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Carbonic anhydrase, obstructive sleep apnea and hypertension: Effects of intervention.

Hoff E, Zou D, Schiza S, Demir Y, Grote L, Bouloukaki I, Beydemir Ş, Eskandari D, Stenlöf K, Hedner J.

J Sleep Res. 2019 Dec 6:e12956. doi: 10.1111/jsr.12956. [Epub ahead of print]


Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea.

Malhotra A, Shapiro C, Pepin JL, Hedner J, Ahmed M, Foldvary-Schaefer N, Strollo PJ, Mayer G, Sarmiento K, Baladi M, Chandler P, Lee L, Schwab R.

Sleep. 2019 Nov 6. pii: zsz220. doi: 10.1093/sleep/zsz220. [Epub ahead of print]


Non-typeable Haemophilus influenzae protein vaccine in adults with COPD: A phase 2 clinical trial.

Wilkinson TMA, Schembri S, Brightling C, Bakerly ND, Lewis K, MacNee W, Rombo L, Hedner J, Allen M, Walker PP, De Ryck I, Tasciotti A, Casula D, Moris P, Testa M, Arora AK.

Vaccine. 2019 Sep 24;37(41):6102-6111. doi: 10.1016/j.vaccine.2019.07.100. Epub 2019 Aug 22.


Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA).

Gunduz C, Basoglu OK, Hedner J, Bonsignore MR, Hein H, Staats R, Bouloukaki I, Roisman G, Pataka A, Sliwinski P, Ludka O, Pepin JL, Grote L; European Sleep Apnoea Database collaborators.

J Intern Med. 2019 Dec;286(6):676-688. doi: 10.1111/joim.12952. Epub 2019 Jul 25.


Drug therapy for obstructive sleep apnea: From pump to pill?

Cistulli PA, Hedner J.

Sleep Med Rev. 2019 Aug;46:A1-A3. doi: 10.1016/j.smrv.2019.05.002. Epub 2019 May 21. No abstract available.


Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study.

Pataka A, Bonsignore MR, Ryan S, Riha RL, Pepin JL, Schiza S, Basoglu OK, Sliwinski P, Ludka O, Steiropoulos P, Anttalainen U, McNicholas WT, Hedner J, Grote L; ESADA study group.

Eur Respir J. 2019 Jun 20;53(6). pii: 1900091. doi: 10.1183/13993003.00091-2019. Print 2019 Jun. No abstract available.


Comment to the Editorial by KS Park and EW Kang "Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?"

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR.

J Thorac Dis. 2019 Mar;11(Suppl 3):S480-S482. doi: 10.21037/jtd.2019.01.93. No abstract available.


Sleep deprivation and plasma biomarkers for Alzheimer's disease.

Olsson M, Ärlig J, Hedner J, Blennow K, Zetterberg H.

Sleep Med. 2019 May;57:92-93. doi: 10.1016/j.sleep.2018.12.029. Epub 2019 Feb 12. No abstract available.


A randomized trial to determine the impact of indacaterol/glycopyrronium on nighttime oxygenation and symptoms in patients with moderate-to-severe COPD: the DuoSleep study.

Lehmann S, Ringbæk T, Løkke A, Grote L, Hedner J, Lindberg E.

Int J Chron Obstruct Pulmon Dis. 2019 Jan 9;14:199-210. doi: 10.2147/COPD.S184127. eCollection 2019.


Use of the Clinical Global Impression scale in sleep apnea patients - Results from the ESADA database.

Dieltjens M, Verbraecken JA, Hedner J, Vanderveken OM, Steiropoulos P, Kvamme JA, Saaresranta T, Tkacova R, Marrone O, Dogas Z, Schiza S, Grote L; ESADA collaborators.

Sleep Med. 2019 Jul;59:56-65. doi: 10.1016/j.sleep.2018.10.028. Epub 2018 Nov 14.


Insomnia and cardiorespiratory fitness in a middle-aged population: the SCAPIS pilot study.

Zou D, Wennman H, Ekblom Ö, Grote L, Arvidsson D, Blomberg A, Torén K, Bergström G, Börjesson M, Hedner J.

Sleep Breath. 2019 Mar;23(1):319-326. doi: 10.1007/s11325-018-1765-9. Epub 2018 Dec 13.


Solriamfetol for the Treatment of Excessive Sleepiness in OSA: A Placebo-Controlled Randomized Withdrawal Study.

Strollo PJ Jr, Hedner J, Collop N, Lorch DG Jr, Chen D, Carter LP, Lu Y, Lee L, Black J, Pépin JL, Redline S; Tones 4 Study Investigators.

