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Items: 1 to 50 of 129

1.

Research activity and capability in the European reference network MetabERN.

Heard JM, Bellettato C, van Lingen C, Scarpa M; MetabERN collaboration group.

Orphanet J Rare Dis. 2019 May 29;14(1):119. doi: 10.1186/s13023-019-1091-8.

2.

Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial.

Tardieu M, Zérah M, Gougeon ML, Ausseil J, de Bournonville S, Husson B, Zafeiriou D, Parenti G, Bourget P, Poirier B, Furlan V, Artaud C, Baugnon T, Roujeau T, Crystal RG, Meyer C, Deiva K, Heard JM.

Lancet Neurol. 2017 Sep;16(9):712-720. doi: 10.1016/S1474-4422(17)30169-2. Epub 2017 Jul 14.

PMID:
28713035
3.

Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice.

Baldo G, Lorenzini DM, Santos DS, Mayer FQ, Vitry S, Bigou S, Heard JM, Matte U, Giugliani R.

Mol Genet Metab. 2015 Feb;114(2):138-45. doi: 10.1016/j.ymgme.2014.12.301. Epub 2014 Dec 13.

PMID:
25541102
4.

Oxidative stress is independent of inflammation in the neurodegenerative Sanfilippo syndrome type B.

Trudel S, Trécherel E, Gomila C, Peltier M, Aubignat M, Gubler B, Morlière P, Heard JM, Ausseil J.

J Neurosci Res. 2015 Mar;93(3):424-32. doi: 10.1002/jnr.23497. Epub 2014 Oct 21.

PMID:
25332157
5.

Heparan sulfate saccharides modify focal adhesions: implication in mucopolysaccharidosis neuropathophysiology.

Bruyère J, Roy E, Ausseil J, Lemonnier T, Teyre G, Bohl D, Etienne-Manneville S, Lortat-Jacob H, Heard JM, Vitry S.

J Mol Biol. 2015 Feb 27;427(4):775-791. doi: 10.1016/j.jmb.2014.09.012. Epub 2014 Sep 28.

PMID:
25268803
6.

Removal of albumin and immunoglobulins from canine cerebrospinal fluid using depletion kits: a feasibility study.

Günther R, Krause E, Schümann M, Ausseil J, Heard JM, Blasig IE, Haseloff RF.

Fluids Barriers CNS. 2014 Jun 23;11:14. doi: 10.1186/2045-8118-11-14. eCollection 2014.

7.

Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial.

Tardieu M, Zérah M, Husson B, de Bournonville S, Deiva K, Adamsbaum C, Vincent F, Hocquemiller M, Broissand C, Furlan V, Ballabio A, Fraldi A, Crystal RG, Baugnon T, Roujeau T, Heard JM, Danos O.

Hum Gene Ther. 2014 Jun;25(6):506-16. doi: 10.1089/hum.2013.238. Epub 2014 May 5.

PMID:
24524415
8.

GM130 gain-of-function induces cell pathology in a model of lysosomal storage disease.

Roy E, Bruyère J, Flamant P, Bigou S, Ausseil J, Vitry S, Heard JM.

Hum Mol Genet. 2012 Apr 1;21(7):1481-95. doi: 10.1093/hmg/ddr584. Epub 2011 Dec 12.

PMID:
22156940
9.

Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

Hum Mol Genet. 2011 Sep 15;20(18):3653-66. doi: 10.1093/hmg/ddr285. Epub 2011 Jun 17.

PMID:
21685203
10.

Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece.

Héron B, Mikaeloff Y, Froissart R, Caridade G, Maire I, Caillaud C, Levade T, Chabrol B, Feillet F, Ogier H, Valayannopoulos V, Michelakakis H, Zafeiriou D, Lavery L, Wraith E, Danos O, Heard JM, Tardieu M.

Am J Med Genet A. 2011 Jan;155A(1):58-68. doi: 10.1002/ajmg.a.33779.

PMID:
21204211
11.

Safe, efficient, and reproducible gene therapy of the brain in the dog models of Sanfilippo and Hurler syndromes.

Ellinwood NM, Ausseil J, Desmaris N, Bigou S, Liu S, Jens JK, Snella EM, Mohammed EE, Thomson CB, Raoul S, Joussemet B, Roux F, Chérel Y, Lajat Y, Piraud M, Benchaouir R, Hermening S, Petry H, Froissart R, Tardieu M, Ciron C, Moullier P, Parkes J, Kline KL, Maire I, Vanier MT, Heard JM, Colle MA.

Mol Ther. 2011 Feb;19(2):251-9. doi: 10.1038/mt.2010.265. Epub 2010 Dec 7.

12.

Neurotrophin 3 improves delayed reconstruction of sensory pathways after cervical dorsal root injury.

Liu S, Blanchard S, Bigou S, Vitry S, Bohl D, Heard JM.

