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Items: 1 to 50 of 172


The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation.

Bousard A, Raposo AC, Żylicz JJ, Picard C, Pires VB, Qi Y, Gil C, Syx L, Chang HY, Heard E, da Rocha ST.

EMBO Rep. 2019 Aug 27:e48019. doi: 10.15252/embr.201948019. [Epub ahead of print]


Applying intersectionality theory in health promotion research and practice.

Heard E, Fitzgerald L, Wigginton B, Mutch A.

Health Promot Int. 2019 Aug 7. pii: daz080. doi: 10.1093/heapro/daz080. [Epub ahead of print]


Advances in epigenetics link genetics to the environment and disease.

Cavalli G, Heard E.

Nature. 2019 Jul;571(7766):489-499. doi: 10.1038/s41586-019-1411-0. Epub 2019 Jul 24. Review.


How can HIV/STI testing services be more accessible and acceptable for gender and sexually diverse young people? A brief report exploring young people's perspectives in Queensland.

Heard E, Oost E, McDaid L, Mutch A, Dean J, Fitzgerald L.

Health Promot J Austr. 2019 Jun 7. doi: 10.1002/hpja.263. [Epub ahead of print]


Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.

Barros de Andrade E Sousa L, Jonkers I, Syx L, Dunkel I, Chaumeil J, Picard C, Foret B, Chen CJ, Lis JT, Heard E, Schulz EG, Marsico A.

Genome Res. 2019 Jul;29(7):1087-1099. doi: 10.1101/gr.245027.118. Epub 2019 Jun 7.


The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG, Galupa R, Gard C, Servant N, Picard C, Davies J, Szempruch AJ, Zhan Y, Żylicz JJ, Nora EP, Lameiras S, de Wit E, Gentien D, Baulande S, Giorgetti L, Guttman M, Hughes JR, Higgs DR, Gribnau J, Heard E.

Nat Genet. 2019 Jun;51(6):1024-1034. doi: 10.1038/s41588-019-0412-0. Epub 2019 May 27.


A symmetric toggle switch explains the onset of random X inactivation in different mammals.

Mutzel V, Okamoto I, Dunkel I, Saitou M, Giorgetti L, Heard E, Schulz EG.

Nat Struct Mol Biol. 2019 May;26(5):350-360. doi: 10.1038/s41594-019-0214-1. Epub 2019 Apr 8.


Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation.

Pollex T, Heard E.

Nat Genet. 2019 Feb;51(2):285-295. doi: 10.1038/s41588-018-0305-7. Epub 2019 Jan 14.


The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome.

Gdula MR, Nesterova TB, Pintacuda G, Godwin J, Zhan Y, Ozadam H, McClellan M, Moralli D, Krueger F, Green CM, Reik W, Kriaucionis S, Heard E, Dekker J, Brockdorff N.

Nat Commun. 2019 Jan 3;10(1):30. doi: 10.1038/s41467-018-07907-2.


The Implication of Early Chromatin Changes in X Chromosome Inactivation.

Żylicz JJ, Bousard A, Žumer K, Dossin F, Mohammad E, da Rocha ST, Schwalb B, Syx L, Dingli F, Loew D, Cramer P, Heard E.

Cell. 2019 Jan 10;176(1-2):182-197.e23. doi: 10.1016/j.cell.2018.11.041. Epub 2018 Dec 27.


'In the Islands people don't really talk about this stuff, so you go through life on your own': An arts-based study exploring intimate relationships with young people in Samoa.

Heard E, Fitzgerald L, Va'ai S, Collins F, Whittaker M, Mutch A.

Cult Health Sex. 2019 May;21(5):526-542. doi: 10.1080/13691058.2018.1492021. Epub 2018 Oct 3.


Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME.

Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27. Review.


X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation.

Galupa R, Heard E.

Annu Rev Genet. 2018 Nov 23;52:535-566. doi: 10.1146/annurev-genet-120116-024611. Epub 2018 Sep 26. Review.


[France, a refuge for researchers in danger].

Prochiantz A, Heard E.

Med Sci (Paris). 2018 Aug-Sep;34(8-9):635-636. doi: 10.1051/medsci/20183408001. Epub 2018 Sep 19. French. No abstract available.


Live Imaging of Xist RNA.

Masui O, Heard E, Koseki H.

Methods Mol Biol. 2018;1861:67-72. doi: 10.1007/978-1-4939-8766-5_6.


Effective normalization for copy number variation in Hi-C data.

Servant N, Varoquaux N, Heard E, Barillot E, Vert JP.

