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Items: 1 to 50 of 126

1.

Introducing LNAzo: More Rigidity for Improved Photocontrol of Oligonucleotide Hybridization.

Grebenovsky N, Luma L, Müller P, Heckel A.

Chemistry. 2019 Sep 20;25(53):12298-12302. doi: 10.1002/chem.201903240. Epub 2019 Aug 28.

PMID:
31386225
2.

Phosphodiester photo-tethers for the (multi-)cyclic conformational caging of oligonucleotides.

Müller P, Seyfried P, Frühauf A, Heckel A.

Methods Enzymol. 2019;624:89-111. doi: 10.1016/bs.mie.2019.04.019. Epub 2019 May 7.

PMID:
31370937
3.

Global response of diacylglycerol kinase towards substrate binding observed by 2D and 3D MAS NMR.

Möbius K, Kazemi S, Güntert P, Jakob A, Heckel A, Becker-Baldus J, Glaubitz C.

Sci Rep. 2019 Mar 8;9(1):3995. doi: 10.1038/s41598-019-40264-8.

4.

A light-responsive RNA aptamer for an azobenzene derivative.

Lotz TS, Halbritter T, Kaiser C, Rudolph MM, Kraus L, Groher F, Steinwand S, Wachtveitl J, Heckel A, Suess B.

Nucleic Acids Res. 2019 Feb 28;47(4):2029-2040. doi: 10.1093/nar/gky1225.

5.

"End-to-end" stacking of small dsRNA.

Erlenbach N, Grünewald C, Krstic B, Heckel A, Prisner TF.

RNA. 2019 Feb;25(2):239-246. doi: 10.1261/rna.068130.118. Epub 2018 Nov 7.

PMID:
30404925
6.

Low-Threshold Reversible Electron-Induced and Selective Photoinduced Switching of Azobenzene Derivatives under Ambient Conditions.

Yadav K, Mahapatra S, Halbritter T, Heckel A, Gopakumar TG.

J Phys Chem Lett. 2018 Nov 1;9(21):6326-6333. doi: 10.1021/acs.jpclett.8b02875. Epub 2018 Oct 22.

PMID:
30346779
7.

Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging.

Seyfried P, Heinz M, Pintér G, Klötzner DP, Becker Y, Bolte M, Jonker HRA, Stelzl LS, Hummer G, Schwalbe H, Heckel A.

Chemistry. 2018 Nov 27;24(66):17568-17576. doi: 10.1002/chem.201804040. Epub 2018 Nov 5.

PMID:
30199112
8.

Can Mitochondrial DNA be CRISPRized: Pro and Contra.

Loutre R, Heckel AM, Smirnova A, Entelis N, Tarassov I.

IUBMB Life. 2018 Dec;70(12):1233-1239. doi: 10.1002/iub.1919. Epub 2018 Sep 5. Review.

PMID:
30184317
9.

A light-triggered transmembrane porin.

Kahlstatt J, Reiß P, Halbritter T, Essen LO, Koert U, Heckel A.

Chem Commun (Camb). 2018 Aug 23;54(69):9623-9626. doi: 10.1039/c8cc05221b.

PMID:
30095845
10.

Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies including Light Control and NMR Spectroscopy.

Keyhani S, Goldau T, Blümler A, Heckel A, Schwalbe H.

Angew Chem Int Ed Engl. 2018 Sep 10;57(37):12017-12021. doi: 10.1002/anie.201807125. Epub 2018 Aug 10.

PMID:
30007102
11.

Anti-replicative recombinant 5S rRNA molecules can modulate the mtDNA heteroplasmy in a glucose-dependent manner.

Loutre R, Heckel AM, Jeandard D, Tarassov I, Entelis N.

PLoS One. 2018 Jun 18;13(6):e0199258. doi: 10.1371/journal.pone.0199258. eCollection 2018.

12.

A New Photocage Derived from Fluorene.

Reinfelds M, von Cosel J, Falahati K, Hamerla C, Slanina T, Burghardt I, Heckel A.

Chemistry. 2018 Sep 3;24(49):13026-13035. doi: 10.1002/chem.201802390. Epub 2018 Jul 26.