Neurosurgery. 2011 Feb;68(2):450-61; discussion 461. doi: 10.1227/NEU.0b013e318200512f.

PMID:
21135740
13.

Storage problems in lysosomal diseases.

Heard JM, Bruyère J, Roy E, Bigou S, Ausseil J, Vitry S.

Biochem Soc Trans. 2010 Dec;38(6):1442-7. doi: 10.1042/BST0381442.

PMID:
21118104
14.

Storage vesicles in neurons are related to Golgi complex alterations in mucopolysaccharidosis IIIB.

Vitry S, Bruyère J, Hocquemiller M, Bigou S, Ausseil J, Colle MA, Prévost MC, Heard JM.

Am J Pathol. 2010 Dec;177(6):2984-99. doi: 10.2353/ajpath.2010.100447. Epub 2010 Oct 29.

15.

GAP43 overexpression and enhanced neurite outgrowth in mucopolysaccharidosis type IIIB cortical neuron cultures.

Hocquemiller M, Vitry S, Bigou S, Bruyère J, Ausseil J, Heard JM.

J Neurosci Res. 2010 Jan;88(1):202-13. doi: 10.1002/jnr.22190.

PMID:
19658197
16.

Enhanced degradation of synaptophysin by the proteasome in mucopolysaccharidosis type IIIB.

Vitry S, Ausseil J, Hocquemiller M, Bigou S, Dos Santos Coura R, Heard JM.

Mol Cell Neurosci. 2009 May;41(1):8-18. doi: 10.1016/j.mcn.2009.01.001. Epub 2009 Jan 21.

PMID:
19386237
17.

Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution.

Ciron C, Cressant A, Roux F, Raoul S, Cherel Y, Hantraye P, Déglon N, Schwartz B, Barkats M, Heard JM, Tardieu M, Moullier P, Colle MA.

Hum Gene Ther. 2009 Apr;20(4):350-60. doi: 10.1089/hum.2008.155.

PMID:
19272011
18.

Combination of microsurgery and gene therapy for spinal dorsal root injury repair.

Liu S, Bohl D, Blanchard S, Bacci J, Saïd G, Heard JM.

Mol Ther. 2009 Jun;17(6):992-1002. doi: 10.1038/mt.2009.23. Epub 2009 Feb 24.

19.

Directed evolution of motor neurons from genetically engineered neural precursors.

Bohl D, Liu S, Blanchard S, Hocquemiller M, Haase G, Heard JM.

Stem Cells. 2008 Oct;26(10):2564-75. doi: 10.1634/stemcells.2008-0371. Epub 2008 Jul 17.

20.

Early neurodegeneration progresses independently of microglial activation by heparan sulfate in the brain of mucopolysaccharidosis IIIB mice.

Ausseil J, Desmaris N, Bigou S, Attali R, Corbineau S, Vitry S, Parent M, Cheillan D, Fuller M, Maire I, Vanier MT, Heard JM.

PLoS One. 2008 May 28;3(5):e2296. doi: 10.1371/journal.pone.0002296.

21.

Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice.

Cheillan D, Malleval C, Ausseil J, Vitry S, Heard JM, Maire I, Honnorat J, Belin MF, Touret M.

Mol Genet Metab. 2008 May;94(1):135-8. doi: 10.1016/j.ymgme.2008.01.009. Epub 2008 Mar 5.

PMID:
18325808
22.

Gene therapy of the brain in the dog model of Hurler's syndrome.

Ciron C, Desmaris N, Colle MA, Raoul S, Joussemet B, Vérot L, Ausseil J, Froissart R, Roux F, Chérel Y, Ferry N, Lajat Y, Schwartz B, Vanier MT, Maire I, Tardieu M, Moullier P, Heard JM.

Ann Neurol. 2006 Aug;60(2):204-13.

PMID:
16718701
23.

alpha-L-Iduronidase transport in neurites.

Chen F, Vitry S, Hocquemiller M, Desmaris N, Ausseil J, Heard JM.

Mol Genet Metab. 2006 Apr;87(4):349-58. Epub 2006 Jan 24.

PMID:
16439176
24.

Forced expression of the motor neuron determinant HB9 in neural stem cells affects neurogenesis.

Bréjot T, Blanchard S, Hocquemiller M, Haase G, Liu S, Nosjean A, Heard JM, Bohl D.

Exp Neurol. 2006 Mar;198(1):167-82. Epub 2006 Jan 24.

PMID:
16434037
25.

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

Carro E, Trejo JL, Spuch C, Bohl D, Heard JM, Torres-Aleman I.

Neurobiol Aging. 2006 Nov;27(11):1618-31. Epub 2005 Nov 7.

PMID:
16274856
26.

Reinnervation of hind limb extremity after lumbar dorsal root ganglion injury.

Liu S, Bréjot T, Cressant A, Bacci J, Saïd G, Tadié M, Heard JM.

