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Antigen presentation by dendritic cells for B cell activation.

Heath WR, Kato Y, Steiner TM, Caminschi I.

Curr Opin Immunol. 2019 Jun;58:44-52. doi: 10.1016/j.coi.2019.04.003. Epub 2019 May 6. Review.


Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection.

Harpur CM, Kato Y, Dewi ST, Stankovic S, Johnson DN, Bedoui S, Whitney PG, Lahoud MH, Caminschi I, Heath WR, Brooks AG, Gebhardt T.

J Immunol. 2019 Feb 1;202(3):653-663. doi: 10.4049/jimmunol.1800218. Epub 2018 Dec 31.


CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver.

Holz LE, Prier JE, Freestone D, Steiner TM, English K, Johnson DN, Mollard V, Cozijnsen A, Davey GM, Godfrey DI, Yui K, Mackay LK, Lahoud MH, Caminschi I, McFadden GI, Bertolino P, Fernandez-Ruiz D, Heath WR.

Cell Rep. 2018 Oct 2;25(1):68-79.e4. doi: 10.1016/j.celrep.2018.08.094.


Cerebral Malaria in Mouse and Man.

Ghazanfari N, Mueller SN, Heath WR.

Front Immunol. 2018 Sep 10;9:2016. doi: 10.3389/fimmu.2018.02016. eCollection 2018. Review.


IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.

James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A.

J Immunol. 2018 Feb 15;200(4):1443-1456. doi: 10.4049/jimmunol.1700782. Epub 2018 Jan 10.


Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses.

Park SL, Zaid A, Hor JL, Christo SN, Prier JE, Davies B, Alexandre YO, Gregory JL, Russell TA, Gebhardt T, Carbone FR, Tscharke DC, Heath WR, Mueller SN, Mackay LK.

Nat Immunol. 2018 Feb;19(2):183-191. doi: 10.1038/s41590-017-0027-5. Epub 2018 Jan 8.


Migratory CD11b+ conventional dendritic cells induce T follicular helper cell-dependent antibody responses.

Krishnaswamy JK, Gowthaman U, Zhang B, Mattsson J, Szeponik L, Liu D, Wu R, White T, Calabro S, Xu L, Collet MA, Yurieva M, Alsén S, Fogelstrand P, Walter A, Heath WR, Mueller SN, Yrlid U, Williams A, Eisenbarth SC.

Sci Immunol. 2017 Dec 1;2(18). pii: eaam9169. doi: 10.1126/sciimmunol.aam9169.


Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells.

Whitney PG, Makhlouf C, MacLeod B, Ma JZ, Gressier E, Greyer M, Hochheiser K, Bachem A, Zaid A, Voehringer D, Heath WR, Wagle MV, Parish I, Russell TA, Smith SA, Tscharke DC, Gebhardt T, Bedoui S.

J Virol. 2018 Jan 17;92(3). pii: e01508-17. doi: 10.1128/JVI.01508-17. Print 2018 Feb 1.


Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+ Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria.

Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR.

J Immunol. 2017 Dec 15;199(12):4165-4179. doi: 10.4049/jimmunol.1700186. Epub 2017 Oct 30.


Chemokine Receptor-Dependent Control of Skin Tissue-Resident Memory T Cell Formation.

Zaid A, Hor JL, Christo SN, Groom JR, Heath WR, Mackay LK, Mueller SN.

J Immunol. 2017 Oct 1;199(7):2451-2459. doi: 10.4049/jimmunol.1700571. Epub 2017 Aug 30.


A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment.

Sierro F, Evrard M, Rizzetto S, Melino M, Mitchell AJ, Florido M, Beattie L, Walters SB, Tay SS, Lu B, Holz LE, Roediger B, Wong YC, Warren A, Ritchie W, McGuffog C, Weninger W, Le Couteur DG, Ginhoux F, Britton WJ, Heath WR, Saunders BM, McCaughan GW, Luciani F, MacDonald KPA, Ng LG, Bowen DG, Bertolino P.

