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Items: 1 to 50 of 621

1.

A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out.

Hoeksma J, Misset T, Wever C, Kemmink J, Kruijtzer J, Versluis K, Liskamp RMJ, Boons GJ, Heck AJR, Boekhout T, den Hertog J.

Sci Rep. 2019 Nov 26;9(1):17546. doi: 10.1038/s41598-019-54127-9.

2.

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice.

Muha V, Williamson R, Hills R, McNeilly AD, McWilliams TG, Alonso J, Schimpl M, Leney AC, Heck AJR, Sutherland C, Read KD, McCrimmon RJ, Brooks SP, van Aalten DMF.

Open Biol. 2019 Nov 29;9(11):190192. doi: 10.1098/rsob.190192. Epub 2019 Nov 27.

3.

Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation.

Reiding KR, Franc V, Huitema MG, Brouwer E, Heeringa P, Heck AJR.

J Biol Chem. 2019 Nov 12. pii: jbc.RA119.011098. doi: 10.1074/jbc.RA119.011098. [Epub ahead of print]

4.

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods.

De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Gruber C, Shao C, Zaia J, Evers W, Pangelley S, Suckau D, Wiechmann A, Resemann A, Jabs W, Beck A, Froehlich JW, Huang C, Li Y, Liu Y, Sun S, Wang Y, Seo Y, An HJ, Reichardt NC, Ruiz JE, Archer-Hartmann S, Azadi P, Bell L, Lakos Z, An Y, Cipollo JF, Pučić-Baković M, Štambuk J, Lauc G, Li X, Wang PG, Bock A, Hennig R, Rapp E, Creskey M, Cyr T, Nakano M, Sugiyama T, Leung PA, Link-Lenczowski P, Jaworek J, Yang SJ, Zhang H, Kelly T, Klapoetke S, Cao R, Kim JY, Lee HK, Lee J, Yoo JS, Kim SR, Suh SK, de Haan N, Falck D, Lageveen-Kammeijer GSM, Wuhrer M, Emery RJ, Kozak RP, Liew LP, Royle L, Urbanowicz PA, Packer N, Song X, Everest-Dass A, Lattová E, Cajic S, Alagesan K, Kolarich D, Kasali T, Lindo V, Chen Y, Goswami K, Gau B, Amunugama R, Jones R, Stroop CJM, Kato K, Yagi H, Kondo S, Yuen CT, Harazono A, Shi X, Magnelli P, Kasper BT, Mahal LK, Harvey DJ, O'Flaherty RM, Rudd PM, Saldova R, Hecht ES, Muddiman DC, Kang J, Bhoskar P, Menard D, Saati A, Merle C, Mast S, Tep S, Truong J, Nishikaze T, Sekiya S, Shafer A, Funaoka S, Toyoda M, de Vreugd P, Caron C, Pradhan P, Tan NC, Mechref Y, Patil S, Rohrer JS, Chakrabarti R, Dadke D, Lahori M, Zou C, Cairo CW, Reiz B, Whittal RM, Lebrilla C, Wu LD, Guttman A, Szigeti M, Kremkow BG, Lee K, Sihlbom C, Adamczyk B, Jin C, Karlsson NG, Örnros J, Larson G, Nilsson J, Meyer B, Wiegandt A, Komatsu E, Perreault H, Bodnar ED, Said N, Francois YN, Leize-Wagner E, Maier S, Zeck A, Heck AJR, Yang Y, Haselberg R, Yu YQ, Alley W, Leone JW, Yuan H, Stein SE.

Mol Cell Proteomics. 2019 Oct 7. pii: mcp.RA119.001677. doi: 10.1074/mcp.RA119.001677. [Epub ahead of print]

5.

Expanding the mass range for UVPD-based native top-down mass spectrometry.

Greisch JF, Tamara S, Scheltema RA, Maxwell HWR, Fagerlund RD, Fineran PC, Tetter S, Hilvert D, Heck AJR.

Chem Sci. 2019 Jul 1;10(30):7163-7171. doi: 10.1039/c9sc01857c. eCollection 2019 Aug 14.

6.

Identification of a tumor-specific allo-HLA-restricted γδTCR.

Kierkels GJJ, Scheper W, Meringa AD, Johanna I, Beringer DX, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen JHW, San José E, Fuchs K, Griffioen M, Falkenburg JH, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck AJR, Shultz LD, Ishikawa F, Nishimura MI, Sebestyén Z, Kuball J.

Blood Adv. 2019 Oct 8;3(19):2870-2882. doi: 10.1182/bloodadvances.2019032409.

7.

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome.

Yan K, Yang J, Zhang Z, McLaughlin SH, Chang L, Fasci D, Ehrenhofer-Murray AE, Heck AJR, Barford D.