Exp Neurol. 2005 Dec;196(2):401-12. Epub 2005 Oct 3.

PMID:
16202409
27.

Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum.

Cressant A, Desmaris N, Verot L, Bréjot T, Froissart R, Vanier MT, Maire I, Heard JM.

J Neurosci. 2004 Nov 10;24(45):10229-39.

28.

Prevention of neuropathology in the mouse model of Hurler syndrome.

Desmaris N, Verot L, Puech JP, Caillaud C, Vanier MT, Heard JM.

Ann Neurol. 2004 Jul;56(1):68-76.

PMID:
15236403
29.
30.

Efficient reinnervation of hindlimb muscles by thoracic motor neurons after nerve cross-anastomosis in rats.

Liu S, Damhieu P, Devanze P, Saïd G, Heard JM, Tadié M.

J Neurosurg. 2003 Nov;99(5):879-85.

PMID:
14609168
31.

Gene therapy for mucopolysaccharidosis.

Bosch A, Heard JM.

Int Rev Neurobiol. 2003;55:271-96. Review. No abstract available.

PMID:
12968541
32.
33.

Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.

Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marmé F, Chérel Y, Salvetti A, Hurtrel B, Heard JM, Rivière Y, Moullier P.

J Virol. 2002 Nov;76(22):11605-11.

34.

Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration.

Salaün C, Gyan E, Rodrigues P, Heard JM.

J Virol. 2002 May;76(9):4304-11.

35.

HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread.

Sol-Foulon N, Moris A, Nobile C, Boccaccio C, Engering A, Abastado JP, Heard JM, van Kooyk Y, Schwartz O.

Immunity. 2002 Jan;16(1):145-55.

37.

Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis.

Maréchal V, Prevost MC, Petit C, Perret E, Heard JM, Schwartz O.

J Virol. 2001 Nov;75(22):11166-77.

38.

Production and neurotropism of lentivirus vectors pseudotyped with lyssavirus envelope glycoproteins.

Desmaris N, Bosch A, Salaün C, Petit C, Prévost MC, Tordo N, Perrin P, Schwartz O, de Rocquigny H, Heard JM.

Mol Ther. 2001 Aug;4(2):149-56.

39.

Nef is required for efficient HIV-1 replication in cocultures of dendritic cells and lymphocytes.

Petit C, Buseyne F, Boccaccio C, Abastado JP, Heard JM, Schwartz O.

Virology. 2001 Jul 20;286(1):225-36.

40.

Transmembrane topology of PiT-2, a phosphate transporter-retrovirus receptor.

Salaün C, Rodrigues P, Heard JM.

J Virol. 2001 Jun;75(12):5584-92.

41.
42.

MHC-I-restricted presentation of HIV-1 virion antigens without viral replication.

Buseyne F, Le Gall S, Boccaccio C, Abastado JP, Lifson JD, Arthur LO, Rivière Y, Heard JM, Schwartz O.

Nat Med. 2001 Mar;7(3):344-9.

PMID:
11231634
43.

Efficient expression of the vascular endothelial growth factor gene in vitro and in vivo, using an adeno-associated virus vector.

Byun J, Heard JM, Huh JE, Park SJ, Jung EA, Jeong JO, Gwon HC, Kim DK.

J Mol Cell Cardiol. 2001 Feb;33(2):295-305.

PMID:
11162134
44.

Ectopic expression of active processed form of atrial natriuretic peptide in skeletal myoblasts.

Byun J, Kim SH, Kim SZ, Heard JM, Huh JE, Choe YH, Park SJ, Jung EA, Kim DK.

Biochem Biophys Res Commun. 2000 Apr 13;270(2):637-42.

PMID:
10753676
45.

Delivering erythropoietin through genetically engineered cells.

Bohl D, Heard JM.

J Am Soc Nephrol. 2000 Nov;11 Suppl 16:S159-62. Review.

46.

Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

Le Gall S, Buseyne F, Trocha A, Walker BD, Heard JM, Schwartz O.

J Virol. 2000 Oct;74(19):9256-66.

47.
48.

Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer.

Bosch A, Perret E, Desmaris N, Trono D, Heard JM.

Hum Gene Ther. 2000 May 20;11(8):1139-50.

PMID:
10834616
49.

Improvement of erythropoiesis in beta-thalassemic mice by continuous erythropoietin delivery from muscle.

Bohl D, Bosch A, Cardona A, Salvetti A, Heard JM.

Blood. 2000 May 1;95(9):2793-8.

PMID:
10779423
50.

Complete atherosclerosis regression after human ApoE gene transfer in ApoE-deficient/nude mice.

Desurmont C, Caillaud JM, Emmanuel F, Benoit P, Fruchart JC, Castro G, Branellec D, Heard JM, Duverger N.

Arterioscler Thromb Vasc Biol. 2000 Feb;20(2):435-42.

PMID:
10669641

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