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Items: 1 to 50 of 83

1.

Effects of Pregnancy on the Pharmacokinetics of Metformin.

Liao MZ, Flood Nichols SK, Ahmed M, Clark S, Hankins GD, Caritis S, Venkataramanan R, Haas D, Quinney SK, Haneline LS, Tita AT, Manuck T, Wang J, Thummel KE, Brown LM, Ren Z, Easterling TR, Hebert MF.

Drug Metab Dispos. 2020 Apr;48(4):264-271. doi: 10.1124/dmd.119.088435. Epub 2020 Jan 24.

2.

Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Brown LM, Ren Z, Brown Z, Easterling TR, Hebert MF.

Clin Pharmacol Ther. 2019 Dec 23. doi: 10.1002/cpt.1749. [Epub ahead of print]

PMID:
31869430
3.

Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.

Shuster DL, Shireman LM, Ma X, Shen DD, Flood Nichols SK, Ahmed MS, Clark S, Caritis S, Venkataramanan R, Haas DM, Quinney SK, Haneline LS, Tita AT, Manuck TA, Thummel KE, Morris Brown L, Ren Z, Brown Z, Easterling TR, Hebert MF.

J Clin Pharmacol. 2020 Apr;60(4):540-549. doi: 10.1002/jcph.1549. Epub 2019 Nov 19.

PMID:
31742716
4.

Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice.

Zha W, Hu T, Hebert MF, Wang J.

J Pharmacol Exp Ther. 2019 Oct;371(1):113-120. doi: 10.1124/jpet.118.255380. Epub 2019 Jul 15.

PMID:
31308195
5.

Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.

Han LW, Ryu RJ, Cusumano M, Easterling TR, Phillips BR, Risler LJ, Shen DD, Hebert MF.

J Clin Pharmacol. 2019 Dec;59(12):1678-1689. doi: 10.1002/jcph.1477. Epub 2019 Jun 30. Erratum in: J Clin Pharmacol. 2020 Apr;60(4):550.

PMID:
31257615
6.

Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin during Pregnancy.

Lee N, Hebert MF, Wagner DJ, Easterling TR, Liang CJ, Rice K, Wang J.

Mol Pharmacol. 2018 Oct;94(4):1125-1131. doi: 10.1124/mol.118.112482. Epub 2018 Jul 16.

7.

Prednisone Pharmacokinetics During Pregnancy and Lactation.

Ryu RJ, Easterling TR, Caritis SN, Venkataramanan R, Umans JG, Ahmed MS, Clark S, Kantrowitz-Gordon I, Hays K, Bennett B, Honaker MT, Thummel KE, Shen DD, Hebert MF.

J Clin Pharmacol. 2018 Sep;58(9):1223-1232. doi: 10.1002/jcph.1122. Epub 2018 May 7.

8.

Patterns of prednisone use during pregnancy in women with rheumatoid arthritis: Daily and cumulative dose.

Palmsten K, Rolland M, Hebert MF, Clowse MEB, Schatz M, Xu R, Chambers CD.

Pharmacoepidemiol Drug Saf. 2018 Apr;27(4):430-438. doi: 10.1002/pds.4410. Epub 2018 Feb 28.

9.

Pharmacokinetics of dacarbazine (DTIC) in pregnancy.

Kantrowitz-Gordon I, Hays K, Kayode O, Kumar AR, Kaplan HG, Reid JM, Safgren SL, Ames MM, Easterling TR, Hebert MF.

Cancer Chemother Pharmacol. 2018 Mar;81(3):455-460. doi: 10.1007/s00280-017-3511-6. Epub 2018 Jan 5.

10.

Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance.

Zha W, Ho HTB, Hu T, Hebert MF, Wang J.

Sci Rep. 2017 Apr 25;7(1):1137. doi: 10.1038/s41598-017-01291-5.

11.

Pregnancy Increases the Renal Secretion of N1-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin.

Bergagnini-Kolev MC, Hebert MF, Easterling TR, Lin YS.

Drug Metab Dispos. 2017 Mar;45(3):325-329. doi: 10.1124/dmd.116.073841. Epub 2017 Jan 9.

12.

Ondansetron Exposure Changes in a Pregnant Woman.

Lemon LS, Zhang H, Hebert MF, Hankins GD, Haas DM, Caritis SN, Venkataramanan R.

Pharmacotherapy. 2016 Sep;36(9):e139-41. doi: 10.1002/phar.1796. Epub 2016 Jul 25.

