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Adenoviral strategies to overcome innate cellular responses to infection.

Sohn SY, Hearing P.

FEBS Lett. 2019 Nov 13. doi: 10.1002/1873-3468.13680. [Epub ahead of print] Review.


Adenovirus major core protein condenses DNA in clusters and bundles, modulating genome release and capsid internal pressure.

Martín-González N, Hernando-Pérez M, Condezo GN, Pérez-Illana M, Šiber A, Reguera D, Ostapchuk P, Hearing P, San Martín C, de Pablo PJ.

Nucleic Acids Res. 2019 Sep 26;47(17):9231-9242. doi: 10.1093/nar/gkz687.


An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein.

Nebenzahl-Sharon K, Sharf R, Amer J, Shalata H, Khoury-Haddad H, Sohn SY, Ayoub N, Hearing P, Kleinberger T.

J Virol. 2019 Sep 12;93(19). pii: e02253-18. doi: 10.1128/JVI.02253-18. Print 2019 Oct 1.


Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization.

Soriano AM, Crisostomo L, Mendez M, Graves D, Frost JR, Olanubi O, Whyte PF, Hearing P, Pelka P.

J Virol. 2019 May 1;93(10). pii: e00157-19. doi: 10.1128/JVI.00157-19. Print 2019 May 15.


Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.

Nebenzahl-Sharon K, Shalata H, Sharf R, Amer J, Khoury-Haddad H, Sohn SY, Ayoub N, Hearing P, Kleinberger T.

J Virol. 2019 May 1;93(10). pii: e01365-18. doi: 10.1128/JVI.01365-18. Print 2019 May 15.


Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications.

Sohn SY, Hearing P.

MBio. 2019 Feb 26;10(1). pii: e00022-19. doi: 10.1128/mBio.00022-19.


Protect NIH's DNA advisory committee.

Adelman ZN, Albritton LM, Boris-Lawrie K, Buchmeier MJ, Cannon P, Cho M, DiGiusto D, Donahue JK, Federoff HJ, Hammarskjold ML, Hardison AD, Hearing P, Lee B, Lee DA, Porteus MH, Ross LF, Ross SR, Wooley DP, Zoloth L.

Science. 2018 Oct 26;362(6413):409-410. doi: 10.1126/science.aav2483. No abstract available.


The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection.

Ostapchuk P, Suomalainen M, Zheng Y, Boucke K, Greber UF, Hearing P.

PLoS Pathog. 2017 Jun 19;13(6):e1006455. doi: 10.1371/journal.ppat.1006455. eCollection 2017 Jun.


Adenovirus Early Proteins and Host Sumoylation.

Sohn SY, Hearing P.

MBio. 2016 Sep 20;7(5). pii: e01154-16. doi: 10.1128/mBio.01154-16. Review.


The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.

Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB.

Cell Host Microbe. 2016 Sep 14;20(3):296-306. doi: 10.1016/j.chom.2016.07.018. Epub 2016 Aug 25.


A core viral protein binds host nucleosomes to sequester immune danger signals.

Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD.

Nature. 2016 Jul 7;535(7610):173-7. Epub 2016 Jun 29.


The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1γ sumoylation and poly-SUMO chain elongation.

Sohn SY, Hearing P.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):6725-30. doi: 10.1073/pnas.1603872113. Epub 2016 May 31.


The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of General Transcription Factor TFII-I to Direct Proteasomal Degradation.

Bridges RG, Sohn SY, Wright J, Leppard KN, Hearing P.

MBio. 2016 Jan 26;7(1):e02184-15. doi: 10.1128/mBio.02184-15.


E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection.

Zheng Y, Stamminger T, Hearing P.

PLoS Pathog. 2016 Jan 25;12(1):e1005415. doi: 10.1371/journal.ppat.1005415. eCollection 2016 Jan.


Impact of Adenovirus E4-ORF3 Oligomerization and Protein Localization on Cellular Gene Expression.

Vink EI, Zheng Y, Yeasmin R, Stamminger T, Krug LT, Hearing P.

Viruses. 2015 May 13;7(5):2428-49. doi: 10.3390/v7052428.


Proteomic analysis of ubiquitin-like posttranslational modifications induced by the adenovirus E4-ORF3 protein.

Sohn SY, Bridges RG, Hearing P.

J Virol. 2015 Feb;89(3):1744-55. doi: 10.1128/JVI.02892-14. Epub 2014 Nov 19.


The use of chromatin immunoprecipitation (ChIP) to study the binding of viral proteins to the adenovirus genome in vivo.

Zheng Y, Hearing P.

Methods Mol Biol. 2014;1089:79-87. doi: 10.1007/978-1-62703-679-5_6.


The adenovirus L4-33K protein regulates both late gene expression patterns and viral DNA packaging.

Wu K, Guimet D, Hearing P.

J Virol. 2013 Jun;87(12):6739-47. doi: 10.1128/JVI.00652-13. Epub 2013 Apr 3.


The adenovirus L4-22K protein is multifunctional and is an integral component of crucial aspects of infection.

Wu K, Orozco D, Hearing P.

J Virol. 2012 Oct;86(19):10474-83. doi: 10.1128/JVI.01463-12. Epub 2012 Jul 18.


Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.

Sohn SY, Hearing P.

J Virol. 2012 Sep;86(18):9656-65. doi: 10.1128/JVI.01273-12. Epub 2012 Jun 27.


Biophysical and functional analyses suggest that adenovirus E4-ORF3 protein requires higher-order multimerization to function against promyelocytic leukemia protein nuclear bodies.

Patsalo V, Yondola MA, Luan B, Shoshani I, Kisker C, Green DF, Raleigh DP, Hearing P.

