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Items: 1 to 50 of 601

1.

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye TT, Heck AJR, Calvo F, Agudo-Ibáñez L, Crespo P, Matallanas D, Kolch W.

Cell Rep. 2019 Mar 12;26(11):3100-3115.e7. doi: 10.1016/j.celrep.2019.02.038.

2.

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome.

Demmers LC, Heck AJR, Wu W.

J Proteome Res. 2019 Feb 26. doi: 10.1021/acs.jproteome.8b00821. [Epub ahead of print]

PMID:
30784271
3.

Proteomic Profiling of Mouse Helper T Cell Differentiation.

van den Ham HJ, Binai NA, Zaaraoui-Boutahar F, Heck AJR, Andeweg AC.

Proteomics. 2019 Feb 13:e1800045. doi: 10.1002/pmic.201800045. [Epub ahead of print]

PMID:
30758134
4.

Toward an efficient workflow for the analysis of the human milk peptidome.

Dingess KA, van den Toorn HWP, Mank M, Stahl B, Heck AJR.

Anal Bioanal Chem. 2019 Feb 2. doi: 10.1007/s00216-018-01566-4. [Epub ahead of print]

PMID:
30710207
5.

PaDuA: A Python Library for High-Throughput (Phospho)proteomics Data Analysis.

Ressa A, Fitzpatrick M, van den Toorn H, Heck AJR, Altelaar M.

J Proteome Res. 2019 Feb 1;18(2):576-584. doi: 10.1021/acs.jproteome.8b00576. Epub 2018 Dec 21.

6.

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I.

Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127. doi: 10.1038/s41594-018-0156-z. Epub 2018 Dec 3.

PMID:
30510221
7.

Discovery and quantification of non-human proteins in human milk.

Zhu J, Garrigues L, Van den Toorn H, Stahl B, Heck AJR.

J Proteome Res. 2018 Nov 29. doi: 10.1021/acs.jproteome.8b00550. [Epub ahead of print]

8.

Phosphopeptide fragmentation and site localization by mass spectrometry; an update.

Potel CM, Lemeer S, Heck AJR.

Anal Chem. 2018 Nov 20. doi: 10.1021/acs.analchem.8b04746. [Epub ahead of print]

9.

Efficient and robust proteome-wide approaches for cross-linking mass spectrometry.

Klykov O, Steigenberger B, Pektaş S, Fasci D, Heck AJR, Scheltema RA.

Nat Protoc. 2018 Dec;13(12):2964-2990. doi: 10.1038/s41596-018-0074-x.

PMID:
30446747
10.

Label-free targeted LC-ESI-MS2 analysis of human milk oligosaccharides (HMOS) and related human milk groups with enhanced structural selectivity.

Mank M, Welsch P, Heck AJR, Stahl B.

Anal Bioanal Chem. 2019 Jan;411(1):231-250. doi: 10.1007/s00216-018-1434-7. Epub 2018 Nov 16.

PMID:
30443773
11.

Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Čaval T, Zhu J, Tian W, Remmelzwaal S, Yang Z, Clausen H, Heck AJR.

Mol Cell Proteomics. 2019 Jan;18(1):16-27. doi: 10.1074/mcp.RA118.000967. Epub 2018 Sep 20.

PMID:
30237200
12.

A New Tool to Reveal Bacterial Signaling Mechanisms in Antibiotic Treatment and Resistance.

Lin MH, Potel CM, Tehrani KHME, Heck AJR, Martin NI, Lemeer S.

Mol Cell Proteomics. 2018 Dec;17(12):2496-2507. doi: 10.1074/mcp.RA118.000880. Epub 2018 Sep 19.

PMID:
30232125
13.

Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes.

Šoštarić N, O'Reilly FJ, Giansanti P, Heck AJR, Gavin AC, van Noort V.

Mol Cell Proteomics. 2018 Dec;17(12):2387-2401. doi: 10.1074/mcp.RA118.000892. Epub 2018 Sep 4.

PMID:
30181345
14.

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.

Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Piñeiro-Yañez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M.

Nat Commun. 2018 Aug 29;9(1):3501. doi: 10.1038/s41467-018-05742-z.

15.

Direct quality control of glycoengineered erythropoietin variants.

Čaval T, Tian W, Yang Z, Clausen H, Heck AJR.

Nat Commun. 2018 Aug 21;9(1):3342. doi: 10.1038/s41467-018-05536-3.

16.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Fasci D, van Ingen H, Scheltema RA, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):2018-2033. doi: 10.1074/mcp.RA118.000924. Epub 2018 Jul 18.

PMID:
30021884
17.

A Protein-Based Encapsulation System with Calcium-Controlled Cargo Loading and Detachment.

