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Items: 1 to 50 of 87

1.

Defining consensus opinion to develop randomised controlled trials in rare diseases using Bayesian design: An example of a proposed trial of adalimumab versus pamidronate for children with CNO/CRMO.

Ramanan AV, Hampson LV, Lythgoe H, Jones AP, Hardwick B, Hind H, Jacobs B, Vasileiou D, Wadsworth I, Ambrose N, Davidson J, Ferguson PJ, Herlin T, Kavirayani A, Killeen OG, Compeyrot-Lacassagne S, Laxer RM, Roderick M, Swart JF, Hedrich CM, Beresford MW.

PLoS One. 2019 Jun 5;14(6):e0215739. doi: 10.1371/journal.pone.0215739. eCollection 2019.

2.

The role of epigenetics in paediatric rheumatic disease.

Charras A, Hedrich CM.

Curr Opin Rheumatol. 2019 May 28. doi: 10.1097/BOR.0000000000000627. [Epub ahead of print]

PMID:
31145124
3.

Vasculitis in Juvenile-Onset Systemic Lupus Erythematosus.

Smith EMD, Lythgoe H, Hedrich CM.

Front Pediatr. 2019 May 9;7:149. doi: 10.3389/fped.2019.00149. eCollection 2019. Review.

4.

Interference of canakinumab with commercial IL-1β ELISAs.

Linge M, Hedrich CM, Rösen-Wolff A, Winkler S.

Clin Immunol. 2019 May 13;205:6-7. doi: 10.1016/j.clim.2019.05.008. [Epub ahead of print] No abstract available.

PMID:
31096037
5.

Outcomes following mycophenolate mofetil versus cyclophosphamide induction treatment for proliferative juvenile-onset lupus nephritis.

Smith E, Al-Abadi E, Armon K, Bailey K, Ciurtin C, Davidson J, Gardner-Medwin J, Haslam K, Hawley D, Leahy A, Leone V, McErlane F, Mewar D, Modgil G, Moots R, Pilkington C, Ramanan A, Rangaraj S, Riley P, Sridhar A, Wilkinson N, Beresford MW, Hedrich CM.

Lupus. 2019 Apr;28(5):613-620. doi: 10.1177/0961203319836712. Epub 2019 Mar 14.

PMID:
30871425
6.

Childhood Vasculitis.

Schnabel A, Hedrich CM.

Front Pediatr. 2019 Jan 10;6:421. doi: 10.3389/fped.2018.00421. eCollection 2018. Review.

7.

Kawasaki Disease.

Hedrich CM, Schnabel A, Hospach T.

Front Pediatr. 2018 Jul 10;6:198. doi: 10.3389/fped.2018.00198. eCollection 2018. Review.

8.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface.

Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann SR, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna SW, Czabotar PE, Wicks IP, De Nardo D, Hedrich CM, Zeng H, Masters SL.

J Allergy Clin Immunol. 2018 Dec;142(6):1956-1967.e6. doi: 10.1016/j.jaci.2018.04.033. Epub 2018 May 17.

9.

Juvenile-onset systemic lupus erythematosus (jSLE) - Pathophysiological concepts and treatment options.

Hedrich CM, Smith EMD, Beresford MW.

Best Pract Res Clin Rheumatol. 2017 Aug;31(4):488-504. doi: 10.1016/j.berh.2018.02.001. Epub 2018 Mar 1. Review.

PMID:
29773269
10.

CD14+ monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression.

Brandt D, Sohr E, Pablik J, Schnabel A, Kapplusch F, Mäbert K, Girschick JH, Morbach H, Thielemann F, Hofmann SR, Hedrich CM.

Clin Immunol. 2018 Nov;196:77-84. doi: 10.1016/j.clim.2018.04.011. Epub 2018 Apr 30.

PMID:
29723617
11.

IL10 promoter haplotypes may contribute to altered cytokine expression and systemic inflammation in celiac disease.

Hofmann SR, Laass MW, Fehrs A, Schuppan D, Zevallos VF, Salminger D, Mäbert K, Hedrich CM.

Clin Immunol. 2018 May;190:15-21. doi: 10.1016/j.clim.2018.02.010. Epub 2018 Feb 24.

PMID:
29481982
12.

Cell-Specific Requirements for STAT Proteins and Type I IFN Receptor Signaling Discretely Regulate IL-24 and IL-10 Expression in NK Cells and Macrophages.

Dabitao D, Hedrich CM, Wang F, Vacharathit V, Bream JH.

J Immunol. 2018 Mar 15;200(6):2154-2164. doi: 10.4049/jimmunol.1701340. Epub 2018 Feb 7.

13.