PMID:
29889321
13.

A red-shifted two-photon-only caging group for three-dimensional photorelease.

Becker Y, Unger E, Fichte MAH, Gacek DA, Dreuw A, Wachtveitl J, Walla PJ, Heckel A.

Chem Sci. 2018 Feb 9;9(10):2797-2802. doi: 10.1039/c7sc05182d. eCollection 2018 Mar 14.

14.

Life times of metastable states guide regulatory signaling in transcriptional riboswitches.

Helmling C, Klötzner DP, Sochor F, Mooney RA, Wacker A, Landick R, Fürtig B, Heckel A, Schwalbe H.

Nat Commun. 2018 Mar 5;9(1):944. doi: 10.1038/s41467-018-03375-w.

15.

Sensitized Two-Photon Activation of Coumarin Photocages.

Hammer CA, Falahati K, Jakob A, Klimek R, Burghardt I, Heckel A, Wachtveitl J.

J Phys Chem Lett. 2018 Mar 15;9(6):1448-1453. doi: 10.1021/acs.jpclett.7b03364. Epub 2018 Mar 8.

PMID:
29498870
16.

Light Regulation of DNA Minicircle Dimerization by Utilizing Azobenzene C-Nucleosides.

Grebenovsky N, Goldau T, Bolte M, Heckel A.

Chemistry. 2018 Mar 7;24(14):3425-3428. doi: 10.1002/chem.201706003. Epub 2018 Feb 8.

PMID:
29418024
17.

Controlling Photochemistry via Isotopomers and IR Pre-excitation.

Kern-Michler D, Neumann C, Mielke N, van Wilderen LJGW, Reinfelds M, von Cosel J, Santoro F, Heckel A, Burghardt I, Bredenbeck J.

J Am Chem Soc. 2018 Jan 24;140(3):926-931. doi: 10.1021/jacs.7b08723. Epub 2018 Jan 12.

PMID:
29182322
18.

Dorsal root ganglia hypertrophy as in vivo correlate of oxaliplatin-induced polyneuropathy.

Apostolidis L, Schwarz D, Xia A, Weiler M, Heckel A, Godel T, Heiland S, Schlemmer HP, Jäger D, Bendszus M, Bäumer P.

PLoS One. 2017 Aug 24;12(8):e0183845. doi: 10.1371/journal.pone.0183845. eCollection 2017.

19.

A new photoactivatable near-infrared-emitting QCy7 fluorophore for single-molecule super-resolution microscopy.

Klötzner DP, Klehs K, Heilemann M, Heckel A.

Chem Commun (Camb). 2017 Aug 31;53(71):9874-9877. doi: 10.1039/c7cc04996j.

PMID:
28825088
20.

Pyridine-Spiropyran Derivative as a Persistent, Reversible Photoacid in Water.

Halbritter T, Kaiser C, Wachtveitl J, Heckel A.

J Org Chem. 2017 Aug 4;82(15):8040-8047. doi: 10.1021/acs.joc.7b01268. Epub 2017 Jul 19.

PMID:
28686024
21.

A Two-Photon-Photocleavable Linker for Triggering Light-Induced Strand Breaks in Oligonucleotides.

Weyel XMM, Fichte MAH, Heckel A.

ACS Chem Biol. 2017 Aug 18;12(8):2183-2190. doi: 10.1021/acschembio.7b00367. Epub 2017 Jul 14.

PMID:
28678467
22.

Light-inducible antimiR-92a as a therapeutic strategy to promote skin repair in healing-impaired diabetic mice.

Lucas T, Schäfer F, Müller P, Eming SA, Heckel A, Dimmeler S.

Nat Commun. 2017 May 2;8:15162. doi: 10.1038/ncomms15162.

23.

Lanthanide Ions Coupled with Photoinduced Electron Transfer Generate Strong Reduction Potentials from Visible Light.

Meyer AU, Slanina T, Heckel A, König B.

Chemistry. 2017 Jun 12;23(33):7900-7904. doi: 10.1002/chem.201701665. Epub 2017 May 19.

PMID:
28429580
24.

