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Items: 1 to 50 of 76

1.

MEN1-related PanNETs: identifying unmet clinical needs and future directives.

Pieterman CRC, Sadowski SM, Maxwell JE, Katz MHG, Lines KE, Heaphy CM, Tirosh A, Blau JE, Perrier N, Lewis MA, Metzcar JP, Halperin DM, Thakker RV, Valk GD.

Endocr Relat Cancer. 2020 Feb 1. pii: ERC-19-0441.R1. doi: 10.1530/ERC-19-0441. [Epub ahead of print] Review.

PMID:
32069215
2.

Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas.

Felsenstein M, Trujillo MA, Huang B, Nanda N, Jiang Z, Jeong YJ, Pflüger M, Goggins MG, Hruban RH, Thompson ED, Heaphy CM, Roberts NJ, Wood LD.

Lab Invest. 2020 Jan 31. doi: 10.1038/s41374-020-0372-0. [Epub ahead of print]

PMID:
32005909
3.

High Extratumoral Mast Cell Counts Are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes.

Hempel Sullivan H, Heaphy CM, Kulac I, Cuka N, Lu J, Barber JR, De Marzo AM, Lotan TL, Joshu CE, Sfanos KS.

Cancer Epidemiol Biomarkers Prev. 2020 Jan 13. doi: 10.1158/1055-9965.EPI-19-0962. [Epub ahead of print]

PMID:
31932412
4.

Racial Difference in Prostate Cancer Cell Telomere Lengths in Men with Higher Grade Prostate Cancer: A Clue to the Racial Disparity in Prostate Cancer Outcomes.

Heaphy CM, Joshu CE, Barber JR, Davis C, Zarinshenas R, De Marzo AM, Lotan TL, Sfanos KS, Meeker AK, Platz EA.

Cancer Epidemiol Biomarkers Prev. 2020 Jan 8. doi: 10.1158/1055-9965.EPI-19-1462. [Epub ahead of print]

PMID:
31915143
5.

Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration.

Hackeng WM, Morsink FHM, Moons LMG, Heaphy CM, Offerhaus GJA, Dreijerink KMA, Brosens LAA.

Diagn Cytopathol. 2019 Dec 17. doi: 10.1002/dc.24368. [Epub ahead of print]

PMID:
31846235
6.

Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells.

Graham MK, Kim J, Da J, Brosnan-Cashman JA, Rizzo A, Baena Del Valle JA, Chia L, Rubenstein M, Davis C, Zheng Q, Cope L, Considine M, Haffner MC, De Marzo AM, Meeker AK, Heaphy CM.

Mol Cancer Res. 2019 Dec;17(12):2480-2491. doi: 10.1158/1541-7786.MCR-19-0654. Epub 2019 Oct 14.

PMID:
31611308
7.

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.

Tomasetti C, Poling J, Roberts NJ, London NR Jr, Pittman ME, Haffner MC, Rizzo A, Baras A, Karim B, Kim A, Heaphy CM, Meeker AK, Hruban RH, Iacobuzio-Donahue CA, Vogelstein B.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20482-20488. doi: 10.1073/pnas.1905722116. Epub 2019 Sep 23.

PMID:
31548407
8.

Surviving Telomere Attrition with the MiDAS Touch.

Flynn RL, Heaphy CM.

Trends Genet. 2019 Nov;35(11):783-785. doi: 10.1016/j.tig.2019.08.008. Epub 2019 Sep 13.

PMID:
31526614
9.

Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors.

Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA.

Nat Med. 2019 Oct;25(10):1627. doi: 10.1038/s41591-019-0573-5.

PMID:
31501535
10.

Telomere alterations in neurofibromatosis type 1-associated solid tumors.

Rodriguez FJ, Graham MK, Brosnan-Cashman JA, Barber JR, Davis C, Vizcaino MA, Palsgrove DN, Giannini C, Pekmezci M, Dahiya S, Gokden M, Noë M, Wood LD, Pratilas CA, Morris CD, Belzberg A, Blakeley J, Heaphy CM.