J Biol Chem. 2012 Jun 29;287(27):22573-83. doi: 10.1074/jbc.M112.344234. Epub 2012 May 9.


Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif.

Vink EI, Yondola MA, Wu K, Hearing P.

Virology. 2012 Jan 20;422(2):317-25. doi: 10.1016/j.virol.2011.10.033. Epub 2011 Nov 27.


Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.

Sitaraman V, Hearing P, Ward CB, Gnatenko DV, Wimmer E, Mueller S, Skiena S, Bahou WF.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14294-9. doi: 10.1073/pnas.1102883108. Epub 2011 Aug 15.


The adenovirus E4 11 k protein binds and relocalizes the cytoplasmic P-body component Ddx6 to aggresomes.

Greer AE, Hearing P, Ketner G.

Virology. 2011 Aug 15;417(1):161-8. doi: 10.1016/j.virol.2011.05.017. Epub 2011 Jun 22.


Adenovirus structural protein IIIa is involved in the serotype specificity of viral DNA packaging.

Ma HC, Hearing P.

J Virol. 2011 Aug;85(15):7849-55. doi: 10.1128/JVI.00467-11. Epub 2011 Jun 1.


Unnatural amino acid incorporation onto adenoviral (Ad) coat proteins facilitates chemoselective modification and retargeting of Ad type 5 vectors.

Banerjee PS, Ostapchuk P, Hearing P, Carrico IS.

J Virol. 2011 Aug;85(15):7546-54. doi: 10.1128/JVI.00118-11. Epub 2011 May 25.


Altering the Ad5 packaging domain affects the maturation of the Ad particles.

Alba R, Cots D, Ostapchuk P, Bosch A, Hearing P, Chillon M.

PLoS One. 2011;6(5):e19564. doi: 10.1371/journal.pone.0019564. Epub 2011 May 18.


Adenovirus sequesters phosphorylated STAT1 at viral replication centers and inhibits STAT dephosphorylation.

Sohn SY, Hearing P.

J Virol. 2011 Aug;85(15):7555-62. doi: 10.1128/JVI.00513-11. Epub 2011 May 18.


Characterization of Empty adenovirus particles assembled in the absence of a functional adenovirus IVa2 protein.

Ostapchuk P, Almond M, Hearing P.

J Virol. 2011 Jun;85(11):5524-31. doi: 10.1128/JVI.02538-10. Epub 2011 Mar 30.


Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.

Karen KA, Hearing P.

J Virol. 2011 May;85(9):4135-42. doi: 10.1128/JVI.02540-10. Epub 2011 Feb 23.


Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.

Banerjee PS, Ostapchuk P, Hearing P, Carrico I.

J Am Chem Soc. 2010 Oct 6;132(39):13615-7. doi: 10.1021/ja104547x.


LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

Tang M, Naidu D, Hearing P, Handwerger S, Tabibzadeh S.

Endocrinology. 2010 Mar;151(3):1320-30. doi: 10.1210/en.2009-1081. Epub 2010 Jan 7.


Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.

Karen KA, Hoey PJ, Young CS, Hearing P.

J Virol. 2009 May;83(9):4565-73. doi: 10.1128/JVI.00042-09. Epub 2009 Feb 25.


Altered bioavailability of platelet-derived factor VIII during thrombocytosis reverses phenotypic efficacy in haemophilic mice.

Damon AL, Scudder LE, Gnatenko DV, Sitaraman V, Hearing P, Jesty J, Bahou WF.

Thromb Haemost. 2008 Dec;100(6):1111-22.


Adenovirus IVa2 protein binds ATP.

Ostapchuk P, Hearing P.

J Virol. 2008 Oct;82(20):10290-4. doi: 10.1128/JVI.00882-08. Epub 2008 Jul 30.


Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.

Ullman AJ, Hearing P.

J Virol. 2008 Aug;82(15):7325-35. doi: 10.1128/JVI.00723-08. Epub 2008 May 14.


Role for the L1-52/55K protein in the serotype specificity of adenovirus DNA packaging.

Wohl BP, Hearing P.

J Virol. 2008 May;82(10):5089-92. doi: 10.1128/JVI.00040-08. Epub 2008 Mar 12.


Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral response.

Ullman AJ, Reich NC, Hearing P.

J Virol. 2007 May;81(9):4744-52. Epub 2007 Feb 14.


The L4 22-kilodalton protein plays a role in packaging of the adenovirus genome.

Ostapchuk P, Anderson ME, Chandrasekhar S, Hearing P.

J Virol. 2006 Jul;80(14):6973-81.


Tet responsive and adenovirus based constructs for regulated in vivo expression of Lefty.

Mikhailik A, Tang M, Hearing P, Ravishankar V, Tabibzadeh S.

Front Biosci. 2006 Jan 1;11:883-8.


Control of adenovirus packaging.

Ostapchuk P, Hearing P.

J Cell Biochem. 2005 Sep 1;96(1):25-35.


Modeling gene expression in the mouse uterine horn by in vivo adenovirus-mediated gene delivery.

Tang M, Hearing P, Tabibzadeh S.

Front Biosci. 2005 Sep 1;10:2904-7.


Functional interaction of the adenovirus IVa2 protein with adenovirus type 5 packaging sequences.

Ostapchuk P, Yang J, Auffarth E, Hearing P.

J Virol. 2005 Mar;79(5):2831-8.


Induction of genes involved in cell cycle progression by interleukin-4.

McDonald C, Vanscoy S, Hearing P, Reich NC.

J Interferon Cytokine Res. 2004 Dec;24(12):729-38.


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