Lizatović R, Assent M, Barendregt A, Dahlin J, Bille A, Satzinger K, Tupina D, Heck AJR, Wennmalm S, André I.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11334-11338. doi: 10.1002/anie.201806466. Epub 2018 Jul 30.

PMID:
29975817
18.

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Ressa A, Bosdriesz E, de Ligt J, Mainardi S, Maddalo G, Prahallad A, Jager M, de la Fonteijne L, Fitzpatrick M, Groten S, Altelaar AFM, Bernards R, Cuppen E, Wessels L, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):1892-1908. doi: 10.1074/mcp.RA117.000486. Epub 2018 Jul 3.

PMID:
29970458
19.

Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin.

Lin YH, Franc V, Heck AJR.

J Proteome Res. 2018 Aug 3;17(8):2861-2869. doi: 10.1021/acs.jproteome.8b00318. Epub 2018 Jul 13.

20.

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.

van de Waterbeemd M, Tamara S, Fort KL, Damoc E, Franc V, Bieri P, Itten M, Makarov A, Ban N, Heck AJR.

Nat Commun. 2018 Jun 27;9(1):2493. doi: 10.1038/s41467-018-04853-x.

21.

Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Magliozzi R, Carrero ZI, Low TY, Yuniati L, Valdes-Quezada C, Kruiswijk F, van Wijk K, Heck AJR, Jackson CL, Guardavaccaro D.

Cell Rep. 2018 Jun 12;23(11):3381-3391.e4. doi: 10.1016/j.celrep.2018.05.031.

22.

Actin from the apicomplexan Neospora caninum (NcACT) has different isoforms in 2D electrophoresis.

Baroni L, Pollo-Oliveira L, Heck AJ, Altelaar AM, Yatsuda AP.

Parasitology. 2019 Jan;146(1):33-41. doi: 10.1017/S0031182018000872. Epub 2018 Jun 6.

PMID:
29871709
23.

Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.

Potel CM, Fasci D, Heck AJR.

FEBS J. 2018 Aug;285(15):2856-2868. doi: 10.1111/febs.14525. Epub 2018 Jun 19.

PMID:
29863788
24.

Vaccine antigens modulate the innate response of monocytes to Al(OH)3.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, van Riet E, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

PLoS One. 2018 May 29;13(5):e0197885. doi: 10.1371/journal.pone.0197885. eCollection 2018.

25.

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).

Lill JR, van Veelen PA, Tenzer S, Admon A, Caron E, Elias JE, Heck AJR, Marcilla M, Marino F, Müller M, Peters B, Purcell A, Sette A, Sturm T, Ternette N, Vizcaíno JA, Bassani-Sternberg M.

Proteomics. 2018 Jun;18(12):e1800110. doi: 10.1002/pmic.201800110.

26.

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.

Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Desai M, Bricault S, Wörner TP, Snijder J, Geerlof A, Fuchs H, Hrabĕ de Angelis M, Heck AJR, Jasanoff A, Ntziachristos V, Plitzko J, Westmeyer GG.

Nat Commun. 2018 May 18;9(1):1990. doi: 10.1038/s41467-018-04227-3.

27.

Distinct Stabilities of the Structurally Homologous Heptameric Co-Chaperonins GroES and gp31.

Dyachenko A, Tamara S, Heck AJR.

J Am Soc Mass Spectrom. 2019 Jan;30(1):7-15. doi: 10.1007/s13361-018-1910-5. Epub 2018 May 7. Erratum in: J Am Soc Mass Spectrom. 2019 Mar;30(3):561.

28.

Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe.

van der Laarse SAM, Leney AC, Heck AJR.

FEBS J. 2018 Sep;285(17):3152-3167. doi: 10.1111/febs.14491. Epub 2018 May 13. Review.

PMID:
29717537
29.

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L Jr, Heck AJR, Wehrens XHT.

Circulation. 2018 Oct 9;138(15):1569-1581. doi: 10.1161/CIRCULATIONAHA.118.034361.

PMID:
29669786
30.

CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation.

Wu W, Zaal EA, Berkers CR, Lemeer S, Heck AJR.

Mol Cell Proteomics. 2018 Aug;17(8):1502-1514. doi: 10.1074/mcp.RA118.000708. Epub 2018 Apr 18.

PMID:
29669735
31.

TMEM59 potentiates Wnt signaling by promoting signalosome formation.

Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9.

32.

TREM-1 multimerization is essential for its activation on monocytes and neutrophils.

Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M.

Cell Mol Immunol. 2018 Mar 22. doi: 10.1038/s41423-018-0003-5. [Epub ahead of print]

PMID:
29568119
33.

Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.

