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Letter to the Editor on "A Meta-Analysis of Outcomes in Total Hip Arthroplasty Recipients Following Pelvic Irradiation".

Christ AB, Healey JH, Fabbri N.

J Arthroplasty. 2019 Sep 20. pii: S0883-5403(19)30907-6. doi: 10.1016/j.arth.2019.09.024. [Epub ahead of print] No abstract available.


A Molecular Study of Synovial Chondromatosis.

Agaram NP, Zhang L, Dickson BC, Swanson D, Sung YS, Panicek DM, Hameed M, Healey JH, Antonescu CR.

Genes Chromosomes Cancer. 2019 Oct 7. doi: 10.1002/gcc.22812. [Epub ahead of print]


Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial.

Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators.

Lancet. 2019 Aug 10;394(10197):478-487. doi: 10.1016/S0140-6736(19)30764-0. Epub 2019 Jun 19.


Clinical Genomic Sequencing of Pediatric and Adult Osteosarcoma Reveals Distinct Molecular Subsets with Potentially Targetable Alterations.

Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, Jungbluth AA, Frosina D, Slotkin E, Shukla N, Meyers P, Healey JH, Hameed M, Ladanyi M.

Clin Cancer Res. 2019 Jun 7. doi: 10.1158/1078-0432.CCR-18-4032. [Epub ahead of print]


Should the Use of Biologic Agents in Patients With Renal and Lung Cancer Affect Our Surgical Management of Femoral Metastases?

Gutowski CJ, Zmistowski B, Fabbri N, Boland PJ, Healey JH.

Clin Orthop Relat Res. 2019 Apr;477(4):707-714. doi: 10.1097/CORR.0000000000000434.


Editorial Comment: 2017 Musculoskeletal Tumor Society Proceedings.

Healey JH.

Clin Orthop Relat Res. 2019 Apr;477(4):705-706. doi: 10.1097/CORR.0000000000000653. No abstract available.


Editorial Comment: Selected Proceedings of ISOLS 2017.

Healey JH.

Clin Orthop Relat Res. 2018 Sep;476(9):1717-1718. doi: 10.1097/CORR.0000000000000420. No abstract available.


Low dose radiotherapy is associated with local complications but not disease control in sacral chordoma.

Houdek MT, Rose PS, Hevesi M, Schwab JH, Griffin AM, Healey JH, Petersen IA, DeLaney TF, Chung PW, Yaszemski MJ, Wunder JS, Hornicek FJ, Boland PJ, Sim FH, Ferguson PC; Other Members of the Sacral Tumor Society.

J Surg Oncol. 2019 Jun;119(7):856-863. doi: 10.1002/jso.25399. Epub 2019 Feb 7.


The measurement of physical functioning among patients with Tenosynovial Giant Cell Tumor (TGCT) using the Patient-Reported Outcomes Measurement Information System (PROMIS).

Gelhorn HL, Ye X, Speck RM, Tong S, Healey JH, Bukata SV, Lackman RD, Murray L, Maclaine G, Lenderking WR, Hsu HH, Lin PS, Tap WD.

J Patient Rep Outcomes. 2019 Feb 4;3(1):6. doi: 10.1186/s41687-019-0099-0.


Chemotherapy Curtails Bone Formation From Compliant Compression Fixation of Distal Femoral Endoprostheses.

Elalfy MA, Boland PJ, Healey JH.

Clin Orthop Relat Res. 2019 Jan;477(1):206-216. doi: 10.1097/CORR.0000000000000512.


Discovery of a periosteal stem cell mediating intramembranous bone formation.

Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, Shim JH, Hameed M, Healey JH, Bostrom MP, Landau DA, Greenblatt MB.

Nature. 2018 Oct;562(7725):133-139. doi: 10.1038/s41586-018-0554-8. Epub 2018 Sep 24.


CORR Insights®: Can Machine-learning Techniques Be Used for 5-year Survival Prediction of Patients With Chondrosarcoma?

Healey JH.

