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[Molecular tumor board prostate cancer].

Seitz AK, Heck MM, Kamer MW, Grüllich C.

Urologe A. 2019 May 2. doi: 10.1007/s00120-019-0933-2. [Epub ahead of print] Review. German.


Treatment Outcome, Toxicity, and Predictive Factors for Radioligand Therapy with 177Lu-PSMA-I&T in Metastatic Castration-resistant Prostate Cancer.

Heck MM, Tauber R, Schwaiger S, Retz M, D'Alessandria C, Maurer T, Gafita A, Wester HJ, Gschwend JE, Weber WA, Schwaiger M, Knorr K, Eiber M.

Eur Urol. 2019 Jun;75(6):920-926. doi: 10.1016/j.eururo.2018.11.016. Epub 2018 Nov 22.


Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial.

Gschwend JE, Heck MM, Lehmann J, Rübben H, Albers P, Wolff JM, Frohneberg D, de Geeter P, Heidenreich A, Kälble T, Stöckle M, Schnöller T, Stenzl A, Müller M, Truss M, Roth S, Liehr UB, Leißner J, Bregenzer T, Retz M.

Eur Urol. 2019 Apr;75(4):604-611. doi: 10.1016/j.eururo.2018.09.047. Epub 2018 Oct 15.


One-Stop-Shop Whole-Body 68Ga-PSMA-11 PET/MRI Compared with Clinical Nomograms for Preoperative T and N Staging of High-Risk Prostate Cancer.

Thalgott M, Düwel C, Rauscher I, Heck MM, Haller B, Gafita A, Gschwend JE, Schwaiger M, Maurer T, Eiber M.

J Nucl Med. 2018 Dec;59(12):1850-1856. doi: 10.2967/jnumed.117.207696. Epub 2018 May 24.


99mTechnetium-based Prostate-specific Membrane Antigen-radioguided Surgery in Recurrent Prostate Cancer.

Maurer T, Robu S, Schottelius M, Schwamborn K, Rauscher I, van den Berg NS, van Leeuwen FWB, Haller B, Horn T, Heck MM, Gschwend JE, Schwaiger M, Wester HJ, Eiber M.

Eur Urol. 2019 Apr;75(4):659-666. doi: 10.1016/j.eururo.2018.03.013. Epub 2018 Apr 4.


Molecular Lymph Node Status for Prognostic Stratification of Prostate Cancer Patients Undergoing Radical Prostatectomy with Extended Pelvic Lymph Node Dissection.

Heck MM, Retz M, Bandur M, Souchay M, Vitzthum E, Weirich G, Schuster T, Autenrieth M, Kübler H, Maurer T, Thalgott M, Herkommer K, Gschwend JE, Nawroth R.

Clin Cancer Res. 2018 May 15;24(10):2342-2349. doi: 10.1158/1078-0432.CCR-17-3771. Epub 2018 Feb 20.


Efficacy, Predictive Factors, and Prediction Nomograms for 68Ga-labeled Prostate-specific Membrane Antigen-ligand Positron-emission Tomography/Computed Tomography in Early Biochemical Recurrent Prostate Cancer After Radical Prostatectomy.

Rauscher I, Düwel C, Haller B, Rischpler C, Heck MM, Gschwend JE, Schwaiger M, Maurer T, Eiber M.

Eur Urol. 2018 May;73(5):656-661. doi: 10.1016/j.eururo.2018.01.006. Epub 2018 Jan 19.


Isl1β Overexpression With Key β Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion.

Jung Y, Zhou R, Kato T, Usui JK, Muratani M, Oishi H, Heck MMS, Takahashi S.

Endocrinology. 2018 Feb 1;159(2):869-882. doi: 10.1210/en.2017-00663.


Preliminary results on response assessment using 68Ga-HBED-CC-PSMA PET/CT in patients with metastatic prostate cancer undergoing docetaxel chemotherapy.