Franc V, Zhu J, Heck AJR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1099-1110. doi: 10.1007/s13361-018-1901-6. Epub 2018 Mar 12.

34.

Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment.

Potel CM, Lin MH, Heck AJR, Lemeer S.

Mol Cell Proteomics. 2018 May;17(5):1028-1034. doi: 10.1074/mcp.TIR117.000518. Epub 2018 Feb 15.

PMID:
29449344
35.

Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation.

Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH.

Mol Cell Proteomics. 2018 Dec;17(12):2297-2308. doi: 10.1074/mcp.RA118.000652. Epub 2018 Feb 8.

36.

Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics.

Potel CM, Lin MH, Heck AJR, Lemeer S.

Nat Methods. 2018 Mar;15(3):187-190. doi: 10.1038/nmeth.4580. Epub 2018 Jan 29.

PMID:
29377012
37.

Parsimonious Charge Deconvolution for Native Mass Spectrometry.

Bern M, Caval T, Kil YJ, Tang W, Becker C, Carlson E, Kletter D, Sen KI, Galy N, Hagemans D, Franc V, Heck AJR.

J Proteome Res. 2018 Mar 2;17(3):1216-1226. doi: 10.1021/acs.jproteome.7b00839. Epub 2018 Feb 8.

38.

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM.

J Lipid Res. 2018 Mar;59(3):515-530. doi: 10.1194/jlr.M082354. Epub 2018 Jan 17.

39.

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus.

Huijbers MME, van Alen I, Wu JW, Barendregt A, Heck AJR, van Berkel WJH.

Molecules. 2018 Jan 16;23(1). pii: E184. doi: 10.3390/molecules23010184.

40.

Novel identified aluminum hydroxide-induced pathways prove monocyte activation and pro-inflammatory preparedness.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, Mommen GPM, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

J Proteomics. 2018 Mar 20;175:144-155. doi: 10.1016/j.jprot.2017.12.021. Epub 2018 Jan 6.

41.

Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer.

Fort KL, Cramer CN, Voinov VG, Vasil'ev YV, Lopez NI, Beckman JS, Heck AJR.

J Proteome Res. 2018 Feb 2;17(2):926-933. doi: 10.1021/acs.jproteome.7b00622. Epub 2017 Dec 28.

42.

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.

Liu F, Lössl P, Rabbitts BM, Balaban RS, Heck AJR.

Mol Cell Proteomics. 2018 Feb;17(2):216-232. doi: 10.1074/mcp.RA117.000470. Epub 2017 Dec 8.

43.

Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.

Leloup N, Lössl P, Meijer DH, Brennich M, Heck AJR, Thies-Weesie DME, Janssen BJC.

Nat Commun. 2017 Nov 22;8(1):1708. doi: 10.1038/s41467-017-01485-5.

44.

Connecting color with assembly in the fluorescent B-phycoerythrin protein complex.

Leney AC, Tschanz A, Heck AJR.

FEBS J. 2018 Jan;285(1):178-187. doi: 10.1111/febs.14331. Epub 2017 Nov 28.

45.

Expanding the structural analysis capabilities on an Orbitrap-based mass spectrometer for large macromolecular complexes.

Fort KL, van de Waterbeemd M, Boll D, Reinhardt-Szyba M, Belov ME, Sasaki E, Zschoche R, Hilvert D, Makarov AA, Heck AJR.

Analyst. 2017 Dec 18;143(1):100-105. doi: 10.1039/c7an01629h.

PMID:
29138777
46.

Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry.

Rodenburg RNP, Snijder J, van de Waterbeemd M, Schouten A, Granneman J, Heck AJR, Gros P.

Nat Commun. 2017 Nov 3;8(1):1280. doi: 10.1038/s41467-017-01461-z.

47.

Facilitating identification of minimal protein binding domains by cross-linking mass spectrometry.

Liu Q, Remmelzwaal S, Heck AJR, Akhmanova A, Liu F.

Sci Rep. 2017 Oct 18;7(1):13453. doi: 10.1038/s41598-017-13663-y.

48.

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells.

Joshi RN, Binai NA, Marabita F, Sui Z, Altman A, Heck AJR, Tegnér J, Schmidt A.

Front Immunol. 2017 Sep 25;8:1163. doi: 10.3389/fimmu.2017.01163. eCollection 2017.

49.

The SysteMHC Atlas project.

Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1237-D1247. doi: 10.1093/nar/gkx664.

50.

Phosphate Transfer in Activated Protein Complexes Reveals Interaction Sites.

Tamara S, Scheltema RA, Heck AJR, Leney AC.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13641-13644. doi: 10.1002/anie.201706749. Epub 2017 Sep 27.

PMID:
28869719

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