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Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

Aguilar A, Weber J, Boscher J, Freund M, Ziessel C, Eckly A, Magnenat S, Bourdon C, Hechler B, Mangin PH, Gachet C, Lanza F, Léon C.

Blood Adv. 2019 Aug 13;3(15):2368-2380. doi: 10.1182/bloodadvances.2019031286.


Necrotizing soft tissue infection following routine third molar extraction: report of two cases and review of the literature.

Hechler BL, Blakey GH.

Int J Oral Maxillofac Surg. 2019 Jun 18. pii: S0901-5027(19)31176-2. doi: 10.1016/j.ijom.2019.05.010. [Epub ahead of print]


The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice.

El Mdawar MB, Maître B, Magnenat S, Gachet C, Hechler B, de la Salle H.

Sci Rep. 2019 Mar 26;9(1):5159. doi: 10.1038/s41598-019-41742-9.


Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis.

Laurent PA, Hechler B, Solinhac R, Ragab A, Cabou C, Anquetil T, Severin S, Denis CV, Mangin PH, Vanhaesebroeck B, Payrastre B, Gratacap MP.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2041-2053. doi: 10.1161/ATVBAHA.118.311410.


Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ; NASA study group, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F.

Sci Immunol. 2018 Apr 13;3(22). pii: eaan5997. doi: 10.1126/sciimmunol.aan5997.


Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance.

Hechler B, Ravanat C, Gachet C.

Haematologica. 2017 Dec;102(12):e502-e503. doi: 10.3324/haematol.2017.180539. No abstract available.


The role of 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors.

Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, Gasser B, Mazzucotelli JP, Hermine O, Maroteaux L, Monassier L.

Br J Pharmacol. 2017 Nov;174(22):4123-4139. doi: 10.1111/bph.13981. Epub 2017 Oct 15.


Ultrasound versus magnetic resonance imaging of the temporomandibular joint in juvenile idiopathic arthritis: a systematic review.

Hechler BL, Phero JA, Van Mater H, Matthews NS.

Int J Oral Maxillofac Surg. 2018 Jan;47(1):83-89. doi: 10.1016/j.ijom.2017.07.014. Epub 2017 Aug 10. Review.


Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation.

Alberio L, Ravanat C, Hechler B, Mangin PH, Lanza F, Gachet C.

Thromb Haemost. 2017 Jun 2;117(6):1101-1114. doi: 10.1160/TH16-09-0711. Epub 2017 Apr 6.


Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C.

Transfusion. 2016 Sep;56(9):2239-47. doi: 10.1111/trf.13670. Epub 2016 Jun 1.


Platelets are dispensable for antibody-mediated transfusion-related acute lung injury in the mouse.

Hechler B, Maître B, Magnenat S, Heim V, El Mdawar MB, Gachet C, de la Salle H.

J Thromb Haemost. 2016 Jun;14(6):1255-67. doi: 10.1111/jth.13335. Epub 2016 May 21.


ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1.

Lhermusier T, Severin S, Van Rothem J, Garcia C, Bertrand-Michel J, Le Faouder P, Hechler B, Broccardo C, Couvert P, Chimini G, Sié P, Payrastre B.

J Thromb Haemost. 2016 Mar;14(3):585-95. doi: 10.1111/jth.13247. Epub 2016 Feb 17.


Purinergic Receptors in Thrombosis and Inflammation.

Hechler B, Gachet C.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2307-15. doi: 10.1161/ATVBAHA.115.303395. Epub 2015 Sep 10. Review.


Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

Ciciliano JC, Sakurai Y, Myers DR, Fay ME, Hechler B, Meeks S, Li R, Dixon JB, Lyon LA, Gachet C, Lam WA.

Blood. 2015 Aug 6;126(6):817-24. doi: 10.1182/blood-2015-02-628594. Epub 2015 Apr 30.


The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice.

Maître B, Magnenat S, Heim V, Ravanat C, Evans RJ, de la Salle H, Gachet C, Hechler B.

J Immunol. 2015 Jan 15;194(2):739-49. doi: 10.4049/jimmunol.1401786. Epub 2014 Dec 5.


Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate.

Laurent PA, Séverin S, Hechler B, Vanhaesebroeck B, Payrastre B, Gratacap MP.

Blood. 2015 Jan 29;125(5):881-8. doi: 10.1182/blood-2014-07-588335. Epub 2014 Nov 14.


EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis.

Alame G, Mangin PH, Freund M, Riehl N, Magnenat S, Petitou M, Hechler B, Gachet C.

Thromb Haemost. 2015 Feb;113(2):385-95. doi: 10.1160/TH14-05-0399. Epub 2014 Nov 6.


Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, de Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH.

Circulation. 2013 Jul 30;128(5):541-52.


Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis.

Maurer E, Tang C, Schaff M, Bourdon C, Receveur N, Ravanat C, Eckly A, Hechler B, Gachet C, Lanza F, Mangin PH.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1221-9. doi: 10.1161/ATVBAHA.112.301013. Epub 2013 Apr 4.


Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation.

Hechler B, Ohlmann P, Chafey P, Ravanat C, Eckly A, Maurer E, Mangin P, Isola H, Cazenave JP, Gachet C.

Transfusion. 2013 Jun;53(6):1187-200. doi: 10.1111/j.1537-2995.2012.03923.x. Epub 2012 Oct 15.


The future of glycoprotein VI as an antithrombotic target.

Zahid M, Mangin P, Loyau S, Hechler B, Billiald P, Gachet C, Jandrot-Perrus M.

J Thromb Haemost. 2012 Dec;10(12):2418-27. doi: 10.1111/jth.12009. Review.


A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.

Mangin PH, Tang C, Bourdon C, Loyau S, Freund M, Hechler B, Gachet C, Jandrot-Perrus M.

J Pharmacol Exp Ther. 2012 Apr;341(1):156-63. doi: 10.1124/jpet.111.189050. Epub 2012 Jan 11.


P2 receptors and platelet function.

Hechler B, Gachet C.

Purinergic Signal. 2011 Sep;7(3):293-303. doi: 10.1007/s11302-011-9247-6. Epub 2011 Jul 27.


Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation.

Zerr M, Hechler B, Freund M, Magnenat S, Lanois I, Cazenave JP, Léon C, Gachet C.

Circulation. 2011 May 31;123(21):2404-13. doi: 10.1161/CIRCULATIONAHA.110.002139. Epub 2011 May 16.


The antithrombotic activity of EP224283, a neutralizable dual factor Xa inhibitor/glycoprotein IIbIIIa antagonist, exceeds that of the coadministered parent compounds.

Hechler B, Freund M, Alame G, Leguay C, Gaertner S, Cazenave JP, Petitou M, Gachet C.

J Pharmacol Exp Ther. 2011 Aug;338(2):412-20. doi: 10.1124/jpet.111.181321. Epub 2011 Apr 28.


Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.

Hechler B, Gachet C.

Thromb Haemost. 2011 May;105 Suppl 1:S3-12. doi: 10.1160/THS10-11-0730. Epub 2011 Apr 11.


Mechanisms underlying FeCl3-induced arterial thrombosis.

Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, Mangin PH, Gachet C.

J Thromb Haemost. 2011 Apr;9(4):779-89. doi: 10.1111/j.1538-7836.2011.04218.x.


Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.

de Castro S, Maruoka H, Hong K, Kilbey SM 2nd, Costanzi S, Hechler B, Brown GG Jr, Gachet C, Harden TK, Jacobson KA.

Bioconjug Chem. 2010 Jul 21;21(7):1190-205. doi: 10.1021/bc900569u.


A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.

Ravanat C, Strassel C, Hechler B, Schuhler S, Chicanne G, Payrastre B, Gachet C, Lanza F.

Blood. 2010 Aug 19;116(7):1157-64. doi: 10.1182/blood-2010-01-266080. Epub 2010 May 10.


Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization.

Hechler B, Nonne C, Eckly A, Magnenat S, Rinckel JY, Denis CV, Freund M, Cazenave JP, Lanza F, Gachet C.

J Thromb Haemost. 2010 Jan;8(1):173-84. doi: 10.1111/j.1538-7836.2009.03666.x. Epub 2009 Oct 24.


PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors.

Kim Y, Hechler B, Gao ZG, Gachet C, Jacobson KA.

Bioconjug Chem. 2009 Oct 21;20(10):1888-98. doi: 10.1021/bc9001689. Epub 2009 Sep 28.


Studies of mice lacking the GPIb-V-IX complex question the role of this receptor in atherosclerosis.

