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Items: 1 to 50 of 85

1.

Durable multitransgene expression in vivo using systemic, nonviral DNA delivery.

Handumrongkul C, Ye AL, Chmura SA, Soroceanu L, Mack M, Ice RJ, Thistle R, Myers M, Ursu SJ, Liu Y, Kashani-Sabet M, Heath TD, Liggitt D, Lewis DB, Debs R.

Sci Adv. 2019 Nov 27;5(11):eaax0217. doi: 10.1126/sciadv.aax0217. eCollection 2019 Nov.

2.

Postoperative Analgesia Provided by Liposomal Hydromorphone in Client-Owned Dogs Undergoing Limb Amputation.

Krugner-Higby L, Smith LJ, Schmidt B, Steagall PV, Brown C, Heath TD.

J Am Anim Hosp Assoc. 2016 Jan-Feb;52(1):13-21. doi: 10.5326/JAAHA-MS-6113. Epub 2015 Nov 25.

PMID:
26606204
3.

Correction to: ''A Novel Loading Method for Doxycycline Liposomes for Intracellular Drug Delivery: Characterization of In Vitro and In Vivo Release Kinetics and Efficacy in a J774A.1 Cell Line Model of Mycobacterium smegmatis Infection".

Franklin RK, Marcus SA, Talaat AM, KuKanich BK, Sullivan R, Krugner-Higby LA, Heath TD.

Drug Metab Dispos. 2015 Nov;43(11):1805. doi: 10.1124/dmd.115.063602err. No abstract available.

4.
5.

Pharmacokinetics of ammonium sulfate gradient loaded liposome-encapsulated oxymorphone and hydromorphone in healthy dogs.

Smith LJ, Kukanich BK, Krugner-Higby LA, Schmidt BH, Heath TD.

Vet Anaesth Analg. 2013 Sep;40(5):537-45. doi: 10.1111/vaa.12042. Epub 2013 Apr 20.

6.

Antinociceptive effects of long-acting nalbuphine decanoate after intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).

Sanchez-Migallon Guzman D, Braun JM, Steagall PV, Keuler NS, Heath TD, Krugner-Higby LA, Brown CS, Paul-Murphy JR.

Am J Vet Res. 2013 Feb;74(2):196-200. doi: 10.2460/ajvr.74.2.196.

PMID:
23363342
7.

Pharmacokinetics of long-acting nalbuphine decanoate after intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).

Sanchez-Migallon Guzman D, KuKanich B, Heath TD, Krugner-Higby LA, Barker SA, Brown CS, Paul-Murphy JR.

Am J Vet Res. 2013 Feb;74(2):191-5. doi: 10.2460/ajvr.74.2.191.

PMID:
23363341
8.

Epidural administration of liposome-encapsulated hydromorphone provides extended analgesia in a rodent model of stifle arthritis.

Schmidt JR, Krugner-Higby L, Heath TD, Sullivan R, Smith LJ.

J Am Assoc Lab Anim Sci. 2011 Jul;50(4):507-12.

9.

Experimental pharmacodynamics and analgesic efficacy of liposome-encapsulated hydromorphone in dogs.

Krugner-Higby L, Smith L, Schmidt B, Wunsch L, Smetana A, Brown C, Heath TD.

J Am Anim Hosp Assoc. 2011 May-Jun;47(3):185-95. doi: 10.5326/JAAHA-MS-5599. Epub 2011 Apr 15.

PMID:
21498589
10.

Pharmacokinetics and behavioral effects of liposomal hydromorphone suitable for perioperative use in rhesus macaques.

Krugner-Higby L, KuKanich B, Schmidt B, Heath TD, Brown C.

Psychopharmacology (Berl). 2011 Aug;216(4):511-23. doi: 10.1007/s00213-011-2239-y. Epub 2011 Mar 15.

11.

A mathematical relationship for hydromorphone loading into liposomes with trans-membrane ammonium sulfate gradients.

Tu S, McGinnis T, Krugner-Higby L, Heath TD.

J Pharm Sci. 2010 Jun;99(6):2672-80. doi: 10.1002/jps.22017.

12.

Evaluation of liposome-encapsulated butorphanol tartrate for alleviation of experimentally induced arthritic pain in green-cheeked conures (Pyrrhura molinae).

