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Items: 1 to 50 of 120

1.

Gonococcal Colony Typing.

Heckels JE.

Methods Mol Biol. 2019;1997:77-85. doi: 10.1007/978-1-4939-9496-0_5.

PMID:
31119618
2.

Vaccine Potential and Diversity of the Putative Cell Binding Factor (CBF, NMB0345/NEIS1825) Protein of Neisseria meningitidis.

Humbert MV, Hung MC, Phillips R, Akoto C, Hill A, Tan WM, Heckels JE, Christodoulides M.

PLoS One. 2016 Aug 9;11(8):e0160403. doi: 10.1371/journal.pone.0160403. eCollection 2016.

3.

Vaccine potential of bacterial macrophage infectivity potentiator (MIP)-like peptidyl prolyl cis/trans isomerase (PPIase) proteins.

Humbert MV, Almonacid Mendoza HL, Jackson AC, Hung MC, Bielecka MK, Heckels JE, Christodoulides M.

Expert Rev Vaccines. 2015;14(12):1633-49. doi: 10.1586/14760584.2015.1095638. Epub 2015 Oct 15. Review.

PMID:
26468663
4.

A putative amino acid ABC transporter substrate-binding protein, NMB1612, from Neisseria meningitidis, induces murine bactericidal antibodies against meningococci expressing heterologous NMB1612 proteins.

Hung MC, Humbert MV, Laver JR, Phillips R, Heckels JE, Christodoulides M.

Vaccine. 2015 Aug 26;33(36):4486-94. doi: 10.1016/j.vaccine.2015.07.032. Epub 2015 Jul 21.

PMID:
26207592
5.

Recombinant protein truncation strategy for inducing bactericidal antibodies to the macrophage infectivity potentiator protein of Neisseria meningitidis and circumventing potential cross-reactivity with human FK506-binding proteins.

Bielecka MK, Devos N, Gilbert M, Hung MC, Weynants V, Heckels JE, Christodoulides M.

Infect Immun. 2015 Feb;83(2):730-42. doi: 10.1128/IAI.01815-14. Epub 2014 Dec 1.

6.

Immuno-proteomic analysis of human immune responses to experimental Neisseria meningitidis outer membrane vesicle vaccines identifies potential cross-reactive antigens.

Williams JN, Weynants V, Poolman JT, Heckels JE, Christodoulides M.

Vaccine. 2014 Mar 5;32(11):1280-6. doi: 10.1016/j.vaccine.2013.12.070. Epub 2014 Jan 30.

PMID:
24486354
7.

Potential of the adhesin complex protein of Neisseria meningitidis for next-generation meningococcal vaccines.

Hung MC, Heckels JE, Christodoulides M.

Expert Rev Vaccines. 2013 Sep;12(9):981-4. doi: 10.1586/14760584.2013.828881. No abstract available.

PMID:
24053391
8.

Immunization with recombinant Chaperonin60 (Chp60) outer membrane protein induces a bactericidal antibody response against Neisseria meningitidis.

Phillips R, Williams JN, Tan WM, Bielecka MK, Thompson H, Hung MC, Heckels JE, Christodoulides M.

Vaccine. 2013 May 24;31(22):2584-90. doi: 10.1016/j.vaccine.2013.03.033. Epub 2013 Apr 6.

PMID:
23566947
9.

The adhesin complex protein (ACP) of Neisseria meningitidis is a new adhesin with vaccine potential.

Hung MC, Heckels JE, Christodoulides M.

MBio. 2013 Feb 26;4(2). pii: e00041-13. doi: 10.1128/mBio.00041-13.

10.

Group B Streptococcus interactions with human meningeal cells and astrocytes in vitro.

Alkuwaity K, Taylor A, Heckels JE, Doran KS, Christodoulides M.

PLoS One. 2012;7(8):e42660. doi: 10.1371/journal.pone.0042660. Epub 2012 Aug 10.

11.

Neisseria gonorrhoeae pilus attenuates cytokine response of human fallopian tube explants.

Velasquez L, García K, Morales F, Heckels JE, Orihuela P, Rodas PI, Christodoulides M, Cardenas H.

J Biomed Biotechnol. 2012;2012:491298. doi: 10.1155/2012/491298. Epub 2012 Jan 24.

