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Items: 1 to 50 of 94

1.

Self-Assembling Supramolecular Nanostructures Constructed from de Novo Extender Protein Nanobuilding Blocks.

Kobayashi N, Inano K, Sasahara K, Sato T, Miyazawa K, Fukuma T, Hecht MH, Song C, Murata K, Arai R.

ACS Synth Biol. 2018 May 18;7(5):1381-1394. doi: 10.1021/acssynbio.8b00007. Epub 2018 May 8.

PMID:
29690759
2.

Artificial Gene Amplification in Escherichia coli Reveals Numerous Determinants for Resistance to Metal Toxicity.

Hoegler KJ, Hecht MH.

J Mol Evol. 2018 Feb;86(2):103-110. doi: 10.1007/s00239-018-9830-3. Epub 2018 Jan 22.

PMID:
29356848
3.

A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli.

Donnelly AE, Murphy GS, Digianantonio KM, Hecht MH.

Nat Chem Biol. 2018 Mar;14(3):253-255. doi: 10.1038/nchembio.2550. Epub 2018 Jan 15.

PMID:
29334382
4.

Are natural proteins special? Can we do that?

Hecht MH, Zarzhitsky S, Karas C, Chari S.

Curr Opin Struct Biol. 2018 Feb;48:124-132. doi: 10.1016/j.sbi.2017.11.009. Epub 2018 Jan 3. Review.

PMID:
29306103
5.

A Non-natural Protein Rescues Cells Deleted for a Key Enzyme in Central Metabolism.

Digianantonio KM, Korolev M, Hecht MH.

ACS Synth Biol. 2017 Apr 21;6(4):694-700. doi: 10.1021/acssynbio.6b00336. Epub 2017 Jan 19.

PMID:
28055179
6.

A protein constructed de novo enables cell growth by altering gene regulation.

Digianantonio KM, Hecht MH.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2400-5. doi: 10.1073/pnas.1600566113. Epub 2016 Feb 16.

7.

A de novo protein confers copper resistance in Escherichia coli.

Hoegler KJ, Hecht MH.

Protein Sci. 2016 Jul;25(7):1249-59. doi: 10.1002/pro.2871. Epub 2016 Jan 25.

8.

De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic.

Murphy GS, Greisman JB, Hecht MH.

J Mol Biol. 2016 Jan 29;428(2 Pt A):399-411. doi: 10.1016/j.jmb.2015.12.008. Epub 2015 Dec 18.

9.

Self-Assembling Nano-Architectures Created from a Protein Nano-Building Block Using an Intermolecularly Folded Dimeric de Novo Protein.

Kobayashi N, Yanase K, Sato T, Unzai S, Hecht MH, Arai R.

J Am Chem Soc. 2015 Sep 9;137(35):11285-93. doi: 10.1021/jacs.5b03593. Epub 2015 Jul 14.

PMID:
26120734
10.

Divergent evolution of a bifunctional de novo protein.

Smith BA, Mularz AE, Hecht MH.

Protein Sci. 2015 Feb;24(2):246-52. doi: 10.1002/pro.2611. Epub 2014 Dec 26.

11.

Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42.

McKoy AF, Chen J, Schupbach T, Hecht MH.

Chem Biol Drug Des. 2014 Nov;84(5):505-12. doi: 10.1111/cbdd.12341. Epub 2014 May 21.

12.

Proteins from an unevolved library of de novo designed sequences bind a range of small molecules.

Cherny I, Korolev M, Koehler AN, Hecht MH.

ACS Synth Biol. 2012 Apr 20;1(4):130-8. doi: 10.1021/sb200018e. Epub 2012 Apr 2.

13.

The Icebreaker Life Mission to Mars: a search for biomolecular evidence for life.

McKay CP, Stoker CR, Glass BJ, Davé AI, Davila AF, Heldmann JL, Marinova MM, Fairen AG, Quinn RC, Zacny KA, Paulsen G, Smith PH, Parro V, Andersen DT, Hecht MH, Lacelle D, Pollard WH.

Astrobiology. 2013 Apr;13(4):334-53. doi: 10.1089/ast.2012.0878. Epub 2013 Apr 5.

PMID:
23560417
14.

A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.

McKoy AF, Chen J, Schupbach T, Hecht MH.

J Biol Chem. 2012 Nov 9;287(46):38992-9000. doi: 10.1074/jbc.M112.348037. Epub 2012 Sep 19.

15.

Directed evolution of the peroxidase activity of a de novo-designed protein.

Patel SC, Hecht MH.

Protein Eng Des Sel. 2012 Sep;25(9):445-52. doi: 10.1093/protein/gzs025. Epub 2012 Jun 3.

PMID:
22665824
16.