13.

Prenatal pharmacogenomics: a promising area for research.

Dorfman EH, Cheng EY, Hebert MF, Thummel KE, Burke W.

Pharmacogenomics J. 2016 Aug;16(4):303-4. doi: 10.1038/tpj.2016.33. Epub 2016 May 10.

14.

Population pharmacokinetics of 17α-hydroxyprogesterone caproate in singleton gestation.

Sharma S, Caritis S, Hankins G, Miodovnik M, Hebert MF, Mattison D, Venkataramanan R.

Br J Clin Pharmacol. 2016 Oct;82(4):1084-93. doi: 10.1111/bcp.12990. Epub 2016 Jul 13.

15.

Pregnancy-related pharmacokinetic changes.

Tasnif Y, Morado J, Hebert MF.

Clin Pharmacol Ther. 2016 Jul;100(1):53-62. doi: 10.1002/cpt.382. Epub 2016 May 14. Review.

PMID:
27082931
16.

Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial.

Costantine MM, Cleary K, Hebert MF, Ahmed MS, Brown LM, Ren Z, Easterling TR, Haas DM, Haneline LS, Caritis SN, Venkataramanan R, West H, D'Alton M, Hankins G; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric-Fetal Pharmacology Research Units Network.

Am J Obstet Gynecol. 2016 Jun;214(6):720.e1-720.e17. doi: 10.1016/j.ajog.2015.12.038. Epub 2015 Dec 23.

17.

Pharmacokinetics of metoprolol during pregnancy and lactation.

Ryu RJ, Eyal S, Easterling TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF.

J Clin Pharmacol. 2016 May;56(5):581-9. doi: 10.1002/jcph.631. Epub 2015 Dec 4.

18.

Population pharmacokinetics of oseltamivir in non-pregnant and pregnant women.

Pillai VC, Han K, Beigi RH, Hankins GD, Clark S, Hebert MF, Easterling TR, Zajicek A, Ren Z, Caritis SN, Venkataramanan R.

Br J Clin Pharmacol. 2015 Nov;80(5):1042-50. doi: 10.1111/bcp.12691. Epub 2015 Aug 18.

19.

Identification of CYP3A7 for glyburide metabolism in human fetal livers.

Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat JD, Hebert MF, Shen DD, Thummel KE, Mao Q.

Biochem Pharmacol. 2014 Dec 15;92(4):690-700. doi: 10.1016/j.bcp.2014.09.025. Epub 2014 Oct 22.

20.

Gestational diabetes mellitus management with oral hypoglycemic agents.

Ryu RJ, Hays KE, Hebert MF.

Semin Perinatol. 2014 Dec;38(8):508-15. doi: 10.1053/j.semperi.2014.08.012. Epub 2014 Oct 12. Review.

21.

Basic obstetric pharmacology.

Zhao Y, Hebert MF, Venkataramanan R.

Semin Perinatol. 2014 Dec;38(8):475-86. doi: 10.1053/j.semperi.2014.08.011. Epub 2014 Oct 1. Review.

22.

Taste of a pill: organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands.

Lee N, Duan H, Hebert MF, Liang CJ, Rice KM, Wang J.

J Biol Chem. 2014 Sep 26;289(39):27055-64. doi: 10.1074/jbc.M114.570564. Epub 2014 Aug 8.

23.

Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.

Shuster DL, Risler LJ, Liang CK, Rice KM, Shen DD, Hebert MF, Thummel KE, Mao Q.

J Pharmacol Exp Ther. 2014 Aug;350(2):425-34. doi: 10.1124/jpet.114.213470. Epub 2014 Jun 4.

24.

Pharmacokinetics of doxorubicin in pregnant women.

Ryu RJ, Eyal S, Kaplan HG, Akbarzadeh A, Hays K, Puhl K, Easterling TR, Berg SL, Scorsone KA, Feldman EM, Umans JG, Miodovnik M, Hebert MF.

Cancer Chemother Pharmacol. 2014 Apr;73(4):789-97. doi: 10.1007/s00280-014-2406-z. Epub 2014 Feb 15.

25.

Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.

Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J.

Drug Metab Dispos. 2013 Dec;41(12):2225-32. doi: 10.1124/dmd.113.054072. Epub 2013 Oct 7.

26.

A pharmacologic approach to the use of glyburide in pregnancy.

Caritis SN, Hebert MF.

Obstet Gynecol. 2013 Jun;121(6):1309-12. doi: 10.1097/AOG.0b013e31829007f0.

