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Items: 44


Alteration of 28S rRNA 2'-O-methylation by etoposide correlates with decreased SMN phosphorylation and reduced Drosha levels.

Burke MF, McLaurin DM, Logan MK, Hebert MD.

Biol Open. 2019 Mar 27;8(3). pii: bio041848. doi: 10.1242/bio.041848.


Altered dynamics of scaRNA2 and scaRNA9 in response to stress correlates with disrupted nuclear organization.

Logan MK, Burke MF, Hebert MD.

Biol Open. 2018 Sep 27;7(9). pii: bio037101. doi: 10.1242/bio.037101.


Identification of additional regulatory RNPs that impact rRNA and U6 snRNA methylation.

Burke MF, Logan MK, Hebert MD.

Biol Open. 2018 Aug 10;7(8). pii: bio036095. doi: 10.1242/bio.036095.


Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity.

Poole AR, Vicino I, Adachi H, Yu YT, Hebert MD.

Biol Open. 2017 Sep 15;6(9):1342-1354. doi: 10.1242/bio.028092.


Towards an understanding of regulating Cajal body activity by protein modification.

Hebert MD, Poole AR.

RNA Biol. 2017 Jun 3;14(6):761-778. doi: 10.1080/15476286.2016.1243649. Epub 2016 Oct 7. Review.


Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis.

Poole AR, Enwerem II, Vicino IA, Coole JB, Smith SV, Hebert MD.

RNA Biol. 2016 Oct 2;13(10):955-972. Epub 2016 Jul 15.


SMN and coilin negatively regulate dyskerin association with telomerase RNA.

Poole AR, Hebert MD.

Biol Open. 2016 Jun 15;5(6):726-35. doi: 10.1242/bio.018804.


Cajal body proteins differentially affect the processing of box C/D scaRNPs.

Enwerem II, Wu G, Yu YT, Hebert MD.

PLoS One. 2015 Apr 13;10(4):e0122348. doi: 10.1371/journal.pone.0122348. eCollection 2015.


Coilin association with Box C/D scaRNA suggests a direct role for the Cajal body marker protein in scaRNP biogenesis.

Enwerem II, Velma V, Broome HJ, Kuna M, Begum RA, Hebert MD.

Biol Open. 2014 Apr 15;3(4):240-9. doi: 10.1242/bio.20147443.


Phosphorylation regulates coilin activity and RNA association.

Broome HJ, Carrero ZI, Douglas HE, Hebert MD.

Biol Open. 2013 Feb 26;2(4):407-15. doi: 10.1242/bio.20133863. Print 2013 Apr 15.


Signals controlling Cajal body assembly and function.

Hebert MD.

Int J Biochem Cell Biol. 2013 Jul;45(7):1314-7. doi: 10.1016/j.biocel.2013.03.019. Epub 2013 Apr 10. Review.


Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.

Broome HJ, Hebert MD.

J Mol Biol. 2013 Feb 22;425(4):713-24. doi: 10.1016/j.jmb.2012.12.014. Epub 2012 Dec 27.


Regulated specific proteolysis of the Cajal body marker protein coilin.

Velma V, Broome HJ, Hebert MD.

Chromosoma. 2012 Dec;121(6):629-42. doi: 10.1007/s00412-012-0387-4. Epub 2012 Oct 14.


Coilin levels modulate cell cycle progression and γH2AX levels in etoposide treated U2OS cells.

Velma V, Carrero ZI, Allen CB, Hebert MD.

FEBS Lett. 2012 Sep 21;586(19):3404-9. doi: 10.1016/j.febslet.2012.07.054. Epub 2012 Aug 7.


In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing.

Broome HJ, Hebert MD.

PLoS One. 2012;7(4):e36300. doi: 10.1371/journal.pone.0036300. Epub 2012 Apr 27.


Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product.

Carrero ZI, Velma V, Douglas HE, Hebert MD.

PLoS One. 2011;6(10):e25743. doi: 10.1371/journal.pone.0025743. Epub 2011 Oct 3.


Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage.

Gilder AS, Do PM, Carrero ZI, Cosman AM, Broome HJ, Velma V, Martinez LA, Hebert MD.

Mol Biol Cell. 2011 Apr;22(7):1070-9. doi: 10.1091/mbc.E10-08-0731. Epub 2011 Feb 2.


Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining.

Velma V, Carrero ZI, Cosman AM, Hebert MD.

FEBS Lett. 2010 Dec 1;584(23):4735-9. doi: 10.1016/j.febslet.2010.11.004. Epub 2010 Nov 9.


Phosphorylation and the Cajal body: modification in search of function.

Hebert MD.

Arch Biochem Biophys. 2010 Apr 15;496(2):69-76. doi: 10.1016/ Epub 2010 Mar 1. Review.


A thermally targeted peptide inhibitor of symmetrical dimethylation inhibits cancer-cell proliferation.

