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2003 1
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HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350.
Lin Y, Gong H, Liu J, Hu Z, Gao M, Yu W, Liu J. Lin Y, et al. Cell Death Dis. 2023 Dec 4;14(12):794. doi: 10.1038/s41419-023-06322-w. Cell Death Dis. 2023. PMID: 38049396 Free PMC article.
In this study, we found that HECW1 decreased the survival rate of glioma cells and enhanced iron accumulation, lipid peroxidation, whereas ZNF350 showed the opposite effect. ...We demonstrate that HECW1 induces ferroptosis and highlight the value of HECW1 and …
In this study, we found that HECW1 decreased the survival rate of glioma cells and enhanced iron accumulation, lipid peroxidation, wh …
Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma.
Wang C, Dong K, Wang Y, Peng G, Song X, Yu Y, Shen P, Cui X. Wang C, et al. BMC Cancer. 2021 Aug 4;21(1):890. doi: 10.1186/s12885-021-08631-9. BMC Cancer. 2021. PMID: 34348693 Free PMC article.
Even after multivariable adjustment, HECW1, TNM stage, and SSIGN score served as independent risk factors. ...CONCLUSION: HECW1 is a novel prognostic biomarker and therapeutic target in ccRCC, and integrating intratumoral HECW1 expression with established cli …
Even after multivariable adjustment, HECW1, TNM stage, and SSIGN score served as independent risk factors. ...CONCLUSION: HECW1 …
Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
Ban D, Xiang Z, Yu P, Liu Y. Ban D, et al. Appl Biochem Biotechnol. 2022 Nov;194(11):5151-5166. doi: 10.1007/s12010-022-03999-1. Epub 2022 Jun 14. Appl Biochem Biotechnol. 2022. PMID: 35699802
However, the molecular mechanisms of SCI remain not entirely elucidated. This study was directed toward exploring the circ Hecw1 involved in the mechanism of lipopolysaccharide (LPS)-triggered inflammation damage in neuronal cells. ...Western blot analysis was performed fo …
However, the molecular mechanisms of SCI remain not entirely elucidated. This study was directed toward exploring the circ Hecw1 invo …
E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4.
Lu C, Ning G, Si P, Zhang C, Liu W, Ge W, Cui K, Zhang R, Ge S. Lu C, et al. Biochem Cell Biol. 2021 Oct;99(5):675-681. doi: 10.1139/bcb-2020-0505. Epub 2021 Feb 2. Biochem Cell Biol. 2021. PMID: 33529121
Upregulation of HECW1 markedly enhanced the proliferation of NSCLC cells, whereas downregulation of HECW1 significantly inhibited proliferation. Moreover, the expression levels of HECW1 positively correlated with the migration and invasiveness of NSCLC cells. …
Upregulation of HECW1 markedly enhanced the proliferation of NSCLC cells, whereas downregulation of HECW1 significantly inhibi …
HECW1 restrains cervical cancer cell growth by promoting DVL1 ubiquitination and downregulating the activation of Wnt/beta-catenin signaling.
Xu Z, Guo Y, Wang L, Cui J. Xu Z, et al. Exp Cell Res. 2024 Feb 15;435(2):113949. doi: 10.1016/j.yexcr.2024.113949. Epub 2024 Jan 23. Exp Cell Res. 2024. PMID: 38266865
However, the function of HECW1 in cervical cancer (CC) remains unknown. Clinical analysis showed that HECW1 is significantly decreased in CC tumor tissues. ...Inhibition of DVL1 restrained the promotion effect of HECW1 suppression on cell proliferation. In vi …
However, the function of HECW1 in cervical cancer (CC) remains unknown. Clinical analysis showed that HECW1 is significantly d …
The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system.
Liu J, Dong S, Li L, Wang H, Zhao J, Zhao Y. Liu J, et al. Cell Signal. 2019 Jun;58:91-98. doi: 10.1016/j.cellsig.2019.03.005. Epub 2019 Mar 5. Cell Signal. 2019. PMID: 30849519 Free PMC article.
Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1), targets TTF1 for its ubiquitination and degradation, while downregulation of HECW1 attenuates PMA-induced TTF1 ubiquitination and …
Furthermore, we demonstrate that an E3 ubiquitin ligase, named HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1 …
Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis.
Jin Z, Liu H, Xu C. Jin Z, et al. Biol Reprod. 2020 Feb 14;102(2):376-387. doi: 10.1093/biolre/ioz194. Biol Reprod. 2020. PMID: 31616916
Based on the following experiments and GEO dataset screening, we found that estrogen regulates the expression level of Scribble by HECW1 through ubiquitination of Scribble protein. At last, we verified the expression of Scribble, HECW1, and aromatase P450 in eutopic …
Based on the following experiments and GEO dataset screening, we found that estrogen regulates the expression level of Scribble by HECW1 …
Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1.
Haouari S, Andres CR, Lanznaster D, Marouillat S, Brulard C, Dangoumau A, Ung D, Veyrat-Durebex C, Laumonnier F, Blasco H, Couratier P, Corcia P, Vourc'h P; French ALS network FILSLAN. Haouari S, et al. Int J Mol Sci. 2023 Jan 9;24(2):1268. doi: 10.3390/ijms24021268. Int J Mol Sci. 2023. PMID: 36674783 Free PMC article.
Other variants of interest were discovered in new genes studied in this disease, in particular in the HECW1 gene. We have shown that the HECT E3 ligase called NEDL1, encoded by the HECW1 gene, is expressed in neurons, mainly in their somas. ...These results give new …
Other variants of interest were discovered in new genes studied in this disease, in particular in the HECW1 gene. We have shown that …
Two distinct E3 ligases, SCF(FBXL19) and HECW1, degrade thyroid transcription factor 1 in normal thyroid epithelial and follicular thyroid carcinoma cells, respectively.
Liu J, Dong S, Wang H, Li L, Ye Q, Li Y, Miao J, Jhiang S, Zhao J, Zhao Y. Liu J, et al. FASEB J. 2019 Sep;33(9):10538-10550. doi: 10.1096/fj.201900415R. Epub 2019 Jun 25. FASEB J. 2019. PMID: 31238008 Free PMC article.
Overexpression of E3 ubiquitin protein ligase 1 containing HECT, C2, and WW domain (HECW1) induced TTF1 degradation and ubiquitination in Htori3 cells but not in FTC133 cells. ...-Liu, J., Dong, S., Wang, H., Li, L., Ye, Q., Li, Y., Miao, J., Jhiang, S., Zhao, J., Zhao, Y. …
Overexpression of E3 ubiquitin protein ligase 1 containing HECT, C2, and WW domain (HECW1) induced TTF1 degradation and ubiquitinatio …
Alu Deletions in LAMA2 and CDH4 Genes Are Key Components of Polygenic Predictors of Longevity.
Erdman VV, Karimov DD, Tuktarova IA, Timasheva YR, Nasibullin TR, Korytina GF. Erdman VV, et al. Int J Mol Sci. 2022 Nov 4;23(21):13492. doi: 10.3390/ijms232113492. Int J Mol Sci. 2022. PMID: 36362280 Free PMC article.
Attaining longevity was associated with the combinations LAMA2*ID + CDH4*D (OR = 2.23, P(Bonf) = 1.90 10(-2)) and CDH4*DD + LAMA2*ID + HECW1*D (OR = 4.58, P(Bonf) = 9.00 10(-3)) among persons aged between 18 and 89 years, LAMA2*ID + CDH4*D + SEMA6A*I for individuals below …
Attaining longevity was associated with the combinations LAMA2*ID + CDH4*D (OR = 2.23, P(Bonf) = 1.90 10(-2)) and CDH4*DD + LAMA2*ID + HE …
29 results