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Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults.

Rabin JS, Perea RD, Buckley RF, Johnson KA, Sperling RA, Hedden T.

Neurobiol Aging. 2019 May 16;81:38-46. doi: 10.1016/j.neurobiolaging.2019.05.005. [Epub ahead of print]


Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study.

Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall GA, Chhatwal JP, Rentz DM, Sperling RA, Johnson K.

JAMA Neurol. 2019 Jun 3. doi: 10.1001/jamaneurol.2019.1424. [Epub ahead of print]


An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.

Yang HS, Chhatwal JP, Xu J, White CC, Hanseeuw B, Rabin JS, Papp KV, Buckley RF, Schultz AP, Properzi MJ, Gatchel JR, Amariglio RE, Donovan NJ, Mormino EC, Hedden T, Marshall GA, Rentz DM, Johnson KA, De Jager PL, Sperling RA.

J Alzheimers Dis. 2019;68(3):1161-1170. doi: 10.3233/JAD-180788.


Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults.

Buckley RF, Mormino EC, Rabin JS, Hohman TJ, Landau S, Hanseeuw BJ, Jacobs HIL, Papp KV, Amariglio RE, Properzi MJ, Schultz AP, Kirn D, Scott MR, Hedden T, Farrell M, Price J, Chhatwal J, Rentz DM, Villemagne VL, Johnson KA, Sperling RA.

JAMA Neurol. 2019 Feb 4. doi: 10.1001/jamaneurol.2018.4693. [Epub ahead of print]


Vascular Risk and β-Amyloid Are Synergistically Associated with Cortical Tau.

Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

Ann Neurol. 2019 Feb;85(2):272-279. doi: 10.1002/ana.25399. Epub 2019 Jan 7.


The impact of amyloid-beta and tau on prospective cognitive decline in older individuals.

Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, Rabin JS, Jacobs H, Yang HS, Properzi M, Kirn DR, Rentz DM, Johnson KA.

Ann Neurol. 2019 Feb;85(2):181-193. doi: 10.1002/ana.25395. Epub 2019 Jan 21.


Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA.

J Neurosci. 2019 Jan 16;39(3):548-556. doi: 10.1523/JNEUROSCI.1397-18.2018. Epub 2018 Nov 27.


The Lifespan Human Connectome Project in Aging: An overview.

Bookheimer SY, Salat DH, Terpstra M, Ances BM, Barch DM, Buckner RL, Burgess GC, Curtiss SW, Diaz-Santos M, Elam JS, Fischl B, Greve DN, Hagy HA, Harms MP, Hatch OM, Hedden T, Hodge C, Japardi KC, Kuhn TP, Ly TK, Smith SM, Somerville LH, Uğurbil K, van der Kouwe A, Van Essen D, Woods RP, Yacoub E.

Neuroimage. 2019 Jan 15;185:335-348. doi: 10.1016/j.neuroimage.2018.10.009. Epub 2018 Oct 15.


Dedifferentiation of caudate functional connectivity and striatal dopamine transporter density predict memory change in normal aging.

Rieckmann A, Johnson KA, Sperling RA, Buckner RL, Hedden T.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10160-10165. doi: 10.1073/pnas.1804641115. Epub 2018 Sep 17.


Anticholinergic Amnesia is Mediated by Alterations in Human Network Connectivity Architecture.

Chhatwal JP, Schultz AP, Hedden T, Boot BP, Wigman S, Rentz D, Johnson KA, Sperling RA.

Cereb Cortex. 2018 Sep 6. doi: 10.1093/cercor/bhy214. [Epub ahead of print]


Connectome-derived diffusion characteristics of the fornix in Alzheimer's disease.

Perea RD, Rabin JS, Fujiyoshi MG, Neal TE, Smith EE, Van Dijk KRA, Hedden T.

Neuroimage Clin. 2018 Apr 27;19:331-342. doi: 10.1016/j.nicl.2018.04.029. eCollection 2018.


Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts.

Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, Maruff P, Donohue MC, Rentz DM, Kirn D, Hedden T, Chhatwal J, Schultz AP, Johnson KA, Villemagne VL, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging, Biomarker and Lifestyle study of ageing; Harvard Aging Brain Study.

Alzheimers Dement. 2018 Sep;14(9):1193-1203. doi: 10.1016/j.jalz.2018.04.010. Epub 2018 May 24.


Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study.

Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

JAMA Neurol. 2018 Sep 1;75(9):1124-1131. doi: 10.1001/jamaneurol.2018.1123.


The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults.

Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV.

Alzheimers Dement (Amst). 2017 Nov 23;10:121-129. doi: 10.1016/j.dadm.2017.11.003. eCollection 2018.


Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.

Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C Jr, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, Laske C, Koeppe RA, Galasko DR, Xiong C, Masters CL, Schofield PR, Kinnunen KM, Salloway S, Martins RN, McDade E, Cairns NJ, Buckles VD, Morris JC, Bateman R, Sperling RA; Dominantly Inherited Alzheimer Network.

Brain. 2018 May 1;141(5):1486-1500. doi: 10.1093/brain/awy053.


Global White Matter Diffusion Characteristics Predict Longitudinal Cognitive Change Independently of Amyloid Status in Clinically Normal Older Adults.

Rabin JS, Perea RD, Buckley RF, Neal TE, Buckner RL, Johnson KA, Sperling RA, Hedden T.

Cereb Cortex. 2019 Mar 1;29(3):1251-1262. doi: 10.1093/cercor/bhy031.


Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.

Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA.

Nat Neurosci. 2018 Mar;21(3):424-431. doi: 10.1038/s41593-018-0070-z. Epub 2018 Feb 5.


Functional network integrity presages cognitive decline in preclinical Alzheimer disease.

Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP.

Neurology. 2017 Jul 4;89(1):29-37. doi: 10.1212/WNL.0000000000004059. Epub 2017 Jun 7.


Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals.

Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA.

J Neurosci. 2017 Apr 19;37(16):4323-4331. doi: 10.1523/JNEUROSCI.3263-16.2017. Epub 2017 Mar 17.


Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study.

Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA.

Cereb Cortex. 2017 Sep 1;27(9):4339-4349. doi: 10.1093/cercor/bhw234.


Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals.

Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA.

JAMA Neurol. 2016 Oct 1;73(10):1185-1191. doi: 10.1001/jamaneurol.2016.2237.


Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study.

Fotiadis P, van Rooden S, van der Grond J, Schultz A, Martinez-Ramirez S, Auriel E, Reijmer Y, van Opstal AM, Ayres A, Schwab KM; Alzheimer's Disease Neuroimaging Initiative, Hedden T, Rosand J, Viswanathan A, Wermer M, Terwindt G, Sperling RA, Polimeni JR, Johnson KA, van Buchem MA, Greenberg SM, Gurol ME.

Lancet Neurol. 2016 Jul;15(8):811-819. doi: 10.1016/S1474-4422(16)30030-8. Epub 2016 May 11.


Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease.

Rieckmann A, Van Dijk KR, Sperling RA, Johnson KA, Buckner RL, Hedden T.

Neurobiol Aging. 2016 Jun;42:177-88. doi: 10.1016/j.neurobiolaging.2016.03.016. Epub 2016 Mar 21.


Dopamine transporter availability in clinically normal aging is associated with individual differences in white matter integrity.

Rieckmann A, Hedden T, Younger AP, Sperling RA, Johnson KA, Buckner RL.

Hum Brain Mapp. 2016 Feb;37(2):621-31. doi: 10.1002/hbm.23054. Epub 2015 Nov 6.


MGH-USC Human Connectome Project datasets with ultra-high b-value diffusion MRI.