Acta Neuropathol Commun. 2019 Aug 28;7(1):139. doi: 10.1186/s40478-019-0792-5.

11.

Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.

Zarif JC, Baena-Del Valle JA, Hicks JL, Heaphy CM, Vidal I, Luo J, Lotan TL, Hooper JE, Isaacs WB, Pienta KJ, De Marzo AM.

Eur Urol Oncol. 2019 Jul;2(4):429-436. doi: 10.1016/j.euo.2018.09.014. Epub 2018 Oct 19.

PMID:
31277779
12.

Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors.

Cejas P, Drier Y, Dreijerink KMA, Brosens LAA, Deshpande V, Epstein CB, Conemans EB, Morsink FHM, Graham MK, Valk GD, Vriens MR, Castillo CF, Ferrone CR, Adar T, Bowden M, Whitton HJ, Da Silva A, Font-Tello A, Long HW, Gaskell E, Shoresh N, Heaphy CM, Sicinska E, Kulke MH, Chung DC, Bernstein BE, Shivdasani RA.

Nat Med. 2019 Aug;25(8):1260-1265. doi: 10.1038/s41591-019-0493-4. Epub 2019 Jul 1. Erratum in: Nat Med. 2019 Oct;25(10):1627.

13.

ATRX Mutations in Pineal Parenchymal Tumors of Intermediate Differentiation.

Martínez H, Nagurney M, Wang ZX, Eberhart CG, Heaphy CM, Curtis MT, Rodriguez FJ.

J Neuropathol Exp Neurol. 2019 May 27. pii: nlz050. doi: 10.1093/jnen/nlz050. [Epub ahead of print]

PMID:
31225581
14.

Analysis of Telomere Lengths in p53 Signatures and Incidental Serous Tubal Intraepithelial Carcinomas Without Concurrent Ovarian Cancer.

Asaka S, Davis C, Lin SF, Wang TL, Heaphy CM, Shih IM.

Am J Surg Pathol. 2019 Aug;43(8):1083-1091. doi: 10.1097/PAS.0000000000001283.

PMID:
31107721
15.

Adding the Team into T1 Translational Research: A Case Study of Multidisciplinary Team Science in the Evaluation of Biomarkers of Prostate Cancer Risk and Prognosis.

Marrone MT, Joshu CE, Peskoe SB, De Marzo AM, Heaphy CM, Lupold SE, Meeker AK, Platz EA.

Clin Chem. 2019 Jan;65(1):189-198. doi: 10.1373/clinchem.2018.293365. Epub 2018 Dec 5.

PMID:
30518666
16.

Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases.

Pea A, Yu J, Marchionni L, Noe M, Luchini C, Pulvirenti A, de Wilde RF, Brosens LA, Rezaee N, Javed A, Gobbo S, Regi P, Salvia R, Bassi C, He J, Weiss MJ, Cameron JL, Offerhaus GJA, Hruban RH, Lawlor RT, Scarpa A, Heaphy CM, Wood LD, Wolfgang CL.

Ann Surg. 2018 Oct 17. doi: 10.1097/SLA.0000000000003022. [Epub ahead of print]

PMID:
30339629
17.

Genetic alterations associated with ALTered telomeres.

Brosnan-Cashman JA, Graham MK, Heaphy CM.

Oncotarget. 2018 Sep 18;9(73):33739-33740. doi: 10.18632/oncotarget.26111. eCollection 2018 Sep 18. No abstract available.

18.

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner.

Brosnan-Cashman JA, Yuan M, Graham MK, Rizzo AJ, Myers KM, Davis C, Zhang R, Esopi DM, Raabe EH, Eberhart CG, Heaphy CM, Meeker AK.

PLoS One. 2018 Sep 18;13(9):e0204159. doi: 10.1371/journal.pone.0204159. eCollection 2018.

19.

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia.

Rodriguez FJ, Brosnan-Cashman JA, Allen SJ, Vizcaino MA, Giannini C, Camelo-Piragua S, Webb M, Matsushita M, Wadhwani N, Tabbarah A, Hamideh D, Jiang L, Chen L, Arvanitis LD, Alnajar HH, Barber JR, Rodríguez-Velasco A, Orr B, Heaphy CM.