27.

Tacrolimus placental transfer at delivery and neonatal exposure through breast milk.

Zheng S, Easterling TR, Hays K, Umans JG, Miodovnik M, Clark S, Calamia JC, Thummel KE, Shen DD, Davis CL, Hebert MF.

Br J Clin Pharmacol. 2013 Dec;76(6):988-96. doi: 10.1111/bcp.12122.

28.

Duration of cisplatin excretion in breast milk.

Hays KE, Ryu RJ, Swisher EM, Reed E, McManus T, Rybeck B, Petros WP, Hebert MF.

J Hum Lact. 2013 Nov;29(4):469-72. doi: 10.1177/0890334413479671. Epub 2013 Mar 14.

29.

CYP3A5 gene variation influences cyclosporine A metabolite formation and renal cyclosporine disposition.

Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE.

Transplantation. 2013 Mar 27;95(6):821-7. doi: 10.1097/TP.0b013e31827e6ad9.

30.

Interpreting tacrolimus concentrations during pregnancy and postpartum.

Hebert MF, Zheng S, Hays K, Shen DD, Davis CL, Umans JG, Miodovnik M, Thummel KE, Easterling TR.

Transplantation. 2013 Apr 15;95(7):908-15. doi: 10.1097/TP.0b013e318278d367. Review.

31.

Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice.

Shuster DL, Bammler TK, Beyer RP, Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE, Mao Q.

Drug Metab Dispos. 2013 Feb;41(2):332-42. doi: 10.1124/dmd.112.049718. Epub 2012 Nov 21. Erratum in: Drug Metab Dispos. 2013 Mar;41(3):682.

32.

Measurement and compartmental modeling of the effect of CYP3A5 gene variation on systemic and intrarenal tacrolimus disposition.

Zheng S, Tasnif Y, Hebert MF, Davis CL, Shitara Y, Calamia JC, Lin YS, Shen DD, Thummel KE.

Clin Pharmacol Ther. 2012 Dec;92(6):737-45. doi: 10.1038/clpt.2012.175. Epub 2012 Oct 17.

33.

Pharmacokinetics of tacrolimus during pregnancy.

Zheng S, Easterling TR, Umans JG, Miodovnik M, Calamia JC, Thummel KE, Shen DD, Davis CL, Hebert MF.

Ther Drug Monit. 2012 Dec;34(6):660-70. doi: 10.1097/FTD.0b013e3182708edf.

34.

Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation.

Caritis SN, Sharma S, Venkataramanan R, Hankins GD, Miodovnik M, Hebert MF, Umans JG, Benedetti T, Mattison D, Zajicek A, Fischer D, Jackson A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetrical-Fetal Pharmacology Research Units Network.

Am J Obstet Gynecol. 2012 Nov;207(5):398.e1-8. doi: 10.1016/j.ajog.2012.08.015. Epub 2012 Aug 16.

35.

Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic.

Haas DM, Quinney SK, Clay JM, Renbarger JL, Hebert MF, Clark S, Umans JG, Caritis SN; Obstetric-Fetal Pharmacology Research Units Network.

Am J Perinatol. 2013 Apr;30(4):275-81. doi: 10.1055/s-0032-1323590. Epub 2012 Aug 8.

36.

The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics.

van Hasselt JG, Andrew MA, Hebert MF, Tarning J, Vicini P, Mattison DR.

Br J Clin Pharmacol. 2012 Dec;74(6):932-9. doi: 10.1111/j.1365-2125.2012.04280.x. Review.

37.

A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics.

Quinney SK, Mohamed AN, Hebert MF, Haas DM, Clark S, Umans JG, Caritis SN, Li L.

CPT Pharmacometrics Syst Pharmacol. 2012 Sep 26;1:e2. doi: 10.1038/psp.2012.5.

38.

An inducible cytochrome P450 3A4-dependent vitamin D catabolic pathway.

Wang Z, Lin YS, Zheng XE, Senn T, Hashizume T, Scian M, Dickmann LJ, Nelson SD, Baillie TA, Hebert MF, Blough D, Davis CL, Thummel KE.

Mol Pharmacol. 2012 Apr;81(4):498-509. doi: 10.1124/mol.111.076356. Epub 2011 Dec 28.

39.

Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry.

Wang Z, Senn T, Kalhorn T, Zheng XE, Zheng S, Davis CL, Hebert MF, Lin YS, Thummel KE.

