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Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics.

Samaan GN, Paranagama N, Haque A, Hecht DA, Swairjo MA, Purse BW.

Bioorg Med Chem Lett. 2019 Nov 12:126818. doi: 10.1016/j.bmcl.2019.126818. [Epub ahead of print]


Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells.

Bernatchez JA, Coste M, Beck S, Wells GA, Luna LA, Clark AE, Zhu Z, Hecht D, Rich JN, Sohl CD, Purse BW, Siqueira-Neto JL.

Viruses. 2019 Apr 20;11(4). pii: E365. doi: 10.3390/v11040365.


Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.

Marney MW, Metzger RP, Hecht D, Valafar F.

Tuberculosis (Edinb). 2018 Jan;108:155-162. doi: 10.1016/ Epub 2017 Nov 22.


Comparative genomics analysis of Clostridium difficile epidemic strain DH/NAP11/106.

Kociolek LK, Gerding DN, Hecht DW, Ozer EA.

Microbes Infect. 2018 Apr;20(4):245-253. doi: 10.1016/j.micinf.2018.01.004. Epub 2018 Jan 31.


Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.

Kociolek LK, Ozer EA, Gerding DN, Hecht DW, Patel SJ, Hauser AR.

J Antimicrob Chemother. 2018 May 1;73(5):1222-1229. doi: 10.1093/jac/dkx523.


Complete Genome Sequence of Clostridioides difficile Epidemic Strain DH/NAP11/106/ST-42, Isolated from Stool from a Pediatric Patient with Diarrhea.

Ozer EA, Hauser AR, Gerding DN, Espinosa RO, Hecht DW, Kociolek LK.

Genome Announc. 2017 Sep 21;5(38). pii: e00923-17. doi: 10.1128/genomeA.00923-17.


Why we write (nuclear) history.

Hecht DK.

Br J Hist Sci. 2017 Sep;50(3):537-543. doi: 10.1017/S0007087417000668.


Structure-based analysis of Bacilli and plasmid dihydrofolate reductase evolution.

Alotaibi M, Reyes BD, Le T, Luong P, Valafar F, Metzger RP, Fogel GB, Hecht D.

J Mol Graph Model. 2017 Jan;71:135-153. doi: 10.1016/j.jmgm.2016.10.011. Epub 2016 Nov 22.


Trends in antimicrobial resistance among Bacteroides species and Parabacteroides species in the United States from 2010-2012 with comparison to 2008-2009.

Snydman DR, Jacobus NV, McDermott LA, Goldstein EJ, Harrell L, Jenkins SG, Newton D, Patel R, Hecht DW.

Anaerobe. 2017 Feb;43:21-26. doi: 10.1016/j.anaerobe.2016.11.003. Epub 2016 Nov 17.


Changes in the antibiotic susceptibility of anaerobic bacteria from 2007-2009 to 2010-2012 based on the CLSI methodology.

Hastey CJ, Boyd H, Schuetz AN, Anderson K, Citron DM, Dzink-Fox J, Hackel M, Hecht DW, Jacobus NV, Jenkins SG, Karlsson M, Knapp CC, Koeth LM, Wexler H, Roe-Carpenter DE; From the Ad Hoc Working Group on Antimicrobial Susceptibility Testing of Anaerobic Bacteria of CLSI.

Anaerobe. 2016 Dec;42:27-30. doi: 10.1016/j.anaerobe.2016.07.003. Epub 2016 Jul 15.


CUREs in biochemistry-where we are and where we should go.

Bell JK, Eckdahl TT, Hecht DA, Killion PJ, Latzer J, Mans TL, Provost JJ, Rakus JF, Siebrasse EA, Ellis Bell J.

Biochem Mol Biol Educ. 2017 Jan 2;45(1):7-12. doi: 10.1002/bmb.20989. Epub 2016 Jun 30.


Differences in the Molecular Epidemiology and Antibiotic Susceptibility of Clostridium difficile Isolates in Pediatric and Adult Patients.

Kociolek LK, Gerding DN, Osmolski JR, Patel SJ, Snydman DR, McDermott LA, Hecht DW.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4896-900. doi: 10.1128/AAC.00714-16. Print 2016 Aug.


