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Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions.

Heck AJ, Ostertag T, Schnell L, Fischer S, Agrawalla BK, Winterwerber P, Wirsching E, Fauler M, Frick M, Kuan SL, Weil T, Barth H.

Adv Healthc Mater. 2019 Jul 18:e1900665. doi: 10.1002/adhm.201900665. [Epub ahead of print]


Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification.

Čaval T, Zhu J, Heck AJR.

Anal Chem. 2019 Jul 31. doi: 10.1021/acs.analchem.9b02125. [Epub ahead of print]


Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.


Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT.

Circulation. 2019 Jun 12. doi: 10.1161/CIRCULATIONAHA.119.039642. [Epub ahead of print]


Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces.

Strasser J, de Jong RN, Beurskens FJ, Wang G, Heck AJR, Schuurman J, Parren PWHI, Hinterdorfer P, Preiner J.

Nano Lett. 2019 Jul 10;19(7):4787-4796. doi: 10.1021/acs.nanolett.9b02220. Epub 2019 Jun 11.


Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein.

Lin YH, Zhu J, Meijer S, Franc V, Heck AJR.

Mol Cell Proteomics. 2019 Aug;18(8):1479-1490. doi: 10.1074/mcp.RA119.001411. Epub 2019 May 16.


First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.


Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.

Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM.

Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0.


Gaining Confidence in the Elusive Histidine Phosphoproteome.

Potel CM, Lin MH, Prust N, van den Toorn HWP, Heck AJR, Lemeer S.

Anal Chem. 2019 May 7;91(9):5542-5547. doi: 10.1021/acs.analchem.9b00734. Epub 2019 Apr 23.


An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye TT, Heck AJR, Calvo F, Agudo-Ibáñez L, Crespo P, Matallanas D, Kolch W.

Cell Rep. 2019 Mar 12;26(11):3100-3115.e7. doi: 10.1016/j.celrep.2019.02.038.


Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome.

Demmers LC, Heck AJR, Wu W.

J Proteome Res. 2019 Apr 5;18(4):1634-1643. doi: 10.1021/acs.jproteome.8b00821. Epub 2019 Feb 26.


Proteomic Profiling of Mouse Helper T Cell Differentiation.

van den Ham HJ, Binai NA, Zaaraoui-Boutahar F, Heck AJR, Andeweg AC.

Proteomics. 2019 Apr;19(7):e1800045. doi: 10.1002/pmic.201800045. Epub 2019 Mar 18.


Toward an efficient workflow for the analysis of the human milk peptidome.

Dingess KA, van den Toorn HWP, Mank M, Stahl B, Heck AJR.

Anal Bioanal Chem. 2019 Mar;411(7):1351-1363. doi: 10.1007/s00216-018-01566-4. Epub 2019 Feb 2.


PaDuA: A Python Library for High-Throughput (Phospho)proteomics Data Analysis.

Ressa A, Fitzpatrick M, van den Toorn H, Heck AJR, Altelaar M.

J Proteome Res. 2019 Feb 1;18(2):576-584. doi: 10.1021/acs.jproteome.8b00576. Epub 2018 Dec 21.


Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I.

Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127. doi: 10.1038/s41594-018-0156-z. Epub 2018 Dec 3.


Discovery and Quantification of Nonhuman Proteins in Human Milk.

Zhu J, Garrigues L, Van den Toorn H, Stahl B, Heck AJR.

J Proteome Res. 2019 Jan 4;18(1):225-238. doi: 10.1021/acs.jproteome.8b00550. Epub 2018 Dec 12.


Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update.

Potel CM, Lemeer S, Heck AJR.

Anal Chem. 2019 Jan 2;91(1):126-141. doi: 10.1021/acs.analchem.8b04746. Epub 2018 Dec 5. No abstract available.


Efficient and robust proteome-wide approaches for cross-linking mass spectrometry.

Klykov O, Steigenberger B, Pektaş S, Fasci D, Heck AJR, Scheltema RA.

Nat Protoc. 2018 Dec;13(12):2964-2990. doi: 10.1038/s41596-018-0074-x.


Label-free targeted LC-ESI-MS2 analysis of human milk oligosaccharides (HMOS) and related human milk groups with enhanced structural selectivity.

Mank M, Welsch P, Heck AJR, Stahl B.

Anal Bioanal Chem. 2019 Jan;411(1):231-250. doi: 10.1007/s00216-018-1434-7. Epub 2018 Nov 16.


Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Čaval T, Zhu J, Tian W, Remmelzwaal S, Yang Z, Clausen H, Heck AJR.

Mol Cell Proteomics. 2019 Jan;18(1):16-27. doi: 10.1074/mcp.RA118.000967. Epub 2018 Sep 20.


A New Tool to Reveal Bacterial Signaling Mechanisms in Antibiotic Treatment and Resistance.

Lin MH, Potel CM, Tehrani KHME, Heck AJR, Martin NI, Lemeer S.

Mol Cell Proteomics. 2018 Dec;17(12):2496-2507. doi: 10.1074/mcp.RA118.000880. Epub 2018 Sep 19.


Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes.

Šoštarić N, O'Reilly FJ, Giansanti P, Heck AJR, Gavin AC, van Noort V.

Mol Cell Proteomics. 2018 Dec;17(12):2387-2401. doi: 10.1074/mcp.RA118.000892. Epub 2018 Sep 4.


In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.

Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Piñeiro-Yañez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M.

Nat Commun. 2018 Aug 29;9(1):3501. doi: 10.1038/s41467-018-05742-z.


Direct quality control of glycoengineered erythropoietin variants.

Čaval T, Tian W, Yang Z, Clausen H, Heck AJR.

Nat Commun. 2018 Aug 21;9(1):3342. doi: 10.1038/s41467-018-05536-3.


Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Fasci D, van Ingen H, Scheltema RA, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):2018-2033. doi: 10.1074/mcp.RA118.000924. Epub 2018 Jul 18.


A Protein-Based Encapsulation System with Calcium-Controlled Cargo Loading and Detachment.

Lizatović R, Assent M, Barendregt A, Dahlin J, Bille A, Satzinger K, Tupina D, Heck AJR, Wennmalm S, André I.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11334-11338. doi: 10.1002/anie.201806466. Epub 2018 Jul 30.


A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Ressa A, Bosdriesz E, de Ligt J, Mainardi S, Maddalo G, Prahallad A, Jager M, de la Fonteijne L, Fitzpatrick M, Groten S, Altelaar AFM, Bernards R, Cuppen E, Wessels L, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):1892-1908. doi: 10.1074/mcp.RA117.000486. Epub 2018 Jul 3.


Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin.

Lin YH, Franc V, Heck AJR.

J Proteome Res. 2018 Aug 3;17(8):2861-2869. doi: 10.1021/acs.jproteome.8b00318. Epub 2018 Jul 13.


Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.

van de Waterbeemd M, Tamara S, Fort KL, Damoc E, Franc V, Bieri P, Itten M, Makarov A, Ban N, Heck AJR.

Nat Commun. 2018 Jun 27;9(1):2493. doi: 10.1038/s41467-018-04853-x.


Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Magliozzi R, Carrero ZI, Low TY, Yuniati L, Valdes-Quezada C, Kruiswijk F, van Wijk K, Heck AJR, Jackson CL, Guardavaccaro D.

Cell Rep. 2018 Jun 12;23(11):3381-3391.e4. doi: 10.1016/j.celrep.2018.05.031.


Actin from the apicomplexan Neospora caninum (NcACT) has different isoforms in 2D electrophoresis.

Baroni L, Pollo-Oliveira L, Heck AJ, Altelaar AM, Yatsuda AP.

Parasitology. 2019 Jan;146(1):33-41. doi: 10.1017/S0031182018000872. Epub 2018 Jun 6.


Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.

Potel CM, Fasci D, Heck AJR.

FEBS J. 2018 Aug;285(15):2856-2868. doi: 10.1111/febs.14525. Epub 2018 Jun 19.


Vaccine antigens modulate the innate response of monocytes to Al(OH)3.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, van Riet E, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

PLoS One. 2018 May 29;13(5):e0197885. doi: 10.1371/journal.pone.0197885. eCollection 2018.


Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).

Lill JR, van Veelen PA, Tenzer S, Admon A, Caron E, Elias JE, Heck AJR, Marcilla M, Marino F, Müller M, Peters B, Purcell A, Sette A, Sturm T, Ternette N, Vizcaíno JA, Bassani-Sternberg M.

Proteomics. 2018 Jun;18(12):e1800110. doi: 10.1002/pmic.201800110.


Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.

Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Desai M, Bricault S, Wörner TP, Snijder J, Geerlof A, Fuchs H, Hrabĕ de Angelis M, Heck AJR, Jasanoff A, Ntziachristos V, Plitzko J, Westmeyer GG.

Nat Commun. 2018 May 18;9(1):1990. doi: 10.1038/s41467-018-04227-3.


Distinct Stabilities of the Structurally Homologous Heptameric Co-Chaperonins GroES and gp31.

Dyachenko A, Tamara S, Heck AJR.

J Am Soc Mass Spectrom. 2019 Jan;30(1):7-15. doi: 10.1007/s13361-018-1910-5. Epub 2018 May 7. Erratum in: J Am Soc Mass Spectrom. 2019 Mar;30(3):561.


Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe.

van der Laarse SAM, Leney AC, Heck AJR.

FEBS J. 2018 Sep;285(17):3152-3167. doi: 10.1111/febs.14491. Epub 2018 May 13. Review.


Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L Jr, Heck AJR, Wehrens XHT.

Circulation. 2018 Oct 9;138(15):1569-1581. doi: 10.1161/CIRCULATIONAHA.118.034361.


CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation.

Wu W, Zaal EA, Berkers CR, Lemeer S, Heck AJR.

Mol Cell Proteomics. 2018 Aug;17(8):1502-1514. doi: 10.1074/mcp.RA118.000708. Epub 2018 Apr 18.


TMEM59 potentiates Wnt signaling by promoting signalosome formation.

Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9.


TREM-1 multimerization is essential for its activation on monocytes and neutrophils.

Carrasco K, Boufenzer A, Jolly L, Le Cordier H, Wang G, Heck AJ, Cerwenka A, Vinolo E, Nazabal A, Kriznik A, Launay P, Gibot S, Derive M.

Cell Mol Immunol. 2019 May;16(5):460-472. doi: 10.1038/s41423-018-0003-5. Epub 2018 Mar 22.


Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches.

Franc V, Zhu J, Heck AJR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1099-1110. doi: 10.1007/s13361-018-1901-6. Epub 2018 Mar 12.


Defeating Major Contaminants in Fe3+- Immobilized Metal Ion Affinity Chromatography (IMAC) Phosphopeptide Enrichment.

Potel CM, Lin MH, Heck AJR, Lemeer S.

Mol Cell Proteomics. 2018 May;17(5):1028-1034. doi: 10.1074/mcp.TIR117.000518. Epub 2018 Feb 15.


Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation.

Halim VA, García-Santisteban I, Warmerdam DO, van den Broek B, Heck AJR, Mohammed S, Medema RH.

Mol Cell Proteomics. 2018 Dec;17(12):2297-2308. doi: 10.1074/mcp.RA118.000652. Epub 2018 Feb 8.


Widespread bacterial protein histidine phosphorylation revealed by mass spectrometry-based proteomics.

Potel CM, Lin MH, Heck AJR, Lemeer S.

Nat Methods. 2018 Mar;15(3):187-190. doi: 10.1038/nmeth.4580. Epub 2018 Jan 29.


Parsimonious Charge Deconvolution for Native Mass Spectrometry.

Bern M, Caval T, Kil YJ, Tang W, Becker C, Carlson E, Kletter D, Sen KI, Galy N, Hagemans D, Franc V, Heck AJR.

J Proteome Res. 2018 Mar 2;17(3):1216-1226. doi: 10.1021/acs.jproteome.7b00839. Epub 2018 Feb 8.


A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, Holthuis JCM.

J Lipid Res. 2018 Mar;59(3):515-530. doi: 10.1194/jlr.M082354. Epub 2018 Jan 17.


Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus.

Huijbers MME, van Alen I, Wu JW, Barendregt A, Heck AJR, van Berkel WJH.

Molecules. 2018 Jan 16;23(1). pii: E184. doi: 10.3390/molecules23010184.


Novel identified aluminum hydroxide-induced pathways prove monocyte activation and pro-inflammatory preparedness.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, Mommen GPM, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

J Proteomics. 2018 Mar 20;175:144-155. doi: 10.1016/j.jprot.2017.12.021. Epub 2018 Jan 6.


Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer.

Fort KL, Cramer CN, Voinov VG, Vasil'ev YV, Lopez NI, Beckman JS, Heck AJR.

J Proteome Res. 2018 Feb 2;17(2):926-933. doi: 10.1021/acs.jproteome.7b00622. Epub 2017 Dec 28.

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