. Review.


Intertwined pathways of programmed cell death in immunity.

Hedrick SM, Ch'en IL, Alves BN.

Immunol Rev. 2010 Jul;236:41-53. doi: 10.1111/j.1600-065X.2010.00918.x. Review.


Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation.

Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A.

J Immunol. 2010 Apr 15;184(8):4185-95. doi: 10.4049/jimmunol.0903420. Epub 2010 Mar 15.


Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells.

McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick SM.

J Immunol. 2009 Oct 15;183(8):4838-42. doi: 10.4049/jimmunol.0902208.


Immune system: not so superior.

Hedrick SM.

Science. 2009 Sep 25;325(5948):1623-4. doi: 10.1126/science.325_1623a. No abstract available.


The cunning little vixen: Foxo and the cycle of life and death.

Hedrick SM.

Nat Immunol. 2009 Oct;10(10):1057-63. doi: 10.1038/ni.1784. Epub 2009 Aug 23. Review.


MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.

Fan HY, Liu Z, Shimada M, Sterneck E, Johnson PF, Hedrick SM, Richards JS.

Science. 2009 May 15;324(5929):938-41. doi: 10.1126/science.1171396.


Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells.

Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 May;10(5):504-13. doi: 10.1038/ni.1729. Epub 2009 Apr 12.


Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM.

Nat Immunol. 2009 Feb;10(2):176-84. doi: 10.1038/ni.1689. Epub 2009 Jan 11.


The Erk2 MAPK regulates CD8 T cell proliferation and survival.

D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick SM.

J Immunol. 2008 Dec 1;181(11):7617-29.


Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease.

McGargill MA, Choy C, Wen BG, Hedrick SM.

J Immunol. 2008 Dec 1;181(11):7593-605.


Antigen-mediated T cell expansion regulated by parallel pathways of death.

Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17463-8. doi: 10.1073/pnas.0808043105. Epub 2008 Nov 3.


Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis.

Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T.

J Immunol. 2008 Aug 1;181(3):2084-91.


NF-kappaB as a determinant of distinct cell death pathways.

Ch'en IL, Hedrick SM, Hoffmann A.

Methods Enzymol. 2008;446:175-87. doi: 10.1016/S0076-6879(08)01610-8.


Identification of RIP1 kinase as a specific cellular target of necrostatins.

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J.

Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83.


Thymus lineage commitment: a single switch.

Hedrick SM.

Immunity. 2008 Mar;28(3):297-9. doi: 10.1016/j.immuni.2008.02.011. Review.


A semisynthetic epitope for kinase substrates.

Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM.

Nat Methods. 2007 Jun;4(6):511-6. Epub 2007 May 7.


The CD95 receptor: apoptosis revisited.

Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH.

Cell. 2007 May 4;129(3):447-50.


Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

Broussard C, Fleischacker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ, Schwartzberg PL.

Immunity. 2006 Jul;25(1):93-104. Erratum in: Immunity. 2006 Nov;25(5):849. Fleischecker, Christine [corrected to Fleischacker, Christine].


The TCR of mice and men.

Hedrick SM.

J Immunol. 2006 Mar 1;176(5):2681-2. No abstract available.


The role of erk1 and erk2 in multiple stages of T cell development.

Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick SM.

Immunity. 2005 Oct;23(4):431-43.


DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.

Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM.

Int Immunol. 2005 Nov;17(11):1379-90. Epub 2005 Sep 19.


Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM.

J Immunol. 2005 Sep 15;175(6):3469-73.

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