Strassel C, Hechler B, Bull A, Gachet C, Lanza F.

J Thromb Haemost. 2009 Nov;7(11):1935-8. doi: 10.1111/j.1538-7836.2009.03608.x. Epub 2009 Sep 9. No abstract available.


Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors.

Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave JP, Gachet C.

Circulation. 2008 Aug 12;118(7):754-63. doi: 10.1161/CIRCULATIONAHA.108.788927. Epub 2008 Jul 28.


Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors.

Kim Y, Klutz AM, Hechler B, Gao ZG, Gachet C, Jacobson KA.

Purinergic Signal. 2009 Mar;5(1):39-50. doi: 10.1007/s11302-008-9113-3. Epub 2008 Jul 4.


Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression.

Ohlmann P, Hechler B, Ravanat C, Loyau S, Herrenschmidt N, Wanert F, Jandrot-Perrus M, Gachet C.

J Thromb Haemost. 2008 Jun;6(6):1003-11. doi: 10.1111/j.1538-7836.2008.02976.x. Epub 2008 Apr 14.


Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.

Gao ZG, Hechler B, Besada P, Gachet C, Jacobson KA.

Biochem Pharmacol. 2008 Mar 15;75(6):1341-7. doi: 10.1016/j.bcp.2007.10.037. Epub 2007 Dec 4.


Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers.

Kim Y, Hechler B, Klutz AM, Gachet C, Jacobson KA.

Bioconjug Chem. 2008 Feb;19(2):406-11. doi: 10.1021/bc700327u. Epub 2008 Jan 5.


A high concentration of ADP induces weak platelet granule secretion independently of aggregation and thromboxane A2 production.

Lantz N, Hechler B, Ravanat C, Cazenave JP, Gachet C.

Thromb Haemost. 2007 Nov;98(5):1145-7. No abstract available.


Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain.

Nonne C, Hechler B, Cazenave JP, Gachet C, Lanza F.

J Thromb Haemost. 2008 Jan;6(1):210-2. Epub 2007 Nov 5. No abstract available.


Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Léon C, Eckly A, Hechler B, Aleil B, Freund M, Ravanat C, Jourdain M, Nonne C, Weber J, Tiedt R, Gratacap MP, Severin S, Cazenave JP, Lanza F, Skoda R, Gachet C.

Blood. 2007 Nov 1;110(9):3183-91. Epub 2007 Jul 30.


Identification of platelet factor 4 and beta-thromboglobulin by profiling and liquid chromatography tandem mass spectrometry of supernatant peptides in stored apheresis and buffy-coat platelet concentrates.

Wurtz V, Hechler B, Ohlmann P, Isola H, Schaeffer-Reiss C, Cazenave JP, Van Dorsselaer A, Gachet C.

Transfusion. 2007 Jun;47(6):1099-101. No abstract available.


[Atherothrombosis: transposition of the models to the clinic and reciprocally].

Gachet C, Hechler B, Nonne C, Cazenave JP, Lanza F, Aleil B.

Therapie. 2006 Sep-Oct;61(5):389-94. Review. French.


The platelet P2 receptors in arterial thrombosis.

Gachet C, Léon C, Hechler B.

Blood Cells Mol Dis. 2006 Mar-Apr;36(2):223-7. Epub 2006 Feb 8. Review. Erratum in: Blood Cells Mol Dis. 2012 Aug 15;49(2):120.


MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice.

Hechler B, Nonne C, Roh EJ, Cattaneo M, Cazenave JP, Lanza F, Jacobson KA, Gachet C.

J Pharmacol Exp Ther. 2006 Feb;316(2):556-63. Epub 2005 Oct 19.


A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.

Soulet C, Hechler B, Gratacap MP, Plantavid M, Offermanns S, Gachet C, Payrastre B.

J Thromb Haemost. 2005 Oct;3(10):2296-306.


The platelet P2 receptors in thrombosis.

Gachet C, Hechler B.

Semin Thromb Hemost. 2005 Apr;31(2):162-7. Review.


The P2 receptors in platelet function.

Hechler B, Cattaneo M, Gachet C.

Semin Thromb Hemost. 2005 Apr;31(2):150-61. Review.


Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity.

Nonne C, Lenain N, Hechler B, Mangin P, Cazenave JP, Gachet C, Lanza F.

Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1293-8. Epub 2005 Mar 17.


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