Brain Pathol. 2019 Jan;29(1):126-140. doi: 10.1111/bpa.12646. Epub 2018 Oct 17.

20.

Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities.

Trabzonlu L, Kulac I, Zheng Q, Hicks JL, Haffner MC, Nelson WG, Sfanos KS, Ertunc O, Lotan TL, Heaphy CM, Meeker AK, Yegnasubramanian S, De Marzo AM.

Cold Spring Harb Perspect Med. 2019 Apr 1;9(4). pii: a030403. doi: 10.1101/cshperspect.a030403. Review.

PMID:
30082453
21.

Incidentally detected pancreatic neuroendocrine microadenoma with lymph node metastasis.

Kwon JH, Kim HJ, Park DH, Lee YJ, Heaphy CM, Klöppel G, Hruban RH, Hong SM.

Virchows Arch. 2018 Nov;473(5):649-653. doi: 10.1007/s00428-018-2407-0. Epub 2018 Jul 12.

PMID:
30003325
22.

Racial differences in maternal and umbilical cord blood leukocyte telomere length and their correlations.

Weber KA, Heaphy CM, Joshu CE, Lu J, Rohrmann S, Bienstock JL, Agurs-Collins T, Meeker AK, Platz EA.

Cancer Causes Control. 2018 Aug;29(8):759-767. doi: 10.1007/s10552-018-1054-8. Epub 2018 Jul 6.

23.

Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association.

Palsgrove DN, Brosnan-Cashman JA, Giannini C, Raghunathan A, Jentoft M, Bettegowda C, Gokden M, Lin D, Yuan M, Lin MT, Heaphy CM, Rodriguez FJ.

Mod Pathol. 2018 Dec;31(12):1787-1800. doi: 10.1038/s41379-018-0103-x. Epub 2018 Jul 4.

24.

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease.

Bell WR, Meeker AK, Rizzo A, Rajpara S, Rosenthal IM, Flores Bellver M, Aparicio Domingo S, Zhong X, Barber JR, Joshu CE, Canto-Soler MV, Eberhart CG, Heaphy CM.

Brain Pathol. 2019 Jan;29(1):45-52. doi: 10.1111/bpa.12618. Epub 2018 May 23.

PMID:
29668072
25.

Cocaine use may induce telomere shortening in individuals with HIV infection.

Lai S, Heaphy CM, Rizzo AJ, Celentano DD, Gerstenblith G, Li J, Moore RD, Treisman G, Chen S, Foster P, Kickler T, Lai H.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):11-17. doi: 10.1016/j.pnpbp.2018.01.015. Epub 2018 Feb 2.

26.

Current or recent smoking is associated with more variable telomere length in prostate stromal cells and prostate cancer cells.

Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon G, Lee TK, Hicks JL, De Marzo AM, Meeker AK, Platz EA.

Prostate. 2018 Feb;78(3):233-238. doi: 10.1002/pros.23462. Epub 2017 Nov 22.

27.

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer.

Baena-Del Valle JA, Zheng Q, Esopi DM, Rubenstein M, Hubbard GK, Moncaliano MC, Hruszkewycz A, Vaghasia A, Yegnasubramanian S, Wheelan SJ, Meeker AK, Heaphy CM, Graham MK, De Marzo AM.

J Pathol. 2018 Jan;244(1):11-24. doi: 10.1002/path.4980. Epub 2017 Nov 14.

28.

Alternative lengthening of telomeres and ATRX/DAXX loss can be reliably detected in FNAs of pancreatic neuroendocrine tumors.

VandenBussche CJ, Allison DB, Graham MK, Charu V, Lennon AM, Wolfgang CL, Hruban RH, Heaphy CM.

Cancer Cytopathol. 2017 Jul;125(7):544-551. doi: 10.1002/cncy.21857. Epub 2017 Apr 3.

29.

