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4D electron microscopy of T cell activation.

Lu Y, Yoo BK, Ng AHC, Kim J, Yeom S, Tang J, Lin MM, Zewail AH, Heath JR.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22014-22019. doi: 10.1073/pnas.1914078116. Epub 2019 Oct 14.


Framing technology challenges associated with improving cancer immunotherapies.

Heath JR.

Lab Chip. 2019 Oct 9;19(20):3366-3367. doi: 10.1039/c9lc90103e. No abstract available.


MATE-Seq: microfluidic antigen-TCR engagement sequencing.

Ng AHC, Peng S, Xu AM, Noh WJ, Guo K, Bethune MT, Chour W, Choi J, Yang S, Baltimore D, Heath JR.

Lab Chip. 2019 Sep 10;19(18):3011-3021. doi: 10.1039/c9lc00538b.


Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Zhu Y, Smith DJ, Zhou Y, Li YR, Yu J, Lee D, Wang YC, Di Biase S, Wang X, Hardoy C, Ku J, Tsao T, Lin LJ, Pham AT, Moon H, McLaughlin J, Cheng D, Hollis RP, Campo-Fernandez B, Urbinati F, Wei L, Pang L, Rezek V, Berent-Maoz B, Macabali MH, Gjertson D, Wang X, Galic Z, Kitchen SG, An DS, Hu-Lieskovan S, Kaplan-Lefko PJ, De Oliveira SN, Seet CS, Larson SM, Forman SJ, Heath JR, Zack JA, Crooks GM, Radu CG, Ribas A, Kohn DB, Witte ON, Yang L.

Cell Stem Cell. 2019 Oct 3;25(4):542-557.e9. doi: 10.1016/j.stem.2019.08.004. Epub 2019 Sep 5.


Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood.

Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR.

Cell Rep. 2019 Sep 3;28(10):2728-2738.e7. doi: 10.1016/j.celrep.2019.07.106.


Inhibition of heme sequestration of histidine-rich protein 2 using multiple epitope-targeted peptides.

Liang J, Bunck DN, Mishra A, Hong S, Idso MN, Heath JR.

J Pept Sci. 2019 Sep;25(9):e3203. doi: 10.1002/psc.3203. Epub 2019 Jul 25.


Phenotypic heterogeneity and evolution of melanoma cells associated with targeted therapy resistance.

Su Y, Bintz M, Yang Y, Robert L, Ng AHC, Liu V, Ribas A, Heath JR, Wei W.

PLoS Comput Biol. 2019 Jun 5;15(6):e1007034. doi: 10.1371/journal.pcbi.1007034. eCollection 2019 Jun.


Protein-Catalyzed Capture Agents.

Agnew HD, Coppock MB, Idso MN, Lai BT, Liang J, McCarthy-Torrens AM, Warren CM, Heath JR.

Chem Rev. 2019 Sep 11;119(17):9950-9970. doi: 10.1021/acs.chemrev.8b00660. Epub 2019 Mar 6.


Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.

Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.

J Clin Oncol. 2019 Mar 20;37(9):741-750. doi: 10.1200/JCO.18.01207. Epub 2019 Feb 4.


T cell antigen discovery via trogocytosis.

Li G, Bethune MT, Wong S, Joglekar AV, Leonard MT, Wang JK, Kim JT, Cheng D, Peng S, Zaretsky JM, Su Y, Luo Y, Heath JR, Ribas A, Witte ON, Baltimore D.

Nat Methods. 2019 Feb;16(2):183-190. doi: 10.1038/s41592-018-0305-7. Epub 2019 Jan 28.


T cell antigen discovery via signaling and antigen-presenting bifunctional receptors.

Joglekar AV, Leonard MT, Jeppson JD, Swift M, Li G, Wong S, Peng S, Zaretsky JM, Heath JR, Ribas A, Bethune MT, Baltimore D.

Nat Methods. 2019 Feb;16(2):191-198. doi: 10.1038/s41592-018-0304-8. Epub 2019 Jan 28.


Integrated measurement of intracellular proteins and transcripts in single cells.

Xu AM, Liu Q, Takata KL, Jeoung S, Su Y, Antoshechkin I, Chen S, Thomson M, Heath JR.

Lab Chip. 2018 Oct 23;18(21):3251-3262. doi: 10.1039/c8lc00639c.


Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.

Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC.

Cell. 2018 Jul 26;174(3):672-687.e27. doi: 10.1016/j.cell.2018.06.017.


Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities.

Li Z, Cheng H, Shao S, Lu X, Mo L, Tsang J, Zeng P, Guo Z, Wang S, Nathanson DA, Heath JR, Wei W, Xue M.

Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11554-11558. doi: 10.1002/anie.201803034. Epub 2018 Aug 6.


Allosteric Inhibitor of KRas Identified Using a Barcoded Assay Microchip Platform.

McCarthy AM, Kim J, Museth AK, Henning RK, Heath JE, Winson E, Oh JJ, Liang J, Hong S, Heath JR.

Anal Chem. 2018 Aug 7;90(15):8824-8830. doi: 10.1021/acs.analchem.8b00706. Epub 2018 Jul 19.


Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL.

Rossi J, Paczkowski P, Shen YW, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, Bot A.

Blood. 2018 Aug 23;132(8):804-814. doi: 10.1182/blood-2018-01-828343. Epub 2018 Jun 12.


Correction to A Chemically Synthesized Capture Agent Enables the Selective, Sensitive, and Robust Electrochemical Detection of Anthrax Protective Antigen.

Farrow B, Hong SA, Romero EC, Lai B, Coppock MB, Deyle KM, Finch AS, Stratis-Cullum DN, Agnew HD, Yang S, Heath JR.

ACS Nano. 2018 May 22;12(5):5066. doi: 10.1021/acsnano.8b03441. Epub 2018 May 11. No abstract available.


Modulating the Folding Landscape of Superoxide Dismutase 1 with Targeted Molecular Binders.

Bunck DN, Atsavapranee B, Museth AK, VanderVelde D, Heath JR.

Angew Chem Int Ed Engl. 2018 May 22;57(21):6212-6215. doi: 10.1002/anie.201802269. Epub 2018 Apr 25.


Corrigendum: Epitope Targeting of Tertiary Protein Structure Enables Target-Guided Synthesis of a Potent In-Cell Inhibitor of Botulinum Neurotoxin.

Farrow B, Wong M, Malette J, Lai B, Deyle KM, Das S, Nag A, Agnew HD, Heath JR.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1439. doi: 10.1002/anie.201712967. No abstract available.


A kinetic investigation of interacting, stimulated T cells identifies conditions for rapid functional enhancement, minimal phenotype differentiation, and improved adoptive cell transfer tumor eradication.

Zhou J, Bethune MT, Malkova N, Sutherland AM, Comin-Anduix B, Su Y, Baltimore D, Ribas A, Heath JR.

PLoS One. 2018 Jan 23;13(1):e0191634. doi: 10.1371/journal.pone.0191634. eCollection 2018.


Epitope-Targeted Macrocyclic Peptide Ligand with Picomolar Cooperative Binding to Interleukin-17F.

Lai BT, Wilson JA, Malette Loredo J, Pitram SM, LaBerge NA, Heath JR, Agnew HD.

Chemistry. 2018 Mar 12;24(15):3760-3767. doi: 10.1002/chem.201704752. Epub 2018 Feb 19.


Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance.

Su Y, Wei W, Robert L, Xue M, Tsoi J, Garcia-Diaz A, Homet Moreno B, Kim J, Ng RH, Lee JW, Koya RC, Comin-Anduix B, Graeber TG, Ribas A, Heath JR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13679-13684. doi: 10.1073/pnas.1712064115. Epub 2017 Dec 11.


High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients.

Tang Y, Wang Z, Li Z, Kim J, Deng Y, Li Y, Heath JR, Wei W, Lu S, Shi Q.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2544-2549. doi: 10.1073/pnas.1612229114. Epub 2017 Feb 21. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 4;114(14 ):E2983.


Domain-swapped T cell receptors improve the safety of TCR gene therapy.

Bethune MT, Gee MH, Bunse M, Lee MS, Gschweng EH, Pagadala MS, Zhou J, Cheng D, Heath JR, Kohn DB, Kuhns MS, Uckert W, Baltimore D.

Elife. 2016 Nov 8;5. pii: e19095. doi: 10.7554/eLife.19095.


Protein catalyzed capture agents with tailored performance for in vitro and in vivo applications.

