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Skin platinum deposition in colorectal cancer patients following oxaliplatin-based therapy.

Cao Y, Chang Q, Zhang W, Ornatsky O, Hedley D, Chen EX.

Cancer Chemother Pharmacol. 2019 Sep 13. doi: 10.1007/s00280-019-03956-6. [Epub ahead of print]


A systematic review of screening tools for the detection of autism spectrum disorder in mainland China and surrounding regions.

Wang J, Hedley D, Bury SM, Barbaro J.

Autism. 2019 Aug 20:1362361319871174. doi: 10.1177/1362361319871174. [Epub ahead of print]


Brief Report: Replication and Validation of the Brief Autism Detection in Early Childhood (BADEC) in a Clinical Sample.

Nevill RE, Hedley D, Uljarević M.

J Autism Dev Disord. 2019 Aug 1. doi: 10.1007/s10803-019-04153-3. [Epub ahead of print]


MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides To Enable Labeling with 99mTc(I) Tricarbonyl Complex.

Ku A, Chan C, Aghevlian S, Cai Z, Cescon D, Bratman SV, Ailles L, Hedley DW, Reilly RM.

Mol Pharm. 2019 Aug 5;16(8):3559-3568. doi: 10.1021/acs.molpharmaceut.9b00422. Epub 2019 Jul 11.


Anxiety and Depression from Adolescence to Old Age in Autism Spectrum Disorder.

Uljarević M, Hedley D, Rose-Foley K, Magiati I, Cai RY, Dissanayake C, Richdale A, Trollor J.

J Autism Dev Disord. 2019 Jun 12. doi: 10.1007/s10803-019-04084-z. [Epub ahead of print]


Heart rate increase predicts challenging behavior episodes in preschoolers with autism.

Nuske HJ, Finkel E, Hedley D, Parma V, Tomczuk L, Pellecchia M, Herrington J, Marcus SC, Mandell DS, Dissanayake C.

Stress. 2019 May;22(3):303-311. doi: 10.1080/10253890.2019.1572744. Epub 2019 Mar 1.


Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.

Connor AA, Denroche RE, Jang GH, Lemire M, Zhang A, Chan-Seng-Yue M, Wilson G, Grant RC, Merico D, Lungu I, Bartlett JMS, Chadwick D, Liang SB, Eagles J, Mbabaali F, Miller JK, Krzyzanowski P, Armstrong H, Luo X, Jorgensen LGT, Romero JM, Bavi P, Fischer SE, Serra S, Hafezi-Bakhtiari S, Caglar D, Roehrl MHA, Cleary S, Hollingsworth MA, Petersen GM, Thayer S, Law CHL, Nanji S, Golan T, Smith AL, Borgida A, Dodd A, Hedley D, Wouters BG, O'Kane GM, Wilson JM, Zogopoulos G, Notta F, Knox JJ, Gallinger S.

Cancer Cell. 2019 Feb 11;35(2):267-282.e7. doi: 10.1016/j.ccell.2018.12.010. Epub 2019 Jan 24.


Predictors of mental health and well-being in employed adults with autism spectrum disorder at 12-month follow-up.

Hedley D, Uljarević M, Bury SM, Dissanayake C.

Autism Res. 2019 Mar;12(3):482-494. doi: 10.1002/aur.2064. Epub 2019 Jan 24.


Mobilization of Leukemic Cells Using Plerixafor as Part of a Myeloablative Preparative Regimen for Patients with Acute Myelogenous Leukemia Undergoing Allografting: Assessment of Safety and Tolerability.

Michelis FV, Hedley DW, Malhotra S, Chow S, Loach D, Gupta V, Kim DD, Kuruvilla J, Lipton JH, Viswabandya A, Messner HA.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1158-1163. doi: 10.1016/j.bbmt.2019.01.014. Epub 2019 Jan 14.


Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer.

Gendoo DMA, Denroche RE, Zhang A, Radulovich N, Jang GH, Lemire M, Fischer S, Chadwick D, Lungu IM, Ibrahimov E, Cao PJ, Stein LD, Wilson JM, Bartlett JMS, Tsao MS, Dhani N, Hedley D, Gallinger S, Haibe-Kains B.

PLoS Comput Biol. 2019 Jan 10;15(1):e1006596. doi: 10.1371/journal.pcbi.1006596. eCollection 2019 Jan.


Radioimmunotherapy of PANC-1 Human Pancreatic Cancer Xenografts in NRG Mice with Panitumumab Modified with Metal-Chelating Polymers Complexed to 177Lu.

Aghevlian S, Cai Z, Lu Y, Hedley DW, Winnik MA, Reilly RM.