Chest. 2019 Feb;155(2):364-374. doi: 10.1016/j.chest.2018.11.005. Epub 2018 Nov 22.


Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA).

Anttalainen U, Grote L, Fietze I, Riha RL, Ryan S, Staats R, Hedner J, Saaresranta T; ESADA Study Collaborators.

Sleep Breath. 2019 Sep;23(3):805-814. doi: 10.1007/s11325-018-1757-9. Epub 2018 Nov 22.


The European Sleep Apnoea Database (ESADA) ERS Clinical Research Collaboration: past, present and future.

Bonsignore MR, Hedner J; ESADA study group.

Eur Respir J. 2018 Oct 10;52(4). pii: 1801666. doi: 10.1183/13993003.01666-2018. Print 2018 Oct. No abstract available.


Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database.

Gündüz C, Basoglu OK, Hedner J, Zou D, Bonsignore MR, Hein H, Staats R, Pataka A, Barbe F, Sliwinski P, Kent BD, Pepin JL, Grote L; European Sleep Apnea Database Collaborators.

Respirology. 2018 Dec;23(12):1180-1189. doi: 10.1111/resp.13372. Epub 2018 Aug 21.


Clinical presentation of patients with suspected obstructive sleep apnea and self-reported physician-diagnosed asthma in the ESADA cohort.

Bonsignore MR, Pepin JL, Anttalainen U, Schiza SE, Basoglu OK, Pataka A, Steiropoulos P, Dogas Z, Grote L, Hedner J, McNicholas WT, Marrone O; ESADA Study Group.

J Sleep Res. 2018 Dec;27(6):e12729. doi: 10.1111/jsr.12729. Epub 2018 Jul 11.


Certification of fitness to drive in sleep apnea patients: Are we doing the right thing?

Grote L, Svedmyr S, Hedner J.

J Sleep Res. 2018 Dec;27(6):e12719. doi: 10.1111/jsr.12719. Epub 2018 Jul 1.


Chronic pulmonary disease is associated with pain spreading and restless legs syndrome in middle-aged women-a population-based study.

Ding Z, Stehlik R, Hedner J, Ulfberg J, Grote L.

Sleep Breath. 2019 Mar;23(1):135-142. doi: 10.1007/s11325-018-1673-z. Epub 2018 Jun 4.


Challenges and perspectives in obstructive sleep apnoea: Report by an ad hoc working group of the Sleep Disordered Breathing Group of the European Respiratory Society and the European Sleep Research Society.

Randerath W, Bassetti CL, Bonsignore MR, Farre R, Ferini-Strambi L, Grote L, Hedner J, Kohler M, Martinez-Garcia MA, Mihaicuta S, Montserrat J, Pepin JL, Pevernagie D, Pizza F, Polo O, Riha R, Ryan S, Verbraecken J, McNicholas WT.

Eur Respir J. 2018 Sep 16;52(3). pii: 1702616. doi: 10.1183/13993003.02616-2017. Print 2018 Sep. Review.


Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort.

Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L; ESADA Study Group.

J Sleep Res. 2018 Dec;27(6):e12705. doi: 10.1111/jsr.12705. Epub 2018 May 24.


Morning cortisol and fasting glucose are elevated in women with chronic widespread pain independent of comorbid restless legs syndrome.

Stehlik R, Ulfberg J, Zou D, Hedner J, Grote L.

Scand J Pain. 2018 Apr 25;18(2):187-194. doi: 10.1515/sjpain-2018-0026.


Medications and Their Effects on Sleep and Wake.

Verbraecken J, Hedner J.

Sleep Med Clin. 2018 Jun;13(2):xv-xvi. doi: 10.1016/j.jsmc.2018.03.005. Epub 2018 Mar 26. No abstract available.


Drug Therapy in Obstructive Sleep Apnea.

Hedner J, Zou D.

Sleep Med Clin. 2018 Jun;13(2):203-217. doi: 10.1016/j.jsmc.2018.03.004. Review.


Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA.

Marrone O, Cibella F, Pépin JL, Grote L, Verbraecken J, Saaresranta T, Kvamme JA, Basoglu OK, Lombardi C, McNicholas WT, Hedner J, Bonsignore MR; ESADA Network.

Chest. 2018 Aug;154(2):326-334. doi: 10.1016/j.chest.2018.04.020. Epub 2018 Apr 24.


Acetazolamide Reduces Blood Pressure and Sleep-Disordered Breathing in Patients With Hypertension and Obstructive Sleep Apnea: A Randomized Controlled Trial.

Eskandari D, Zou D, Grote L, Hoff E, Hedner J.

J Clin Sleep Med. 2018 Mar 15;14(3):309-317. doi: 10.5664/jcsm.6968.


Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease.

Olsson M, Ärlig J, Hedner J, Blennow K, Zetterberg H.

Sleep. 2018 May 1;41(5). doi: 10.1093/sleep/zsy025.


Absolute lung size and the sex difference in breathlessness in the general population.

Ekström M, Sundh J, Schiöler L, Lindberg E, Rosengren A, Bergström G, Angerås O, Hedner J, Brandberg J, Bake B, Torén K.

PLoS One. 2018 Jan 5;13(1):e0190876. doi: 10.1371/journal.pone.0190876. eCollection 2018.


REM Sleep Imposes a Vascular Load in COPD Patients Independent of Sleep Apnea.

Grote L, Sommermeyer D, Ficker J, Randerath W, Penzel T, Fietze I, Sanner B, Hedner J, Schneider H.

COPD. 2017 Dec;14(6):565-572. doi: 10.1080/15412555.2017.1365119. Epub 2017 Sep 26.


Perceived sleep deficit is a strong predictor of RLS in multisite pain - A population based study in middle aged females.

Stehlik R, Ulfberg J, Zou D, Hedner J, Grote L.

Scand J Pain. 2017 Oct;17:1-7. doi: 10.1016/j.sjpain.2017.06.003. Epub 2017 Jul 4.


Validity of physician-diagnosed COPD in relation to spirometric definitions of COPD in a general population aged 50-64 years - the SCAPIS pilot study.

Torén K, Murgia N, Olin AC, Hedner J, Brandberg J, Rosengren A, Bergström G.

Int J Chron Obstruct Pulmon Dis. 2017 Aug 4;12:2269-2275. doi: 10.2147/COPD.S136308. eCollection 2017.


Efficacy and safety of almorexant in adult chronic insomnia: a randomized placebo-controlled trial with an active reference.

Black J, Pillar G, Hedner J, Polo O, Berkani O, Mangialaio S, Hmissi A, Zammit G, Hajak G.

Sleep Med. 2017 Aug;36:86-94. doi: 10.1016/j.sleep.2017.05.009. Epub 2017 May 29.


Independent associations between arterial bicarbonate, apnea severity and hypertension in obstructive sleep apnea.

Eskandari D, Zou D, Grote L, Schneider H, Penzel T, Hedner J.

Respir Res. 2017 Jun 28;18(1):130. doi: 10.1186/s12931-017-0607-9.


Chronic Rhinosinusitis Impairs Sleep Quality: Results of the GA2LEN Study.

Bengtsson C, Lindberg E, Jonsson L, Holmström M, Sundbom F, Hedner J, Malinovschi A, Middelveld R, Forsberg B, Janson C.

Sleep. 2017 Jan 1;40(1). doi: 10.1093/sleep/zsw021.


Measures of bronchodilator response of FEV1, FVC and SVC in a Swedish general population sample aged 50-64 years, the SCAPIS Pilot Study.

Torén K, Bake B, Olin AC, Engström G, Blomberg A, Vikgren J, Hedner J, Brandberg J, Persson HL, Sköld CM, Rosengren A, Bergström G, Janson C.

Int J Chron Obstruct Pulmon Dis. 2017 Mar 22;12:973-980. doi: 10.2147/COPD.S127336. eCollection 2017.


Pre-operative screening for obstructive sleep apnoea.

Verbraecken J, Hedner J, Penzel T.

Eur Respir Rev. 2017 Jan 3;26(143). pii: 160012. doi: 10.1183/16000617.0012-2016. Print 2017 Jan. Review.


Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep.

Randerath W, Verbraecken J, Andreas S, Arzt M, Bloch KE, Brack T, Buyse B, De Backer W, Eckert DJ, Grote L, Hagmeyer L, Hedner J, Jennum P, La Rovere MT, Miltz C, McNicholas WT, Montserrat J, Naughton M, Pepin JL, Pevernagie D, Sanner B, Testelmans D, Tonia T, Vrijsen B, Wijkstra P, Levy P.

Eur Respir J. 2017 Jan 18;49(1). pii: 1600959. doi: 10.1183/13993003.00959-2016. Print 2017 Jan.


Vascular stiffness determined from a nocturnal digital pulse wave signal: association with sleep, sleep-disordered breathing, and hypertension.

Svedmyr S, Zou D, Sommermeyer D, Ficker JH, Randerath W, Fietze I, Sanner B, Hedner J, Grote L.

J Hypertens. 2016 Dec;34(12):2427-2433.


Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients.

Saaresranta T, Hedner J, Bonsignore MR, Riha RL, McNicholas WT, Penzel T, Anttalainen U, Kvamme JA, Pretl M, Sliwinski P, Verbraecken J, Grote L; ESADA Study Group.