Coppock MB, Warner CR, Dorsey B, Orlicki JA, Sarkes DA, Lai BT, Pitram SM, Rohde RD, Malette J, Wilson JA, Kearney P, Fang KC, Law SM, Candelario SL, Farrow B, Finch AS, Agnew HD, Heath JR, Stratis-Cullum DN.

Biopolymers. 2017 Mar;108(2). doi: 10.1002/bip.22934.


Harry Kroto (1939-2016).

Heath JR, Curl RF.

Nature. 2016 May 26;533(7604):470. doi: 10.1038/533470a. No abstract available.


Intercellular signaling through secreted proteins induces free-energy gradient-directed cell movement.

Kravchenko-Balasha N, Shin YS, Sutherland A, Levine RD, Heath JR.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5520-5. doi: 10.1073/pnas.1602171113. Epub 2016 May 2.


Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.

Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee WK, Cloughesy TF, Mischel PS, Heath JR, Gini B.

Cancer Cell. 2016 Apr 11;29(4):563-573. doi: 10.1016/j.ccell.2016.03.012.


A Thermodynamic-Based Interpretation of Protein Expression Heterogeneity in Different Glioblastoma Multiforme Tumors Identifies Tumor-Specific Unbalanced Processes.

Kravchenko-Balasha N, Johnson H, White FM, Heath JR, Levine RD.

J Phys Chem B. 2016 Jul 7;120(26):5990-7. doi: 10.1021/acs.jpcb.6b01692. Epub 2016 Apr 12.


Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells.

Xue M, Wei W, Su Y, Johnson D, Heath JR.

J Am Chem Soc. 2016 Mar 9;138(9):3085-93. doi: 10.1021/jacs.5b12187. Epub 2016 Feb 26.


Degradation of Akt using protein-catalyzed capture agents.

Henning RK, Varghese JO, Das S, Nag A, Tang G, Tang K, Sutherland AM, Heath JR.

J Pept Sci. 2016 Apr;22(4):196-200. doi: 10.1002/psc.2858. Epub 2016 Feb 16.


Quantitative assessments of glycolysis from single cells.

Shin YS, Kim J, Johnson D, Dooraghi AA, Mai WX, Ta L, Chatziioannou AF, Phelps ME, Nathanson DA, Heath JR.

Technology (Singap World Sci). 2015 Jun;3(4):172-178. Epub 2015 Jun 25.


Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.

Poovathingal SK, Kravchenko-Balasha N, Shin YS, Levine RD, Heath JR.

Small. 2016 Mar;12(11):1425-31. doi: 10.1002/smll.201501178. Epub 2016 Jan 18.


Single-cell analysis tools for drug discovery and development.

Heath JR, Ribas A, Mischel PS.

Nat Rev Drug Discov. 2016 Mar;15(3):204-16. doi: 10.1038/nrd.2015.16. Epub 2015 Dec 16. Review.


Correction to "Modeling Dioxygen Reduction at Multicopper Oxidase Cathodes".

Agbo P, Heath JR, Gray HB.

J Am Chem Soc. 2015 Dec 23;137(50):15978. doi: 10.1021/jacs.5b11603. Epub 2015 Dec 10. No abstract available.


Nanotechnologies for biomedical science and translational medicine.

Heath JR.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14436-43. doi: 10.1073/pnas.1515202112. Review.


A General Synthetic Approach for Designing Epitope Targeted Macrocyclic Peptide Ligands.

Das S, Nag A, Liang J, Bunck DN, Umeda A, Farrow B, Coppock MB, Sarkes DA, Finch AS, Agnew HD, Pitram S, Lai B, Yu MB, Museth AK, Deyle KM, Lepe B, Rodriguez-Rivera FP, McCarthy A, Alvarez-Villalonga B, Chen A, Heath J, Stratis-Cullum DN, Heath JR.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13219-24. doi: 10.1002/anie.201505243. Epub 2015 Sep 17.


Epitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin.

Farrow B, Wong M, Malette J, Lai B, Deyle KM, Das S, Nag A, Agnew HD, Heath JR.

Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7114-9. doi: 10.1002/anie.201502451. Epub 2015 Apr 29. Erratum in: Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1439.


A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1.