Immunity. 2017 Aug 15;47(2):374-388.e6. doi: 10.1016/j.immuni.2017.07.018.


Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection.

Pizzolla A, Nguyen THO, Smith JM, Brooks AG, Kedzieska K, Heath WR, Reading PC, Wakim LM.

Sci Immunol. 2017 Jun 2;2(12). pii: eaam6970. doi: 10.1126/sciimmunol.aam6970.


Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids.

McNamara HA, Cai Y, Wagle MV, Sontani Y, Roots CM, Miosge LA, O'Connor JH, Sutton HJ, Ganusov VV, Heath WR, Bertolino P, Goodnow CG, Parish IA, Enders A, Cockburn IA.

Sci Immunol. 2017 Mar;2(9). pii: eaaj1996. doi: 10.1126/sciimmunol.aaj1996. Epub 2017 Mar 17.


Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MS, Fogg LG, Nair AS, Liligeto U, Stubbington MJ, Ly LH, Bagger FO, Zwiessele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA.

Sci Immunol. 2017 Mar 3;2(9). pii: eaal2192. doi: 10.1126/sciimmunol.aal2192. Erratum in: Sci Immunol. 2018 Mar 9;3(21):.


Neutrophils are dispensable in the modulation of T cell immunity against cutaneous HSV-1 infection.

Hor JL, Heath WR, Mueller SN.

Sci Rep. 2017 Jan 23;7:41091. doi: 10.1038/srep41091.


Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge.

Gregory JL, Walter A, Alexandre YO, Hor JL, Liu R, Ma JZ, Devi S, Tokuda N, Owada Y, Mackay LK, Smyth GK, Heath WR, Mueller SN.

Cell Rep. 2017 Jan 10;18(2):406-418. doi: 10.1016/j.celrep.2016.12.038.


CD14 is not involved in the uptake of synthetic CpG oligonucleotides.

Li J, Ahmet F, O'Keeffe M, Lahoud MH, Heath WR, Caminschi I.

Mol Immunol. 2017 Jan;81:52-58. doi: 10.1016/j.molimm.2016.11.015. Epub 2016 Dec 12.


Protective immunity to liver-stage malaria.

Holz LE, Fernandez-Ruiz D, Heath WR.

Clin Transl Immunology. 2016 Oct 21;5(10):e105. eCollection 2016 Oct. Review.


Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2016 Oct 18;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. Epub 2016 Sep 27.


Erratum to: Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation.

Proserpio V, Piccolo A, Haim-Vilmovsky L, Kar G, Lönnberg T, Svensson V, Pramanik J, Natarajan KN, Zhai W, Zhang X, Donati G, Kayikci M, Kotar J, McKenzie AN, Montandon R, James KR, Fernandez-Ruiz D, Heath WR, Haque A, Billker O, Woodhouse S, Cicuta P, Nicodemi M, Teichmann SA.

Genome Biol. 2016 Jun 22;17(1):133. No abstract available.


CD4(+) T-cell help amplifies innate signals for primary CD8(+) T-cell immunity.

Bedoui S, Heath WR, Mueller SN.

Immunol Rev. 2016 Jul;272(1):52-64. doi: 10.1111/imr.12426. Review.


Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.

Collins N, Jiang X, Zaid A, Macleod BL, Li J, Park CO, Haque A, Bedoui S, Heath WR, Mueller SN, Kupper TS, Gebhardt T, Carbone FR.

Nat Commun. 2016 May 10;7:11514. doi: 10.1038/ncomms11514.


T Cell Help Amplifies Innate Signals in CD8(+) DCs for Optimal CD8(+) T Cell Priming.

Greyer M, Whitney PG, Stock AT, Davey GM, Tebartz C, Bachem A, Mintern JD, Strugnell RA, Turner SJ, Gebhardt T, O'Keeffe M, Heath WR, Bedoui S.

Cell Rep. 2016 Jan 26;14(3):586-597. doi: 10.1016/j.celrep.2015.12.058. Epub 2016 Jan 7.


Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection.

Hor JL, Whitney PG, Zaid A, Brooks AG, Heath WR, Mueller SN.

