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Items: 1 to 50 of 311

1.

Repression of the Type I Interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in Pancreatic Ductal Adenocarcinoma.

Muthalagu N, Monteverde T, Raffo-Iraolagoitia X, Wiesheu R, Whyte D, Hedley A, Laing S, Kruspig B, Upstill-Goddard R, Shaw R, Neidler S, Rink C, Karim SA, Gyuraszova K, Nixon C, Clark W, Biankin AV, Carlin LM, Coffelt SB, Sansom OJ, Morton JP, Murphy DJ.

Cancer Discov. 2020 Mar 21. pii: CD-19-0620. doi: 10.1158/2159-8290.CD-19-0620. [Epub ahead of print]

2.

RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome.

Rooney N, Mason SM, McDonald L, Däbritz JHM, Campbell KJ, Hedley A, Howard S, Athineos D, Nixon C, Clark W, Leach JDG, Sansom OJ, Edwards J, Cameron ER, Blyth K.

Cancer Res. 2020 Mar 10. pii: canres.3870.2019. doi: 10.1158/0008-5472.CAN-19-3870. [Epub ahead of print]

3.

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT.

Br J Cancer. 2020 Mar;122(6):868-884. doi: 10.1038/s41416-019-0711-3. Epub 2020 Jan 16.

4.

Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.

Loveridge CJ, Slater S, Campbell KJ, Nam NA, Knight J, Ahmad I, Hedley A, Lilla S, Repiscak P, Patel R, Salji M, Fleming J, Mitchell L, Nixon C, Strathdee D, Neilson M, Ntala C, Bryson S, Zanivan S, Edwards J, Robson CN, Goodyear CS, Blyth K, Leung HY.

Oncogene. 2020 Mar;39(11):2450. doi: 10.1038/s41388-019-1149-z.

PMID:
31857667
5.

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration.

Loveridge CJ, Slater S, Campbell KJ, Nam NA, Knight J, Ahmad I, Hedley A, Lilla S, Repiscak P, Patel R, Salji M, Fleming J, Mitchell L, Nixon C, Strathdee D, Neilson M, Ntala C, Bryson S, Zanivan S, Edwards J, Robson CN, Goodyear CS, Blyth K, Leung HY.

Oncogene. 2020 Feb;39(8):1797-1806. doi: 10.1038/s41388-019-1106-x. Epub 2019 Nov 18. Erratum in: Oncogene. 2019 Dec 19;:.

6.

Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.

Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge CJ, Rushworth LK, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom OJ, Leung HY.

Cancer Res. 2020 Feb 1;80(3):576-590. doi: 10.1158/0008-5472.CAN-19-1684. Epub 2019 Nov 12.

7.

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.

Jackstadt R, van Hooff SR, Leach JD, Cortes-Lavaud X, Lohuis JO, Ridgway RA, Wouters VM, Roper J, Kendall TJ, Roxburgh CS, Horgan PG, Nixon C, Nourse C, Gunzer M, Clark W, Hedley A, Yilmaz OH, Rashid M, Bailey P, Biankin AV, Campbell AD, Adams DJ, Barry ST, Steele CW, Medema JP, Sansom OJ.

Cancer Cell. 2019 Sep 16;36(3):319-336.e7. doi: 10.1016/j.ccell.2019.08.003.

8.

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization.

Rudzka DA, Spennati G, McGarry DJ, Chim YH, Neilson M, Ptak A, Munro J, Kalna G, Hedley A, Moralli D, Green C, Mason S, Blyth K, Mullin M, Yin H, Olson MF.

J Cell Sci. 2019 May 31;132(11). pii: jcs224071. doi: 10.1242/jcs.224071.

9.

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Neidler S, Kruspig B, Hewit K, Monteverde T, Gyuraszova K, Braun A, Clark W, James D, Hedley A, Nieswandt B, Shanks E, Dick C, Murphy DJ.

Cancers (Basel). 2019 Apr 29;11(5). pii: E600. doi: 10.3390/cancers11050600.

10.

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Gay DM, Ridgway RA, Müller M, Hodder MC, Hedley A, Clark W, Leach JD, Jackstadt R, Nixon C, Huels DJ, Campbell AD, Bird TG, Sansom OJ.

Nat Commun. 2019 Mar 26;10(1):1453. doi: 10.1038/s41467-019-09465-7.

11.