Anal Biochem. 2011 Nov 1;418(1):126-33. doi: 10.1016/j.ab.2011.06.043. Epub 2011 Jul 13.

40.

Pharmacotherapy and pregnancy: highlights from the Third International Conference for Individualized Pharmacotherapy in Pregnancy.

Haas DM, Gallauresi B, Shields K, Zeitlin D, Clark SM, Hebert MF, Ren Z, Nallani SC, Meslin EM, Feibus KB, Koren G, Goebel WS, Easterling T, Denne SC, Flockhart DA, Renbarger JL.

Clin Transl Sci. 2011 Jun;4(3):204-9. doi: 10.1111/j.1752-8062.2011.00280.x.

41.

Pharmacokinetics of oseltamivir among pregnant and nonpregnant women.

Beigi RH, Han K, Venkataramanan R, Hankins GD, Clark S, Hebert MF, Easterling T, Zajicek A, Ren Z, Mattison DR, Caritis SN; Obstetric-Fetal Pharmacology Research Units Network.

Am J Obstet Gynecol. 2011 Jun;204(6 Suppl 1):S84-8. doi: 10.1016/j.ajog.2011.03.002. Epub 2011 Mar 9.

42.

CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance.

Claessens AJ, Risler LJ, Eyal S, Shen DD, Easterling TR, Hebert MF.

Drug Metab Dispos. 2010 Sep;38(9):1393-6. doi: 10.1124/dmd.110.033878. Epub 2010 Jun 22.

43.

Increased glyburide clearance in the pregnant mouse model.

Zhou L, Zhang Y, Hebert MF, Unadkat JD, Mao Q.

Drug Metab Dispos. 2010 Sep;38(9):1403-6. doi: 10.1124/dmd.110.033837. Epub 2010 Jun 17.

44.

Pharmacotherapy and pregnancy: highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy.

Haas DM, Hebert MF, Soldin OP, Flockhart DA, Madadi P, Nocon JJ, Chambers CD, Hankins GD, Clark S, Wisner KL, Li L, Renbarger JL, Learman LA.

Clin Transl Sci. 2009 Dec;2(6):439-43. doi: 10.1111/j.1752-8062.2009.00166.x.

45.

Contributions of human cytochrome P450 enzymes to glyburide metabolism.

Zhou L, Naraharisetti SB, Liu L, Wang H, Lin YS, Isoherranen N, Unadkat JD, Hebert MF, Mao Q.

Biopharm Drug Dispos. 2010 May;31(4):228-42. doi: 10.1002/bdd.706.

46.

Atenolol pharmacokinetics and excretion in breast milk during the first 6 to 8 months postpartum.

Eyal S, Kim JD, Anderson GD, Buchanan ML, Brateng DA, Carr D, Woodrum DE, Easterling TR, Hebert MF.

J Clin Pharmacol. 2010 Nov;50(11):1301-9. doi: 10.1177/0091270009358708. Epub 2010 Feb 9.

47.

Pharmacokinetics of metformin during pregnancy.

Eyal S, Easterling TR, Carr D, Umans JG, Miodovnik M, Hankins GD, Clark SM, Risler L, Wang J, Kelly EJ, Shen DD, Hebert MF.

Drug Metab Dispos. 2010 May;38(5):833-40. doi: 10.1124/dmd.109.031245. Epub 2010 Jan 29.

48.

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate.

Eyal S, Chung FS, Muzi M, Link JM, Mankoff DA, Kaddoumi A, O'Sullivan F, Hebert MF, Unadkat JD.

J Nucl Med. 2009 May;50(5):798-806. doi: 10.2967/jnumed.108.059360.

49.

Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.

Hebert MF, Ma X, Naraharisetti SB, Krudys KM, Umans JG, Hankins GD, Caritis SN, Miodovnik M, Mattison DR, Unadkat JD, Kelly EJ, Blough D, Cobelli C, Ahmed MS, Snodgrass WR, Carr DB, Easterling TR, Vicini P; Obstetric-Fetal Pharmacology Research Unit Network.

Clin Pharmacol Ther. 2009 Jun;85(6):607-14. doi: 10.1038/clpt.2009.5. Epub 2009 Mar 18.

50.

Physiologically based pharmacokinetic model of midazolam disposition during pregnancy.

Andrew MA, Hebert MF, Vicini P.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5454-7. doi: 10.1109/IEMBS.2008.4650448.

PMID:
19163951

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