Emergence and evolution of an international cluster of MDR Bacteroides fragilis isolates.

Sóki J, Hedberg M, Patrick S, Bálint B, Herczeg R, Nagy I, Hecht DW, Nagy E, Urbán E.

J Antimicrob Chemother. 2016 Sep;71(9):2441-8. doi: 10.1093/jac/dkw175. Epub 2016 May 30.


Enhancing the selectivity of kinase inhibitors in oncology: a chemical biology perspective.

Maddox S, Hecht D, Gustafson JL.

Future Med Chem. 2016;8(3):241-4. doi: 10.4155/fmc.15.193. Epub 2016 Feb 22. No abstract available.


Diversity of Clostridium perfringens isolates from various sources and prevalence of conjugative plasmids.

Park M, Deck J, Foley SL, Nayak R, Songer JG, Seibel JR, Khan SA, Rooney AP, Hecht DW, Rafii F.

Anaerobe. 2016 Apr;38:25-35. doi: 10.1016/j.anaerobe.2015.11.003. Epub 2015 Nov 30.


Fluoroquinolone and Macrolide Exposure Predict Clostridium difficile Infection with the Highly Fluoroquinolone- and Macrolide-Resistant Epidemic C. difficile Strain BI/NAP1/027.

Wieczorkiewicz JT, Lopansri BK, Cheknis A, Osmolski JR, Hecht DW, Gerding DN, Johnson S.

Antimicrob Agents Chemother. 2015 Nov 2;60(1):418-23. doi: 10.1128/AAC.01820-15. Print 2016 Jan.


Susceptibility of Clostridium difficile isolates from a Phase 2 clinical trial of cadazolid and vancomycin in C. difficile infection.

Gerding DN, Hecht DW, Louie T, Nord CE, Talbot GH, Cornely OA, Buitrago M, Best E, Sambol S, Osmolski JR, Kracker H, Locher HH, Charef P, Wilcox M.

J Antimicrob Chemother. 2016 Jan;71(1):213-9. doi: 10.1093/jac/dkv300. Epub 2015 Oct 3.


Contracting and Procurement for Evidence-Based Interventions in Public-Sector Human Services: A Case Study.

Willging CE, Aarons GA, Trott EM, Green AE, Finn N, Ehrhart MG, Hecht DB.

Adm Policy Ment Health. 2016 Sep;43(5):675-692. doi: 10.1007/s10488-015-0681-6.


Impact of a 2-Day Critical Care Ultrasound Course during Fellowship Training: A Pilot Study.

Dinh VA, Giri PC, Rathinavel I, Nguyen E, Hecht D, Dorotta I, Nguyen HB, Chrissian AA.

Crit Care Res Pract. 2015;2015:675041. doi: 10.1155/2015/675041. Epub 2015 Aug 5.


Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors.

Smith DE, Marquez I, Lokensgard ME, Rheingold AL, Hecht DA, Gustafson JL.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11754-9. doi: 10.1002/anie.201506085. Epub 2015 Aug 14.


EBT Fidelity Trajectories Across Training Cohorts Using the Interagency Collaborative Team Strategy.

Chaffin M, Hecht D, Aarons G, Fettes D, Hurlburt M, Ledesma K.

Adm Policy Ment Health. 2016 Mar;43(2):144-56. doi: 10.1007/s10488-015-0627-z.


Mixed-method study of a conceptual model of evidence-based intervention sustainment across multiple public-sector service settings.

Aarons GA, Green AE, Willging CE, Ehrhart MG, Roesch SC, Hecht DB, Chaffin MJ.

Implement Sci. 2014 Dec 10;9:183. doi: 10.1186/s13012-014-0183-z.


Real-time sonographically guided percutaneous dilatational tracheostomy using a long-axis approach compared to the landmark technique.

Dinh VA, Farshidpanah S, Lu S, Stokes P, Chrissian A, Shah H, Giri P, Hecht D, Nguyen HB.

J Ultrasound Med. 2014 Aug;33(8):1407-15. doi: 10.7863/ultra.33.8.1407.


e!DAL--a framework to store, share and publish research data.

