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Items: 23


CDKL5 variants: Improving our understanding of a rare neurologic disorder.

Hector RD, Kalscheuer VM, Hennig F, Leonard H, Downs J, Clarke A, Benke TA, Armstrong J, Pineda M, Bailey MES, Cobb SR.

Neurol Genet. 2017 Dec 15;3(6):e200. doi: 10.1212/NXG.0000000000000200. eCollection 2017 Dec.


Radically truncated MeCP2 rescues Rett syndrome-like neurological defects.

Tillotson R, Selfridge J, Koerner MV, Gadalla KKE, Guy J, De Sousa D, Hector RD, Cobb SR, Bird A.

Nature. 2017 Oct 19;550(7676):398-401. doi: 10.1038/nature24058. Epub 2017 Oct 11.


High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast.

Burlacu E, Lackmann F, Aguilar LC, Belikov S, Nues RV, Trahan C, Hector RD, Dominelli-Whiteley N, Cockroft SL, Wieslander L, Oeffinger M, Granneman S.

Nat Commun. 2017 Sep 28;8(1):714. doi: 10.1038/s41467-017-00761-8.


Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome.

Gadalla KKE, Vudhironarit T, Hector RD, Sinnett S, Bahey NG, Bailey MES, Gray SJ, Cobb SR.

Mol Ther Methods Clin Dev. 2017 Apr 22;5:180-190. doi: 10.1016/j.omtm.2017.04.007. eCollection 2017 Jun 16.


Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery.

Sinnett SE, Hector RD, Gadalla KKE, Heindel C, Chen D, Zaric V, Bailey MES, Cobb SR, Gray SJ.

Mol Ther Methods Clin Dev. 2017 Apr 19;5:106-115. doi: 10.1016/j.omtm.2017.04.006. eCollection 2017 Jun 16.


Characterisation of Cdkl5 transcript isoforms in rat.

Hector RD, Dando O, Ritakari TE, Kind PC, Bailey ME, Cobb SR.

Gene. 2017 Mar 1;603:21-26. doi: 10.1016/j.gene.2016.12.001. Epub 2016 Dec 7.


Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.

Hector RD, Dando O, Landsberger N, Kilstrup-Nielsen C, Kind PC, Bailey ME, Cobb SR.

PLoS One. 2016 Jun 17;11(6):e0157758. doi: 10.1371/journal.pone.0157758. eCollection 2016.


Transcriptome-wide RNA processing kinetics revealed using extremely short 4tU labeling.

Barrass JD, Reid JE, Huang Y, Hector RD, Sanguinetti G, Beggs JD, Granneman S.

Genome Biol. 2015 Dec 17;16:282. doi: 10.1186/s13059-015-0848-1.


Randomized controlled trial of storytelling compared to a personal risk tool intervention on colorectal cancer screening in low-income patients.

Larkey LK, McClain D, Roe DJ, Hector RD, Lopez AM, Sillanpaa B, Gonzalez J.

Am J Health Promot. 2015 Nov-Dec;30(2):e59-70. doi: 10.4278/ajhp.131111-QUAN-572. Epub 2015 Jan 23.


Snapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution.

Hector RD, Burlacu E, Aitken S, Le Bihan T, Tuijtel M, Zaplatina A, Cook AG, Granneman S.

Nucleic Acids Res. 2014 Oct 29;42(19):12138-54. doi: 10.1093/nar/gku815. Epub 2014 Sep 8.


PAR-CLIP data indicate that Nrd1-Nab3-dependent transcription termination regulates expression of hundreds of protein coding genes in yeast.

Webb S, Hector RD, Kudla G, Granneman S.

Genome Biol. 2014 Jan 7;15(1):R8. doi: 10.1186/gb-2014-15-1-r8.


Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.

Volanakis A, Passoni M, Hector RD, Shah S, Kilchert C, Granneman S, Vasiljeva L.

Genes Dev. 2013 Sep 15;27(18):2025-38. doi: 10.1101/gad.221960.113.


Role of DNA methylation in expression and transmission of porcine endogenous retroviruses.

