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Items: 11


The functional interlink between AR and MMP9/VEGF signaling axis is mediated through PIP5K1α/pAKT in prostate cancer.

Larsson P, Syed Khaja AS, Semenas J, Wang T, Sarwar M, Dizeyi N, Simoulis A, Hedblom A, Wai SN, Ødum N, Persson JL.

Int J Cancer. 2019 Aug 5. doi: 10.1002/ijc.32607. [Epub ahead of print]


Heme detoxification by heme oxygenase-1 reinstates proliferative and immune balances upon genotoxic tissue injury.

Hedblom A, Hejazi SM, Canesin G, Choudhury R, Hanafy KA, Csizmadia E, Persson JL, Wegiel B.

Cell Death Dis. 2019 Jan 25;10(2):72. doi: 10.1038/s41419-019-1342-6.


Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.

Seth P, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B.

Cancer Res. 2017 Jul 1;77(13):3632-3643. doi: 10.1158/0008-5472.CAN-16-2938. Epub 2017 Apr 26.


Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.

Wang Y, Hedblom A, Koerner SK, Li M, Jernigan FE, Wegiel B, Sun L.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5703-5706. doi: 10.1016/j.bmcl.2016.10.063. Epub 2016 Oct 24.


Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow.

Miftakhova R, Hedblom A, Semenas J, Robinson B, Simoulis A, Malm J, Rizvanov A, Heery DM, Mongan NP, Maitland NJ, Allegrucci C, Persson JL.

Cancer Res. 2016 Apr 15;76(8):2453-64. doi: 10.1158/0008-5472.CAN-15-2340. Epub 2016 Feb 26.


Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches.

Miftakhova R, Hedblom A, Batkiewicz L, Anagnosaki L, Zhang Y, Sjölander A, Wingren AG, Wolgemuth DJ, Persson JL.

Cell Cycle. 2015;14(12):1948-60. doi: 10.1080/15384101.2015.1026513.


The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.

Semenas J, Hedblom A, Miftakhova RR, Sarwar M, Larsson R, Shcherbina L, Johansson ME, Härkönen P, Sterner O, Persson JL.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3689-98. doi: 10.1073/pnas.1405801111. Epub 2014 Jul 28.


Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells.

Wegiel B, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun BS, Soares M, Persson JL, Otterbein LE.

Cell Death Dis. 2014 Mar 20;5:e1139. doi: 10.1038/cddis.2014.97.


CDK1 interacts with RARγ and plays an important role in treatment response of acute myeloid leukemia.

Hedblom A, Laursen KB, Miftakhova R, Sarwar M, Anagnostaki L, Bredberg A, Mongan NP, Gudas LJ, Persson JL.

Cell Cycle. 2013 Apr 15;12(8):1251-66. doi: 10.4161/cc.24313. Epub 2013 Mar 21.


DNA methylation in ATRA-treated leukemia cell lines lacking a PML-RAR chromosome translocation.

Miftakhova R, Sandberg T, Hedblom A, Nevzorova T, Persson JL, Bredberg A.

Anticancer Res. 2012 Nov;32(11):4715-22. Erratum in: Anticancer Res. 2013 Apr;33(4):1783.


Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.

Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14491-6. doi: 10.1073/pnas.1102295108. Epub 2011 Aug 17.

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