Clin Orthop Relat Res. 2018 Oct;476(10):2049-2051. doi: 10.1097/CORR.0000000000000474. No abstract available.


Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.


HPMA-Copolymer Nanocarrier Targets Tumor-Associated Macrophages in Primary and Metastatic Breast Cancer.

Zimel MN, Horowitz CB, Rajasekhar VK, Christ AB, Wei X, Wu J, Wojnarowicz PM, Wang D, Goldring SR, Purdue PE, Healey JH.

Mol Cancer Ther. 2017 Dec;16(12):2701-2710. doi: 10.1158/1535-7163.MCT-15-0995. Epub 2017 Aug 22.


Tumor Xenografts of Human Clear Cell Renal Cell Carcinoma But Not Corresponding Cell Lines Recapitulate Clinical Response to Sunitinib: Feasibility of Using Biopsy Samples.

Dong Y, Manley BJ, Becerra MF, Redzematovic A, Casuscelli J, Tennenbaum DM, Reznik E, Han S, Benfante N, Chen YB, Arcila ME, Aras O, Voss MH, Feldman DR, Motzer RJ, Fabbri N, Healey JH, Boland PJ, Chawla M, Durack JC, Lee CH, Coleman JA, Russo P, Hakimi AA, Cheng EH, Hsieh JJ.

Eur Urol Focus. 2017 Dec;3(6):590-598. doi: 10.1016/j.euf.2016.08.005. Epub 2016 Aug 25.


Pathologically Benign Lymph Nodes Can Mimic Malignancy on Imaging in Patients With Angiomatoid Fibrous Histiocytoma.

Ulaner GA, Healey JH, Athanasian EA.

Clin Orthop Relat Res. 2017 Sep;475(9):2274-2279. doi: 10.1007/s11999-017-5388-4. Epub 2017 May 23.


CORR Insights®: Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone.

Healey JH.

Clin Orthop Relat Res. 2017 Jun;475(6):1664-1667. doi: 10.1007/s11999-017-5292-y. Epub 2017 Feb 27. No abstract available.


Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles.

Sansone P, Berishaj M, Rajasekhar VK, Ceccarelli C, Chang Q, Strillacci A, Savini C, Shapiro L, Bowman RL, Mastroleo C, De Carolis S, Daly L, Benito-Martin A, Perna F, Fabbri N, Healey JH, Spisni E, Cricca M, Lyden D, Bonafé M, Bromberg J.

Cancer Res. 2017 Apr 15;77(8):1927-1941. doi: 10.1158/0008-5472.CAN-16-2129. Epub 2017 Feb 15. Erratum in: Cancer Res. 2017 Oct 1;77(19):5438.


Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma.

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN, Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M.

Nat Commun. 2017 Feb 13;8:14292. doi: 10.1038/ncomms14292.


FDG PET/CT Assesses the Risk of Femoral Pathological Fractures in Patients With Metastatic Breast Cancer.

Ulaner GA, Zindman AM, Zheng J, Kim TW, Healey JH.

Clin Nucl Med. 2017 Apr;42(4):264-270. doi: 10.1097/RLU.0000000000001580.


Can We Estimate Short- and Intermediate-term Survival in Patients Undergoing Surgery for Metastatic Bone Disease?

Forsberg JA, Wedin R, Boland PJ, Healey JH.

Clin Orthop Relat Res. 2017 Apr;475(4):1252-1261. doi: 10.1007/s11999-016-5187-3. Epub 2016 Dec 1.


Editorial Comment: Symposium: 2015 Meetings of the Musculoskeletal Tumor Society and the International Society of Limb Salvage.

Healey JH.

Clin Orthop Relat Res. 2017 Mar;475(3):604-606. doi: 10.1007/s11999-016-5170-z. Epub 2016 Nov 28. No abstract available.


What questionnaires to use when measuring quality of life in sacral tumor patients: the updated sacral tumor survey.

van Wulfften Palthe ODR, Janssen SJ, Wunder JS, Ferguson PC, