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Items: 48

1.

An 'airy hairy' problem.

Heath RJ, Bakshi A, Sutton C, Stewart LC, Cohen SN.

Clin Exp Dermatol. 2019 May 29. doi: 10.1111/ced.13981. [Epub ahead of print] No abstract available.

PMID:
31140639
2.

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance.

Vanarotti M, Evison BJ, Actis ML, Inoue A, McDonald ET, Shao Y, Heath RJ, Fujii N.

Bioorg Med Chem. 2018 May 15;26(9):2345-2353. doi: 10.1016/j.bmc.2018.03.028. Epub 2018 Mar 19.

3.

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.

Diouf B, Lin W, Goktug A, Grace CRR, Waddell MB, Bao J, Shao Y, Heath RJ, Zheng JJ, Shelat AA, Relling MV, Chen T, Evans WE.

SLAS Discov. 2018 Feb;23(2):164-173. doi: 10.1177/2472555217735035. Epub 2017 Oct 6.

4.

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.

Heath RJ, Goel G, Baxt LA, Rush JS, Mohanan V, Paulus GLC, Jani V, Lassen KG, Xavier RJ.

Cell Rep. 2016 Nov 22;17(9):2183-2194. doi: 10.1016/j.celrep.2016.11.005.

5.

Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo.

Meliopoulos VA, Marvin SA, Freiden P, Moser LA, Nighot P, Ali R, Blikslager A, Reddivari M, Heath RJ, Koci MD, Schultz-Cherry S.

MBio. 2016 Nov 1;7(6). pii: e01494-16. doi: 10.1128/mBio.01494-16.

6.

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Cao Z, Conway KL, Heath RJ, Rush JS, Leshchiner ES, Ramirez-Ortiz ZG, Nedelsky NB, Huang H, Ng A, Gardet A, Cheng SC, Shamji AF, Rioux JD, Wijmenga C, Netea MG, Means TK, Daly MJ, Xavier RJ.

Immunity. 2015 Oct 20;43(4):715-26. doi: 10.1016/j.immuni.2015.10.005.

7.

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ.

Cell Rep. 2015 Jun 30;11(12):1905-18. doi: 10.1016/j.celrep.2015.05.045. Epub 2015 Jun 18.

8.

Generation of a lentiviral vector producer cell clone for human Wiskott-Aldrich syndrome gene therapy.

Wielgosz MM, Kim YS, Carney GG, Zhan J, Reddivari M, Coop T, Heath RJ, Brown SA, Nienhuis AW.

Mol Ther Methods Clin Dev. 2015 Jan 21;2:14063. doi: 10.1038/mtm.2014.63. eCollection 2015.

9.

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA).

Evison BJ, Actis ML, Wu SZ, Shao Y, Heath RJ, Yang L, Fujii N.

Bioorg Med Chem. 2014 Nov 15;22(22):6333-43. doi: 10.1016/j.bmc.2014.09.058. Epub 2014 Oct 8.

10.

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Lassen KG, Kuballa P, Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L, Horn H, Mercer J, Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly MJ, Virgin HW, Schreiber SL, Stappenbeck TS, Xavier RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7741-6. doi: 10.1073/pnas.1407001111. Epub 2014 May 12.

11.

Crystal structure of the avian astrovirus capsid spike.

DuBois RM, Freiden P, Marvin S, Reddivari M, Heath RJ, White SW, Schultz-Cherry S.

J Virol. 2013 Jul;87(14):7853-63. doi: 10.1128/JVI.03139-12. Epub 2013 May 8.

12.

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium.

Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ.

Cell Host Microbe. 2012 Dec 13;12(6):778-90. doi: 10.1016/j.chom.2012.10.019.

13.

Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity.

DuBois RM, Zaraket H, Reddivari M, Heath RJ, White SW, Russell CJ.

PLoS Pathog. 2011 Dec;7(12):e1002398. doi: 10.1371/journal.ppat.1002398. Epub 2011 Dec 1.

14.

Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging.

Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM.

J Vis Exp. 2011 Jul 28;(53). pii: 3123. doi: 10.3791/3123.

15.

Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Heath RJ, Leong JM, Visegrády B, Machesky LM, Xavier RJ.

PLoS Pathog. 2011 Apr;7(4):e1001332. doi: 10.1371/journal.ppat.1001332. Epub 2011 Apr 7.