Seitz AK, Rauscher I, Haller B, Krönke M, Luther S, Heck MM, Horn T, Gschwend JE, Schwaiger M, Eiber M, Maurer T.

Eur J Nucl Med Mol Imaging. 2018 Apr;45(4):602-612. doi: 10.1007/s00259-017-3887-x. Epub 2017 Nov 28.


AR-V7 in Peripheral Whole Blood of Patients with Castration-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide.

Seitz AK, Thoene S, Bietenbeck A, Nawroth R, Tauber R, Thalgott M, Schmid S, Secci R, Retz M, Gschwend JE, Ruland J, Winter C, Heck MM.

Eur Urol. 2017 Nov;72(5):828-834. doi: 10.1016/j.eururo.2017.07.024. Epub 2017 Aug 14.


Wntless promotes bladder cancer growth and acts synergistically as a molecular target in combination with cisplatin.

Schmid SC, Sathe A, Guerth F, Seitz AK, Heck MM, Maurer T, Schwarzenböck SM, Krause BJ, Schulz WA, Stoehr R, Gschwend JE, Retz M; German Bladder Cancer Network, Nawroth R.

Urol Oncol. 2017 Sep;35(9):544.e1-544.e10. doi: 10.1016/j.urolonc.2017.04.015. Epub 2017 May 10.


[PSMA-targeted radioligand therapy in prostate cancer].

Heck MM, Retz M, Tauber R, Knorr K, Kratochwil C, Eiber M.

Urologe A. 2017 Jan;56(1):32-39. doi: 10.1007/s00120-016-0274-3. Review. German.


Radiation Dosimetry for 177Lu-PSMA I&T in Metastatic Castration-Resistant Prostate Cancer: Absorbed Dose in Normal Organs and Tumor Lesions.

Okamoto S, Thieme A, Allmann J, D'Alessandria C, Maurer T, Retz M, Tauber R, Heck MM, Wester HJ, Tamaki N, Fendler WP, Herrmann K, Pfob CH, Scheidhauer K, Schwaiger M, Ziegler S, Eiber M.

J Nucl Med. 2017 Mar;58(3):445-450. doi: 10.2967/jnumed.116.178483. Epub 2016 Sep 22.


A role for the metalloprotease invadolysin in insulin signaling and adipogenesis.

Chang CW, Abhinav K, Di Cara F, Panagakou I, Vass S, Heck MM.

Biol Chem. 2017 Mar;398(3):373-393. doi: 10.1515/hsz-2016-0226.


A 2-Gene Panel Derived From Prostate Cancer-Enhanced Transcripts in Whole Blood Is Prognostic for Survival and Predicts Treatment Benefit in Metastatic Castration-Resistant Prostate Cancer.

Heck MM, Thalgott M, Schmid SC, Oh WK, Gong Y, Wang L, Zhu J, Seitz AK, Porst D, Höppner M, Retz M, Gschwend JE, Nawroth R.

Prostate. 2016 Sep;76(13):1160-8. doi: 10.1002/pros.23202. Epub 2016 May 16.


Chromogranin A and neurone-specific enolase serum levels as predictors of treatment outcome in patients with metastatic castration-resistant prostate cancer undergoing abiraterone therapy.

Heck MM, Thaler MA, Schmid SC, Seitz AK, Tauber R, Kübler H, Maurer T, Thalgott M, Hatzichristodoulou G, Höppner M, Nawroth R, Luppa PB, Gschwend JE, Retz M.

BJU Int. 2017 Jan;119(1):30-37. doi: 10.1111/bju.13493. Epub 2016 Apr 27.


Systemic Radioligand Therapy with (177)Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer.

Heck MM, Retz M, D'Alessandria C, Rauscher I, Scheidhauer K, Maurer T, Storz E, Janssen F, Schottelius M, Wester HJ, Gschwend JE, Schwaiger M, Tauber R, Eiber M.

