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A genome-wide association study implicates that the TTC39C gene is associated with diabetic maculopathy with decreased visual acuity.

Meng W, Chan BW, Ezeonwumelu C, Hébert HL, Campbell A, Soler V, Palmer CN.

Ophthalmic Genet. 2019 Jun;40(3):252-258. doi: 10.1080/13816810.2019.1633549. Epub 2019 Jul 2.


CryoEM: a crystals to single particles round-trip.

Hebert H.

Curr Opin Struct Biol. 2019 Jun 21;58:59-67. doi: 10.1016/ [Epub ahead of print] Review.


Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase.

Jang S, Kang C, Yang HS, Jung T, Hebert H, Chung KY, Kim SJ, Hohng S, Song JJ.

Genes Dev. 2019 Jun 1;33(11-12):620-625. doi: 10.1101/gad.323790.118. Epub 2019 Mar 28.


DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain.

Pascal MMV, Themistocleous AC, Baron R, Binder A, Bouhassira D, Crombez G, Finnerup NB, Gierthmühlen J, Granovsky Y, Groop L, Hebert HL, Jensen TS, Johnsen K, McCarthy MI, Meng W, Palmer CNA, Rice ASC, Serra J, Solà R, Yarnitsky D, Smith BH, Attal N, Bennett DLH.

Version 2. Wellcome Open Res. 2019 Feb 1 [revised 2019 Jan 1];3:63. doi: 10.12688/wellcomeopenres.14576.2. eCollection 2018.


A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.

Meng W, Shah KP, Pollack S, Toppila I, Hebert HL, McCarthy MI, Groop L, Ahlqvist E, Lyssenko V, Agardh E, Daniell M, Kaidonis G, Craig JE, Mitchell P, Liew G, Kifley A, Wang JJ, Christiansen MW, Jensen RA, Penman A, Hancock HA, Chen CJ, Correa A, Kuo JZ, Li X, Chen YI, Rotter JI, Klein R, Klein B, Wong TY, Morris AD, Doney ASF, Colhoun HM, Price AL, Burdon KP, Groop PH, Sandholm N, Grassi MA, Sobrin L, Palmer CNA; Wellcome Trust Case Control Consortium 2 (WTCCC2), Surrogate markers for Micro- and Macro-vascular hard endpoints for Innovative diabetes Tools (SUMMIT) study group.

Acta Ophthalmol. 2018 Nov;96(7):e811-e819. doi: 10.1111/aos.13769. Epub 2018 Sep 4.


A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein.

Sarr M, Kronqvist N, Chen G, Aleksis R, Purhonen P, Hebert H, Jaudzems K, Rising A, Johansson J.

FEBS J. 2018 May;285(10):1873-1885. doi: 10.1111/febs.14451. Epub 2018 Apr 14.


Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface.

Söderberg CAG, Månsson C, Bernfur K, Rutsdottir G, Härmark J, Rajan S, Al-Karadaghi S, Rasmussen M, Höjrup P, Hebert H, Emanuelsson C.

Sci Rep. 2018 Mar 26;8(1):5199. doi: 10.1038/s41598-018-23035-9.


Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.

J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. Epub 2018 Feb 13.


Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding.

Yoon J, Kim SJ, An S, Cho S, Leitner A, Jung T, Aebersold R, Hebert H, Cho US, Song JJ.

J Mol Biol. 2018 Mar 16;430(6):822-841. doi: 10.1016/j.jmb.2018.01.015. Epub 2018 Jan 31.


A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).

Meng W, Adams MJ, Hebert HL, Deary IJ, McIntosh AM, Smith BH.

EBioMedicine. 2018 Feb;28:180-186. doi: 10.1016/j.ebiom.2018.01.023. Epub 2018 Jan 31.


Systematic review and meta-analysis of genetic risk factors for neuropathic pain.

Veluchamy A, Hébert HL, Meng W, Palmer CNA, Smith BH.

Pain. 2018 May;159(5):825-848. doi: 10.1097/j.pain.0000000000001164.


Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.

Chen G, Abelein A, Nilsson HE, Leppert A, Andrade-Talavera Y, Tambaro S, Hemmingsson L, Roshan F, Landreh M, Biverstål H, Koeck PJB, Presto J, Hebert H, Fisahn A, Johansson J.

Nat Commun. 2017 Dec 12;8(1):2081. doi: 10.1038/s41467-017-02056-4.


Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS).