Immunity. 2015 Sep 15;43(3):554-65. doi: 10.1016/j.immuni.2015.07.020. Epub 2015 Aug 18. Erratum in: Immunity. 2015 Sep 15;43(3):615.


Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall.

Kato Y, Zaid A, Davey GM, Mueller SN, Nutt SL, Zotos D, Tarlinton DM, Shortman K, Lahoud MH, Heath WR, Caminschi I.

J Immunol. 2015 Aug 1;195(3):1006-14. doi: 10.4049/jimmunol.1500767. Epub 2015 Jun 22.


Krüppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets.

Bedoui S, Heath WR.

Immunity. 2015 May 19;42(5):785-7. doi: 10.1016/j.immuni.2015.04.020.


Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates.

Li J, Ahmet F, Sullivan LC, Brooks AG, Kent SJ, De Rose R, Salazar AM, Reis e Sousa C, Shortman K, Lahoud MH, Heath WR, Caminschi I.

Eur J Immunol. 2015 Mar;45(3):854-64. doi: 10.1002/eji.201445127. Epub 2015 Jan 14.


Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1.

Macleod BL, Bedoui S, Hor JL, Mueller SN, Russell TA, Hollett NA, Heath WR, Tscharke DC, Brooks AG, Gebhardt T.

PLoS Pathog. 2014 Aug 14;10(8):e1004303. doi: 10.1371/journal.ppat.1004303. eCollection 2014 Aug.


Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald DM, McGuffog CM, Meyer NJ, Alexander IE, Parish IA, Heath WR, Weninger W, Bishop GA, Gamble JR, McCaughan GW, Bertolino P, Bowen DG.

J Immunol. 2014 Sep 1;193(5):2087-95. doi: 10.4049/jimmunol.1400037. Epub 2014 Jul 28.


CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR.

PLoS Pathog. 2014 May 22;10(5):e1004135. doi: 10.1371/journal.ppat.1004135. eCollection 2014 May.


Persistence of skin-resident memory T cells within an epidermal niche.

Zaid A, Mackay LK, Rahimpour A, Braun A, Veldhoen M, Carbone FR, Manton JH, Heath WR, Mueller SN.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5307-12. doi: 10.1073/pnas.1322292111. Epub 2014 Mar 24.


The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin.

Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon ML, Vega-Ramos J, Lauzurica P, Mueller SN, Stefanovic T, Tscharke DC, Heath WR, Inouye M, Carbone FR, Gebhardt T.

Nat Immunol. 2013 Dec;14(12):1294-301. doi: 10.1038/ni.2744. Epub 2013 Oct 27.


The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells.

Heath WR, Carbone FR.

Nat Immunol. 2013 Oct;14(10):978-85. doi: 10.1038/ni.2680. Epub 2013 Sep 18. Review.


DEC-205 is a cell surface receptor for CpG oligonucleotides.

Caminschi I, Meuter S, Heath WR.

Oncoimmunology. 2013 Mar 1;2(3):e23128.


Distinct resident and recirculating memory T cell subsets in non-lymphoid tissues.

Carbone FR, Mackay LK, Heath WR, Gebhardt T.

Curr Opin Immunol. 2013 Jun;25(3):329-33. doi: 10.1016/j.coi.2013.05.007. Epub 2013 Jun 5. Review.


Memory T cell subsets, migration patterns, and tissue residence.

Mueller SN, Gebhardt T, Carbone FR, Heath WR.

Annu Rev Immunol. 2013;31:137-61. doi: 10.1146/annurev-immunol-032712-095954. Epub 2012 Dec 3. Review.


Identification of a MHC I-restricted epitope of DsRed in C57BL/6 mice.

Davey GM, Mueller SN, van Vliet C, Gigowski M, Zaid A, Davies B, Carbone FR, Heath WR.

Mol Immunol. 2013 Apr;53(4):450-2. doi: 10.1016/j.molimm.2012.10.003. Epub 2012 Nov 9.


Peripheral tissue surveillance and residency by memory T cells.