BMC Bioinformatics. 2018 Sep 6;19(1):313. doi: 10.1186/s12859-018-2256-5.


Exploring Intimate Partner Violence in Polynesia: A Scoping Review.

Heard E, Fitzgerald L, Whittaker M, Va'ai S, Mutch A.

Trauma Violence Abuse. 2018 Aug 20:1524838018795504. doi: 10.1177/1524838018795504. [Epub ahead of print]


Suiga/Change: An Ethnodrama Exploring Challenges in Intimate Relationships With Young People in Samoa.

Heard E, Fitzgerald L, Va'ai S, Collins F, Mutch A.

Violence Against Women. 2019 Mar;25(3):297-312. doi: 10.1177/1077801218778388. Epub 2018 Jul 2.


Transcriptome Profiling of Single Mouse Oocytes.

Borensztein M, Syx L, Servant N, Heard E.

Methods Mol Biol. 2018;1818:51-65. doi: 10.1007/978-1-4939-8603-3_7.


The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products.

Furlan G, Gutierrez Hernandez N, Huret C, Galupa R, van Bemmel JG, Romito A, Heard E, Morey C, Rougeulle C.

Mol Cell. 2018 May 3;70(3):462-472.e8. doi: 10.1016/j.molcel.2018.03.024.


Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease, and Evolution.

Galupa R, Heard E.

Cold Spring Harb Symp Quant Biol. 2017;82:267-278. doi: 10.1101/sqb.2017.82.035030. Epub 2018 Apr 23.


Using Applied Theater in Primary, Secondary, and Tertiary Prevention of Intimate Partner Violence: A Systematic Review.

Heard E, Mutch A, Fitzgerald L.

Trauma Violence Abuse. 2017 Jan 1:1524838017750157. doi: 10.1177/1524838017750157. [Epub ahead of print]


Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass.

Borensztein M, Okamoto I, Syx L, Guilbaud G, Picard C, Ancelin K, Galupa R, Diabangouaya P, Servant N, Barillot E, Surani A, Saitou M, Chen CJ, Anastassiadis K, Heard E.

Nat Commun. 2017 Nov 3;8(1):1297. doi: 10.1038/s41467-017-01415-5.


Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.

Loda A, Brandsma JH, Vassilev I, Servant N, Loos F, Amirnasr A, Splinter E, Barillot E, Poot RA, Heard E, Gribnau J.

Nat Commun. 2017 Sep 25;8(1):690. doi: 10.1038/s41467-017-00528-1.



Heard E, Brockdorff N.

Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733). pii: 20160353. doi: 10.1098/rstb.2016.0353. No abstract available.


Corrigendum: Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.

Xu J, Carter AC, Gendrel AV, Attia M, Loftus J, Greenleaf WJ, Tibshirani R, Heard E, Chang HY.

Nat Genet. 2017 May 26;49(6):970. doi: 10.1038/ng0617-970a. No abstract available.


RNA FISH to Study Zygotic Genome Activation in Early Mouse Embryos.

Ranisavljevic N, Okamoto I, Heard E, Ancelin K.

Methods Mol Biol. 2017;1605:133-145. doi: 10.1007/978-1-4939-6988-3_9.


X chromosome inactivation: new players in the initiation of gene silencing.

Pinheiro I, Heard E.

F1000Res. 2017 Mar 27;6. pii: F1000 Faculty Rev-344. doi: 10.12688/f1000research.10707.1. eCollection 2017. Review.


Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation.

da Rocha ST, Heard E.

Nat Struct Mol Biol. 2017 Mar 3;24(3):197-204. doi: 10.1038/nsmb.3370. Review.


Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.

Borensztein M, Syx L, Ancelin K, Diabangouaya P, Picard C, Liu T, Liang JB, Vassilev I, Galupa R, Servant N, Barillot E, Surani A, Chen CJ, Heard E.

Nat Struct Mol Biol. 2017 Mar;24(3):226-233. doi: 10.1038/nsmb.3365. Epub 2017 Jan 30.


Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells.

Xu J, Carter AC, Gendrel AV, Attia M, Loftus J, Greenleaf WJ, Tibshirani R, Heard E, Chang HY.

Nat Genet. 2017 Mar;49(3):377-386. doi: 10.1038/ng.3769. Epub 2017 Jan 23. Erratum in: Nat Genet. 2017 May 26;49(6):970.


XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development.

Vallot C, Patrat C, Collier AJ, Huret C, Casanova M, Liyakat Ali TM, Tosolini M, Frydman N, Heard E, Rugg-Gunn PJ, Rougeulle C.