Matouskov√° M, Vesely P, Daniel P, Mattiuzzo G, Hector RD, Scobie L, Takeuchi Y, Hejnar J.

J Virol. 2013 Nov;87(22):12110-20. doi: 10.1128/JVI.03262-12. Epub 2013 Aug 28.


Long-term IgG response to porcine Neu5Gc antigens without transmission of PERV in burn patients treated with porcine skin xenografts.

Scobie L, Padler-Karavani V, Le Bas-Bernardet S, Crossan C, Blaha J, Matouskova M, Hector RD, Cozzi E, Vanhove B, Charreau B, Blancho G, Bourdais L, Tallacchini M, Ribes JM, Yu H, Chen X, Kracikova J, Broz L, Hejnar J, Vesely P, Takeuchi Y, Varki A, Soulillou JP.

J Immunol. 2013 Sep 15;191(6):2907-15. doi: 10.4049/jimmunol.1301195. Epub 2013 Aug 14.


High-resolution human cytomegalovirus transcriptome.

Gatherer D, Seirafian S, Cunningham C, Holton M, Dargan DJ, Baluchova K, Hector RD, Galbraith J, Herzyk P, Wilkinson GW, Davison AJ.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19755-60. doi: 10.1073/pnas.1115861108. Epub 2011 Nov 22.


Health state preferences are equivalent in the United States and Trinidad and Tobago.

Hector RD Sr, Anderson JP, Paul RC, Weiss RE, Hays RD, Kaplan RM.

Qual Life Res. 2010 Jun;19(5):729-38. doi: 10.1007/s11136-010-9630-8. Epub 2010 Mar 17.


A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity.

Scobie L, Hector RD, Grant L, Bell M, Nielsen AA, Meikle S, Philbey A, Thrasher AJ, Cameron ER, Blyth K, Neil JC.

Mol Ther. 2009 Jun;17(6):1031-8. doi: 10.1038/mt.2009.59. Epub 2009 Mar 31. Erratum in: Mol Ther. 2009 Aug;17(8):1483. Philbey, Adrain [corrected to Philbey, Adrian]; Thrasher, Adrain J [corrected to Thrasher, Adrian J].


Porcine endogenous retrovirus transmission characteristics from a designated pathogen-free herd.

Garkavenko O, Wynyard S, Nathu D, Muzina M, Muzina Z, Scobie L, Hector RD, Croxson MC, Tan P, Elliott BR.

Transplant Proc. 2008 Mar;40(2):590-3. doi: 10.1016/j.transproceed.2008.01.051.


Evaluation of the validity of the Quality of Well-being Scale in Trinidad and Tobago.

Hector RD, Anderson JP, Paul RC, Ponce N, Hays RD, Weiss RE, Kaplan RM.

West Indian Med J. 2008 Mar;57(2):135-40.


Porcine endogenous retrovirus (PERV) and its transmission characteristics: a study of the New Zealand designated pathogen-free herd.

Garkavenko O, Wynyard S, Nathu D, Simond D, Muzina M, Muzina Z, Scobie L, Hector RD, Croxson MC, Tan P, Elliott BR.

Cell Transplant. 2008;17(12):1381-8.


Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses.

Hector RD, Meikle S, Grant L, Wilkinson RA, Fishman JA, Scobie L.

Xenotransplantation. 2007 May;14(3):222-6.


Genetic content of wild-type human cytomegalovirus.

Dolan A, Cunningham C, Hector RD, Hassan-Walker AF, Lee L, Addison C, Dargan DJ, McGeoch DJ, Gatherer D, Emery VC, Griffiths PD, Sinzger C, McSharry BP, Wilkinson GW, Davison AJ.

J Gen Virol. 2004 May;85(Pt 5):1301-12.


Application of polymerase chain reaction with oligoligation assay to determine genotype in individuals presenting with congenital adrenal hyperplasia.

Hogg JE, Gaffney D, Hector RD, Coleman MM, Wallace AM.

Ann Clin Biochem. 2002 May;39(Pt 3):293-303.


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