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

Gay DM, Ridgway RA, Müller M, Hodder MC, Hedley A, Clark W, Leach JD, Jackstadt R, Nixon C, Huels DJ, Campbell AD, Bird TG, Sansom OJ.

Nat Commun. 2019 Feb 13;10(1):723. doi: 10.1038/s41467-019-08586-3. Erratum in: Nat Commun. 2019 Mar 26;10(1):1453.

12.

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.

13.

Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells.

Carruthers RD, Ahmed SU, Ramachandran S, Strathdee K, Kurian KM, Hedley A, Gomez-Roman N, Kalna G, Neilson M, Gilmour L, Stevenson KH, Hammond EM, Chalmers AJ.

Cancer Res. 2018 Sep 1;78(17):5060-5071. doi: 10.1158/0008-5472.CAN-18-0569. Epub 2018 Jul 5.

14.

The ERBB network facilitates KRAS-driven lung tumorigenesis.

Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden KH, Martins CP, Murphy DJ.

Sci Transl Med. 2018 Jun 20;10(446). pii: eaao2565. doi: 10.1126/scitranslmed.aao2565. Erratum in: Sci Transl Med. 2018 Nov 21;10(468):.

15.

Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.

Patel R, Fleming J, Mui E, Loveridge C, Repiscak P, Blomme A, Harle V, Salji M, Ahmad I, Teo K, Hamdy FC, Hedley A, van den Broek N, Mackay G, Edwards J, Sansom OJ, Leung HY.

EMBO Mol Med. 2018 Apr;10(4). pii: e8347. doi: 10.15252/emmm.201708347.

16.

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.

Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ.

Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2.

17.

Transcriptomic profiling of human breast and melanoma cells selected by migration through narrow constraints.

Rudzka DA, Clark W, Hedley A, Kalna G, Olson MF.

Sci Data. 2017 Nov 14;4:170172. doi: 10.1038/sdata.2017.172.

18.

Calcium signalling links MYC to NUAK1.

Monteverde T, Tait-Mulder J, Hedley A, Knight JR, Sansom OJ, Murphy DJ.

Oncogene. 2018 Feb 22;37(8):982-992. doi: 10.1038/onc.2017.394. Epub 2017 Nov 6.

19.

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis.

Cammareri P, Vincent DF, Hodder MC, Ridgway RA, Murgia C, Nobis M, Campbell AD, Varga J, Huels DJ, Subramani C, Prescott KLH, Nixon C, Hedley A, Barry ST, Greten FR, Inman GJ, Sansom OJ.

Cell Death Differ. 2017 Oct;24(10):1681-1693. doi: 10.1038/cdd.2017.92. Epub 2017 Jun 16.

20.

Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM.

Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.

21.

Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.

Loveridge CJ, Mui EJ, Patel R, Tan EH, Ahmad I, Welsh M, Galbraith J, Hedley A, Nixon C, Blyth K, Sansom O, Leung HY.

Cancer Res. 2017 Jun 15;77(12):3158-3168. doi: 10.1158/0008-5472.CAN-16-2565. Epub 2017 May 17.

22.

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.

23.

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8290-5. doi: 10.1073/pnas.1601571113. Epub 2016 Jun 29.

24.

Minimum 5-Year Results With Duracon Press-Fit Metal-Backed Patellae.

Hedley AK.

Am J Orthop (Belle Mead NJ). 2016 Feb;45(2):61-5.

PMID:
26866314
25.

The smoke-free legislation in Hong Kong: its impact on mortality.

Thach TQ, McGhee SM, So JC, Chau J, Chan EK, Wong CM, Hedley AJ.

Tob Control. 2016 Nov;25(6):685-691. doi: 10.1136/tobaccocontrol-2015-052496. Epub 2015 Nov 19.

PMID:
26585706
26.

E-cadherin can limit the transforming properties of activating β-catenin mutations.

Huels DJ, Ridgway RA, Radulescu S, Leushacke M, Campbell AD, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed KR, Meniel VS, Maguire A, Doyle B, Söderberg O, Barker N, Watson A, Larue L, Clarke AR, Sansom OJ.

EMBO J. 2015 Sep 14;34(18):2321-33. doi: 10.15252/embj.201591739. Epub 2015 Aug 3.

27.

Satellite-Based Estimates of Long-Term Exposure to Fine Particles and Association with Mortality in Elderly Hong Kong Residents.