12.

Analysis of the immune response to Neisseria meningitidis using a proteomics approach.

Williams JN, Christodoulides M, Heckels JE.

Methods Mol Biol. 2012;799:343-60. doi: 10.1007/978-1-61779-346-2_20.

PMID:
21993655
13.

The Neisseria meningitidis macrophage infectivity potentiator protein induces cross-strain serum bactericidal activity and is a potential serogroup B vaccine candidate.

Hung MC, Salim O, Williams JN, Heckels JE, Christodoulides M.

Infect Immun. 2011 Sep;79(9):3784-91. doi: 10.1128/IAI.05019-11. Epub 2011 Jun 27.

14.

Nitric oxide is not involved in Neisseria gonorrhoeae-induced cellular damage of human Fallopian tubes in vitro.

García KP, Rubilar PS, Vargas MF, Cárdenas H, Rios MA, Orihuela PA, Vargas RH, Fuhrer J, Heckels JE, Christodoulides M, Velásquez LA.

Biol Res. 2010;43(1):39-50. doi: /S0716-97602010000100006. Epub 2010 May 7.

15.
16.

Immunoproteomic analysis of the development of natural immunity in subjects colonized by Neisseria meningitidis reveals potential vaccine candidates.

Williams JN, Skipp PJ, O'Connor CD, Christodoulides M, Heckels JE.

Infect Immun. 2009 Nov;77(11):5080-9. doi: 10.1128/IAI.00701-09. Epub 2009 Sep 8.

17.

Neuropeptide alpha-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro.

Kumar P, Williams JN, Durkin KL, Heckels JE, Friedmann PS, Healy E, Christodoulides M.

Inflamm Res. 2010 Feb;59(2):105-13. doi: 10.1007/s00011-009-0076-9. Epub 2009 Aug 15.

PMID:
19685205
18.

A cyanobacterial lipopolysaccharide antagonist inhibits cytokine production induced by Neisseria meningitidis in a human whole-blood model of septicemia.

Jemmett K, Macagno A, Molteni M, Heckels JE, Rossetti C, Christodoulides M.

Infect Immun. 2008 Jul;76(7):3156-63. doi: 10.1128/IAI.00110-08. Epub 2008 Apr 28.

19.

A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis.

Zhu D, Williams JN, Rice J, Stevenson FK, Heckels JE, Christodoulides M.

Infect Immun. 2008 Jan;76(1):334-8. Epub 2007 Oct 29.

20.

Proteomic analysis of outer membranes and vesicles from wild-type serogroup B Neisseria meningitidis and a lipopolysaccharide-deficient mutant.

Williams JN, Skipp PJ, Humphries HE, Christodoulides M, O'Connor CD, Heckels JE.

Infect Immun. 2007 Mar;75(3):1364-72. Epub 2006 Dec 11.

21.

Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis.

Fowler MI, Yin KY, Humphries HE, Heckels JE, Christodoulides M.

Infect Immun. 2006 Nov;74(11):6467-78. Epub 2006 Sep 5.

22.

Infection of human fallopian tube epithelial cells with Neisseria gonorrhoeae protects cells from tumor necrosis factor alpha-induced apoptosis.

Morales P, Reyes P, Vargas M, Rios M, Imarai M, Cardenas H, Croxatto H, Orihuela P, Vargas R, Fuhrer J, Heckels JE, Christodoulides M, Velasquez L.

Infect Immun. 2006 Jun;74(6):3643-50.

23.

Multivalent liposome-based vaccines containing different serosubtypes of PorA protein induce cross-protective bactericidal immune responses against Neisseria meningitidis.

Humphries HE, Williams JN, Blackstone R, Jolley KA, Yuen HM, Christodoulides M, Heckels JE.

Vaccine. 2006 Jan 9;24(1):36-44. Epub 2005 Aug 2.

PMID:
16105711
24.

A novel porA-based real-time PCR for detection of meningococcal carriage.

Jordens JZ, Heckels JE.

J Med Microbiol. 2005 May;54(Pt 5):463-6.

PMID:
15824424
25.

Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling.

Humphries HE, Triantafilou M, Makepeace BL, Heckels JE, Triantafilou K, Christodoulides M.