Gebhardt T, Mueller SN, Heath WR, Carbone FR.

Trends Immunol. 2013 Jan;34(1):27-32. doi: 10.1016/ Epub 2012 Oct 2. Review.


DEC-205 is a cell surface receptor for CpG oligonucleotides.

Lahoud MH, Ahmet F, Zhang JG, Meuter S, Policheni AN, Kitsoulis S, Lee CN, O'Keeffe M, Sullivan LC, Brooks AG, Berry R, Rossjohn J, Mintern JD, Vega-Ramos J, Villadangos JA, Nicola NA, Nussenzweig MC, Stacey KJ, Shortman K, Heath WR, Caminschi I.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16270-5. doi: 10.1073/pnas.1208796109. Epub 2012 Sep 17.


Hair follicles: gatekeepers to the epidermis.

Heath WR, Mueller SN.

Nat Immunol. 2012 Jul 19;13(8):715-7. doi: 10.1038/ni.2374.


Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.

Chang PP, Lee SK, Hu X, Davey G, Duan G, Cho JH, Karupiah G, Sprent J, Heath WR, Bertram EM, Vinuesa CG.

J Immunol. 2012 Jul 15;189(2):701-10. doi: 10.4049/jimmunol.1102432. Epub 2012 Jun 8.


Targeting Dendritic Cells in vivo for Cancer Therapy.

Caminschi I, Maraskovsky E, Heath WR.

Front Immunol. 2012 Feb 7;3:13. doi: 10.3389/fimmu.2012.00013. eCollection 2012.


Proteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) gene.

Leong DW, Komen JC, Hewitt CA, Arnaud E, McKenzie M, Phipson B, Bahlo M, Laskowski A, Kinkel SA, Davey GM, Heath WR, Voss AK, Zahedi RP, Pitt JJ, Chrast R, Sickmann A, Ryan MT, Smyth GK, Thorburn DR, Scott HS.

J Biol Chem. 2012 Jun 8;287(24):20652-63. doi: 10.1074/jbc.M111.327601. Epub 2012 Apr 25.


Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.

Mackay LK, Stock AT, Ma JZ, Jones CM, Kent SJ, Mueller SN, Heath WR, Carbone FR, Gebhardt T.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7037-42. doi: 10.1073/pnas.1202288109. Epub 2012 Apr 16.


Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27.

Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR.

J Immunol. 2012 Mar 1;188(5):2046-56. No abstract available.


Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.

Mackay LK, Wakim L, van Vliet CJ, Jones CM, Mueller SN, Bannard O, Fearon DT, Heath WR, Carbone FR.

J Immunol. 2012 Mar 1;188(5):2173-8. doi: 10.4049/jimmunol.1102719. Epub 2012 Jan 23.


NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.

Kupz A, Guarda G, Gebhardt T, Sander LE, Short KR, Diavatopoulos DA, Wijburg OL, Cao H, Waithman JC, Chen W, Fernandez-Ruiz D, Whitney PG, Heath WR, Curtiss R 3rd, Tschopp J, Strugnell RA, Bedoui S.

Nat Immunol. 2012 Jan 8;13(2):162-9. doi: 10.1038/ni.2195.


Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3(-/-) mice.

Caminschi I, Vremec D, Ahmet F, Lahoud MH, Villadangos JA, Murphy KM, Heath WR, Shortman K.

Mol Immunol. 2012 Feb;50(1-2):9-17. doi: 10.1016/j.molimm.2011.11.008. Epub 2011 Dec 29.


Reactive murine lymph nodes uniquely permit parenchymal access for T cells that enter via the afferent lymphatics.

Eidsmo L, Stock AT, Heath WR, Bedoui S, Carbone FR.

J Pathol. 2012 Apr;226(5):806-13. doi: 10.1002/path.3975. Epub 2012 Feb 17.


A local role for CD103+ dendritic cells in atherosclerosis.

Bedoui S, Heath WR.

Immunity. 2011 Nov 23;35(5):665-7. doi: 10.1016/j.immuni.2011.11.005.

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