16.

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions.

Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM.

PLoS One. 2010 Dec 31;5(12):e15215. doi: 10.1371/journal.pone.0015215.

17.

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

Ng AC, Eisenberg JM, Heath RJ, Huett A, Robinson CM, Nau GJ, Xavier RJ.

Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4631-8. doi: 10.1073/pnas.1000093107. Epub 2010 Jun 29.

18.

Autophagy, immunity and human disease.

Heath RJ, Xavier RJ.

Curr Opin Gastroenterol. 2009 Nov;25(6):512-20. doi: 10.1097/MOG.0b013e32833104f1. Review.

19.

F-BAR domains: multifunctional regulators of membrane curvature.

Heath RJ, Insall RH.

J Cell Sci. 2008 Jun 15;121(Pt 12):1951-4. doi: 10.1242/jcs.023895. Review. No abstract available.

20.

Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles.

Heath RJ, Insall RH.

J Cell Sci. 2008 Apr 1;121(Pt 7):1054-64. doi: 10.1242/jcs.021113. Epub 2008 Mar 11.

21.

Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.

Yun MK, Nourse A, White SW, Rock CO, Heath RJ.

J Mol Biol. 2007 Jun 8;369(3):794-811. Epub 2007 Mar 30.

22.

Fatty acid biosynthesis as a target for novel antibacterials.

Heath RJ, Rock CO.

Curr Opin Investig Drugs. 2004 Feb;5(2):146-53. Review.

23.

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

Marrakchi H, Dewolf WE Jr, Quinn C, West J, Polizzi BJ, So CY, Holmes DJ, Reed SL, Heath RJ, Payne DJ, Rock CO, Wallis NG.

Biochem J. 2003 Mar 15;370(Pt 3):1055-62.

24.

The Claisen condensation in biology.

Heath RJ, Rock CO.

Nat Prod Rep. 2002 Oct;19(5):581-96. Review.

PMID:
12430724
25.

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics.

Heath RJ, White SW, Rock CO.

Appl Microbiol Biotechnol. 2002 May;58(6):695-703. Epub 2002 Mar 7. Review.

PMID:
12021787
26.

Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.

Kwak BY, Zhang YM, Yun M, Heath RJ, Rock CO, Jackowski S, Park HW.

J Biol Chem. 2002 Feb 8;277(6):4343-50. Epub 2001 Nov 12.

27.

Lipid biosynthesis as a target for antibacterial agents.

Heath RJ, White SW, Rock CO.

Prog Lipid Res. 2001 Nov;40(6):467-97. Review.

PMID:
11591436
28.

The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.

Rock CO, Heath RJ, Park HW, Jackowski S.

J Bacteriol. 2001 Aug;183(16):4927-31.

29.

Bacterial fatty-acid biosynthesis: an antibacterial drug target waiting to be exploited.

Heath RJ.

Drug Discov Today. 2001 Jul 1;6(14):715. No abstract available.

PMID:
11445460
30.

The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli.

Xu Y, Heath RJ, Li Z, Rock CO, White SW.

J Biol Chem. 2001 May 18;276(20):17373-9. Epub 2001 Feb 13.

31.

Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III.

Zhang YM, Rao MS, Heath RJ, Price AC, Olson AJ, Rock CO, White SW.

J Biol Chem. 2001 Mar 16;276(11):8231-8. Epub 2000 Nov 14.

32.

Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism.

Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO.

J Biol Chem. 2001 Mar 2;276(9):6551-9. Epub 2000 Oct 24.

33.

The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis.

Heath RJ, Su N, Murphy CK, Rock CO.

J Biol Chem. 2000 Dec 22;275(51):40128-33.

34.

A triclosan-resistant bacterial enzyme.

Heath RJ, Rock CO.

Nature. 2000 Jul 13;406(6792):145-6. No abstract available. Erratum in: Nature 2000 Aug 24;406(6798):848.

PMID:
10910344
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38.

Mechanism of triclosan inhibition of bacterial fatty acid synthesis.

Heath RJ, Rubin JR, Holland DR, Zhang E, Snow ME, Rock CO.

J Biol Chem. 1999 Apr 16;274(16):11110-4.

40.

Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis.

Heath RJ, Yu YT, Shapiro MA, Olson E, Rock CO.

J Biol Chem. 1998 Nov 13;273(46):30316-20.

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