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Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE.

Nat Biomed Eng. 2018 Dec;2(12):955-967. doi: 10.1038/s41551-018-0280-4. Epub 2018 Sep 10.


New Molecular Scaffolds for Fluorescent Voltage Indicators.

Boggess SC, Gandhi SS, Siemons BA, Huebsch N, Healy KE, Miller EW.

ACS Chem Biol. 2019 Mar 15;14(3):390-396. doi: 10.1021/acschembio.8b00978. Epub 2019 Feb 8.


Matrix-assisted cell transplantation for tissue vascularization.

Browne S, Healy KE.

Adv Drug Deliv Rev. 2018 Dec 31. pii: S0169-409X(18)30320-X. doi: 10.1016/j.addr.2018.12.016. [Epub ahead of print] Review.


A combined hiPSC-derived endothelial cell and in vitro microfluidic platform for assessing biomaterial-based angiogenesis.

Natividad-Diaz SL, Browne S, Jha AK, Ma Z, Hossainy S, Kurokawa YK, George SC, Healy KE.

Biomaterials. 2019 Feb;194:73-83. doi: 10.1016/j.biomaterials.2018.11.032. Epub 2018 Nov 28.


Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.

Tveito A, Jæger KH, Huebsch N, Charrez B, Edwards AG, Wall S, Healy KE.

Sci Rep. 2018 Dec 4;8(1):17626. doi: 10.1038/s41598-018-35858-7.


Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.

Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S.

Biotechnol Bioeng. 2018 Aug;115(8):1958-1970. doi: 10.1002/bit.26709. Epub 2018 Apr 27.


Multivalent conjugates of basic fibroblast growth factor enhance in vitro proliferation and migration of endothelial cells.

Zbinden A, Browne S, Altiok EI, Svedlund FL, Jackson WM, Healy KE.

Biomater Sci. 2018 May 1;6(5):1076-1083. doi: 10.1039/c7bm01052d.


TGF-β1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels.

Browne S, Jha AK, Ameri K, Marcus SG, Yeghiazarians Y, Healy KE.

PLoS One. 2018 Mar 22;13(3):e0194679. doi: 10.1371/journal.pone.0194679. eCollection 2018.


Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.

Giannobile WV, Chai Y, Chen Y, Healy KE, Klein O, Lane N, Longaker MT, Lotz JC, Mooney DJ, Sfeir CS, Urata M, Wagner WR, Wu BM, Kohn DH.

J Dent Res. 2018 Apr;97(4):361-363. doi: 10.1177/0022034518761346. No abstract available.


Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.

Hoang P, Wang J, Conklin BR, Healy KE, Ma Z.

Nat Protoc. 2018 Apr;13(4):723-737. doi: 10.1038/nprot.2018.006. Epub 2018 Mar 15.


Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues.

Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A.

Cell Metab. 2018 Mar 6;27(3):602-615.e4. doi: 10.1016/j.cmet.2018.02.005.


Gellan Gum Hydrogels with Enzyme-Sensitive Biodegradation and Endothelial Cell Biorecognition Sites.

da Silva LP, Jha AK, Correlo VM, Marques AP, Reis RL, Healy KE.

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201700686. Epub 2018 Feb 1.


Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.

Povsic TJ, Scott R, Mahaffey KW, Blaustein R, Edelberg JM, Lefkowitz MP, Solomon SD, Fox JC, Healy KE, Khakoo AY, Losordo DW, Malik FI, Monia BP, Montgomery RL, Riesmeyer J, Schwartz GG, Zelenkofske SL, Wu JC, Wasserman SM, Roe MT.

Cardiovasc Drugs Ther. 2017 Aug;31(4):445-458. doi: 10.1007/s10557-017-6739-9. Review.


WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue.

Loskill P, Sezhian T, Tharp KM, Lee-Montiel FT, Jeeawoody S, Reese WM, Zushin PH, Stahl A, Healy KE.

Lab Chip. 2017 May 2;17(9):1645-1654. doi: 10.1039/c6lc01590e.


A Bioengineering Approach to Myopia Control Tested in a Guinea Pig Model.

Garcia MB, Jha AK, Healy KE, Wildsoet CF.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1875-1886. doi: 10.1167/iovs.16-20694.


Drug-eluting biodegradable ureteral stent: New approach for urothelial tumors of upper urinary tract cancer.