Mol Pharm. 2019 Feb 4;16(2):768-778. doi: 10.1021/acs.molpharmaceut.8b01040. Epub 2019 Jan 10.


If you've employed one person with autism …: An individual difference approach to the autism advantage at work.

Bury SM, Hedley D, Uljarević M, Dissanayake C, Gal E.

Autism. 2019 Aug;23(6):1607-1608. doi: 10.1177/1362361318794937. Epub 2018 Aug 22.


Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients.

Cao Y, Chang Q, Cabanero M, Zhang W, Hafezi-Bakhtiari S, Hedley D, Darling G, Quereshy F, Jang R, Elimova E, Knox J, Ornatsky O, Serra S, Chen E.

J Gastrointest Cancer. 2018 Aug 16. doi: 10.1007/s12029-018-0153-9. [Epub ahead of print]


The ongoing challenge of large anal cancers: prospective long term outcomes of intensity-modulated radiation therapy with concurrent chemotherapy.

Hosni A, Han K, Le LW, Ringash J, Brierley J, Wong R, Dinniwell R, Brade A, Dawson LA, Cummings BJ, Krzyzanowska MK, Chen EX, Hedley D, Knox J, Easson AM, Lindsay P, Craig T, Kim J.

Oncotarget. 2018 Apr 17;9(29):20439-20450. doi: 10.18632/oncotarget.24926. eCollection 2018 Apr 17.


Risk and protective factors underlying depression and suicidal ideation in Autism Spectrum Disorder.

Hedley D, Uljarević M, Foley KR, Richdale A, Trollor J.

Depress Anxiety. 2018 Jul;35(7):648-657. doi: 10.1002/da.22759. Epub 2018 Apr 16.


Brief report: Poor self-regulation as a predictor of individual differences in adaptive functioning in young children with autism spectrum disorder.

Uljarević M, Hedley D, Nevill R, Evans DW, Cai RY, Butter E, Mulick JA.

Autism Res. 2018 Aug;11(8):1157-1165. doi: 10.1002/aur.1953. Epub 2018 Apr 6.


Comparison of Practice Guidelines, BRCAPRO, and Genetic Counselor Estimates to Identify Germline BRCA1 and BRCA2 Mutations in Pancreatic Cancer.

Grant RC, Holter S, Borgida A, Dhani NC, Hedley DW, Knox JJ, Akbari MR, Zogopoulos G, Gallinger S.

J Genet Couns. 2018 Aug;27(4):988-995. doi: 10.1007/s10897-018-0212-1. Epub 2018 Feb 13.


Panitumumab Modified with Metal-Chelating Polymers (MCP) Complexed to 111In and 177Lu-An EGFR-Targeted Theranostic for Pancreatic Cancer.

Aghevlian S, Lu Y, Winnik MA, Hedley DW, Reilly RM.

Mol Pharm. 2018 Mar 5;15(3):1150-1159. doi: 10.1021/acs.molpharmaceut.7b01000. Epub 2018 Jan 30.


Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

Aung KL, Fischer SE, Denroche RE, Jang GH, Dodd A, Creighton S, Southwood B, Liang SB, Chadwick D, Zhang A, O'Kane GM, Albaba H, Moura S, Grant RC, Miller JK, Mbabaali F, Pasternack D, Lungu IM, Bartlett JMS, Ghai S, Lemire M, Holter S, Connor AA, Moffitt RA, Yeh JJ, Timms L, Krzyzanowski PM, Dhani N, Hedley D, Notta F, Wilson JM, Moore MJ, Gallinger S, Knox JJ.

Clin Cancer Res. 2018 Mar 15;24(6):1344-1354. doi: 10.1158/1078-0432.CCR-17-2994. Epub 2017 Dec 29.


Impact of tissue transport on PET hypoxia quantification in pancreatic tumours.

Taylor E, Gottwald J, Yeung I, Keller H, Milosevic M, Dhani NC, Siddiqui I, Hedley DW, Jaffray DA.

EJNMMI Res. 2017 Dec 22;7(1):101. doi: 10.1186/s13550-017-0347-3.


Emotion Regulation Strategies in Preschoolers with Autism: Associations with Parent Quality of Life and Family Functioning.

Nuske HJ, Hedley D, Tseng CH, Begeer S, Dissanayake C.

J Autism Dev Disord. 2018 Apr;48(4):1287-1300. doi: 10.1007/s10803-017-3391-y.


Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.