Domain-swapped dimeric structure of a stable and functional de novo four-helix bundle protein, WA20.

Arai R, Kobayashi N, Kimura A, Sato T, Matsuo K, Wang AF, Platt JM, Bradley LH, Hecht MH.

J Phys Chem B. 2012 Jun 14;116(23):6789-97. doi: 10.1021/jp212438h. Epub 2012 Apr 10.

PMID:
22397676
17.

Laser ablation-miniature mass spectrometer for elemental and isotopic analysis of rocks.

Sinha MP, Neidholdt EL, Hurowitz J, Sturhahn W, Beard B, Hecht MH.

Rev Sci Instrum. 2011 Sep;82(9):094102. doi: 10.1063/1.3626794.

PMID:
21974601
18.

Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.

Armstrong AH, Chen J, McKoy AF, Hecht MH.

Biochemistry. 2011 May 17;50(19):4058-67. doi: 10.1021/bi200268w. Epub 2011 Apr 22.

19.

Novel proteins: from fold to function.

Smith BA, Hecht MH.

Curr Opin Chem Biol. 2011 Jun;15(3):421-6. doi: 10.1016/j.cbpa.2011.03.006. Epub 2011 Apr 5. Review.

PMID:
21474363
20.

Binding of small molecules to cavity forming mutants of a de novo designed protein.

Das A, Wei Y, Pelczer I, Hecht MH.

Protein Sci. 2011 Apr;20(4):702-11. doi: 10.1002/pro.601. Epub 2011 Mar 7.

21.

De novo designed proteins from a library of artificial sequences function in Escherichia coli and enable cell growth.

Fisher MA, McKinley KL, Bradley LH, Viola SR, Hecht MH.

PLoS One. 2011 Jan 4;6(1):e15364. doi: 10.1371/journal.pone.0015364.

22.

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions.

Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU, Vabulas RM.

Cell. 2011 Jan 7;144(1):67-78. doi: 10.1016/j.cell.2010.11.050.

23.

Small molecule microarrays enable the discovery of compounds that bind the Alzheimer's Aβ peptide and reduce its cytotoxicity.

Chen J, Armstrong AH, Koehler AN, Hecht MH.

J Am Chem Soc. 2010 Dec 1;132(47):17015-22. doi: 10.1021/ja107552s. Epub 2010 Nov 9.

24.

Mars water-ice clouds and precipitation.

Whiteway JA, Komguem L, Dickinson C, Cook C, Illnicki M, Seabrook J, Popovici V, Duck TJ, Davy R, Taylor PA, Pathak J, Fisher D, Carswell AI, Daly M, Hipkin V, Zent AP, Hecht MH, Wood SE, Tamppari LK, Renno N, Moores JE, Lemmon MT, Daerden F, Smith PH.

Science. 2009 Jul 3;325(5936):68-70. doi: 10.1126/science.1172344.

25.

Detection of perchlorate and the soluble chemistry of martian soil at the Phoenix lander site.

Hecht MH, Kounaves SP, Quinn RC, West SJ, Young SM, Ming DW, Catling DC, Clark BC, Boynton WV, Hoffman J, Deflores LP, Gospodinova K, Kapit J, Smith PH.

Science. 2009 Jul 3;325(5936):64-7. doi: 10.1126/science.1172466.

26.

Evidence for calcium carbonate at the Mars Phoenix landing site.

Boynton WV, Ming DW, Kounaves SP, Young SM, Arvidson RE, Hecht MH, Hoffman J, Niles PB, Hamara DK, Quinn RC, Smith PH, Sutter B, Catling DC, Morris RV.

Science. 2009 Jul 3;325(5936):61-4. doi: 10.1126/science.1172768.

27.

H2O at the Phoenix landing site.

Smith PH, Tamppari LK, Arvidson RE, Bass D, Blaney D, Boynton WV, Carswell A, Catling DC, Clark BC, Duck T, Dejong E, Fisher D, Goetz W, Gunnlaugsson HP, Hecht MH, Hipkin V, Hoffman J, Hviid SF, Keller HU, Kounaves SP, Lange CF, Lemmon MT, Madsen MB, Markiewicz WJ, Marshall J, McKay CP, Mellon MT, Ming DW, Morris RV, Pike WT, Renno N, Staufer U, Stoker C, Taylor P, Whiteway JA, Zent AP.

Science. 2009 Jul 3;325(5936):58-61. doi: 10.1126/science.1172339.

28.

Cofactor binding and enzymatic activity in an unevolved superfamily of de novo designed 4-helix bundle proteins.

Patel SC, Bradley LH, Jinadasa SP, Hecht MH.

Protein Sci. 2009 Jul;18(7):1388-400. doi: 10.1002/pro.147.

29.