Picosecond activation of the DEACM photocage unravelled by VIS-pump-IR-probe spectroscopy.

van Wilderen LJ, Neumann C, Rodrigues-Correia A, Kern-Michler D, Mielke N, Reinfelds M, Heckel A, Bredenbeck J.

Phys Chem Chem Phys. 2017 Mar 1;19(9):6487-6496. doi: 10.1039/c6cp07022a.

PMID:
28197598
25.

Activity-dependent spatially localized miRNA maturation in neuronal dendrites.

Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM.

Science. 2017 Feb 10;355(6325):634-637. doi: 10.1126/science.aaf8995.

PMID:
28183980
26.

Photo-Tethers for the (Multi-)Cyclic, Conformational Caging of Long Oligonucleotides.

Seyfried P, Eiden L, Grebenovsky N, Mayer G, Heckel A.

Angew Chem Int Ed Engl. 2017 Jan 2;56(1):359-363. doi: 10.1002/anie.201610025. Epub 2016 Nov 29.

PMID:
27897376
27.

Three-Dimensional Control of DNA Hybridization by Orthogonal Two-Color Two-Photon Uncaging.

Fichte MA, Weyel XM, Junek S, Schäfer F, Herbivo C, Goeldner M, Specht A, Wachtveitl J, Heckel A.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8948-52. doi: 10.1002/anie.201603281. Epub 2016 Jun 13.

PMID:
27294300
28.

Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.

Thevarpadam J, Bessi I, Binas O, Gonçalves DP, Slavov C, Jonker HR, Richter C, Wachtveitl J, Schwalbe H, Heckel A.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2738-42. doi: 10.1002/anie.201510269. Epub 2016 Jan 25.

PMID:
26805928
29.

Sensitive detection of cancer cells using light-mediated apta-PCR.

Civit L, Pinto A, Rodrigues-Correia A, Heckel A, O'Sullivan CK, Mayer G.

Methods. 2016 Mar 15;97:104-9. doi: 10.1016/j.ymeth.2015.11.018. Epub 2015 Nov 23.

PMID:
26615953
30.

Azobenzene C-Nucleosides for Photocontrolled Hybridization of DNA at Room Temperature.

Goldau T, Murayama K, Brieke C, Asanuma H, Heckel A.

Chemistry. 2015 Dec 1;21(49):17870-6. doi: 10.1002/chem.201503303. Epub 2015 Oct 22.

PMID:
26489532
31.

Caged Fluoride: Photochemistry and Applications of 4-Hydroxyphenacyl Fluoride.

Slanina T, Šebej P, Heckel A, Givens RS, Klán P.

Org Lett. 2015 Oct 2;17(19):4814-7. doi: 10.1021/acs.orglett.5b02374.

PMID:
26378924
32.

Ultrafast Spectroscopy of Hydroxy-Substituted Azobenzenes in Water.

Steinwand S, Halbritter T, Rastädter D, Ortiz-Sánchez JM, Burghardt I, Heckel A, Wachtveitl J.

Chemistry. 2015 Oct 26;21(44):15720-31. doi: 10.1002/chem.201501863. Epub 2015 Sep 8.

PMID:
26345463
33.

A two-photon activatable amino acid linker for the induction of fluorescence.

Friedrich F, Klehs K, Fichte MA, Junek S, Heilemann M, Heckel A.

Chem Commun (Camb). 2015 Oct 28;51(84):15382-5. doi: 10.1039/c5cc05700k.

PMID:
26343765
34.

In Search of an Efficient Photoswitch for Functional RNA: Design Principles from a Microscopic Analysis of Azobenzene-linker-RNA Dynamics with Different Linkers.

Mondal P, Biswas M, Goldau T, Heckel A, Burghardt I.

J Phys Chem B. 2015 Aug 27;119(34):11275-86. doi: 10.1021/acs.jpcb.5b03118. Epub 2015 Jul 20.

PMID:
26125118
35.

Peripheral Nerve Diffusion Tensor Imaging: Assessment of Axon and Myelin Sheath Integrity.

Heckel A, Weiler M, Xia A, Ruetters M, Pham M, Bendszus M, Heiland S, Baeumer P.

PLoS One. 2015 Jun 26;10(6):e0130833. doi: 10.1371/journal.pone.0130833. eCollection 2015.