Cell Microbiol. 2005 Mar;7(3):415-30.

PMID:
15679844
26.

Development of immunity to serogroup B meningococci during carriage of Neisseria meningitidis in a cohort of university students.

Jordens JZ, Williams JN, Jones GR, Christodoulides M, Heckels JE.

Infect Immun. 2004 Nov;72(11):6503-10.

27.

Activation of human dendritic cells by the PorA protein of Neisseria meningitidis.

Al-Bader T, Jolley KA, Humphries HE, Holloway J, Heckels JE, Semper AE, Friedmann PS, Christodoulides M.

Cell Microbiol. 2004 Jul;6(7):651-62.

PMID:
15186401
28.

Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges.

Fowler MI, Weller RO, Heckels JE, Christodoulides M.

Cell Microbiol. 2004 Jun;6(6):555-67.

PMID:
15104596
29.

Recombinant meningococcal PorA protein, expressed using a vector system with potential for human vaccination, induces a bactericidal immune response.

Humphries HE, Williams JN, Christodoulides M, Heckels JE.

Vaccine. 2004 Mar 29;22(11-12):1564-9.

PMID:
15063582
30.

Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis.

Al-Bader T, Christodoulides M, Heckels JE, Holloway J, Semper AE, Friedmann PS.

Infect Immun. 2003 Oct;71(10):5590-7.

31.

Serological correlates of protection against meningococci in a cohort of university students, before and during an outbreak of serogroup C infection.

Williams JN, Jones GR, Christodoulides M, Heckels JE.

J Infect Dis. 2003 May 1;187(9):1433-41. Epub 2003 Apr 15.

PMID:
12717625
32.

Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae.

Maisey K, Nardocci G, Imarai M, Cardenas H, Rios M, Croxatto HB, Heckels JE, Christodoulides M, Velasquez LA.

Infect Immun. 2003 Jan;71(1):527-32.

33.
34.

Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines.

Christodoulides M, Makepeace BL, Partridge KA, Kaur D, Fowler MI, Weller RO, Heckels JE.

Infect Immun. 2002 Aug;70(8):4035-44.

35.
36.

Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles.

Jordens JZ, Williams JN, Jones GR, Heckels JE.

J Clin Microbiol. 2002 Jan;40(1):75-9.

38.
39.

Epitope mapping.

Heckels JE, Christodoulides M.

Methods Mol Med. 2001;66:361-70. doi: 10.1385/1-59259-148-5:361.

PMID:
21336768
40.

Recombinant proteins in vaccine development.

Christodoulides M, Jolley KA, Heckels JE.

Methods Mol Med. 2001;66:167-80. doi: 10.1385/1-59259-148-5:167.

PMID:
21336755
41.

Interactions of Neisseria meningitidis with cells of the human meninges.

Hardy SJ, Christodoulides M, Weller RO, Heckels JE.

Mol Microbiol. 2000 May;36(4):817-29.

42.

Lack of immunity in university students before an outbreak of serogroup C meningococcal infection.

Jones GR, Williams JN, Christodoulides M, Jolley K, Heckels JE.

J Infect Dis. 2000 Mar;181(3):1172-5.

PMID:
10720549
43.

Interaction of primary human endometrial cells with Neisseria gonorrhoeae expressing green fluorescent protein.

Christodoulides M, Everson JS, Liu BL, Lambden PR, Watt PJ, Thomas EJ, Heckels JE.

Mol Microbiol. 2000 Jan;35(1):32-43.

45.

Reply

Jones GR, Christodoulides M, Heckels JE.

J Infect Dis. 1999 Jul;180(1):242-3. No abstract available.

PMID:
10354015
47.

Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization.

Jones GR, Christodoulides M, Brooks JL, Miller AR, Cartwright KA, Heckels JE.

J Infect Dis. 1998 Aug;178(2):451-9.

PMID:
9697726
49.

Recombinational reassortment among opa genes from ET-37 complex Neisseria meningitidis isolates of diverse geographical origins.

Hobbs MM, Malorny B, Prasad P, Morelli G, Kusecek B, Heckels JE, Cannon JG, Achtman M.

Microbiology. 1998 Jan;144 ( Pt 1):157-66.

PMID:
9467908
50.

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