Nature. 2019 Oct;574(7777):278-282. doi: 10.1038/s41586-019-1609-1. Epub 2019 Oct 2.

PMID:
31578520
8.

PhoX: An IMAC-Enrichable Cross-Linking Reagent.

Steigenberger B, Pieters RJ, Heck AJR, Scheltema RA.

ACS Cent Sci. 2019 Sep 25;5(9):1514-1522. doi: 10.1021/acscentsci.9b00416. Epub 2019 Aug 19.

9.

High-Throughput Assessment of Kinome-wide Activation States.

Schmidlin T, Debets DO, van Gelder CAGH, Stecker KE, Rontogianni S, van den Eshof BL, Kemper K, Lips EH, van den Biggelaar M, Peeper DS, Heck AJR, Altelaar M.

Cell Syst. 2019 Oct 23;9(4):366-374.e5. doi: 10.1016/j.cels.2019.08.005. Epub 2019 Sep 11.

10.

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering.

van der Schoot JMS, Fennemann FL, Valente M, Dolen Y, Hagemans IM, Becker AMD, Le Gall CM, van Dalen D, Cevirgel A, van Bruggen JAC, Engelfriet M, Caval T, Bentlage AEH, Fransen MF, Nederend M, Leusen JHW, Heck AJR, Vidarsson G, Figdor CG, Verdoes M, Scheeren FA.

Sci Adv. 2019 Aug 28;5(8):eaaw1822. doi: 10.1126/sciadv.aaw1822. eCollection 2019 Aug.

11.

Activation of Human Monocytes by Colloidal Aluminum Salts.

Vrieling H, Kooijman S, de Ridder JW, Thies-Weesie DME, Soema PC, Jiskoot W, van Riet E, Heck AJR, Philipse AP, Kersten GFA, Meiring HD, Pennings JL, Metz B.

J Pharm Sci. 2019 Aug 23. pii: S0022-3549(19)30511-8. doi: 10.1016/j.xphs.2019.08.014. [Epub ahead of print]

12.

Supramolecular Toxin Complexes for Targeted Pharmacological Modulation of Polymorphonuclear Leukocyte Functions.

Heck AJ, Ostertag T, Schnell L, Fischer S, Agrawalla BK, Winterwerber P, Wirsching E, Fauler M, Frick M, Kuan SL, Weil T, Barth H.

Adv Healthc Mater. 2019 Sep;8(17):e1900665. doi: 10.1002/adhm.201900665. Epub 2019 Jul 18.

PMID:
31318180
13.

Simply Extending the Mass Range in Electron Transfer Higher Energy Collisional Dissociation Increases Confidence in N-Glycopeptide Identification.

Čaval T, Zhu J, Heck AJR.

Anal Chem. 2019 Aug 20;91(16):10401-10406. doi: 10.1021/acs.analchem.9b02125. Epub 2019 Jul 31.

14.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.

15.

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.

Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT.

Circulation. 2019 Aug 20;140(8):681-693. doi: 10.1161/CIRCULATIONAHA.119.039642. Epub 2019 Jun 12.

PMID:
31185731
16.

Unraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces.

Strasser J, de Jong RN, Beurskens FJ, Wang G, Heck AJR, Schuurman J, Parren PWHI, Hinterdorfer P, Preiner J.

Nano Lett. 2019 Jul 10;19(7):4787-4796. doi: 10.1021/acs.nanolett.9b02220. Epub 2019 Jun 11.

PMID:
31184907
17.

Glycoproteogenomics: A Frequent Gene Polymorphism Affects the Glycosylation Pattern of the Human Serum Fetuin/α-2-HS-Glycoprotein.

Lin YH, Zhu J, Meijer S, Franc V, Heck AJR.

Mol Cell Proteomics. 2019 Aug;18(8):1479-1490. doi: 10.1074/mcp.RA119.001411. Epub 2019 May 16.

18.

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.

19.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.

Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM.

Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0.

20.

Gaining Confidence in the Elusive Histidine Phosphoproteome.

Potel CM, Lin MH, Prust N, van den Toorn HWP, Heck AJR, Lemeer S.

Anal Chem. 2019 May 7;91(9):5542-5547. doi: 10.1021/acs.analchem.9b00734. Epub 2019 Apr 23.

21.

An Integrated Global Analysis of Compartmentalized HRAS Signaling.

Santra T, Herrero A, Rodriguez J, von Kriegsheim A, Iglesias-Martinez LF, Schwarzl T, Higgins D, Aye TT, Heck AJR, Calvo F, Agudo-Ibáñez L, Crespo P, Matallanas D, Kolch W.

Cell Rep. 2019 Mar 12;26(11):3100-3115.e7. doi: 10.1016/j.celrep.2019.02.038.