SLE-Associated Defects Promote Altered T Cell Function.

Crispin JC, Hedrich CM, Suárez-Fueyo A, Comte D, Tsokos GC.

Crit Rev Immunol. 2017;37(1):39-58. doi: 10.1615/CritRevImmunol.2018025213. Review.

14.

TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity.

Brandt D, Hedrich CM.

Autoimmun Rev. 2018 Apr;17(4):422-430. doi: 10.1016/j.autrev.2018.02.001. Epub 2018 Feb 9. Review.

PMID:
29428806
15.

Mechanistic aspects of epigenetic dysregulation in SLE.

Hedrich CM.

Clin Immunol. 2018 Nov;196:3-11. doi: 10.1016/j.clim.2018.02.002. Epub 2018 Feb 6.

PMID:
29425851
16.

Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis.

Hofmann SR, Böttger F, Range U, Lück C, Morbach H, Girschick HJ, Suttorp M, Hedrich CM.

Front Pediatr. 2017 Dec 1;5:256. doi: 10.3389/fped.2017.00256. eCollection 2017.

17.

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes.

Grinstein L, Endter K, Hedrich CM, Reinke S, Luksch H, Schulze F, Robertson AAB, Cooper MA, Rösen-Wolff A, Winkler S.

Clin Immunol. 2018 Jun;191:100-109. doi: 10.1016/j.clim.2017.11.011. Epub 2017 Nov 26.

PMID:
29183866
18.

Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions.

Zhao Y, Wu EY, Oliver MS, Cooper AM, Basiaga ML, Vora SS, Lee TC, Fox E, Amarilyo G, Stern SM, Dvergsten JA, Haines KA, Rouster-Stevens KA, Onel KB, Cherian J, Hausmann JS, Miettunen P, Cellucci T, Nuruzzaman F, Taneja A, Barron KS, Hollander MC, Lapidus SK, Li SC, Ozen S, Girschick H, Laxer RM, Dedeoglu F, Hedrich CM, Ferguson PJ; Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis Study Group and the Childhood Arthritis and Rheumatology Research Alliance Scleroderma, Vasculitis, Autoinflammatory and Rare Diseases Subcommittee.

Arthritis Care Res (Hoboken). 2018 Aug;70(8):1228-1237. doi: 10.1002/acr.23462. Epub 2018 Jul 12.

PMID:
29112802
19.

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment.

Hofmann SR, Kapplusch F, Girschick HJ, Morbach H, Pablik J, Ferguson PJ, Hedrich CM.

Curr Osteoporos Rep. 2017 Dec;15(6):542-554. doi: 10.1007/s11914-017-0405-9. Review.

20.

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells.

Bandoła J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Dorschner B, Alexopoulou D, Navratiel K, Roeder I, Dahl A, Hedrich CM, Bonifacio E, Brenner S, Thieme S.

Front Immunol. 2017 Aug 17;8:981. doi: 10.3389/fimmu.2017.00981. eCollection 2017.

21.

[Still's disease in children and adults].

Hedrich CM, Günther C, Aringer M.

Z Rheumatol. 2017 Sep;76(7):595-608. doi: 10.1007/s00393-017-0358-5. German.

PMID:
28755070
22.

Epigenetics in SLE.

Hedrich CM.

Curr Rheumatol Rep. 2017 Sep;19(9):58. doi: 10.1007/s11926-017-0685-1. Review.

23.

The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review.

Hofmann SR, Kapplusch F, Mäbert K, Hedrich CM.

Mol Cell Pediatr. 2017 Dec;4(1):7. doi: 10.1186/s40348-017-0073-y. Epub 2017 Jul 6. Review.

24.

TCR+CD3+CD4-CD8- effector T cells in psoriasis.

Brandt D, Sergon M, Abraham S, Mäbert K, Hedrich CM.

Clin Immunol. 2017 Aug;181:51-59. doi: 10.1016/j.clim.2017.06.002. Epub 2017 Jun 15.

PMID:
28625883
25.