Bidwell GL 3rd, Whittom AA, Thomas E, Lyons D, Hebert MD, Raucher D.

Peptides. 2010 May;31(5):834-41. doi: 10.1016/j.peptides.2010.02.007. Epub 2010 Feb 16.


Coilin phosphorylation mediates interaction with SMN and SmB'.

Toyota CG, Davis MD, Cosman AM, Hebert MD.

Chromosoma. 2010 Apr;119(2):205-15. doi: 10.1007/s00412-009-0249-x. Epub 2009 Dec 8.


Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.

Hearst SM, Gilder AS, Negi SS, Davis MD, George EM, Whittom AA, Toyota CG, Husedzinovic A, Gruss OJ, Hebert MD.

J Cell Sci. 2009 Jun 1;122(Pt 11):1872-81. doi: 10.1242/jcs.044040. Epub 2009 May 12.


Coilin levels and modifications influence artificial reporter splicing.

Whittom AA, Xu H, Hebert MD.

Cell Mol Life Sci. 2008 Apr;65(7-8):1256-71. doi: 10.1007/s00018-008-7587-3.


Targeting the gene in Friedreich ataxia.

Hebert MD.

Biochimie. 2008 Aug;90(8):1131-9. doi: 10.1016/j.biochi.2007.12.005. Epub 2007 Dec 28. Review.


Gene-based approaches toward Friedreich ataxia therapeutics.

Hebert MD, Whittom AA.

Cell Mol Life Sci. 2007 Dec;64(23):3034-43. Review.


Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing.

Sun J, Xu H, Negi S, Subramony SH, Hebert MD.

J Neurosci Res. 2007 Aug 15;85(11):2306-17.


Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1.

Vig PJ, Wei J, Shao Q, Hebert MD, Subramony SH, Sutton LT.

Neurosci Lett. 2007 Jun 8;420(1):53-7. Epub 2007 Apr 5.


Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis.

D'Souza DR, Wei J, Shao Q, Hebert MD, Subramony SH, Vig PJ.

Neurosci Lett. 2006 Nov 27;409(1):5-9. Epub 2006 Oct 11.


Rational selection of small molecules that increase transcription through the GAA repeats found in Friedreich's ataxia.

Grant L, Sun J, Xu H, Subramony SH, Chaires JB, Hebert MD.

FEBS Lett. 2006 Oct 2;580(22):5399-405. Epub 2006 Sep 15.


Interactions between coilin and PIASy partially link Cajal bodies to PML bodies.

Sun J, Xu H, Subramony SH, Hebert MD.

J Cell Sci. 2005 Nov 1;118(Pt 21):4995-5003. Epub 2005 Oct 11.


Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis.

Xu H, Somers ZB, Robinson ML 2nd, Hebert MD.

BMC Cell Biol. 2005 Jul 11;6(1):29.


The C-terminal domain of coilin interacts with Sm proteins and U snRNPs.

Xu H, Pillai RS, Azzouz TN, Shpargel KB, Kambach C, Hebert MD, Schümperli D, Matera AG.

Chromosoma. 2005 Aug;114(3):155-66. Epub 2005 Jul 8.


In vivo kinetics of Cajal body components.

Dundr M, Hebert MD, Karpova TS, Stanek D, Xu H, Shpargel KB, Meier UT, Neugebauer KM, Matera AG, Misteli T.

J Cell Biol. 2004 Mar 15;164(6):831-42.


Control of Cajal body number is mediated by the coilin C-terminus.

Shpargel KB, Ospina JK, Tucker KE, Matera AG, Hebert MD.

J Cell Sci. 2003 Jan 15;116(Pt 2):303-12.


Coilin methylation regulates nuclear body formation.

Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG.

Dev Cell. 2002 Sep;3(3):329-37.


SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG.

Hum Mol Genet. 2002 Jul 15;11(15):1785-95.


Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein.

Hebert MD, Szymczyk PW, Shpargel KB, Matera AG.

Genes Dev. 2001 Oct 15;15(20):2720-9.


The survival motor neurons protein uses its ZPR for nuclear localization.

Matera AG, Hebert MD.

Nat Cell Biol. 2001 Apr;3(4):E93-5. No abstract available.


Self-association of coilin reveals a common theme in nuclear body localization.

Hebert MD, Matera AG.

Mol Biol Cell. 2000 Dec;11(12):4159-71.


Structure and characterization of the murine p80 coilin gene, Coil.

Tucker KE, Massello LK, Gao L, Barber TJ, Hebert MD, Chan EK, Matera AG.

J Struct Biol. 2000 Apr;129(2-3):269-77.


Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodies.

Liu J, Hebert MD, Ye Y, Templeton DJ, Kung H, Matera AG.

J Cell Sci. 2000 May;113 ( Pt 9):1543-52.


Twin carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene.

Curtis SK, Hebert MD, Saha BK.

Am J Med Genet. 2000 Jan 31;90(3):229-32.


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