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Items: 1 to 50 of 114

1.

mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes.

Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A.

J Clin Invest. 2019 Jul 2;130:4124-4137. doi: 10.1172/JCI127021.

2.

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function.

Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R.

Diabetes. 2019 Sep;68(9):1806-1818. doi: 10.2337/db19-0349. Epub 2019 Jun 14.

PMID:
31201281
3.

Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M.

Nat Cell Biol. 2019 Jun;21(6):792. doi: 10.1038/s41556-019-0316-3.

PMID:
30914825
4.

Pancreatic pericytes originate from the embryonic pancreatic mesenchyme.

Harari N, Sakhneny L, Khalifa-Malka L, Busch A, Hertel KJ, Hebrok M, Landsman L.

Dev Biol. 2019 May 1;449(1):14-20. doi: 10.1016/j.ydbio.2019.01.020. Epub 2019 Feb 13.

5.

Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.

Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M.

Nat Cell Biol. 2019 Feb;21(2):263-274. doi: 10.1038/s41556-018-0271-4. Epub 2019 Feb 1. Erratum in: Nat Cell Biol. 2019 Mar 26;:.

PMID:
30710150
6.

The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.

Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H.

J Clin Invest. 2018 Aug 1;128(8):3475-3489. doi: 10.1172/JCI94287. Epub 2018 Jul 16.

7.

Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.

Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M.

Cell Stem Cell. 2018 Jun 1;22(6):810-823. doi: 10.1016/j.stem.2018.05.016. Review.

8.

Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles.

Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ Jr, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G.

Dev Cell. 2018 May 7;45(3):347-361.e5. doi: 10.1016/j.devcel.2018.03.013. Epub 2018 Apr 12.

9.

Replication confers β cell immaturity.

Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M.

Nat Commun. 2018 Feb 2;9(1):485. doi: 10.1038/s41467-018-02939-0.

10.

Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.

Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q.

Stem Cell Reports. 2017 Sep 12;9(3):807-819. doi: 10.1016/j.stemcr.2017.07.012. Epub 2017 Aug 10.

11.

Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.

Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA.

ACS Nano. 2017 Aug 22;11(8):7747-7757. doi: 10.1021/acsnano.7b01239. Epub 2017 Aug 7.

12.

Atypical flat lesions derive from pancreatic acinar cells.

von Figura G, Fahrenkrog-Petersen L, Hidalgo-Sastre A, Hartmann D, Hüser N, Schmid RM, Hebrok M, Roy N, Esposito I.

Pancreatology. 2017 May - Jun;17(3):350-353. doi: 10.1016/j.pan.2017.04.014. Epub 2017 Apr 25.

13.

Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.

Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS.

Clin Cancer Res. 2017 Aug 15;23(16):4865-4874. doi: 10.1158/1078-0432.CCR-16-2987. Epub 2017 Apr 19.

14.

All mixed up: defining roles for β-cell subtypes in mature islets.

Liu JS, Hebrok M.

Genes Dev. 2017 Feb 1;31(3):228-240. doi: 10.1101/gad.294389.116. Review.

15.

Designing β Cells.

Hebrok M.

Cell Metab. 2017 Feb 7;25(2):223-224. doi: 10.1016/j.cmet.2017.01.018.

16.

PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.

Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC.

Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116.

17.

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.

Diabetologia. 2017 Jan;60(1):35-38. Epub 2016 Oct 26.

18.

Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.

Muñoz-Bravo JL, Flores-Martínez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA.

PLoS One. 2016 Oct 13;11(10):e0164714. doi: 10.1371/journal.pone.0164714. eCollection 2016.

19.

Human islets contain four distinct subtypes of β cells.

Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M.

Nat Commun. 2016 Jul 11;7:11756. doi: 10.1038/ncomms11756.

20.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression.

Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM.

Nat Med. 2016 May;22(5):497-505. doi: 10.1038/nm.4082. Epub 2016 Apr 18.

21.

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia.

Hendley AM, Wang YJ, Polireddy K, Alsina J, Ahmed I, Lafaro KJ, Zhang H, Roy N, Savidge SG, Cao Y, Hebrok M, Maitra A, Reynolds AB, Goggins M, Younes M, Iacobuzio-Donahue CA, Leach SD, Bailey JM.

Cancer Res. 2016 Jun 1;76(11):3351-63. doi: 10.1158/0008-5472.CAN-15-2268. Epub 2016 Mar 31.

22.

Life and death of β cells in Type 1 diabetes: A comprehensive review.

Wilcox NS, Rui J, Hebrok M, Herold KC.

J Autoimmun. 2016 Jul;71:51-8. doi: 10.1016/j.jaut.2016.02.001. Epub 2016 Mar 24. Review.

23.

Human pancreatic beta-like cells converted from fibroblasts.

Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S.

Nat Commun. 2016 Jan 6;7:10080. doi: 10.1038/ncomms10080.

24.

Regulation of Cellular Identity in Cancer.

Roy N, Hebrok M.

Dev Cell. 2015 Dec 21;35(6):674-84. doi: 10.1016/j.devcel.2015.12.001. Review.

25.

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation.

Russ HA, Landsman L, Moss CL, Higdon R, Greer RL, Kaihara K, Salamon R, Kolker E, Hebrok M.

Stem Cells Int. 2016;2016:6183562. doi: 10.1155/2016/6183562. Epub 2015 Nov 22.

26.