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

van den Bruck R, Weil PP, Ziegenhals T, Schreiner P, Juranek S, Gödde D, Vogel S, Schuster F, Orth V, Dörner J, Pembaur D, Röper M, Störkel S, Zirngibl H, Wirth S, Jenke ACW, Postberg J, Boy N, Heringer J, Haege G, Glahn EM, Hoffmann GF, Garbade SF, Burgard P, Kölker S, Chao CM, Yahya F, Moiseenko A, Shrestha A, Ahmadvand N, Quantius J, Wilhelm J, El-Agha E, Zimmer KP, Bellusci S, Staufner C, Kölker S, Prokisch H, Hoffmann GF, Seeliger S, Müller M, Hippe A, Steinkraus H, Wauer R, Lachmann B, Hofmann SR, Hedrich CM, Zierk J, Arzideh F, Haeckel R, Rascher W, Rauh M, Metzler M, Thieme S, Bandoła J, Richter C, Ryser M, Jamal A, Ashton MP, von Bonin M, Kuhn M, Hedrich CM, Bonifacio E, Berner R, Brenner S, Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Söder S, Tardieu M, Metzler M, Bruckner-Tuderman L, Schneider H, Bohne F, Langer D, Cencic R, Eggermann T, Zechner U, Pelletier J, Zepp F, Enklaar T, Prawitt D, Pech M, Weckmann M, Heinsen FA, Franke A, Happle C, Dittrich AM, Hansen G, Fuchs O, von Mutius E, Oliver BG, Kopp MV, Paret C, Russo A, Theruvath J, Keller B, El Malki K, Lehmann N, Wingerter A, Neu MA, Aslihan GA, Wagner W, Sommer C, Pietsch T, Seidmann L, Faber J, Schreiner F, Ackermann M, Michalik M, Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J, Fischer HS, Ullrich TL, Bührer C, Czernik C, Schmalisch G, Stein R, Hofmann SR, Hagenbuchner J, Kiechl-Kohlendorfer U, Obexer P, Ausserlechner MJ, Loges NT, Frommer AT, Wallmeier J, Omran H, Öner-Sieben S, Gimpfl M, Rozman J, Irmler M, Beckers J, De Angelis MH, Roscher A, Wolf E, Ensenauer R, Nemes K, Frühwald M, Hasselblatt M, Siebert R, Kordes U, Kool M, Wang H, Hardy H, Refai O, Barwick KES, Zimmerman HH, Weis J, Baple EL, Crosby AH, Cirak S, Hellmuth C, Uhl O, Standl M, Heinrich J, Thiering E, Koletzko B, Blümel L, Kerl K, Picard D, Frühwald MC, Liebau MC, Reifenberger G, Borkhardt A, Hasselblatt M, Remke M, Tews D, Wabitsch M, Fischer-Posovszky P, Westhoff MA, Nonnenmacher L, Langhans J, Schneele L, Trenkler N, Debatin KM.

Mol Cell Pediatr. 2017 May;4(Suppl 1):5. doi: 10.1186/s40348-017-0071-0. No abstract available.

26.

Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis.

Schnabel A, Range U, Hahn G, Berner R, Hedrich CM.

J Rheumatol. 2017 Jul;44(7):1058-1065. doi: 10.3899/jrheum.161255. Epub 2017 May 1.

PMID:
28461645
27.

[Still's disease in children and adults].

Hedrich CM, Günther C, Aringer M.

Hautarzt. 2017 Jun;68(6):497-511. doi: 10.1007/s00105-017-3983-7. Review. German.

PMID:
28451698
28.

Childhood primary large vessel CNS vasculitis: single-centre experience and review of the literature.

Walsh S, Knöfler R, Hahn G, Lohse J, Berner R, Brenner S, Smitka M, von der Hagen M, Hedrich CM.

Clin Exp Rheumatol. 2017 Mar-Apr;35 Suppl 103(1):213-220. Epub 2017 Mar 28. Review.

PMID:
28375836
29.

DNA methylation in systemic lupus erythematosus.

Hedrich CM, Mäbert K, Rauen T, Tsokos GC.

Epigenomics. 2017 Apr;9(4):505-525. doi: 10.2217/epi-2016-0096. Epub 2016 Nov 25. Review.

30.

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies.

Hofmann SR, Schnabel A, Rösen-Wolff A, Morbach H, Girschick HJ, Hedrich CM.

J Rheumatol. 2016 Nov;43(11):1956-1964. Epub 2016 Sep 1. Review.

PMID:
27585682
31.

Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children.

Schnabel A, Range U, Hahn G, Siepmann T, Berner R, Hedrich CM.

Rheumatol Int. 2016 Dec;36(12):1737-1745. Epub 2016 Oct 11.

PMID:
27730289
32.

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division.

Stein R, Kapplusch F, Heymann MC, Russ S, Staroske W, Hedrich CM, Rösen-Wolff A, Hofmann SR.

J Biol Chem. 2016 Aug 26;291(35):18419-29. doi: 10.1074/jbc.M116.718668. Epub 2016 Jul 8.

33.

[Caspase-1 regulates autoinflammation in rheumatic diseases].

Winkler S, Hedrich CM, Rösen-Wolff A.

Z Rheumatol. 2016 Apr;75(3):265-75. doi: 10.1007/s00393-016-0077-3. Review. German.

PMID:
27034076
34.

Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO).