Wong CM, Lai HK, Tsang H, Thach TQ, Thomas GN, Lam KB, Chan KP, Yang L, Lau AK, Ayres JG, Lee SY, Chan WM, Hedley AJ, Lam TH.

Environ Health Perspect. 2015 Nov;123(11):1167-72. doi: 10.1289/ehp.1408264. Epub 2015 Apr 24.

28.

Fumarate induces redox-dependent senescence by modifying glutathione metabolism.

Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E.

Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001.

29.

Did the tobacco industry inflate estimates of illicit cigarette consumption in Asia? An empirical analysis.

Chen J, McGhee SM, Townsend J, Lam TH, Hedley AJ.

Tob Control. 2015 Jun;24(e2):e161-7. doi: 10.1136/tobaccocontrol-2014-051937. Epub 2015 Jan 6.

30.

Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.

Rajan P, Stockley J, Sudbery IM, Fleming JT, Hedley A, Kalna G, Sims D, Ponting CP, Heger A, Robson CN, McMenemin RM, Pedley ID, Leung HY.

BMC Cancer. 2014 Dec 18;14:977. doi: 10.1186/1471-2407-14-977.

31.

Health of catering workers in Hong Kong: impact of the 2006 tobacco control legislation.

Hedley AJ, McGhee SM, Fielding R, Repace JL, Wong CM, Lu SQ, Ho AL, Lai HK, Wong LC, Chen J.

Hong Kong Med J. 2014 Jun;20(3 Suppl 3):42-6. No abstract available.

32.

Smoke-free policies on population health outcomes.

McGhee SM, Wong CM, Schooling CM, Thomas GN, Hedley AJ, Chau J, So J, Chan E, Wong LC, Thach TQ.

Hong Kong Med J. 2014 Jun;20(3 Suppl 3):36-41. No abstract available.

33.

The incidental findings of age-related macular degeneration during diabetic retinopathy screening.

Gangwani R, Lai WW, Sum R, McGhee SM, Chan CW, Hedley AJ, Wong D.

Graefes Arch Clin Exp Ophthalmol. 2014 May;252(5):723-9. doi: 10.1007/s00417-013-2530-1. Epub 2013 Nov 27.

PMID:
24281784
34.

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

Zheng L, MacKenzie ED, Karim SA, Hedley A, Blyth K, Kalna G, Watson DG, Szlosarek P, Frezza C, Gottlieb E.

Cancer Metab. 2013 Mar 21;1(1):12. doi: 10.1186/2049-3002-1-12.

35.

A randomized controlled trial of two different lengths of nicotine replacement therapy for smoking cessation.

Abdullah AS, Hedley AJ, Chan SS, Lam TH.

Biomed Res Int. 2013;2013:961751. doi: 10.1155/2013/961751. Epub 2013 Sep 9.

36.

A method to derive the relationship between the annual and short-term air quality limits--analysis using the WHO Air Quality Guidelines for health protection.

Lai HK, Hedley AJ, Thach TQ, Wong CM.

Environ Int. 2013 Sep;59:86-91. doi: 10.1016/j.envint.2013.05.013. Epub 2013 Jun 19.

37.

Thermal stress associated mortality risk and effect modification by sex and obesity in an elderly cohort of Chinese in Hong Kong.

Xu W, Thach TQ, Chau YK, Lai HK, Lam TH, Chan WM, Lee RS, Hedley AJ, Wong CM.

Environ Pollut. 2013 Jul;178:288-93. doi: 10.1016/j.envpol.2013.03.020. Epub 2013 Apr 13.

38.

Screening for diabetic retinopathy with or without a copayment in a randomized controlled trial: influence of the inverse care law.

Lian JX, McGhee SM, Gangwani RA, Hedley AJ, Lam CL, Yap MK, Lai WW, Chu DW, Wong DS.

Ophthalmology. 2013 Jun;120(6):1247-53. doi: 10.1016/j.ophtha.2012.11.024. Epub 2013 Apr 12.

PMID:
23583166
39.

Impact of the 1990 Hong Kong legislation for restriction on sulfur content in fuel.

Wong CM, Rabl A, Thach TQ, Chau YK, Chan KP, Cowling BJ, Lai HK, Lam TH, McGhee SM, Anderson HR, Hedley AJ.

Res Rep Health Eff Inst. 2012 Aug;(170):5-91.

PMID:
23316618
40.