A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells.

Saini C, Petrenko V, Pulimeno P, Giovannoni L, Berney T, Hebrok M, Howald C, Dermitzakis ET, Dibner C.

Diabetes Obes Metab. 2016 Apr;18(4):355-65. doi: 10.1111/dom.12616. Epub 2016 Jan 22.

PMID:
26662378
27.

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Suriben R, Kaihara KA, Paolino M, Reichelt M, Kummerfeld SK, Modrusan Z, Dugger DL, Newton K, Sagolla M, Webster JD, Liu J, Hebrok M, Dixit VM.

Cell. 2015 Dec 3;163(6):1457-67. doi: 10.1016/j.cell.2015.10.076. Epub 2015 Nov 25.

28.

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ.

Development. 2015 Dec 1;142(23):4010-25. doi: 10.1242/dev.122846. Epub 2015 Oct 19.

29.

DNA methylation directs functional maturation of pancreatic β cells.

Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A.

J Clin Invest. 2015 Jul 1;125(7):2851-60. doi: 10.1172/JCI79956. Epub 2015 Jun 22.

30.

Islet formation in mice and men: lessons for the generation of functional insulin-producing β-cells from human pluripotent stem cells.

Nair G, Hebrok M.

Curr Opin Genet Dev. 2015 Jun;32:171-80. doi: 10.1016/j.gde.2015.03.004. Epub 2015 Apr 21. Review.

31.

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.

Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M.

EMBO J. 2015 Jul 2;34(13):1759-72. doi: 10.15252/embj.201591058. Epub 2015 Apr 23.

32.

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

Roy N, Malik S, Villanueva KE, Urano A, Lu X, Von Figura G, Seeley ES, Dawson DW, Collisson EA, Hebrok M.

Genes Dev. 2015 Mar 15;29(6):658-71. doi: 10.1101/gad.256628.114.

33.

CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.

Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A.

Stem Cell Reports. 2015 Mar 10;4(3):374-89. doi: 10.1016/j.stemcr.2015.01.019. Epub 2015 Feb 26.

34.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

35.

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V.

EMBO J. 2015 Feb 12;34(4):517-30. doi: 10.15252/embj.201489574. Epub 2015 Jan 13.

36.

Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.

Puri S, Folias AE, Hebrok M.

Cell Stem Cell. 2015 Jan 8;16(1):18-31. doi: 10.1016/j.stem.2014.11.001. Epub 2014 Nov 20.

37.

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.

Russ HA, Hebrok M.

EMBO J. 2014 Oct 1;33(19):2135-6. doi: 10.15252/embj.201489751. Epub 2014 Aug 25.

38.

Aberrant innate immune activation following tissue injury impairs pancreatic regeneration.

Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M.

PLoS One. 2014 Jul 10;9(7):e102125. doi: 10.1371/journal.pone.0102125. eCollection 2014.

39.

Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.

Morris JP 4th, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M.

PLoS One. 2014 May 1;9(5):e95486. doi: 10.1371/journal.pone.0095486. eCollection 2014.

40.

Diabetes. Solving human β-cell development--what does the mouse say?

Folias AE, Hebrok M.

Nat Rev Endocrinol. 2014 May;10(5):253-5. doi: 10.1038/nrendo.2014.18. Epub 2014 Feb 25.

PMID:
24566816
41.

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.

von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M.

Nat Cell Biol. 2014 Mar;16(3):255-67. doi: 10.1038/ncb2916. Epub 2014 Feb 23.

42.

Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.

Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S.

Cell Stem Cell. 2014 Feb 6;14(2):228-36. doi: 10.1016/j.stem.2014.01.006.

43.

VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.

Puri S, Akiyama H, Hebrok M.

Genes Dev. 2013 Dec 1;27(23):2563-75. doi: 10.1101/gad.227785.113.

44.

Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.

Puri S, García-Núñez A, Hebrok M, Cano DA.

PLoS One. 2013 Aug 20;8(8):e72213. doi: 10.1371/journal.pone.0072213. eCollection 2013.

45.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

46.

Canonical wnt signaling is required for pancreatic carcinogenesis.

Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M.

Cancer Res. 2013 Aug 1;73(15):4909-22. doi: 10.1158/0008-5472.CAN-12-4384. Epub 2013 Jun 12.

47.

Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.

Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M.

Cell Stem Cell. 2013 Aug 1;13(2):219-29. doi: 10.1016/j.stem.2013.04.004. Epub 2013 May 16.

48.

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

von Figura G, Morris JP 4th, Wright CV, Hebrok M.

Gut. 2014 Apr;63(4):656-64. doi: 10.1136/gutjnl-2012-304287. Epub 2013 May 3.

49.

Control of cell identity in pancreas development and regeneration.

Stanger BZ, Hebrok M.

Gastroenterology. 2013 Jun;144(6):1170-9. doi: 10.1053/j.gastro.2013.01.074. Review.

50.

Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.

Lin WC, Rajbhandari N, Liu C, Sakamoto K, Zhang Q, Triplett AA, Batra SK, Opavsky R, Felsher DW, DiMaio DJ, Hollingsworth MA, Morris JP 4th, Hebrok M, Witkiewicz AK, Brody JR, Rui H, Wagner KU.

Cancer Res. 2013 Mar 15;73(6):1821-30. doi: 10.1158/0008-5472.CAN-12-2067. Epub 2013 Mar 6.

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