Hofmann SR, Kubasch AS, Range U, Laass MW, Morbach H, Girschick HJ, Hedrich CM.

Rheumatol Int. 2016 Jun;36(6):769-79. doi: 10.1007/s00296-016-3466-7. Epub 2016 Mar 21.

PMID:
27000045
35.

Shaping the spectrum - From autoinflammation to autoimmunity.

Hedrich CM.

Clin Immunol. 2016 Apr;165:21-8. doi: 10.1016/j.clim.2016.03.002. Epub 2016 Mar 3. Review.

PMID:
26948930
36.

Acrodermatitis Chronica Atrophicans.

Bruck N, Fiebig B, Schnabel A, Lander F, Berner R, Hedrich CM.

J Pediatr. 2016 Mar;170:335-e1. doi: 10.1016/j.jpeds.2015.11.011. Epub 2015 Dec 10. No abstract available.

PMID:
26687575
37.

Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release.

Hofmann SR, Kubasch AS, Ioannidis C, Rösen-Wolff A, Girschick HJ, Morbach H, Hedrich CM.

Clin Immunol. 2015 Dec;161(2):300-7. doi: 10.1016/j.clim.2015.09.013. Epub 2015 Sep 25.

PMID:
26404542
38.

Fluorescent tags influence the enzymatic activity and subcellular localization of procaspase-1.

Heymann MC, Rabe S, Ruß S, Kapplusch F, Schulze F, Stein R, Winkler S, Hedrich CM, Rösen-Wolff A, Hofmann SR.

Clin Immunol. 2015 Oct;160(2):172-9. doi: 10.1016/j.clim.2015.05.011. Epub 2015 May 27.

PMID:
26025004
39.

Current understanding of the pathophysiology of systemic juvenile idiopathic arthritis (sJIA) and target-directed therapeutic approaches.

Bruck N, Schnabel A, Hedrich CM.

Clin Immunol. 2015 Jul;159(1):72-83. doi: 10.1016/j.clim.2015.04.018. Epub 2015 May 6. Review.

PMID:
25956529
40.

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling.

Hedrich CM, Rauen T, Apostolidis SA, Grammatikos AP, Rodriguez Rodriguez N, Ioannidis C, Kyttaris VC, Crispin JC, Tsokos GC.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13457-62. doi: 10.1073/pnas.1408023111. Epub 2014 Sep 3.

41.

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.

Hedrich CM, Crispin JC, Tsokos GC.

Autoimmunity. 2014 Jun;47(4):234-41. doi: 10.3109/08916934.2013.801462. Epub 2014 Apr 24. Review.

PMID:
24762298
42.

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.

Koga T, Hedrich CM, Mizui M, Yoshida N, Otomo K, Lieberman LA, Rauen T, Crispín JC, Tsokos GC.

J Clin Invest. 2014 May;124(5):2234-45. doi: 10.1172/JCI73411. Epub 2014 Mar 25.

43.

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO).

Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ.

Pediatr Rheumatol Online J. 2013 Dec 23;11(1):47. doi: 10.1186/1546-0096-11-47.

44.

cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.

Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC.

J Biol Chem. 2014 Jan 24;289(4):2361-70. doi: 10.1074/jbc.M113.523605. Epub 2013 Dec 2.

45.

A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field.

Hedrich CM, Hahn G, Girschick HJ, Morbach H.

Expert Rev Clin Immunol. 2013 Sep;9(9):845-54. doi: 10.1586/1744666X.2013.824670. Review.

PMID:
24070048
46.

cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.

Hedrich CM, Rauen T, Crispin JC, Koga T, Ioannidis C, Zajdel M, Kyttaris VC, Tsokos GC.

J Biol Chem. 2013 Nov 1;288(44):31880-7. doi: 10.1074/jbc.M113.508655. Epub 2013 Sep 18.

47.

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

Apostolidis SA, Rauen T, Hedrich CM, Tsokos GC, Crispín JC.

J Biol Chem. 2013 Sep 13;288(37):26775-84. doi: 10.1074/jbc.M113.483743. Epub 2013 Aug 5.

49.

Gene-function studies in systemic lupus erythematosus.

Crispín JC, Hedrich CM, Tsokos GC.

Nat Rev Rheumatol. 2013 Aug;9(8):476-84. doi: 10.1038/nrrheum.2013.78. Epub 2013 Jun 4. Review.

PMID:
23732569
50.

Bridging the gap between autoinflammation and autoimmunity.

Hedrich CM, Tsokos GC.

Clin Immunol. 2013 Jun;147(3):151-4. doi: 10.1016/j.clim.2013.03.006. Epub 2013 Mar 26. No abstract available.

PMID:
23587745

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