J Urol. 2016 Aug;196(2):382-91. doi: 10.1016/j.juro.2016.02.2969. Epub 2016 Mar 8.


Evaluation of Computed Tomography for Lymph Node Staging in Bladder Cancer Prior to Radical Cystectomy.

Horn T, Zahel T, Adt N, Schmid SC, Heck MM, Thalgott MK, Hatzichristodoulou G, Haller B, Autenrieth M, Kübler HR, Gschwend JE, Holzapfel K, Maurer T.

Urol Int. 2016;96(1):51-6. doi: 10.1159/000440889. Epub 2015 Oct 30.


Detection of Circulating Tumor Cells in Locally Advanced High-risk Prostate Cancer During Neoadjuvant Chemotherapy and Radical Prostatectomy.

Thalgott M, Rack B, Horn T, Heck MM, Eiber M, Kübler H, Retz M, Gschwend JE, Andergassen U, Nawroth R.

Anticancer Res. 2015 Oct;35(10):5679-85.


A robust blood gene expression-based prognostic model for castration-resistant prostate cancer.

Wang L, Gong Y, Chippada-Venkata U, Heck MM, Retz M, Nawroth R, Galsky M, Tsao CK, Schadt E, de Bono J, Olmos D, Zhu J, Oh WK.

BMC Med. 2015 Aug 21;13:201. doi: 10.1186/s12916-015-0442-0.


Categorical versus continuous circulating tumor cell enumeration as early surrogate marker for therapy response and prognosis during docetaxel therapy in metastatic prostate cancer patients.

Thalgott M, Rack B, Eiber M, Souvatzoglou M, Heck MM, Kronester C, Andergassen U, Kehl V, Krause BJ, Gschwend JE, Retz M, Nawroth R.

BMC Cancer. 2015 Jun 9;15:458. doi: 10.1186/s12885-015-1478-4.


Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.

Rao SG, Janiszewski MM, Duca E, Nelson B, Abhinav K, Panagakou I, Vass S, Heck MM.

Nucleic Acids Res. 2015 Apr 20;43(7):3546-62. doi: 10.1093/nar/gkv211. Epub 2015 Mar 16.


Circulating tumor cells versus objective response assessment predicting survival in metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy.

Thalgott M, Heck MM, Eiber M, Souvatzoglou M, Hatzichristodoulou G, Kehl V, Krause BJ, Rack B, Retz M, Gschwend JE, Andergassen U, Nawroth R.

J Cancer Res Clin Oncol. 2015 Aug;141(8):1457-64. doi: 10.1007/s00432-015-1936-z. Epub 2015 Feb 24.


Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy.

Sathe A, Guerth F, Cronauer MV, Heck MM, Thalgott M, Gschwend JE, Retz M, Nawroth R.

Br J Cancer. 2014 Nov 25;111(11):2103-13. doi: 10.1038/bjc.2014.534. Epub 2014 Nov 4.


Prognostic value of 11C-choline PET/CT and CT for predicting survival of bladder cancer patients treated with radical cystectomy.

Maurer T, Horn T, Souvatzoglou M, Eiber M, Beer AJ, Heck MM, Haller B, Gschwend JE, Schwaiger M, Treiber U, Krause BJ.

Urol Int. 2014;93(2):207-13. doi: 10.1159/000357686. Epub 2014 Jul 9.


Preoperative lymph node staging in patients with primary prostate cancer: comparison and correlation of quantitative imaging parameters in diffusion-weighted imaging and 11C-choline PET/CT.

Vag T, Heck MM, Beer AJ, Souvatzoglou M, Weirich G, Holzapfel K, Rummeny EJ, Schwaiger M, Krause BJ, Eiber M.

Eur Radiol. 2014 Aug;24(8):1821-6. doi: 10.1007/s00330-014-3240-8. Epub 2014 Jun 3. Erratum in: Eur Radiol. 2014 Aug;24(8):1827.