Structure and dynamics of de novo proteins from a designed superfamily of 4-helix bundles.

Go A, Kim S, Baum J, Hecht MH.

Protein Sci. 2008 May;17(5):821-32. doi: 10.1110/ps.073377908.

30.

Mutations enhance the aggregation propensity of the Alzheimer's A beta peptide.

Kim W, Hecht MH.

J Mol Biol. 2008 Mar 21;377(2):565-74. doi: 10.1016/j.jmb.2007.12.079. Epub 2008 Jan 11.

31.

Peroxidase activity of de novo heme proteins immobilized on electrodes.

Das A, Hecht MH.

J Inorg Biochem. 2007 Nov;101(11-12):1820-6. Epub 2007 Jul 27.

32.

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide.

Kim W, Kim Y, Min J, Kim DJ, Chang YT, Hecht MH.

ACS Chem Biol. 2006 Aug 22;1(7):461-9.

PMID:
17168524
33.

Protein design by binary patterning of polar and nonpolar amino acids.

Bradley LH, Wei Y, Thumfort P, Wurth C, Hecht MH.

Methods Mol Biol. 2007;352:155-66.

PMID:
17041264
34.

Generic hydrophobic residues are sufficient to promote aggregation of the Alzheimer's Abeta42 peptide.

Kim W, Hecht MH.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15824-9. Epub 2006 Oct 12.

35.

De novo proteins from binary-patterned combinatorial libraries.

Bradley LH, Thumfort PP, Hecht MH.

Methods Mol Biol. 2006;340:53-69. Review.

PMID:
16957332
36.

Electrochemical and ligand binding studies of a de novo heme protein.

Das A, Trammell SA, Hecht MH.

Biophys Chem. 2006 Sep 20;123(2-3):102-12. Epub 2006 Apr 29.

PMID:
16730114
37.

Combinatorial approaches to probe the sequence determinants of protein aggregation and amyloidogenicity.

Wurth C, Kim W, Hecht MH.

Protein Pept Lett. 2006;13(3):279-86. Review.

PMID:
16515456
38.

Nanografting de novo proteins onto gold surfaces.

Hu Y, Das A, Hecht MH, Scoles G.

Langmuir. 2005 Sep 27;21(20):9103-9.

PMID:
16171339
39.

Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.

Kim W, Hecht MH.

J Biol Chem. 2005 Oct 14;280(41):35069-76. Epub 2005 Aug 3.

40.

An intein-based genetic selection allows the construction of a high-quality library of binary patterned de novo protein sequences.

Bradley LH, Kleiner RE, Wang AF, Hecht MH, Wood DW.

Protein Eng Des Sel. 2005 Apr;18(4):201-7. Epub 2005 Apr 22.

PMID:
15849217
41.

Ab initio prediction of the three-dimensional structure of a de novo designed protein: a double-blind case study.

Klepeis JL, Wei Y, Hecht MH, Floudas CA.

Proteins. 2005 Feb 15;58(3):560-70.

PMID:
15609306
42.

De novo proteins from designed combinatorial libraries.

Hecht MH, Das A, Go A, Bradley LH, Wei Y.

Protein Sci. 2004 Jul;13(7):1711-23. Review.

43.

Enzyme-like proteins from an unselected library of designed amino acid sequences.

Wei Y, Hecht MH.

Protein Eng Des Sel. 2004 Jan;17(1):67-75.

PMID:
14985539
44.

Mars Surveyor Program '01 Mars Environmental Compatibility Assessment wet chemistry lab: a sensor array for chemical analysis of the Martian soil.

Kounaves SP, Lukow SR, Comeau BP, Hecht MH, Grannan-Feldman SM, Manatt K, West SJ, Wen X, Frant M, Gillette T.

J Geophys Res. 2003 Jul 25;108(E7):13-1 - 13-12.

PMID:
14686320
45.

Solution structure of a de novo protein from a designed combinatorial library.

Wei Y, Kim S, Fela D, Baum J, Hecht MH.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13270-3. Epub 2003 Oct 30.

46.
47.

Stably folded de novo proteins from a designed combinatorial library.

Wei Y, Liu T, Sazinsky SL, Moffet DA, Pelczer I, Hecht MH.

Protein Sci. 2003 Jan;12(1):92-102.

48.
49.

Template-directed assembly of a de novo designed protein.

Brown CL, Aksay IA, Saville DA, Hecht MH.

J Am Chem Soc. 2002 Jun 19;124(24):6846-8.

PMID:
12059204
50.

UV Raman monitoring of histidine protonation and H-(2)H exchange in plastocyanin.

Wu Q, Li F, Wang W, Hecht MH, Spiro TG.

J Inorg Biochem. 2002 Feb;88(3-4):381-7.

PMID:
11897354

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