Hébert HL, Shepherd B, Milburn K, Veluchamy A, Meng W, Carr F, Donnelly LA, Tavendale R, Leese G, Colhoun HM, Dow E, Morris AD, Doney AS, Lang CC, Pearson ER, Smith BH, Palmer CNA.

Int J Epidemiol. 2018 Apr 1;47(2):380-381j. doi: 10.1093/ije/dyx140. No abstract available.


The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC.

Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. Epub 2017 Aug 30.


Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation.

Kuang Q, Purhonen P, Ålander J, Svensson R, Hoogland V, Winerdal J, Spahiu L, Ottosson-Wadlund A, Jegerschöld C, Morgenstern R, Hebert H.

Sci Rep. 2017 Aug 11;7(1):7897. doi: 10.1038/s41598-017-07912-3.


Structures of apolipoprotein A-I in high density lipoprotein generated by electron microscopy and biased simulations.

Zhu L, Petrlova J, Gysbers P, Hebert H, Wallin S, Jegerschöld C, Lagerstedt JO.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2726-2738. doi: 10.1016/j.bbagen.2017.07.017. Epub 2017 Jul 25.


A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

Meng W, Veluchamy A, Hébert HL, Campbell A, Colhoun HM, Palmer CNA.

Br J Dermatol. 2017 Dec;177(6):1664-1670. doi: 10.1111/bjd.15787. Epub 2017 Nov 27.


Efficient protein production inspired by how spiders make silk.

Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.

Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504.


RNA activation-independent DNA targeting of the Type III CRISPR-Cas system by a Csm complex.

Park KH, An Y, Jung TY, Baek IY, Noh H, Ahn WC, Hebert H, Song JJ, Kim JH, Oh BH, Woo EJ.

EMBO Rep. 2017 May;18(5):826-840. doi: 10.15252/embr.201643700. Epub 2017 Mar 31.


Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity.

Rutsdottir G, Härmark J, Weide Y, Hebert H, Rasmussen MI, Wernersson S, Respondek M, Akke M, Højrup P, Koeck PJB, Söderberg CAG, Emanuelsson C.

J Biol Chem. 2017 May 12;292(19):8103-8121. doi: 10.1074/jbc.M116.766816. Epub 2017 Mar 21.


Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy.

B Kumar R, Zhu L, Hebert H, Jegerschöld C.

J Vis Exp. 2017 Mar 5;(121). doi: 10.3791/55148.


US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States.

Saran R, Robinson B, Abbott KC, Agodoa LY, Albertus P, Ayanian J, Balkrishnan R, Bragg-Gresham J, Cao J, Chen JL, Cope E, Dharmarajan S, Dietrich X, Eckard A, Eggers PW, Gaber C, Gillen D, Gipson D, Gu H, Hailpern SM, Hall YN, Han Y, He K, Hebert H, Helmuth M, Herman W, Heung M, Hutton D, Jacobsen SJ, Ji N, Jin Y, Kalantar-Zadeh K, Kapke A, Katz R, Kovesdy CP, Kurtz V, Lavalee D, Li Y, Lu Y, McCullough K, Molnar MZ, Montez-Rath M, Morgenstern H, Mu Q, Mukhopadhyay P, Nallamothu B, Nguyen DV, Norris KC, O'Hare AM, Obi Y, Pearson J, Pisoni R, Plattner B, Port FK, Potukuchi P, Rao P, Ratkowiak K, Ravel V, Ray D, Rhee CM, Schaubel DE, Selewski DT, Shaw S, Shi J, Shieu M, Sim JJ, Song P, Soohoo M, Steffick D, Streja E, Tamura MK, Tentori F, Tilea A, Tong L, Turf M, Wang D, Wang M, Woodside K, Wyncott A, Xin X, Zang W, Zepel L, Zhang S, Zho H, Hirth RA, Shahinian V.

Am J Kidney Dis. 2017 Mar;69(3 Suppl 1):A7-A8. doi: 10.1053/j.ajkd.2016.12.004. Review. No abstract available. Erratum in: Am J Kidney Dis. 2017 May;69(5):712.


Biomimetic spinning of artificial spider silk from a chimeric minispidroin.

Andersson M, Jia Q, Abella A, Lee XY, Landreh M, Purhonen P, Hebert H, Tenje M, Robinson CV, Meng Q, Plaza GR, Johansson J, Rising A.

Nat Chem Biol. 2017 Mar;13(3):262-264. doi: 10.1038/nchembio.2269. Epub 2017 Jan 9.


Risk factors for neuropathic pain in diabetes mellitus.

Hébert HL, Veluchamy A, Torrance N, Smith BH.