Paul-Murphy JR, Krugner-Higby LA, Tourdot RL, Sladky KK, Klauer JM, Keuler NS, Brown CS, Heath TD.

Am J Vet Res. 2009 Oct;70(10):1211-9. doi: 10.2460/ajvr.70.10.1211.

13.

Analgesic effects of carprofen and liposome-encapsulated butorphanol tartrate in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.

Paul-Murphy JR, Sladky KK, Krugner-Higby LA, Stading BR, Klauer JM, Keuler NS, Brown CS, Heath TD.

Am J Vet Res. 2009 Oct;70(10):1201-10. doi: 10.2460/ajvr.70.10.1201.

PMID:
19795934
14.

Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model.

Wagner EJ, Brown CS, Mather JR, Scholcoff C, Krugner-Higby L, Heath TD.

J Pharm Sci. 2010 Apr;99(4):1800-9. doi: 10.1002/jps.21950.

PMID:
19780135
15.

Pharmacokinetics and behavioral effects of an extended-release, liposome-encapsulated preparation of oxymorphone in rhesus macaques.

Krugner-Higby L, KuKanich B, Schmidt B, Heath TD, Brown C, Smith LJ.

J Pharmacol Exp Ther. 2009 Jul;330(1):135-41. doi: 10.1124/jpet.108.150052. Epub 2009 Apr 7.

16.

Pharmacokinetics of a controlled-release liposome-encapsulated hydromorphone administered to healthy dogs.

Smith LJ, KuKanich B, Hogan BK, Brown C, Heath TD, Krugner-Higby LA.

J Vet Pharmacol Ther. 2008 Oct;31(5):415-22. doi: 10.1111/j.1365-2885.2008.00974.x.

17.

Liposome dependent delivery of S-adenosyl methionine to cells by liposomes: a potential treatment for liver disease.

Wagner EJ, Krugner-Higby L, Heath TD.

J Pharm Sci. 2009 Feb;98(2):573-82. doi: 10.1002/jps.21460.

PMID:
18642386
18.

A single dose of liposome-encapsulated hydromorphone provides extended analgesia in a rat model of neuropathic pain.

Smith LJ, Valenzuela JR, Krugner-Higby LA, Brown C, Heath TD.

Comp Med. 2006 Dec;56(6):487-92.

PMID:
17219779
19.

Serum concentrations and analgesic effects of liposome-encapsulated and standard butorphanol tartrate in parrots.

Sladky KK, Krugner-Higby L, Meek-Walker E, Heath TD, Paul-Murphy J.

Am J Vet Res. 2006 May;67(5):775-81.

PMID:
16649909
20.
21.

Suppression of cold ischemic injury in stored kidneys by the antimicrobial peptide bactenecin.

McAnulty JF, Foley JD, Reid TW, Heath TD, Waller KR, Murphy CJ.

Cryobiology. 2004 Dec;49(3):230-40.

PMID:
15615609
22.

Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy.

Clark MD, Krugner-Higby L, Smith LJ, Heath TD, Clark KL, Olson D.

Comp Med. 2004 Oct;54(5):558-63.

PMID:
15575370
23.

Sedative effects and serum drug concentrations of oxymorphone and metabolites after subcutaneous administration of a liposome-encapsulated formulation in dogs.

Smith LJ, Krugner-Higby L, Trepanier LA, Flaska DE, Joers V, Heath TD.

J Vet Pharmacol Ther. 2004 Oct;27(5):369-72. No abstract available.

PMID:
15500576
24.

The effect of liposome size on the final lipid/DNA ratio of cationic lipoplexes.

Gonçalves E, Debs RJ, Heath TD.

Biophys J. 2004 Mar;86(3):1554-63.

25.

A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain.

Smith LJ, Krugner-Higby L, Clark M, Wendland A, Heath TD.

Comp Med. 2003 Jun;53(3):280-7.

PMID:
12868573
26.

Liposome-encapsulated oxymorphone hydrochloride provides prolonged relief of postsurgical visceral pain in rats.

Krugner-Higby L, Smith L, Clark M, Heath TD, Dahly E, Schiffman B, Hubbard-VanStelle S, Ney D, Wendland A.

Comp Med. 2003 Jun;53(3):270-9.

PMID:
12868572
27.

Liposome-encapsulated oxymorphone prevents hyperalgesia for 7 days in a rat model of neuropathic pain.

Smith LJ, Krugner-Higby L, Clark M, Wendland A, Heath TD.