PLoS One. 2016 Oct 4;11(10):e0163439. doi: 10.1371/journal.pone.0163439. eCollection 2016.


Parameters of Overnight Pulse Wave under Treatment in Obstructive Sleep Apnea.

Randerath WJ, Treml M, Priegnitz C, Hedner J, Sommermeyer D, Zou D, Ficker JH, Fietze I, Penzel T, Sanner B, Grote L.

Respiration. 2016;92(3):136-43. doi: 10.1159/000448248. Epub 2016 Aug 31.


A randomised, open-label, crossover study of the dopamine agonist, pramipexole, in patients with sleep bruxism.

Cahlin BJ, Hedner J, Dahlström L.

J Sleep Res. 2017 Feb;26(1):64-72. doi: 10.1111/jsr.12440. Epub 2016 Jul 17.


Vital capacity and COPD: the Swedish CArdioPulmonary bioImage Study (SCAPIS).

Torén K, Olin AC, Lindberg A, Vikgren J, Schiöler L, Brandberg J, Johnsson Å, Engström G, Persson HL, Sköld M, Hedner J, Lindberg E, Malinovschi A, Piitulainen E, Wollmer P, Rosengren A, Janson C, Blomberg A, Bergström G.

Int J Chron Obstruct Pulmon Dis. 2016 May 2;11:927-33. doi: 10.2147/COPD.S104644. eCollection 2016.


Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study.

Marrone O, Battaglia S, Steiropoulos P, Basoglu OK, Kvamme JA, Ryan S, Pepin JL, Verbraecken J, Grote L, Hedner J, Bonsignore MR; ESADA study group.

J Sleep Res. 2016 Dec;25(6):739-745. doi: 10.1111/jsr.12426. Epub 2016 May 18.


Modafinil/armodafinil in obstructive sleep apnoea: a systematic review and meta-analysis.

Chapman JL, Vakulin A, Hedner J, Yee BJ, Marshall NS.

Eur Respir J. 2016 May;47(5):1420-8. doi: 10.1183/13993003.01509-2015. Epub 2016 Feb 4. Review.


Detection of cardiovascular risk from a photoplethysmographic signal using a matching pursuit algorithm.

Sommermeyer D, Zou D, Ficker JH, Randerath W, Fischer C, Penzel T, Sanner B, Hedner J, Grote L.

Med Biol Eng Comput. 2016 Jul;54(7):1111-21. doi: 10.1007/s11517-015-1410-8. Epub 2015 Nov 4.


The diagnostic method has a strong influence on classification of obstructive sleep apnea.

Escourrou P, Grote L, Penzel T, Mcnicholas WT, Verbraecken J, Tkacova R, Riha RL, Hedner J; ESADA Study Group.

J Sleep Res. 2015 Dec;24(6):730-8. doi: 10.1111/jsr.12318. Epub 2015 Aug 14.


Increased Carbonic Anhydrase Activity is Associated with Sleep Apnea Severity and Related Hypoxemia.

Wang T, Eskandari D, Zou D, Grote L, Hedner J.

Sleep. 2015 Jul 1;38(7):1067-73. doi: 10.5665/sleep.4814.


Attention deficits detected in cognitive tests differentiate between sleep apnea patients with or without a motor vehicle accident.

Karimi M, Hedner J, Zou D, Eskandari D, Lundquist AC, Grote L.

Sleep Med. 2015 Apr;16(4):528-33. doi: 10.1016/j.sleep.2014.11.015. Epub 2015 Feb 4.


Sleep apnea-related risk of motor vehicle accidents is reduced by continuous positive airway pressure: Swedish Traffic Accident Registry data.

Karimi M, Hedner J, Häbel H, Nerman O, Grote L.

Sleep. 2015 Mar 1;38(3):341-9. doi: 10.5665/sleep.4486.


Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study.

Tkacova R, McNicholas WT, Javorsky M, Fietze I, Sliwinski P, Parati G, Grote L, Hedner J; European Sleep Apnoea Database study collaborators.

Eur Respir J. 2014 Oct;44(4):931-41. doi: 10.1183/09031936.00225113. Epub 2014 Aug 7.


Driving habits and risk factors for traffic accidents among sleep apnea patients--a European multi-centre cohort study.

Karimi M, Hedner J, Lombardi C, Mcnicholas WT, Penzel T, Riha RL, Rodenstein D, Grote L; Esada Study Group.

J Sleep Res. 2014 Dec;23(6):689-699. doi: 10.1111/jsr.12171. Epub 2014 Jul 7.

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