Health impact assessment of marine emissions in Pearl River Delta region.

Lai HK, Tsang H, Chau J, Lee CH, McGhee SM, Hedley AJ, Wong CM.

Mar Pollut Bull. 2013 Jan 15;66(1-2):158-63. doi: 10.1016/j.marpolbul.2012.09.029. Epub 2012 Nov 21.

PMID:
23177239
41.

Smoking reduction intervention for smokers not willing to quit smoking: a randomised controlled trial.

Lam TH, Chan SS, Abdullah AS, Wong VT, Chan AY, Hedley AJ.

Hong Kong Med J. 2012 Aug;18 Suppl 3:4-8. No abstract available.

42.

Effect of influenza on cardiorespiratory and all-cause mortality in Hong Kong, Singapore and Guangzhou.

Wong CM, Peiris JS, Yang L, Chan KP, Thach TQ, Lai HK, Lim WW, Hedley AJ, He J, Chen P, Ou C, Deng A, Zhang X, Zhou D, Ma S, Chow A.

Hong Kong Med J. 2012 Feb;18 Suppl 2:8-11.

43.

Influenza associated mortality in the subtropics and tropics: results from three Asian cities.

Yang L, Ma S, Chen PY, He JF, Chan KP, Chow A, Ou CQ, Deng AP, Hedley AJ, Wong CM, Peiris JS.

Vaccine. 2011 Nov 8;29(48):8909-14. doi: 10.1016/j.vaccine.2011.09.071. Epub 2011 Sep 28.

44.

How does socioeconomic development affect COPD mortality? An age-period-cohort analysis from a recently transitioned population in China.

Chen J, Schooling CM, Johnston JM, Hedley AJ, McGhee SM.

PLoS One. 2011;6(9):e24348. doi: 10.1371/journal.pone.0024348. Epub 2011 Sep 15.

45.

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E.

Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363.

PMID:
21849978
46.

Magnitude of cement-device interfacial stresses with and without tibial stemming: impact of BMI.

Gopalakrishnan A, Hedley AK, Kester MA.

J Knee Surg. 2011 Mar;24(1):3-8.

PMID:
21618932
47.

Lung function and exposure to workplace second-hand smoke during exemptions from smoking ban legislation: an exposure-response relationship based on indoor PM2.5 and urinary cotinine levels.

Lai HK, Hedley AJ, Repace J, So C, Lu QY, McGhee SM, Fielding R, Wong CM.

Thorax. 2011 Jul;66(7):615-23. doi: 10.1136/thx.2011.160291. Epub 2011 May 6.

PMID:
21551212
48.

Part 5. Public health and air pollution in Asia (PAPA): a combined analysis of four studies of air pollution and mortality.

Wong CM, Vichit-Vadakan N, Vajanapoom N, Ostro B, Thach TQ, Chau PY, Chan EK, Chung RY, Ou CQ, Yang L, Peiris JS, Thomas GN, Lam TH, Wong TW, Hedley AJ, Kan H, Chen B, Zhao N, London SJ, Song G, Chen G, Zhang Y, Jiang L, Qian Z, He Q, Lin HM, Kong L, Zhou D, Liang S, Zhu Z, Liao D, Liu W, Bentley CM, Dan J, Wang B, Yang N, Xu S, Gong J, Wei H, Sun H, Qin Z; HEI Health Review Committee.

Res Rep Health Eff Inst. 2010 Nov;(154):377-418.

PMID:
21446215
49.

Part 4. Interaction between air pollution and respiratory viruses: time-series study of daily mortality and hospital admissions in Hong Kong.

Wong CM, Thach TQ, Chau PY, Chan EK, Chung RY, Ou CQ, Yang L, Peiris JS, Thomas GN, Lam TH, Wong TW, Hedley AJ; HEI Health Review Committee.

Res Rep Health Eff Inst. 2010 Nov;(154):283-362.

PMID:
21446214
50.

Secondhand smoke (SHS) exposures: workplace exposures, related perceptions of SHS risk, and reactions to smoking in catering workers in smoking and nonsmoking premises.

Lu SQ, Fielding R, Hedley AJ, Wong LC, Lai HK, Wong CM, Repace JL, McGhee SM.

Nicotine Tob Res. 2011 May;13(5):344-52. doi: 10.1093/ntr/ntr001. Epub 2011 Mar 23.

PMID:
21430065

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