Vet Anaesth Analg. 2003 Apr;30(2):115-116. doi: 10.1046/j.1467-2995.2003.00133_36.x. Epub 2016 Nov 15. No abstract available.

PMID:
28404409
28.
29.

Strain-based genetic differences regulate the efficiency of systemic gene delivery as well as expression.

Liu Y, Liggitt HD, Dow S, Handumrongkul C, Heath TD, Debs RJ.

J Biol Chem. 2002 Feb 15;277(7):4966-72. Epub 2001 Dec 3.

30.
32.

Efficient gene expression in skin wound sites following local plasmid injection.

Meuli M, Liu Y, Liggitt D, Kashani-Sabet M, Knauer S, Meuli-Simmen C, Harrison MR, Adzick NS, Heath TD, Debs RJ.

J Invest Dermatol. 2001 Jan;116(1):131-5.

33.

Non-replicating Epstein-Barr virus-based plasmids extend gene expression and can improve gene therapy in vivo.

Tu G, Kirchmaier AL, Liggitt D, Liu Y, Liu S, Yu WH, Heath TD, Thor A, Debs RJ.

J Biol Chem. 2000 Sep 29;275(39):30408-16.

34.
35.

Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.

Dow SW, Elmslie RE, Fradkin LG, Liggitt DH, Heath TD, Willson AP, Potter TA.

Hum Gene Ther. 1999 Dec 10;10(18):2961-72.

PMID:
10609657
36.

Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes.

Gaensler KM, Tu G, Bruch S, Liggitt D, Lipshutz GS, Metkus A, Harrison M, Heath TD, Debs RJ.

Nat Biotechnol. 1999 Dec;17(12):1188-92.

PMID:
10585716
37.

Gene expression along the cerebral-spinal axis after regional gene delivery.

Meuli-Simmen C, Liu Y, Yeo TT, Liggitt D, Tu G, Yang T, Meuli M, Knauer S, Heath TD, Longo FM, Debs RJ.

Hum Gene Ther. 1999 Nov 1;10(16):2689-700.

PMID:
10566897
38.

Systemic and local interferon gamma gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice.

Dow SW, Schwarze J, Heath TD, Potter TA, Gelfand EW.

Hum Gene Ther. 1999 Aug 10;10(12):1905-14.

PMID:
10466624
39.

Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously.

Dow SW, Fradkin LG, Liggitt DH, Willson AP, Heath TD, Potter TA.

J Immunol. 1999 Aug 1;163(3):1552-61.

40.

Systemic gene delivery expands the repertoire of effective antiangiogenic agents.

Liu Y, Thor A, Shtivelman E, Cao Y, Tu G, Heath TD, Debs RJ.

J Biol Chem. 1999 May 7;274(19):13338-44.

41.

Topical gene delivery to murine skin.

Yu WH, Kashani-Sabet M, Liggitt D, Moore D, Heath TD, Debs RJ.

J Invest Dermatol. 1999 Mar;112(3):370-5.

42.

Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo.

Mounkes LC, Zhong W, Cipres-Palacin G, Heath TD, Debs RJ.

J Biol Chem. 1998 Oct 2;273(40):26164-70.

43.

Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery.

Liu Y, Mounkes LC, Liggitt HD, Brown CS, Solodin I, Heath TD, Debs RJ.

Nat Biotechnol. 1997 Feb;15(2):167-73.

PMID:
9035144
45.

A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery.

Solodin I, Brown CS, Bruno MS, Chow CY, Jang EH, Debs RJ, Heath TD.

Biochemistry. 1995 Oct 17;34(41):13537-44.

PMID:
7577942
47.
48.

Mixtures of tight-binding enzyme inhibitors. Kinetic analysis by a recursive rate equation.

Kuzmic P, Ng KY, Heath TD.

Anal Biochem. 1992 Jan;200(1):68-73.

PMID:
1595902
49.

Ocular cicatricial disease. Drug effects in vitro on cell proliferation, contraction, and viability.

Heath TD, Brown CS, Stern WH.

Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1245-51.

PMID:
2365556
50.

Leakage and delivery of liposome-encapsulated methotrexate-gamma-aspartate in a chemically defined medium.

Comiskey SJ, Heath TD.

Biochim Biophys Acta. 1990 May 24;1024(2):307-17.

PMID:
2354182

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