Influence of In Utero Maternal and Neonate Factors on Cord Blood Leukocyte Telomere Length: Clues to the Racial Disparity in Prostate Cancer?

Weber KA, Heaphy CM, Rohrmann S, Gonzalez B, Bienstock JL, Agurs-Collins T, Platz EA, Meeker AK.

Prostate Cancer. 2016;2016:3691650. doi: 10.1155/2016/3691650. Epub 2016 Dec 14.

30.

Absence of Cytomegalovirus in Glioblastoma and Other High-grade Gliomas by Real-time PCR, Immunohistochemistry, and In Situ Hybridization.

Holdhoff M, Guner G, Rodriguez FJ, Hicks JL, Zheng Q, Forman MS, Ye X, Grossman SA, Meeker AK, Heaphy CM, Eberhart CG, De Marzo AM, Arav-Boger R.

Clin Cancer Res. 2017 Jun 15;23(12):3150-3157. doi: 10.1158/1078-0432.CCR-16-1490. Epub 2016 Dec 29.

31.

Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas.

Rodriguez FJ, Vizcaino MA, Blakeley J, Heaphy CM.

Acta Neuropathol. 2016 Nov;132(5):761-763. Epub 2016 Sep 20. No abstract available.

PMID:
27650176
32.

Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival.

Kim JY, Brosnan-Cashman JA, An S, Kim SJ, Song KB, Kim MS, Kim MJ, Hwang DW, Meeker AK, Yu E, Kim SC, Hruban RH, Heaphy CM, Hong SM.

Clin Cancer Res. 2017 Mar 15;23(6):1598-1606. doi: 10.1158/1078-0432.CCR-16-1147. Epub 2016 Sep 23.

33.

Aberrant Menin expression is an early event in pancreatic neuroendocrine tumorigenesis.

Hackeng WM, Brosens LA, Poruk KE, Noë M, Hosoda W, Poling JS, Rizzo A, Campbell-Thompson M, Atkinson MA, Konukiewitz B, Klöppel G, Heaphy CM, Meeker AK, Wood LD.

Hum Pathol. 2016 Oct;56:93-100. doi: 10.1016/j.humpath.2016.06.006. Epub 2016 Jun 21.

PMID:
27342911
34.

High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors.

Shekhani MT, Barber JR, Bezerra SM, Heaphy CM, Gonzalez Roibon ND, Taheri D, Reis LO, Guner G, Joshu CE, Netto GJ, Meeker AK.

Hum Pathol. 2016 Aug;54:106-12. doi: 10.1016/j.humpath.2016.03.015. Epub 2016 Apr 13.

PMID:
27085557
35.

Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.

Suryo Rahmanto Y, Jung JG, Wu RC, Kobayashi Y, Heaphy CM, Meeker AK, Wang TL, Shih IeM.

J Biol Chem. 2016 Apr 29;291(18):9690-9. doi: 10.1074/jbc.M115.707612. Epub 2016 Mar 7.

36.

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy.

Bodelon C, Heaphy CM, Meeker AK, Geller B, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP, Patel DA, Brinton LA, Sherman ME, Gierach GL.

BMC Cancer. 2015 Oct 30;15:823. doi: 10.1186/s12885-015-1860-2.

37.

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes.

Cochran RL, Cidado J, Kim M, Zabransky DJ, Croessmann S, Chu D, Wong HY, Beaver JA, Cravero K, Erlanger B, Parsons H, Heaphy CM, Meeker AK, Lauring J, Park BH.

Oncotarget. 2015 Sep 22;6(28):25240-51. doi: 10.18632/oncotarget.4595.

38.

Visualization of Telomere Integrity and Function In Vitro and In Vivo Using Immunofluorescence Techniques.

Cesare AJ, Heaphy CM, O'Sullivan RJ.

Curr Protoc Cytom. 2015 Jul 1;73:12.40.1-12.40.31. doi: 10.1002/0471142956.cy1240s73.

39.

Telomere length alterations unique to invasive lobular carcinoma.

Heaphy CM, Asch-Kendrick R, Argani P, Meeker AK, Cimino-Mathews A.