Pain. 2017 Apr;158(4):560-568. doi: 10.1097/j.pain.0000000000000785. No abstract available.


Molecular Architecture of  Yeast Chromatin Assembly Factor 1.

Kim D, Setiaputra D, Jung T, Chung J, Leitner A, Yoon J, Aebersold R, Hebert H, Yip CK, Song JJ.

Sci Rep. 2016 May 25;6:26702. doi: 10.1038/srep26702.


A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract.

Chang C, Zhang K, Veluchamy A, Hébert HL, Looker HC, Colhoun HM, Palmer CN, Meng W.

Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2246-50. doi: 10.1167/iovs.16-19332. Erratum in: Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2637.


Shell thickness determination of polymer-shelled microbubbles using transmission electron microscopy.

Härmark J, Hebert H, Koeck PJ.

Micron. 2016 Jun;85:39-43. doi: 10.1016/j.micron.2016.03.009. Epub 2016 Apr 1.


Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs.

Kumar RB, Zhu L, Idborg H, Rådmark O, Jakobsson PJ, Rinaldo-Matthis A, Hebert H, Jegerschöld C.

PLoS One. 2016 Mar 24;11(3):e0152116. doi: 10.1371/journal.pone.0152116. eCollection 2016.


Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function.

Vijayvargia R, Epand R, Leitner A, Jung TY, Shin B, Jung R, Lloret A, Singh Atwal R, Lee H, Lee JM, Aebersold R, Hebert H, Song JJ, Seong IS.

Elife. 2016 Mar 22;5:e11184. doi: 10.7554/eLife.11184.


Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis.

Smith RL, Hébert HL, Massey J, Bowes J, Marzo-Ortega H, Ho P, McHugh NJ, Worthington J, Barton A, Griffiths CE, Warren RB.

Arch Dermatol Res. 2016 Apr;308(3):201-5. doi: 10.1007/s00403-016-1620-4. Epub 2016 Feb 1.


Microfluidic Integration of a Cloth-Based Hybridization Array System (CHAS) for Rapid, Colorimetric Detection of Enterohemorrhagic Escherichia coli (EHEC) Using an Articulated, Centrifugal Platform.

Geissler M, Clime L, Hoa XD, Morton KJ, Hébert H, Poncelet L, Mounier M, Deschênes M, Gauthier ME, Huszczynski G, Corneau N, Blais BW, Veres T.

Anal Chem. 2015 Oct 20;87(20):10565-72. doi: 10.1021/acs.analchem.5b03085. Epub 2015 Oct 7.


Two-Dimensional Crystallization Procedure, from Protein Expression to Sample Preparation.

Kuang Q, Purhonen P, Hebert H.

Biomed Res Int. 2015;2015:693869. doi: 10.1155/2015/693869. Epub 2015 Aug 27. Review.


Size controlled protein nanoemulsions for active targeting of folate receptor positive cells.

Loureiro A, Nogueira E, Azoia NG, Sárria MP, Abreu AS, Shimanovich U, Rollett A, Härmark J, Hebert H, Guebitz G, Bernardes GJ, Preto A, Gomes AC, Cavaco-Paulo A.

Colloids Surf B Biointerfaces. 2015 Nov 1;135:90-8. doi: 10.1016/j.colsurfb.2015.06.073. Epub 2015 Jul 17.


Peptide Anchor for Folate-Targeted Liposomal Delivery.

Nogueira E, Mangialavori IC, Loureiro A, Azoia NG, Sárria MP, Nogueira P, Freitas J, Härmark J, Shimanovich U, Rollett A, Lacroix G, Bernardes GJ, Guebitz G, Hebert H, Moreira A, Carmo AM, Rossi JP, Gomes AC, Preto A, Cavaco-Paulo A.

Biomacromolecules. 2015 Sep 14;16(9):2904-10. doi: 10.1021/acs.biomac.5b00823. Epub 2015 Aug 11.


Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A.

Nat Commun. 2015 Jul 6;6:7741. doi: 10.1038/ncomms8741. No abstract available.


Structure of potassium channels.

Kuang Q, Purhonen P, Hebert H.

Cell Mol Life Sci. 2015 Oct;72(19):3677-93. doi: 10.1007/s00018-015-1948-5. Epub 2015 Jun 13. Review.


A Refined Single-Particle Reconstruction Procedure to Process Two-Dimensional Crystal Images from Transmission Electron Microscopy.

Kuang Q, Purhonen P, Pattipaka T, Ayele YH, Hebert H, Koeck PJ.

Microsc Microanal. 2015 Aug;21(4):876-85. doi: 10.1017/S1431927615000616. Epub 2015 May 20.


Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert HL, Wallace C, Massey J, Bruce IN, Bluett J, Feletar M, Morgan AW, Marzo-Ortega H, Donohoe G, Morris DW, Helliwell P, Ryan AW, Kane D, Warren RB, Korendowych E, Alenius GM, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown MA, Ho P, Behrens F, Burkhardt H, Reis A, Barton A.

Nat Commun. 2015 Feb 5;6:6046. doi: 10.1038/ncomms7046. Erratum in: Nat Commun. 2015;6:7741.


Free RCK arrangement in Kch, a putative escherichia coli potassium channel, as suggested by electron crystallography.

Kuang Q, Purhonen P, Jegerschöld C, Koeck PJB, Hebert H.

Structure. 2015 Jan 6;23(1):199-205. doi: 10.1016/j.str.2014.10.018. Epub 2014 Dec 11.


The gut microbiota influences blood-brain barrier permeability in mice.

Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyás B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S.

Sci Transl Med. 2014 Nov 19;6(263):263ra158. doi: 10.1126/scitranslmed.3009759. Erratum in: Sci Transl Med. 2014 Dec 10;6(266):266er7. Guan, Ng Lai [corrected to Ng, Lai Guan].


Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions.

Hébert HL, Bowes J, Smith RL, Flynn E, Parslew R, Alsharqi A, McHugh NJ, Barker JN, Griffiths CE, Barton A, Warren RB.

Br J Dermatol. 2015 Apr;172(4):933-9. doi: 10.1111/bjd.13340. Epub 2015 Feb 5.


Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly.

Nilsson HE, Ambort D, Bäckström M, Thomsson E, Koeck PJB, Hansson GC, Hebert H.

J Mol Biol. 2014 Jul 15;426(14):2567-2579. doi: 10.1016/j.jmb.2014.04.027. Epub 2014 May 8.


On the interplay of shell structure with low- and high-frequency mechanics of multifunctional magnetic microbubbles.

Poehlmann M, Grishenkov D, Kothapalli SV, Härmark J, Hebert H, Philipp A, Hoeller R, Seuss M, Kuttner C, Margheritelli S, Paradossi G, Fery A.

Soft Matter. 2014 Jan 7;10(1):214-26. doi: 10.1039/c3sm51560e.


Polymorphisms in IL-1B distinguish between psoriasis of early and late onset.

Hébert HL, Bowes J, Smith RL, McHugh NJ, Barker JNWN, Griffiths CEM, Barton A, Warren RB.

J Invest Dermatol. 2014 May;134(5):1459-1462. doi: 10.1038/jid.2013.485. Epub 2013 Nov 12. No abstract available.


The projection structure of Kch, a putative potassium channel in Escherichia coli, by electron crystallography.

Kuang Q, Purhonen P, Jegerschöld C, Hebert H.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):237-43. doi: 10.1016/j.bbamem.2013.09.006. Epub 2013 Sep 19.


Liposome and protein based stealth nanoparticles.

Nogueira E, Loureiro A, Nogueira P, Freitas J, Almeida CR, Härmark J, Hebert H, Moreira A, Carmo AM, Preto A, Gomes AC, Cavaco-Pauloa A.

Faraday Discuss. 2013;166:417-29.


Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

Gustafsson JK, Ermund A, Ambort D, Johansson ME, Nilsson HE, Thorell K, Hebert H, Sjövall H, Hansson GC.

J Exp Med. 2012 Jul 2;209(7):1263-72. doi: 10.1084/jem.20120562. Epub 2012 Jun 18.


Magnetite nanoparticles can be coupled to microbubbles to support multimodal imaging.

Brismar TB, Grishenkov D, Gustafsson B, Härmark J, Barrefelt A, Kothapalli SV, Margheritelli S, Oddo L, Caidahl K, Hebert H, Paradossi G.

Biomacromolecules. 2012 May 14;13(5):1390-9. doi: 10.1021/bm300099f. Epub 2012 Apr 10.


Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin.

Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJ, Hebert H, Hansson GC.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5645-50. doi: 10.1073/pnas.1120269109. Epub 2012 Mar 26.


Genetic susceptibility to psoriasis and psoriatic arthritis: implications for therapy.

Hébert HL, Ali FR, Bowes J, Griffiths CE, Barton A, Warren RB.

Br J Dermatol. 2012 Mar;166(3):474-82. doi: 10.1111/j.1365-2133.2011.10712.x. Review.


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