[Molecular diagnostics and molecular staging: new developments on the way to daily clinical practice?].

Heck MM, Gschwend JE.

Urologe A. 2014 Apr;53(4):467-8. doi: 10.1007/s00120-014-3477-5. German. No abstract available.


[Detection of circulating tumor cells from peripheral blood in prostate cancer].

Thalgott M, Heck MM, Pantel K.

Urologe A. 2014 Apr;53(4):509-13. doi: 10.1007/s00120-014-3444-1. Review. German.


[Molecular lymph node staging in prostate and bladder cancer].

Heck MM, Retz M, Nawroth R.

Urologe A. 2014 Apr;53(4):484-90. doi: 10.1007/s00120-014-3441-4. Review. German.


Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer.

Thalgott M, Horn T, Heck MM, Maurer T, Eiber M, Retz M, Autenrieth M, Herkommer K, Krause BJ, Gschwend JE, Treiber U, Kübler HR.

J Hematol Oncol. 2014 Mar 5;7:20. doi: 10.1186/1756-8722-7-20.


Prospective comparison of computed tomography, diffusion-weighted magnetic resonance imaging and [11C]choline positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer patients.

Heck MM, Souvatzoglou M, Retz M, Nawroth R, Kübler H, Maurer T, Thalgott M, Gramer BM, Weirich G, Rondak IC, Rummeny EJ, Schwaiger M, Gschwend JE, Krause B, Eiber M.

Eur J Nucl Med Mol Imaging. 2014 Apr;41(4):694-701. doi: 10.1007/s00259-013-2634-1. Epub 2013 Dec 3.


Invadolysin, a conserved lipid-droplet-associated metalloproteinase, is required for mitochondrial function in Drosophila.

Di Cara F, Duca E, Dunbar DR, Cagney G, Heck MM.

J Cell Sci. 2013 Oct 15;126(Pt 20):4769-81. doi: 10.1242/jcs.133306. Epub 2013 Aug 13.


Enzalutamide (formerly MDV3100) prolongs survival in docetaxel-pretreated castration-resistant prostate cancer patients.

Heck MM, Gschwend JE, Retz M.

Transl Androl Urol. 2013 Jun;2(2):92-3. doi: 10.3978/j.issn.2223-4683.2012.11.02. No abstract available.


Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster.

Catterson JH, Heck MM, Hartley PS.

PLoS One. 2013 May 15;8(5):e62958. doi: 10.1371/journal.pone.0062958. Print 2013.


Topography of lymph node metastases in prostate cancer patients undergoing radical prostatectomy and extended lymphadenectomy: results of a combined molecular and histopathologic mapping study.

Heck MM, Retz M, Bandur M, Souchay M, Vitzthum E, Weirich G, Mollenhauer M, Schuster T, Autenrieth M, Kübler H, Maurer T, Thalgott M, Herkommer K, Gschwend JE, Nawroth R.

Eur Urol. 2014 Aug;66(2):222-9. doi: 10.1016/j.eururo.2013.02.007. Epub 2013 Feb 18.


Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio).

Vass S, Heck MM.

Exp Cell Res. 2013 May 1;319(8):1198-212. doi: 10.1016/j.yexcr.2013.02.005. Epub 2013 Feb 16.


Detection of circulating tumor cells in different stages of prostate cancer.

Thalgott M, Rack B, Maurer T, Souvatzoglou M, Eiber M, Kreß V, Heck MM, Andergassen U, Nawroth R, Gschwend JE, Retz M.

J Cancer Res Clin Oncol. 2013 May;139(5):755-63. doi: 10.1007/s00432-013-1377-5. Epub 2013 Jan 29.


Rational indication for docetaxel rechallenge in metastatic castration-resistant prostate cancer.

Heck MM, Thalgott M, Retz M, Wolf P, Maurer T, Nawroth R, Hatzichristodoulou G, Gschwend JE, Kübler H.