Arend D, Lange M, Chen J, Colmsee C, Flemming S, Hecht D, Scholz U.

BMC Bioinformatics. 2014 Jun 24;15:214. doi: 10.1186/1471-2105-15-214.


Mixed-methods feasibility study on the cultural adaptation of a child abuse prevention model.

Beasley LO, Silovsky JF, Owora A, Burris L, Hecht D, DeMoraes-Huffine P, Cruz I, Tolma E.

Child Abuse Negl. 2014 Sep;38(9):1496-507. doi: 10.1016/j.chiabu.2014.04.017. Epub 2014 May 15.


Contribution of intestinal barrier damage, microbial translocation and HIV-1 infection status to an inflammaging signature.

Steele AK, Lee EJ, Vestal B, Hecht D, Dong Z, Rapaport E, Koeppe J, Campbell TB, Wilson CC.

PLoS One. 2014 May 12;9(5):e97171. doi: 10.1371/journal.pone.0097171. eCollection 2014.


Cerebral lateralization of pro- and anti-social tendencies.

Hecht D.

Exp Neurobiol. 2014 Mar;23(1):1-27. doi: 10.5607/en.2014.23.1.1. Epub 2014 Mar 27. Review.


Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.

Miesel L, Hecht DW, Osmolski JR, Gerding D, Flattery A, Li F, Lan J, Lipari P, Polishook JD, Liang L, Liu J, Olsen DB, Singh SB.

Antimicrob Agents Chemother. 2014;58(4):2387-92. doi: 10.1128/AAC.00021-14. Epub 2014 Feb 10.


An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia.

Dillon SM, Lee EJ, Kotter CV, Austin GL, Dong Z, Hecht DK, Gianella S, Siewe B, Smith DM, Landay AL, Robertson CE, Frank DN, Wilson CC.

Mucosal Immunol. 2014 Jul;7(4):983-94. doi: 10.1038/mi.2013.116. Epub 2014 Jan 8.


The neural basis of optimism and pessimism.

Hecht D.

Exp Neurobiol. 2013 Sep;22(3):173-99. doi: 10.5607/en.2013.22.3.173. Epub 2013 Sep 30. Review.


Bi-frontal direct current stimulation affects delay discounting choices.

Hecht D, Walsh V, Lavidor M.

Cogn Neurosci. 2013;4(1):7-11. doi: 10.1080/17588928.2011.638139. Epub 2012 Jan 10.


Increased Escherichia coli-induced interleukin-23 production by CD16+ monocytes correlates with systemic immune activation in untreated HIV-1-infected individuals.

Manuzak JA, Dillon SM, Lee EJ, Dong ZM, Hecht DK, Wilson CC.

J Virol. 2013 Dec;87(24):13252-62. doi: 10.1128/JVI.01767-13. Epub 2013 Sep 25.


Modeling the evolution of drug resistance in malaria.

Hecht D, Fogel GB.

J Comput Aided Mol Des. 2012 Dec;26(12):1343-53. doi: 10.1007/s10822-012-9618-2. Epub 2012 Nov 21.


How to make a villain: Rachel Carson and the politics of anti-environmentalism.

Hecht DK.

Endeavour. 2012 Dec;36(4):149-55. doi: 10.1016/j.endeavour.2012.10.004. Epub 2012 Nov 21.


Cefoxitin is both an inhibitor of class A beta-lactamase of Xanthomonas campestris pv. campestris str. 17 and an inducer of its gene.

Tsuey-Ching Y, Hecht D, Tsai JJ, Hu RM.

Res Microbiol. 2012 Sep-Oct;163(8):550-6. doi: 10.1016/j.resmic.2012.08.003. Epub 2012 Aug 5.


Dynamic adaptation process to implement an evidence-based child maltreatment intervention.

Aarons GA, Green AE, Palinkas LA, Self-Brown S, Whitaker DJ, Lutzker JR, Silovsky JF, Hecht DB, Chaffin MJ.

Implement Sci. 2012 Apr 18;7:32. doi: 10.1186/1748-5908-7-32.