Fan Q, Witzel T, Nummenmaa A, Van Dijk KRA, Van Horn JD, Drews MK, Somerville LH, Sheridan MA, Santillana RM, Snyder J, Hedden T, Shaw EE, Hollinshead MO, Renvall V, Zanzonico R, Keil B, Cauley S, Polimeni JR, Tisdall D, Buckner RL, Wedeen VJ, Wald LL, Toga AW, Rosen BR.

Neuroimage. 2016 Jan 1;124(Pt B):1108-1114. doi: 10.1016/j.neuroimage.2015.08.075. Epub 2015 Sep 10.


Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging.

Auriel E, Westover MB, Bianchi MT, Reijmer Y, Martinez-Ramirez S, Ni J, Van Etten E, Frosch MP, Fotiadis P, Schwab K, Vashkevich A, Boulouis G, Younger AP, Johnson KA, Sperling RA, Hedden T, Gurol ME, Viswanathan A, Greenberg SM.

Stroke. 2015 Aug;46(8):2129-35. doi: 10.1161/STROKEAHA.115.009208. Epub 2015 Jul 9.


Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers.

Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA.

Neurology. 2015 Jul 7;85(1):48-55. doi: 10.1212/WNL.0000000000001704. Epub 2015 Jun 10.


Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities.

Reijmer YD, Schultz AP, Leemans A, O'Sullivan MJ, Gurol ME, Sperling R, Greenberg SM, Viswanathan A, Hedden T.

Neuroimage. 2015 Aug 15;117:222-9. doi: 10.1016/j.neuroimage.2015.05.054. Epub 2015 May 27.


Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer's disease.

Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM.

Neuropsychologia. 2015 Jul;73:169-75. doi: 10.1016/j.neuropsychologia.2015.04.034. Epub 2015 May 19.


Odor identification and Alzheimer disease biomarkers in clinically normal elderly.

Growdon ME, Schultz AP, Dagley AS, Amariglio RE, Hedden T, Rentz DM, Johnson KA, Sperling RA, Albers MW, Marshall GA.

Neurology. 2015 May 26;84(21):2153-60. doi: 10.1212/WNL.0000000000001614. Epub 2015 May 1.


Harvard Aging Brain Study: Dataset and accessibility.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP.

Neuroimage. 2017 Jan;144(Pt B):255-258. doi: 10.1016/j.neuroimage.2015.03.069. Epub 2015 Apr 3.


Functional Connectivity in Multiple Cortical Networks Is Associated with Performance Across Cognitive Domains in Older Adults.

Shaw EE, Schultz AP, Sperling RA, Hedden T.

Brain Connect. 2015 Oct;5(8):505-16. doi: 10.1089/brain.2014.0327. Epub 2015 Jun 23.


Resting-state anticorrelations between medial and lateral prefrontal cortex: association with working memory, aging, and individual differences.

Keller JB, Hedden T, Thompson TW, Anteraper SA, Gabrieli JD, Whitfield-Gabrieli S.

Cortex. 2015 Mar;64:271-80. doi: 10.1016/j.cortex.2014.12.001. Epub 2014 Dec 13.


Challenges and opportunities in linking brain-based biomarkers to person-specific variation in cognition: pumping up the volume.

Hedden T, Growdon JH.

JAMA Neurol. 2015 Feb;72(2):149-51. doi: 10.1001/jamaneurol.2014.3832. No abstract available.


Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an (11)C altropane positron emission tomography study.

Marquie M, Locascio JJ, Rentz DM, Becker JA, Hedden T, Johnson KA, Growdon JH, Gomperts SN.

Alzheimers Res Ther. 2014 Aug 27;6(5-8):52. doi: 10.1186/s13195-014-0052-7. eCollection 2014.


Multiple Brain Markers are Linked to Age-Related Variation in Cognition.

Hedden T, Schultz AP, Rieckmann A, Mormino EC, Johnson KA, Sperling RA, Buckner RL.