BJU Int. 2012 Dec;110(11 Pt B):E635-40. doi: 10.1111/j.1464-410X.2012.11364.x. Epub 2012 Aug 13.


Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.

Bolukbasi E, Vass S, Cobbe N, Nelson B, Simossis V, Dunbar DR, Heck MM.

Open Biol. 2012 Jan;2(1):110031. doi: 10.1098/rsob.110031.


[Chemotherapy for bladder cancer: 2012 Update. From AUO ("Arbeitsgemeinschaft Urologische Onkologie") and IABC ("Interdisziplinäre Arbeitsgruppe BlasenCarcinom")].

Heck MM, Gschwend JE, Retz M; Arbeitsgemeinschaft Urologische Onkologie; Interdisziplinäre Arbeitsgruppe BlasenCarcinom.

Urologe A. 2012 Jun;51(6):829-36. doi: 10.1007/s00120-012-2822-9. German.


A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity.

Longworth MS, Walker JA, Anderssen E, Moon NS, Gladden A, Heck MM, Ramaswamy S, Dyson NJ.

PLoS Genet. 2012;8(4):e1002618. doi: 10.1371/journal.pgen.1002618. Epub 2012 Apr 5.


[Compassionate use of abiraterone and cabazitaxel: first experiences in docetaxel-pretreated castration-resistant prostate cancer patients].

Heck MM, Höppner M, Horn T, Thalgott M, Gschwend JE, Retz M.

Urologe A. 2012 Mar;51(3):390-7. doi: 10.1007/s00120-012-2804-y. German.


Effect of family history on outcome in German patients treated with radical prostatectomy for clinically localised prostate cancer.

Heck MM, Kron M, Gschwend JE, Herkommer K.

Eur J Cancer. 2012 Jun;48(9):1312-7. doi: 10.1016/j.ejca.2011.10.002. Epub 2011 Nov 5.


A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response.

Howell L, Sampson CJ, Xavier MJ, Bolukbasi E, Heck MM, Williams MJ.

Immunogenetics. 2012 Feb;64(2):155-61. doi: 10.1007/s00251-011-0571-3. Epub 2011 Sep 27.


Glucocorticoid-mediated inhibition of angiogenic changes in human endothelial cells is not caused by reductions in cell proliferation or migration.

Logie JJ, Ali S, Marshall KM, Heck MM, Walker BR, Hadoke PW.

PLoS One. 2010 Dec 31;5(12):e14476. doi: 10.1371/journal.pone.0014476.


[Update on chemotherapy for bladder cancer. Update 2010].

Heck MM, Gschwend JE, Retz M.

Urologe A. 2010 Oct;49(10):1294-300. doi: 10.1007/s00120-010-2380-y. Review. German.


Dietary modulation of Drosophila sleep-wake behaviour.

Catterson JH, Knowles-Barley S, James K, Heck MM, Harmar AJ, Hartley PS.

PLoS One. 2010 Aug 10;5(8):e12062. doi: 10.1371/journal.pone.0012062.


The conserved metalloprotease invadolysin localizes to the surface of lipid droplets.

Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, Heck MM.

J Cell Sci. 2009 Sep 15;122(Pt 18):3414-23. doi: 10.1242/jcs.044610. Epub 2009 Aug 25.


Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells.

Crevel G, Hashimoto R, Vass S, Sherkow J, Yamaguchi M, Heck MM, Cotterill S.

PLoS One. 2007 Sep 5;2(9):e833.


Sequential loading of cohesin subunits during the first meiotic prophase of grasshoppers.

Valdeolmillos AM, Viera A, Page J, Prieto I, Santos JL, Parra MT, Heck MM, Martínez-A C, Barbero JL, Suja JA, Rufas JS.

PLoS Genet. 2007 Feb 23;3(2):e28. Epub 2007 Jan 2.

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