A statewide trial of the SafeCare home-based services model with parents in Child Protective Services.

Chaffin M, Hecht D, Bard D, Silovsky JF, Beasley WH.

Pediatrics. 2012 Mar;129(3):509-15. doi: 10.1542/peds.2011-1840. Epub 2012 Feb 20.


Provider cultural competency, client satisfaction, and engagement in home-based programs to treat child abuse and neglect.

Damashek A, Bard D, Hecht D.

Child Maltreat. 2012 Feb;17(1):56-66. doi: 10.1177/1077559511423570. Epub 2011 Oct 17.


Constructing a scientist: expert authority and public images of Rachel Carson.

Hecht DK.

Hist Stud Nat Sci. 2011;41(3):277-302.


Structural-based analysis of dihydrofolate reductase evolution.

Hecht D, Tran J, Fogel GB.

Mol Phylogenet Evol. 2011 Oct;61(1):212-30. doi: 10.1016/j.ympev.2011.06.005. Epub 2011 Jun 17.


Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009.

Snydman DR, Jacobus NV, McDermott LA, Golan Y, Goldstein EJ, Harrell L, Jenkins S, Newton D, Pierson C, Rosenblatt J, Venezia R, Gorbach SL, Queenan AM, Hecht DW.

Anaerobe. 2011 Aug;17(4):147-51. doi: 10.1016/j.anaerobe.2011.05.014. Epub 2011 Jun 2.


Change trajectories during home-based services with chronic child welfare cases.

Chaffin M, Bard D, Hecht D, Silovsky J.

Child Maltreat. 2011 May;16(2):114-25. doi: 10.1177/1077559511402048. Epub 2011 Apr 13.


Carbamazepine and valproate as adjuncts in the treatment of alcohol withdrawal syndrome: a retrospective cohort study.

Eyer F, Schreckenberg M, Hecht D, Adorjan K, Schuster T, Felgenhauer N, Pfab R, Strubel T, Zilker T.

Alcohol Alcohol. 2011 Mar-Apr;46(2):177-84. doi: 10.1093/alcalc/agr005.


Emerging transparent electrodes based on thin films of carbon nanotubes, graphene, and metallic nanostructures.

Hecht DS, Hu L, Irvin G.

Adv Mater. 2011 Apr 5;23(13):1482-513. doi: 10.1002/adma.201003188. Epub 2011 Feb 15. Review.


High conductivity transparent carbon nanotube films deposited from superacid.

Hecht DS, Heintz AM, Lee R, Hu L, Moore B, Cucksey C, Risser S.

Nanotechnology. 2011 Feb 18;22(7):075201. doi: 10.1088/0957-4484/22/7/075201. Epub 2011 Jan 14. Erratum in: Nanotechnology. 2011 Apr 22;22(16):169501.


Anemia in the ICU: are your patients needin' erythropoetin?

Hecht D, Boujoukos A.

Crit Care. 2010;14(6):332. doi: 10.1186/cc9370. Epub 2010 Dec 17. No abstract available.


Carbon nanotube thin films: fabrication, properties, and applications.

Hu L, Hecht DS, Grüner G.

Chem Rev. 2010 Oct 13;110(10):5790-844. doi: 10.1021/cr9002962. No abstract available.


Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens.

Park M, Rooney AP, Hecht DW, Li J, McClane BA, Nayak R, Paine DD, Rafii F.

Arch Microbiol. 2010 Oct;192(10):803-10. doi: 10.1007/s00203-010-0605-5. Epub 2010 Jul 27.


Depression and the hyperactive right-hemisphere.

Hecht D.

Neurosci Res. 2010 Oct;68(2):77-87. doi: 10.1016/j.neures.2010.06.013. Epub 2010 Jul 21. Review.


The novel antibacterial drug XF-70 is a potent inhibitor of Staphylococcus aureus infection of the burn wound.

Hurtuk MG, He LK, Szilagyi A, Gamelli RL, Hecht DW, Kennedy RH, Rhys-Williams W, Love WG, Shankar R.

J Burn Care Res. 2010 May-Jun;31(3):462-9. doi: 10.1097/BCR.0b013e3181db5265.


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