36.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.

Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6.

PMID:
26112443
37.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29.

PMID:
26105194
38.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.

Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30.

PMID:
26077492
39.

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography.

Breckwoldt MO, Stock C, Xia A, Heckel A, Bendszus M, Pham M, Heiland S, Bäumer P.

Invest Radiol. 2015 Aug;50(8):498-504. doi: 10.1097/RLI.0000000000000156.

PMID:
25850359
40.

Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications.

Özçoban C, Halbritter T, Steinwand S, Herzig LM, Kohl-Landgraf J, Askari N, Groher F, Fürtig B, Richter C, Schwalbe H, Suess B, Wachtveitl J, Heckel A.

Org Lett. 2015 Mar 20;17(6):1517-20. doi: 10.1021/acs.orglett.5b00397. Epub 2015 Mar 11.

PMID:
25760939
41.

Mitochondrial targeting of recombinant RNA.

Dovydenko I, Heckel AM, Tonin Y, Gowher A, Venyaminova A, Tarassov I, Entelis N.

Methods Mol Biol. 2015;1265:209-25. doi: 10.1007/978-1-4939-2288-8_16.

PMID:
25634278
42.

Characterization of conformational dynamics of bistable RNA by equilibrium and non-equilibrium NMR.

Fürtig B, Reining A, Sochor F, Oberhauser EM, Heckel A, Schwalbe H.

Curr Protoc Nucleic Acid Chem. 2014 Dec 19;55:11.13.1-16. doi: 10.1002/0471142700.nc1113s55. Review.

PMID:
25631532
43.
44.

Reversible photoswitching of RNA hybridization at room temperature with an azobenzene C-nucleoside.

Goldau T, Murayama K, Brieke C, Steinwand S, Mondal P, Biswas M, Burghardt I, Wachtveitl J, Asanuma H, Heckel A.

Chemistry. 2015 Feb 9;21(7):2845-54. doi: 10.1002/chem.201405840. Epub 2014 Dec 23.

PMID:
25537843
45.

Direct observation of mobility state transitions in RNA trajectories by sensitive single molecule feedback tracking.

Spille JH, Kaminski TP, Scherer K, Rinne JS, Heckel A, Kubitscheck U.

Nucleic Acids Res. 2015 Jan;43(2):e14. doi: 10.1093/nar/gku1194. Epub 2014 Nov 20.

46.

Selective uncaging of DNA through reaction rate selectivity.

Rodrigues-Correia A, Knapp-Bühle D, Engels JW, Heckel A.

Org Lett. 2014 Oct 3;16(19):5128-31. doi: 10.1021/ol502478g. Epub 2014 Sep 18.

PMID:
25232905
47.

Wavelength-selective uncaging of oligonucleotides.

Rodrigues-Correia A, Seyfried P, Heckel A.

Curr Protoc Nucleic Acid Chem. 2014 Jun 24;57:6.11.1-32. doi: 10.1002/0471142700.nc0611s57.

PMID:
24961722
48.

Peripheral neuropathy: detection with diffusion-tensor imaging.

Bäumer P, Pham M, Ruetters M, Heiland S, Heckel A, Radbruch A, Bendszus M, Weiler M.

Radiology. 2014 Oct;273(1):185-93. doi: 10.1148/radiol.14132837. Epub 2014 May 17.

PMID:
24844471
49.

Three-dimensional protein networks assembled by two-photon activation.

Gatterdam V, Ramadass R, Stoess T, Fichte MA, Wachtveitl J, Heckel A, Tampé R.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5680-4. doi: 10.1002/anie.201309930. Epub 2014 Apr 11.

PMID:
24729568
50.

Modeling of antigenomic therapy of mitochondrial diseases by mitochondrially addressed RNA targeting a pathogenic point mutation in mitochondrial DNA.

Tonin Y, Heckel AM, Vysokikh M, Dovydenko I, Meschaninova M, Rötig A, Munnich A, Venyaminova A, Tarassov I, Entelis N.

J Biol Chem. 2014 May 9;289(19):13323-34. doi: 10.1074/jbc.M113.528968. Epub 2014 Apr 1.

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