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Items: 7

1.

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation.

Hédou D, Dubouilh-Benard C, Loaëc N, Meijer L, Fruit C, Besson T.

Molecules. 2016 Jun 18;21(6). pii: E794. doi: 10.3390/molecules21060794.

2.

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

Hédou D, Godeau J, Loaëc N, Meijer L, Fruit C, Besson T.

Molecules. 2016 Apr 30;21(5). pii: E578. doi: 10.3390/molecules21050578.

3.

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P.

J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31.

PMID:
25793650
4.

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.

Foucourt A, Hédou D, Dubouilh-Benard C, Désiré L, Casagrande AS, Leblond B, Loäec N, Meijer L, Besson T.

Molecules. 2014 Sep 29;19(10):15546-71. doi: 10.3390/molecules191015546.

5.

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II.

Foucourt A, Hédou D, Dubouilh-Benard C, Girard A, Taverne T, Casagrande AS, Désiré L, Leblond B, Besson T.

Molecules. 2014 Sep 26;19(10):15411-39. doi: 10.3390/molecules191015411.

6.

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.

Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30. doi: 10.1073/pnas.1410315111. Epub 2014 Aug 25.

7.

Discovery of a novel broad-spectrum antifungal agent derived from albaconazole.

Guillon R, Pagniez F, Picot C, Hédou D, Tonnerre A, Chosson E, Duflos M, Besson T, Logé C, Le Pape P.

ACS Med Chem Lett. 2013 Jan 17;4(2):288-92. doi: 10.1021/ml300429p. eCollection 2013 Feb 14.

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