Barros AA, Browne S, Oliveira C, Lima E, Duarte AR, Healy KE, Reis RL.

Int J Pharm. 2016 Nov 20;513(1-2):227-237. doi: 10.1016/j.ijpharm.2016.08.061. Epub 2016 Aug 31.


Branching Analysis of Multivalent Conjugates Using Size Exclusion Chromatography-Multiangle Light Scattering.

Svedlund FL, Altiok EI, Healy KE.

Biomacromolecules. 2016 Oct 10;17(10):3162-3171. Epub 2016 Sep 12.


sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo.

Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan MF, Healy KE.

PLoS One. 2016 Jun 3;11(6):e0155990. doi: 10.1371/journal.pone.0155990. eCollection 2016.


Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Huebsch N, Loskill P, Deveshwar N, Spencer CI, Judge LM, Mandegar MA, Fox CB, Mohamed TM, Ma Z, Mathur A, Sheehan AM, Truong A, Saxton M, Yoo J, Srivastava D, Desai TA, So PL, Healy KE, Conklin BR.

Sci Rep. 2016 Apr 20;6:24726. doi: 10.1038/srep24726.


Multivalent hyaluronic acid bioconjugates improve sFlt-1 activity in vitro.

Altiok EI, Santiago-Ortiz JL, Svedlund FL, Zbinden A, Jha AK, Bhatnagar D, Loskill P, Jackson WM, Schaffer DV, Healy KE.

Biomaterials. 2016 Jul;93:95-105. doi: 10.1016/j.biomaterials.2016.03.017. Epub 2016 Mar 12.


Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration.

Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE.

Biomaterials. 2016 May;89:136-47. doi: 10.1016/j.biomaterials.2016.02.023. Epub 2016 Mar 3.


μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips.

Loskill P, Marcus SG, Mathur A, Reese WM, Healy KE.

PLoS One. 2015 Oct 6;10(10):e0139587. doi: 10.1371/journal.pone.0139587. eCollection 2015.


In vitro cardiac tissue models: Current status and future prospects.

Mathur A, Ma Z, Loskill P, Jeeawoody S, Healy KE.

Adv Drug Deliv Rev. 2016 Jan 15;96:203-13. doi: 10.1016/j.addr.2015.09.011. Epub 2015 Sep 30. Review.


Matrix-Assisted Transplantation of Functional Beige Adipose Tissue.

Tharp KM, Jha AK, Kraiczy J, Yesian A, Karateev G, Sinisi R, Dubikovskaya EA, Healy KE, Stahl A.

Diabetes. 2015 Nov;64(11):3713-24. doi: 10.2337/db15-0728. Epub 2015 Aug 20.


Directing cell migration and organization via nanocrater-patterned cell-repellent interfaces.

Jeon H, Koo S, Reese WM, Loskill P, Grigoropoulos CP, Healy KE.

Nat Mater. 2015 Sep;14(9):918-23. doi: 10.1038/nmat4342. Epub 2015 Jul 27.


Self-organizing human cardiac microchambers mediated by geometric confinement.

Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE.

Nat Commun. 2015 Jul 14;6:7413. doi: 10.1038/ncomms8413.


Multivalent Conjugates of Sonic Hedgehog Accelerate Diabetic Wound Healing.

Han BW, Layman H, Rode NA, Conway A, Schaffer DV, Boudreau NJ, Jackson WM, Healy KE.

Tissue Eng Part A. 2015 Sep;21(17-18):2366-78. doi: 10.1089/ten.TEA.2014.0281.


Low Fouling Electrospun Scaffolds with Clicked Bioactive Peptides for Specific Cell Attachment.

Rodda AE, Ercole F, Glattauer V, Gardiner J, Nisbet DR, Healy KE, Forsythe JS, Meagher L.

Biomacromolecules. 2015 Jul 13;16(7):2109-18. doi: 10.1021/acs.biomac.5b00483. Epub 2015 Jun 10.


Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate.

Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE.

J Control Release. 2015 Jul 10;209:308-16. doi: 10.1016/j.jconrel.2015.04.034. Epub 2015 Apr 27.


Human iPSC-based cardiac microphysiological system for drug screening applications.

Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE.

Sci Rep. 2015 Mar 9;5:8883. doi: 10.1038/srep08883.


Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels.

Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE.