22.

Pre-fractionation Extends but also Creates a Bias in the Detectable HLA Class Ι Ligandome.

Demmers LC, Heck AJR, Wu W.

J Proteome Res. 2019 Apr 5;18(4):1634-1643. doi: 10.1021/acs.jproteome.8b00821. Epub 2019 Feb 26.

23.

Proteomic Profiling of Mouse Helper T Cell Differentiation.

van den Ham HJ, Binai NA, Zaaraoui-Boutahar F, Heck AJR, Andeweg AC.

Proteomics. 2019 Apr;19(7):e1800045. doi: 10.1002/pmic.201800045. Epub 2019 Mar 18.

PMID:
30758134
24.

Toward an efficient workflow for the analysis of the human milk peptidome.

Dingess KA, van den Toorn HWP, Mank M, Stahl B, Heck AJR.

Anal Bioanal Chem. 2019 Mar;411(7):1351-1363. doi: 10.1007/s00216-018-01566-4. Epub 2019 Feb 2.

25.

PaDuA: A Python Library for High-Throughput (Phospho)proteomics Data Analysis.

Ressa A, Fitzpatrick M, van den Toorn H, Heck AJR, Altelaar M.

J Proteome Res. 2019 Feb 1;18(2):576-584. doi: 10.1021/acs.jproteome.8b00576. Epub 2018 Dec 21.

26.

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I.

Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127. doi: 10.1038/s41594-018-0156-z. Epub 2018 Dec 3.

27.

Discovery and Quantification of Nonhuman Proteins in Human Milk.

Zhu J, Garrigues L, Van den Toorn H, Stahl B, Heck AJR.

J Proteome Res. 2019 Jan 4;18(1):225-238. doi: 10.1021/acs.jproteome.8b00550. Epub 2018 Dec 12.

28.

Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update.

Potel CM, Lemeer S, Heck AJR.

Anal Chem. 2019 Jan 2;91(1):126-141. doi: 10.1021/acs.analchem.8b04746. Epub 2018 Dec 5. No abstract available.

29.

Efficient and robust proteome-wide approaches for cross-linking mass spectrometry.

Klykov O, Steigenberger B, Pektaş S, Fasci D, Heck AJR, Scheltema RA.

Nat Protoc. 2018 Dec;13(12):2964-2990. doi: 10.1038/s41596-018-0074-x.

PMID:
30446747
30.

Label-free targeted LC-ESI-MS2 analysis of human milk oligosaccharides (HMOS) and related human milk groups with enhanced structural selectivity.

Mank M, Welsch P, Heck AJR, Stahl B.

Anal Bioanal Chem. 2019 Jan;411(1):231-250. doi: 10.1007/s00216-018-1434-7. Epub 2018 Nov 16.

PMID:
30443773
31.

Targeted Analysis of Lysosomal Directed Proteins and Their Sites of Mannose-6-phosphate Modification.

Čaval T, Zhu J, Tian W, Remmelzwaal S, Yang Z, Clausen H, Heck AJR.

Mol Cell Proteomics. 2019 Jan;18(1):16-27. doi: 10.1074/mcp.RA118.000967. Epub 2018 Sep 20.

PMID:
30237200
32.

A New Tool to Reveal Bacterial Signaling Mechanisms in Antibiotic Treatment and Resistance.

Lin MH, Potel CM, Tehrani KHME, Heck AJR, Martin NI, Lemeer S.

Mol Cell Proteomics. 2018 Dec;17(12):2496-2507. doi: 10.1074/mcp.RA118.000880. Epub 2018 Sep 19.

33.

Effects of Acetylation and Phosphorylation on Subunit Interactions in Three Large Eukaryotic Complexes.

Šoštarić N, O'Reilly FJ, Giansanti P, Heck AJR, Gavin AC, van Noort V.

Mol Cell Proteomics. 2018 Dec;17(12):2387-2401. doi: 10.1074/mcp.RA118.000892. Epub 2018 Sep 4.

34.

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer.

Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Piñeiro-Yañez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M.

Nat Commun. 2018 Aug 29;9(1):3501. doi: 10.1038/s41467-018-05742-z.

35.

Direct quality control of glycoengineered erythropoietin variants.

Čaval T, Tian W, Yang Z, Clausen H, Heck AJR.

Nat Commun. 2018 Aug 21;9(1):3342. doi: 10.1038/s41467-018-05536-3.

36.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Fasci D, van Ingen H, Scheltema RA, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):2018-2033. doi: 10.1074/mcp.RA118.000924. Epub 2018 Jul 18.

37.

A Protein-Based Encapsulation System with Calcium-Controlled Cargo Loading and Detachment.

Lizatović R, Assent M, Barendregt A, Dahlin J, Bille A, Satzinger K, Tupina D, Heck AJR, Wennmalm S, André I.

Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11334-11338. doi: 10.1002/anie.201806466. Epub 2018 Jul 30.

PMID:
29975817
38.

A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells.

Ressa A, Bosdriesz E, de Ligt J, Mainardi S, Maddalo G, Prahallad A, Jager M, de la Fonteijne L, Fitzpatrick M, Groten S, Altelaar AFM, Bernards R, Cuppen E, Wessels L, Heck AJR.

Mol Cell Proteomics. 2018 Oct;17(10):1892-1908. doi: 10.1074/mcp.RA117.000486. Epub 2018 Jul 3.

39.

Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin.

Lin YH, Franc V, Heck AJR.

J Proteome Res. 2018 Aug 3;17(8):2861-2869. doi: 10.1021/acs.jproteome.8b00318. Epub 2018 Jul 13.

40.

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods.

van de Waterbeemd M, Tamara S, Fort KL, Damoc E, Franc V, Bieri P, Itten M, Makarov A, Ban N, Heck AJR.

Nat Commun. 2018 Jun 27;9(1):2493. doi: 10.1038/s41467-018-04853-x.

41.

Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Magliozzi R, Carrero ZI, Low TY, Yuniati L, Valdes-Quezada C, Kruiswijk F, van Wijk K, Heck AJR, Jackson CL, Guardavaccaro D.

Cell Rep. 2018 Jun 12;23(11):3381-3391.e4. doi: 10.1016/j.celrep.2018.05.031.

42.

Actin from the apicomplexan Neospora caninum (NcACT) has different isoforms in 2D electrophoresis.

Baroni L, Pollo-Oliveira L, Heck AJ, Altelaar AM, Yatsuda AP.

Parasitology. 2019 Jan;146(1):33-41. doi: 10.1017/S0031182018000872. Epub 2018 Jun 6.

PMID:
29871709
43.

Mix and match of the tumor metastasis suppressor Nm23 protein isoforms in vitro and in vivo.

Potel CM, Fasci D, Heck AJR.

FEBS J. 2018 Aug;285(15):2856-2868. doi: 10.1111/febs.14525. Epub 2018 Jun 19.

44.

Vaccine antigens modulate the innate response of monocytes to Al(OH)3.

Kooijman S, Brummelman J, van Els CACM, Marino F, Heck AJR, van Riet E, Metz B, Kersten GFA, Pennings JLA, Meiring HD.

PLoS One. 2018 May 29;13(5):e0197885. doi: 10.1371/journal.pone.0197885. eCollection 2018.

45.

Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE).

Lill JR, van Veelen PA, Tenzer S, Admon A, Caron E, Elias JE, Heck AJR, Marcilla M, Marino F, Müller M, Peters B, Purcell A, Sette A, Sturm T, Ternette N, Vizcaíno JA, Bassani-Sternberg M.

Proteomics. 2018 Jun;18(12):e1800110. doi: 10.1002/pmic.201800110.

46.

Bacterial encapsulins as orthogonal compartments for mammalian cell engineering.

Sigmund F, Massner C, Erdmann P, Stelzl A, Rolbieski H, Desai M, Bricault S, Wörner TP, Snijder J, Geerlof A, Fuchs H, Hrabĕ de Angelis M, Heck AJR, Jasanoff A, Ntziachristos V, Plitzko J, Westmeyer GG.

Nat Commun. 2018 May 18;9(1):1990. doi: 10.1038/s41467-018-04227-3.

47.

Distinct Stabilities of the Structurally Homologous Heptameric Co-Chaperonins GroES and gp31.

Dyachenko A, Tamara S, Heck AJR.

J Am Soc Mass Spectrom. 2019 Jan;30(1):7-15. doi: 10.1007/s13361-018-1910-5. Epub 2018 May 7. Erratum in: J Am Soc Mass Spectrom. 2019 Mar;30(3):561.

48.

Crosstalk between phosphorylation and O-GlcNAcylation: friend or foe.

van der Laarse SAM, Leney AC, Heck AJR.

FEBS J. 2018 Sep;285(17):3152-3167. doi: 10.1111/febs.14491. Epub 2018 May 13. Review.

49.

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L Jr, Heck AJR, Wehrens XHT.

Circulation. 2018 Oct 9;138(15):1569-1581. doi: 10.1161/CIRCULATIONAHA.118.034361.

50.

CTGF/VEGFA-activated Fibroblasts Promote Tumor Migration Through Micro-environmental Modulation.

Wu W, Zaal EA, Berkers CR, Lemeer S, Heck AJR.

Mol Cell Proteomics. 2018 Aug;17(8):1502-1514. doi: 10.1074/mcp.RA118.000708. Epub 2018 Apr 18.

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