Cell Stem Cell. 2017 Jan 5;20(1):102-111. doi: 10.1016/j.stem.2016.10.014. Epub 2016 Dec 15.


Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders.

Shah RR, Cholewa-Waclaw J, Davies FCJ, Paton KM, Chaligne R, Heard E, Abbott CM, Bird AP.

Wellcome Open Res. 2016 Nov 15;1:13. doi: 10.12688/wellcomeopenres.10011.1.


Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N.

Nat Commun. 2016 Nov 28;7:13661. doi: 10.1038/ncomms13661.


3D solutions to complex gene regulation.

Heard E.

Nat Rev Mol Cell Biol. 2016 Nov 21;17(12):739. doi: 10.1038/nrm.2016.154. No abstract available.


Closing the loop: 3C versus DNA FISH.

Giorgetti L, Heard E.

Genome Biol. 2016 Oct 19;17(1):215. Review.


Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes.

Mulugeta E, Wassenaar E, Sleddens-Linkels E, van IJcken WF, Heard E, Grootegoed JA, Just W, Gribnau J, Baarends WM.

Genome Res. 2016 Sep;26(9):1202-10. doi: 10.1101/gr.201665.115. Epub 2016 Aug 10.


Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.

Cantone I, Bagci H, Dormann D, Dharmalingam G, Nesterova T, Brockdorff N, Rougeulle C, Vallot C, Heard E, Chaligne R, Merkenschlager M, Fisher AG.

Nat Commun. 2016 Aug 10;7:12354. doi: 10.1038/ncomms12354.


LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation.

Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E.

Cell. 2016 Jul 28;166(3):782. doi: 10.1016/j.cell.2016.07.013. No abstract available.


Structural organization of the inactive X chromosome in the mouse.

Giorgetti L, Lajoie BR, Carter AC, Attia M, Zhan Y, Xu J, Chen CJ, Kaplan N, Chang HY, Heard E, Dekker J.

Nature. 2016 Jul 28;535(7613):575-9. Epub 2016 Jul 18.


Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation.

Gendrel AV, Marion-Poll L, Katoh K, Heard E.

Semin Cell Dev Biol. 2016 Aug;56:100-110. doi: 10.1016/j.semcdb.2016.04.007. Epub 2016 Apr 19. Review.


Structural Fluctuations of the Chromatin Fiber within Topologically Associating Domains.

Tiana G, Amitai A, Pollex T, Piolot T, Holcman D, Heard E, Giorgetti L.

Biophys J. 2016 Mar 29;110(6):1234-45. doi: 10.1016/j.bpj.2016.02.003.


Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation.

Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseño-Roa L, Liu T, Metzger E, Servant N, Barillot E, Chen CJ, Schüle R, Heard E.

Elife. 2016 Feb 2;5. pii: e08851. doi: 10.7554/eLife.08851.


Culture X: addressing barriers to physical activity in Samoa.

Heard EM, Auvaa L, Conway BA.

Health Promot Int. 2017 Aug 1;32(4):734-742. doi: 10.1093/heapro/dav119.


HiC-Pro: an optimized and flexible pipeline for Hi-C data processing.

Servant N, Varoquaux N, Lajoie BR, Viara E, Chen CJ, Vert JP, Heard E, Dekker J, Barillot E.

Genome Biol. 2015 Dec 1;16:259. doi: 10.1186/s13059-015-0831-x.


Structural and functional diversity of Topologically Associating Domains.

Dekker J, Heard E.

FEBS Lett. 2015 Oct 7;589(20 Pt A):2877-84. doi: 10.1016/j.febslet.2015.08.044. Epub 2015 Sep 5. Review.


[The legacy of Mary F. Lyon (1925-2014)].

Guénet JL, Panthier JJ, Avner P, Heard E, Montagutelli X.

Med Sci (Paris). 2015 Jun-Jul;31(6-7):687-9. doi: 10.1051/medsci/20153106024. Epub 2015 Jul 7. French. No abstract available.


X-chromosome inactivation: new insights into cis and trans regulation.

Galupa R, Heard E.

Curr Opin Genet Dev. 2015 Apr;31:57-66. doi: 10.1016/j.gde.2015.04.002. Epub 2015 May 22. Review.


Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells.

Ciaudo C, Jay F, Okamoto I, Chen CJ, Sarazin A, Servant N, Barillot E, Heard E, Voinnet O.

PLoS Genet. 2015 May 14;11(5):e1005247. doi: 10.1371/journal.pgen.1005247. eCollection 2015 May. No abstract available.

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