Chiu JW, Krzyzanowska MK, Serra S, Knox JJ, Dhani NC, Mackay H, Hedley D, Moore M, Liu G, Burkes RL, Brezden-Masley C, Roehrl MH, Craddock KJ, Tsao MS, Zhang T, Yu C, Kamel-Reid S, Siu LL, Bedard PL, Chen EX.

Clin Colorectal Cancer. 2018 Mar;17(1):73-79. doi: 10.1016/j.clcc.2017.10.010. Epub 2017 Oct 23.


Language profiles in young children with autism spectrum disorder: A community sample using multiple assessment instruments.

Nevill R, Hedley D, Uljarević M, Sahin E, Zadek J, Butter E, Mulick JA.

Autism. 2019 Jan;23(1):141-153. doi: 10.1177/1362361317726245. Epub 2017 Nov 10.


Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.


Staining of Frozen and Formalin-Fixed, Paraffin-Embedded Tissues with Metal-Labeled Antibodies for Imaging Mass Cytometry Analysis.

Chang Q, Ornatsky O, Hedley D.

Curr Protoc Cytom. 2017 Oct 2;82:12.47.1-12.47.8. doi: 10.1002/cpcy.29.


The Hospital Anxiety and Depression scale: Factor structure and psychometric properties in older adolescents and young adults with autism spectrum disorder.

Uljarević M, Richdale AL, McConachie H, Hedley D, Cai RY, Merrick H, Parr JR, Le Couteur A.

Autism Res. 2018 Feb;11(2):258-269. doi: 10.1002/aur.1872. Epub 2017 Sep 18.


Brief Report: Social Support, Depression and Suicidal Ideation in Adults with Autism Spectrum Disorder.

Hedley D, Uljarević M, Wilmot M, Richdale A, Dissanayake C.

J Autism Dev Disord. 2017 Nov;47(11):3669-3677. doi: 10.1007/s10803-017-3274-2.


Developmental delays in emotion regulation strategies in preschoolers with autism.

Nuske HJ, Hedley D, Woollacott A, Thomson P, Macari S, Dissanayake C.

Autism Res. 2017 Nov;10(11):1808-1822. doi: 10.1002/aur.1827. Epub 2017 Jul 11.


Long term responders to palliative chemotherapy for advanced biliary tract cancer.

Doherty MK, McNamara MG, Aneja P, McInerney E, Moignard S, Horgan AM, Jiang H, Panzarella T, Jang R, Dhani N, Hedley D, Knox JJ.

J Gastrointest Oncol. 2017 Apr;8(2):352-360. doi: 10.21037/jgo.2017.03.06.


Mechanical CPR in a child: can one size fit all?

Sugarman L, Hedley D, Crowe S.

BMJ Case Rep. 2017 Apr 24;2017. pii: bcr-2017-219728. doi: 10.1136/bcr-2017-219728.


Transition to work: Perspectives from the autism spectrum.

Hedley D, Cai R, Uljarevic M, Wilmot M, Spoor JR, Richdale A, Dissanayake C.

Autism. 2018 Jul;22(5):528-541. doi: 10.1177/1362361316687697. Epub 2017 Apr 7.


Relationship between early motor milestones and severity of restricted and repetitive behaviors in children and adolescents with autism spectrum disorder.

Uljarević M, Hedley D, Alvares GA, Varcin KJ, Whitehouse AJO.

Autism Res. 2017 Jun;10(6):1163-1168. doi: 10.1002/aur.1763. Epub 2017 Mar 16.


Heterogeneity of sensory features in autism spectrum disorder: Challenges and perspectives for future research.

Uljarević M, Baranek G, Vivanti G, Hedley D, Hudry K, Lane A.

Autism Res. 2017 May;10(5):703-710. doi: 10.1002/aur.1747. Epub 2017 Mar 7.


Imaging Mass Cytometry.

Chang Q, Ornatsky OI, Siddiqui I, Loboda A, Baranov VI, Hedley DW.

Cytometry A. 2017 Feb;91(2):160-169. doi: 10.1002/cyto.a.23053. Epub 2017 Feb 3.


Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts.

Lohse I, Kumareswaran R, Cao P, Pitcher B, Gallinger S, Bristow RG, Hedley DW.

PLoS One. 2016 Dec 29;11(12):e0167272. doi: 10.1371/journal.pone.0167272. eCollection 2016.


Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts.

Lohse I, Mason J, Cao PM, Pintilie M, Bray M, Hedley DW.

Oncotarget. 2017 Jan 10;8(2):3064-3071. doi: 10.18632/oncotarget.13619.


Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts.

Marie-Egyptienne DT, Chaudary N, Kalliomäki T, Hedley DW, Hill RP.

Oncotarget. 2017 Jan 3;8(1):1392-1404. doi: 10.18632/oncotarget.13625.


Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Chaudary N, Pintilie M, Hedley D, Hill RP, Milosevic M, Mackay H.

Br J Cancer. 2017 Jan 3;116(1):50-57. doi: 10.1038/bjc.2016.383. Epub 2016 Nov 22.


Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues.

Chang Q, Ornatsky OI, Siddiqui I, Straus R, Baranov VI, Hedley DW.

Sci Rep. 2016 Nov 4;6:36641. doi: 10.1038/srep36641.


Quantifying hypoxia in human cancers using static PET imaging.

Taylor E, Yeung I, Keller H, Wouters BG, Milosevic M, Hedley DW, Jaffray DA.

Phys Med Biol. 2016 Nov 21;61(22):7957-7974. Epub 2016 Oct 25.


Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.

Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, Palmer D, Ghaneh P, Neoptolemos JP, Buchler M, Petersen G, Thayer S, Hollingsworth MA, Sherker A, Durocher D, Dhani N, Hedley D, Serra S, Pollett A, Roehrl MHA, Bavi P, Bartlett JMS, Cleary S, Wilson JM, Alexandrov LB, Moore M, Wouters BG, McPherson JD, Notta F, Stein LD, Gallinger S.

JAMA Oncol. 2017 Jun 1;3(6):774-783. doi: 10.1001/jamaoncol.2016.3916.


Phase 1/2 Study of the Addition of Cisplatin to Adjuvant Chemotherapy With Image Guided High-Precision Radiation Therapy for Completely Resected Gastric Cancer.

Goody RB, MacKay H, Pitcher B, Oza A, Siu LL, Kim J, Wong RK, Chen E, Swallow C, Knox J, Kassam Z, Cummings B, Feld R, Hedley D, Liu G, Krzyzanowska MK, Dinniwell R, Brade AM, Dawson LA, Pintilie M, Ringash J.

Int J Radiat Oncol Biol Phys. 2016 Dec 1;96(5):994-1002. doi: 10.1016/j.ijrobp.2016.08.034. Epub 2016 Aug 31.


Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.

Edgar LJ, Vellanki RN, McKee TD, Hedley D, Wouters BG, Nitz M.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13159-13163. doi: 10.1002/anie.201607483.


Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.

MacLaughlin CM, Ding L, Jin C, Cao P, Siddiqui I, Hwang DM, Chen J, Wilson BC, Zheng G, Hedley DW.

J Biomed Opt. 2016 Aug 1;21(8):84002. doi: 10.1117/1.JBO.21.8.084002.


Employment programmes and interventions targeting adults with autism spectrum disorder: A systematic review of the literature.

Hedley D, Uljarević M, Cameron L, Halder S, Richdale A, Dissanayake C.

Autism. 2017 Nov;21(8):929-941. doi: 10.1177/1362361316661855. Epub 2016 Aug 18. Review.


Novel regulatory role of neuropilin-1 in endothelial-to-mesenchymal transition and fibrosis in pancreatic ductal adenocarcinoma.

Matkar PN, Singh KK, Rudenko D, Kim YJ, Kuliszewski MA, Prud'homme GJ, Hedley DW, Leong-Poi H.

Oncotarget. 2016 Oct 25;7(43):69489-69506. doi: 10.18632/oncotarget.11060.


FOLFIRINOX for advanced pancreatic cancer: the Princess Margaret Cancer Centre experience.

Chllamma MK, Cook N, Dhani NC, Giby K, Dodd A, Wang L, Hedley DW, Moore MJ, Knox JJ.

Br J Cancer. 2016 Sep 6;115(6):649-54. doi: 10.1038/bjc.2016.222. Epub 2016 Jul 28.


A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer.

Renouf DJ, Hedley D, Krzyzanowska MK, Schmuck M, Wang L, Moore MJ.

Cancer Chemother Pharmacol. 2016 Sep;78(3):541-5. doi: 10.1007/s00280-016-3102-y. Epub 2016 Jul 15.


A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia.

Yee KW, Chen HW, Hedley DW, Chow S, Brandwein J, Schuh AC, Schimmer AD, Gupta V, Sanfelice D, Johnson T, Le LW, Arnott J, Bray MR, Sidor C, Minden MD.

Invest New Drugs. 2016 Oct;34(5):614-24. doi: 10.1007/s10637-016-0375-2. Epub 2016 Jul 12.


Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302.

Lohse I, Rasowski J, Cao P, Pintilie M, Do T, Tsao MS, Hill RP, Hedley DW.

Oncotarget. 2016 Jun 7;7(23):33571-80. doi: 10.18632/oncotarget.9654.

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