Deyle KM, Farrow B, Qiao Hee Y, Work J, Wong M, Lai B, Umeda A, Millward SW, Nag A, Das S, Heath JR.

Nat Chem. 2015 May;7(5):455-62. doi: 10.1038/nchem.2223. Epub 2015 Apr 13.


Chemical methods for the simultaneous quantitation of metabolites and proteins from single cells.

Xue M, Wei W, Su Y, Kim J, Shin YS, Mai WX, Nathanson DA, Heath JR.

J Am Chem Soc. 2015 Apr 1;137(12):4066-9. doi: 10.1021/jacs.5b00944. Epub 2015 Mar 19.


The influence of water on the optical properties of single-layer molybdenum disulfide.

Varghese JO, Agbo P, Sutherland AM, Brar VW, Rossman GR, Gray HB, Heath JR.

Adv Mater. 2015 May 6;27(17):2734-40. doi: 10.1002/adma.201500555. Epub 2015 Mar 18.


Modeling dioxygen reduction at multicopper oxidase cathodes.

Agbo P, Heath JR, Gray HB.

J Am Chem Soc. 2014 Oct 1;136(39):13882-7. doi: 10.1021/ja5077519. Epub 2014 Sep 17. Erratum in: J Am Chem Soc. 2015 Dec 23;137(50):15978.


Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function.

Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J.

J Immunol. 2014 Jul 15;193(2):940-9. doi: 10.4049/jimmunol.1400093. Epub 2014 Jun 16.


Microfluidics-based single-cell functional proteomics for fundamental and applied biomedical applications.

Yu J, Zhou J, Sutherland A, Wei W, Shin YS, Xue M, Heath JR.

Annu Rev Anal Chem (Palo Alto Calif). 2014;7:275-95. doi: 10.1146/annurev-anchem-071213-020323. Epub 2014 Jun 2. Review.


Glioblastoma cellular architectures are predicted through the characterization of two-cell interactions.

Kravchenko-Balasha N, Wang J, Remacle F, Levine RD, Heath JR.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6521-6. doi: 10.1073/pnas.1404462111. Epub 2014 Apr 14.


Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma.

Chodon T, Comin-Anduix B, Chmielowski B, Koya RC, Wu Z, Auerbach M, Ng C, Avramis E, Seja E, Villanueva A, McCannel TA, Ishiyama A, Czernin J, Radu CG, Wang X, Gjertson DW, Cochran AJ, Cornetta K, Wong DJ, Kaplan-Lefko P, Hamid O, Samlowski W, Cohen PA, Daniels GA, Mukherji B, Yang L, Zack JA, Kohn DB, Heath JR, Glaspy JA, Witte ON, Baltimore D, Economou JS, Ribas A.

Clin Cancer Res. 2014 May 1;20(9):2457-65. doi: 10.1158/1078-0432.CCR-13-3017. Epub 2014 Mar 14.


Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis.

Zhao JL, Ma C, O'Connell RM, Mehta A, DiLoreto R, Heath JR, Baltimore D.

Cell Stem Cell. 2014 Apr 3;14(4):445-459. doi: 10.1016/j.stem.2014.01.007. Epub 2014 Feb 20.


Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA.

Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, Eskin A, Hwang K, Wang J, Masui K, Paucar A, Yang H, Ohashi M, Zhu S, Wykosky J, Reed R, Nelson SF, Cloughesy TF, James CD, Rao PN, Kornblum HI, Heath JR, Cavenee WK, Furnari FB, Mischel PS.

Science. 2014 Jan 3;343(6166):72-6. doi: 10.1126/science.1241328. Epub 2013 Dec 5.


A chemical epitope-targeting strategy for protein capture agents: the serine 474 epitope of the kinase Akt2.

Nag A, Das S, Yu MB, Deyle KM, Millward SW, Heath JR.

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):13975-9. doi: 10.1002/anie.201305882. Epub 2013 Nov 19. No abstract available.


A cocktail of thermally stable, chemically synthesized capture agents for the efficient detection of anti-gp41 antibodies from human sera.

Pfeilsticker JA, Umeda A, Farrow B, Hsueh CL, Deyle KM, Kim JT, Lai BT, Heath JR.

PLoS One. 2013 Oct 7;8(10):e76224. doi: 10.1371/journal.pone.0076224. eCollection 2013.

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