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Items: 32

1.

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection.

Buckley CM, Heath VL, Guého A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS.

PLoS Pathog. 2019 Feb 7;15(2):e1007551. doi: 10.1371/journal.ppat.1007551. eCollection 2019 Feb.

2.

Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells.

Noy PJ, Gavin RL, Colombo D, Haining EJ, Reyat JS, Payne H, Thielmann I, Lokman AB, Neag G, Yang J, Lloyd T, Harrison N, Heath VL, Gardiner C, Whitworth KM, Robinson J, Koo CZ, Di Maio A, Harrison P, Lee SP, Michelangeli F, Kalia N, Rainger GE, Nieswandt B, Brill A, Watson SP, Tomlinson MG.

Haematologica. 2018 Dec 20. pii: haematol.2018.194241. doi: 10.3324/haematol.2018.194241. [Epub ahead of print]

3.

RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.

Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ.

Angiogenesis. 2017 Aug;20(3):341-358. doi: 10.1007/s10456-017-9542-0. Epub 2017 Mar 7.

4.

Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors.

Wragg JW, Heath VL, Bicknell R.

Cancer Res. 2017 Feb 15;77(4):1008-1020. doi: 10.1158/0008-5472.CAN-16-1982. Epub 2016 Dec 23.

5.

Tube-Forming Assays.

Brown RM, Meah CJ, Heath VL, Styles IB, Bicknell R.

Methods Mol Biol. 2016;1430:149-57. doi: 10.1007/978-1-4939-3628-1_9.

PMID:
27172951
6.

Glutamate dependent NMDA receptor 2D is a novel angiogenic tumour endothelial marker in colorectal cancer.

Ferguson HJ, Wragg JW, Ward S, Heath VL, Ismail T, Bicknell R.

Oncotarget. 2016 Apr 12;7(15):20440-54. doi: 10.18632/oncotarget.7812.

7.

MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome.

Wragg JW, Finnity JP, Anderson JA, Ferguson HJ, Porfiri E, Bhatt RI, Murray PG, Heath VL, Bicknell R.

Cancer Res. 2016 Apr 15;76(8):2314-26. doi: 10.1158/0008-5472.CAN-15-1364. Epub 2016 Feb 26.

8.

Robo4 vaccines induce antibodies that retard tumor growth.

Zhuang X, Ahmed F, Zhang Y, Ferguson HJ, Steele JC, Steven NM, Nagy Z, Heath VL, Toellner KM, Bicknell R.

Angiogenesis. 2015 Jan;18(1):83-95. doi: 10.1007/s10456-014-9448-z. Epub 2014 Oct 28.

PMID:
25348086
9.

RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.

Wilson E, Leszczynska K, Poulter NS, Edelmann F, Salisbury VA, Noy PJ, Bacon A, Rappoport JZ, Heath JK, Bicknell R, Heath VL.

J Cell Sci. 2014 Jul 15;127(Pt 14):3039-51. doi: 10.1242/jcs.140434. Epub 2014 Jun 13.

10.

The emerging role of tetraspanin microdomains on endothelial cells.

Bailey RL, Herbert JM, Khan K, Heath VL, Bicknell R, Tomlinson MG.

Biochem Soc Trans. 2011 Dec;39(6):1667-73. doi: 10.1042/BST20110745. Review.

PMID:
22103505
11.

The role of RhoJ in endothelial cell biology and angiogenesis.

Leszczynska K, Kaur S, Wilson E, Bicknell R, Heath VL.

Biochem Soc Trans. 2011 Dec;39(6):1606-11. doi: 10.1042/BST20110702. Review.

PMID:
22103495
12.

Shear stress, tip cells and regulators of endothelial migration.

Zhuang X, Cross D, Heath VL, Bicknell R.

Biochem Soc Trans. 2011 Dec;39(6):1571-5. doi: 10.1042/BST20110746. Review.

PMID:
22103489
13.

RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.