Hum Pathol. 2015 Aug;46(8):1197-203. doi: 10.1016/j.humpath.2015.05.001. Epub 2015 May 22.

PMID:
26092192
40.

Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells.

Joshu CE, Peskoe SB, Heaphy CM, Kenfield SA, Van Blarigan EL, Mucci LA, Giovannucci EL, Stampfer MJ, Yoon G, Lee TK, Hicks JL, De Marzo AM, Meeker AK, Platz EA.

Cancer Prev Res (Phila). 2015 Aug;8(8):737-42. doi: 10.1158/1940-6207.CAPR-15-0097. Epub 2015 May 19.

41.

Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial.

Heaphy CM, Gaonkar G, Peskoe SB, Joshu CE, De Marzo AM, Lucia MS, Goodman PJ, Lippman SM, Thompson IM Jr, Platz EA, Meeker AK.

Prostate. 2015 Aug 1;75(11):1160-6. doi: 10.1002/pros.22997. Epub 2015 Apr 20.

42.

Circulating leukocyte telomere length and risk of overall and aggressive prostate cancer.

Julin B, Shui I, Heaphy CM, Joshu CE, Meeker AK, Giovannucci E, De Vivo I, Platz EA.

Br J Cancer. 2015 Feb 17;112(4):769-76. doi: 10.1038/bjc.2014.640. Epub 2015 Jan 6.

43.

Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases.

Dogeas E, Karagkounis G, Heaphy CM, Hirose K, Pawlik TM, Wolfgang CL, Meeker A, Hruban RH, Cameron JL, Choti MA.

J Am Coll Surg. 2014 Apr;218(4):628-35. doi: 10.1016/j.jamcollsurg.2014.01.001. Epub 2014 Jan 10.

44.

Telomere length as a risk factor for hereditary prostate cancer.

Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA, Meeker AK.

Prostate. 2014 Apr;74(4):359-64. doi: 10.1002/pros.22755. Epub 2013 Nov 28.

45.

Tracking the clonal origin of lethal prostate cancer.

Haffner MC, Mosbruger T, Esopi DM, Fedor H, Heaphy CM, Walker DA, Adejola N, Gürel M, Hicks J, Meeker AK, Halushka MK, Simons JW, Isaacs WB, De Marzo AM, Nelson WG, Yegnasubramanian S.

J Clin Invest. 2013 Nov;123(11):4918-22. doi: 10.1172/JCI70354. Epub 2013 Oct 25.

46.

A glioblastoma neurosphere line with alternative lengthening of telomeres.

Heaphy CM, Schreck KC, Raabe E, Mao XG, An P, Chu Q, Poh W, Jiao Y, Rodriguez FJ, Odia Y, Meeker AK, Eberhart CG.

Acta Neuropathol. 2013 Oct;126(4):607-8. No abstract available.

47.

Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death.

Heaphy CM, Yoon GS, Peskoe SB, Joshu CE, Lee TK, Giovannucci E, Mucci LA, Kenfield SA, Stampfer MJ, Hicks JL, De Marzo AM, Platz EA, Meeker AK.

Cancer Discov. 2013 Oct;3(10):1130-41. doi: 10.1158/2159-8290.CD-13-0135. Epub 2013 Jun 18.

48.

Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features.

Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS.

Mod Pathol. 2013 Dec;26(12):1586-93. doi: 10.1038/modpathol.2013.68. Epub 2013 May 3.

49.

Coordinate regulation between expression levels of telomere-binding proteins and telomere length in breast carcinomas.

Butler KS, Hines WC, Heaphy CM, Griffith JK.

Cancer Med. 2012 Oct;1(2):165-75. doi: 10.1002/cam4.14. Epub 2012 Jul 24.

50.

Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression.

Garcia-Rizo C, Fernandez-Egea E, Miller BJ, Oliveira C, Justicia A, Griffith JK, Heaphy CM, Bernardo M, Kirkpatrick B.

Brain Behav Immun. 2013 Feb;28:49-53. doi: 10.1016/j.bbi.2012.11.009. Epub 2012 Dec 1.

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