Cereb Cortex. 2016 Apr;26(4):1388-400. doi: 10.1093/cercor/bhu238. Epub 2014 Oct 14.


Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals.

Mormino EC, Betensky RA, Hedden T, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA.

JAMA Neurol. 2014 Nov;71(11):1379-85. doi: 10.1001/jamaneurol.2014.2031.


Template based rotation: a method for functional connectivity analysis with a priori templates.

Schultz AP, Chhatwal JP, Huijbers W, Hedden T, van Dijk KR, McLaren DG, Ward AM, Wigman S, Sperling RA.

Neuroimage. 2014 Nov 15;102 Pt 2:620-36. doi: 10.1016/j.neuroimage.2014.08.022. Epub 2014 Aug 21.


Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits.

Ward AM, Mormino EC, Huijbers W, Schultz AP, Hedden T, Sperling RA.

Neurobiol Aging. 2015 Jan;36(1):265-72. doi: 10.1016/j.neurobiolaging.2014.06.028. Epub 2014 Jul 3.


Personality influences temporal discounting preferences: behavioral and brain evidence.

Manning J, Hedden T, Wickens N, Whitfield-Gabrieli S, Prelec D, Gabrieli JD.

Neuroimage. 2014 Sep;98:42-9. doi: 10.1016/j.neuroimage.2014.04.066. Epub 2014 May 2.


Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease.

Mormino EC, Betensky RA, Hedden T, Schultz AP, Ward A, Huijbers W, Rentz DM, Johnson KA, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing; Harvard Aging Brain Study.

Neurology. 2014 May 20;82(20):1760-7. doi: 10.1212/WNL.0000000000000431. Epub 2014 Apr 18.


Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults.

Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA.

J Neurosci. 2014 Apr 9;34(15):5200-10. doi: 10.1523/JNEUROSCI.3579-13.2014.


Age differences in medial prefrontal activity for subsequent memory of truth value.

Cassidy BS, Hedden T, Yoon C, Gutchess AH.

Front Psychol. 2014 Feb 7;5:87. doi: 10.3389/fpsyg.2014.00087. eCollection 2014.


Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects.

Ward AM, McLaren DG, Schultz AP, Chhatwal J, Boot BP, Hedden T, Sperling RA.

Sleep. 2013 Nov 1;36(11):1609-15. doi: 10.5665/sleep.3108.


Meta-analysis of amyloid-cognition relations in cognitively normal older adults.

Hedden T, Oh H, Younger AP, Patel TA.

Neurology. 2013 Apr 2;80(14):1341-8. doi: 10.1212/WNL.0b013e31828ab35d.


Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study.

Gurol ME, Viswanathan A, Gidicsin C, Hedden T, Martinez-Ramirez S, Dumas A, Vashkevich A, Ayres AM, Auriel E, van Etten E, Becker A, Carmasin J, Schwab K, Rosand J, Johnson KA, Greenberg SM.

Ann Neurol. 2013 Apr;73(4):529-36. doi: 10.1002/ana.23830. Epub 2013 Feb 19.


The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system.

Ward AM, Schultz AP, Huijbers W, Van Dijk KR, Hedden T, Sperling RA.

Hum Brain Mapp. 2014 Mar;35(3):1061-73. doi: 10.1002/hbm.22234. Epub 2013 Feb 13.


The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks.

Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA.

J Cogn Neurosci. 2013 Jul;25(7):1163-79. doi: 10.1162/jocn_a_00366. Epub 2013 Feb 5.


Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults.

Hedden T, Mormino EC, Amariglio RE, Younger AP, Schultz AP, Becker JA, Buckner RL, Johnson KA, Sperling RA, Rentz DM.

J Neurosci. 2012 Nov 14;32(46):16233-42. doi: 10.1523/JNEUROSCI.2462-12.2012.


The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults.

Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA.

Cereb Cortex. 2013 Jun;23(6):1317-28. doi: 10.1093/cercor/bhs108. Epub 2012 May 14.

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