Kaur S, Leszczynska K, Abraham S, Scarcia M, Hiltbrunner S, Marshall CJ, Mavria G, Bicknell R, Heath VL.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):657-64. doi: 10.1161/ATVBAHA.110.216341. Epub 2010 Dec 9.

PMID:
21148427
14.

Functionally defining the endothelial transcriptome, from Robo4 to ECSCR.

Verissimo AR, Herbert JM, Heath VL, Legg JA, Sheldon H, Andre M, Swain RK, Bicknell R.

Biochem Soc Trans. 2009 Dec;37(Pt 6):1214-7. doi: 10.1042/BST0371214.

PMID:
19909249
15.

Anticancer strategies involving the vasculature.

Heath VL, Bicknell R.

Nat Rev Clin Oncol. 2009 Jul;6(7):395-404. doi: 10.1038/nrclinonc.2009.52. Epub 2009 May 7. Review.

PMID:
19424102
16.

Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors.

Sheldon H, Andre M, Legg JA, Heal P, Herbert JM, Sainson R, Sharma AS, Kitajewski JK, Heath VL, Bicknell R.

FASEB J. 2009 Feb;23(2):513-22. doi: 10.1096/fj.07-098269. Epub 2008 Oct 23.

17.

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains.

Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG.

Biochem J. 2009 Jan 1;417(1):391-400. doi: 10.1042/BJ20081126.

18.

ECSM2, an endothelial specific filamin a binding protein that mediates chemotaxis.

Armstrong LJ, Heath VL, Sanderson S, Kaur S, Beesley JF, Herbert JM, Legg JA, Poulsom R, Bicknell R.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1640-6. doi: 10.1161/ATVBAHA.108.162511. Epub 2008 Jun 12.

PMID:
18556573
19.

A novel method of differential gene expression analysis using multiple cDNA libraries applied to the identification of tumour endothelial genes.

Herbert JM, Stekel D, Sanderson S, Heath VL, Bicknell R.

BMC Genomics. 2008 Apr 7;9:153. doi: 10.1186/1471-2164-9-153.

20.

A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.

Senis YA, Tomlinson MG, García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP.

Mol Cell Proteomics. 2007 Mar;6(3):548-64. Epub 2006 Dec 23.

21.

Slm1 and slm2 are novel substrates of the calcineurin phosphatase required for heat stress-induced endocytosis of the yeast uracil permease.

Bultynck G, Heath VL, Majeed AP, Galan JM, Haguenauer-Tsapis R, Cyert MS.

Mol Cell Biol. 2006 Jun;26(12):4729-45.

23.

Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions.

Michell RH, Heath VL, Lemmon MA, Dove SK.

Trends Biochem Sci. 2006 Jan;31(1):52-63. Epub 2005 Dec 20. Review.

PMID:
16364647
24.

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.

Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A.

J Biol Chem. 2004 Dec 31;279(53):55089-96. Epub 2004 Oct 18.

25.
26.

Checkpoints in the regulation of T helper 1 responses.

Heath VL, Kurata H, Lee HJ, Arai N, O'Garra A.

Curr Top Microbiol Immunol. 2002;266:23-39. Review. No abstract available.

PMID:
12014201
27.

1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.

Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O'Garra A.

J Immunol. 2001 Nov 1;167(9):4974-80.

28.

TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression.

Heath VL, Murphy EE, Crain C, Tomlinson MG, O'Garra A.

Eur J Immunol. 2000 Sep;30(9):2639-49.

29.
31.

Intrathymic expression of genes involved in organ specific autoimmune disease.

Heath VL, Moore NC, Parnell SM, Mason DW.

J Autoimmun. 1998 Aug;11(4):309-18.

PMID:
9776708
32.

The role of the thymus in the control of autoimmunity.

Heath VL, Saoudi A, Seddon BP, Moore NC, Fowell DJ, Mason DW.

J Autoimmun. 1996 Apr;9(2):241-6. Review.

PMID:
8738969

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