Biomaterials. 2015 Apr;47:1-12. doi: 10.1016/j.biomaterials.2014.12.043. Epub 2015 Jan 22.


Why regenerative medicine needs an extracellular matrix.

Prestwich GD, Healy KE.

Expert Opin Biol Ther. 2015 Jan;15(1):3-7. doi: 10.1517/14712598.2015.975200.


Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, Healy KE.

Tissue Eng Part C Methods. 2015 May;21(5):467-79. doi: 10.1089/ten.TEC.2014.0283. Epub 2015 Jan 14.


Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia.

Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, January CT, Healy KE, Kamp TJ, Yamanaka S, Conklin BR.

Stem Cell Reports. 2014 Aug 12;3(2):269-81. doi: 10.1016/j.stemcr.2014.06.003. Epub 2014 Jul 4.


Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels.

Jha AK, Jackson WM, Healy KE.

PLoS One. 2014 Jun 17;9(6):e98640. doi: 10.1371/journal.pone.0098640. eCollection 2014.


Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development.

Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE.

Stem Cell Res Ther. 2013;4 Suppl 1:S14. doi: 10.1186/scrt375. Epub 2013 Dec 20. Review.


Physiologically relevant organs on chips.

Yum K, Hong SG, Healy KE, Lee LP.

Biotechnol J. 2014 Jan;9(1):16-27. doi: 10.1002/biot.201300187. Epub 2013 Dec 4. Review.


Three-dimensional filamentous human diseased cardiac tissue model.

Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE.

Biomaterials. 2014 Feb;35(5):1367-77. doi: 10.1016/j.biomaterials.2013.10.052. Epub 2013 Nov 21.


The effect of multivalent Sonic hedgehog on differentiation of human embryonic stem cells into dopaminergic and GABAergic neurons.

Vazin T, Ashton RS, Conway A, Rode NA, Lee SM, Bravo V, Healy KE, Kane RS, Schaffer DV.

Biomaterials. 2014 Jan;35(3):941-8. doi: 10.1016/j.biomaterials.2013.10.025. Epub 2013 Oct 27.


Multivalent ligands control stem cell behaviour in vitro and in vivo.

Conway A, Vazin T, Spelke DP, Rode NA, Healy KE, Kane RS, Schaffer DV.

Nat Nanotechnol. 2013 Nov;8(11):831-8. doi: 10.1038/nnano.2013.205. Epub 2013 Oct 20.


Engineering the emergence of stem cell therapeutics.

Healy KE, McDevitt TC, Murphy WL, Nerem RM.

Sci Transl Med. 2013 Oct 16;5(207):207ed17. doi: 10.1126/scitranslmed.3007609. No abstract available.


Effect of avidin-like proteins and biotin modification on mesenchymal stem cell adhesion.

Schmidt RC, Healy KE.

Biomaterials. 2013 May;34(15):3758-62. doi: 10.1016/j.biomaterials.2013.01.081. Epub 2013 Feb 27.


Molecular characterization of multivalent bioconjugates by size-exclusion chromatography with multiangle laser light scattering.

Pollock JF, Ashton RS, Rode NA, Schaffer DV, Healy KE.

Bioconjug Chem. 2012 Sep 19;23(9):1794-801. Epub 2012 Aug 23.


Engineered polymer-media interfaces for the long-term self-renewal of human embryonic stem cells.

Irwin EF, Gupta R, Dashti DC, Healy KE.

Biomaterials. 2011 Oct;32(29):6912-9. doi: 10.1016/j.biomaterials.2011.05.058. Epub 2011 Jul 20.


Chemical patterning of ultrathin polymer films by direct-write multiphoton lithography.

Jeon H, Schmidt R, Barton JE, Hwang DJ, Gamble LJ, Castner DG, Grigoropoulos CP, Healy KE.

J Am Chem Soc. 2011 Apr 27;133(16):6138-41. doi: 10.1021/ja200313q. Epub 2011 Mar 31.


Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Pope WH, Jacobs-Sera D, Russell DA, Peebles CL, Al-Atrache Z, Alcoser TA, Alexander LM, Alfano MB, Alford ST, Amy NE, Anderson MD, Anderson AG, Ang AA, Ares M Jr, Barber AJ, Barker LP, Barrett JM, Barshop WD, Bauerle CM, Bayles IM, Belfield KL, Best AA, Borjon A Jr, Bowman CA, Boyer CA, Bradley KW, Bradley VA, Broadway LN, Budwal K, Busby KN, Campbell IW, Campbell AM, Carey A, Caruso SM, Chew RD, Cockburn CL, Cohen LB, Corajod JM, Cresawn SG, Davis KR, Deng L, Denver DR, Dixon BR, Ekram S, Elgin SC, Engelsen AE, English BE, Erb ML, Estrada C, Filliger LZ, Findley AM, Forbes L, Forsyth MH, Fox TM, Fritz MJ, Garcia R, George ZD, Georges AE, Gissendanner CR, Goff S, Goldstein R, Gordon KC, Green RD, Guerra SL, Guiney-Olsen KR, Guiza BG, Haghighat L, Hagopian GV, Harmon CJ, Harmson JS, Hartzog GA, Harvey SE, He S, He KJ, Healy KE, Higinbotham ER, Hildebrandt EN, Ho JH, Hogan GM, Hohenstein VG, Holz NA, Huang VJ, Hufford EL, Hynes PM, Jackson AS, Jansen EC, Jarvik J, Jasinto PG, Jordan TC, Kasza T, Katelyn MA, Kelsey JS, Kerrigan LA, Khaw D, Kim J, Knutter JZ, Ko CC, Larkin GV, Laroche JR, Latif A, Leuba KD, Leuba SI, Lewis LO, Loesser-Casey KE, Long CA, Lopez AJ, Lowery N, Lu TQ, Mac V, Masters IR, McCloud JJ, McDonough MJ, Medenbach AJ, Menon A, Miller R, Morgan BK, Ng PC, Nguyen E, Nguyen KT, Nguyen ET, Nicholson KM, Parnell LA, Peirce CE, Perz AM, Peterson LJ, Pferdehirt RE, Philip SV, Pogliano K, Pogliano J, Polley T, Puopolo EJ, Rabinowitz HS, Resiss MJ, Rhyan CN, Robinson YM, Rodriguez LL, Rose AC, Rubin JD, Ruby JA, Saha MS, Sandoz JW, Savitskaya J, Schipper DJ, Schnitzler CE, Schott AR, Segal JB, Shaffer CD, Sheldon KE, Shepard EM, Shepardson JW, Shroff MK, Simmons JM, Simms EF, Simpson BM, Sinclair KM, Sjoholm RL, Slette IJ, Spaulding BC, Straub CL, Stukey J, Sughrue T, Tang TY, Tatyana LM, Taylor SB, Taylor BJ, Temple LM, Thompson JV, Tokarz MP, Trapani SE, Troum AP, Tsay J, Tubbs AT, Walton JM, Wang DH, Wang H, Warner JR, Weisser EG, Wendler SC, Weston-Hafer KA, Whelan HM, Williamson KE, Willis AN, Wirtshafter HS, Wong TW, Wu P, Yang Yj, Yee BC, Zaidins DA, Zhang B, Zúniga MY, Hendrix RW, Hatfull GF.

PLoS One. 2011 Jan 27;6(1):e16329. doi: 10.1371/journal.pone.0016329.


Surface creasing instability of soft polyacrylamide cell culture substrates.

Saha K, Kim J, Irwin E, Yoon J, Momin F, Trujillo V, Schaffer DV, Healy KE, Hayward RC.

Biophys J. 2010 Dec 15;99(12):L94-6. doi: 10.1016/j.bpj.2010.09.045.


Exploiting bacterial peptide display technology to engineer biomaterials for neural stem cell culture.

Little LE, Dane KY, Daugherty PS, Healy KE, Schaffer DV.

Biomaterials. 2011 Feb;32(6):1484-94. doi: 10.1016/j.biomaterials.2010.10.032. Epub 2010 Dec 3.


Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration.

Wise JK, Sena K, Vranizan K, Pollock JF, Healy KE, Hughes WF, Sumner DR, Virdi AS.

PLoS One. 2010 Oct 1;5(10). pii: e12987. doi: 10.1371/journal.pone.0012987.


Complementary and alternative medicine use among cancer survivors: a population-based study.

Mao JJ, Palmer CS, Healy KE, Desai K, Amsterdam J.

J Cancer Surviv. 2011 Mar;5(1):8-17. doi: 10.1007/s11764-010-0153-7. Epub 2010 Oct 6.

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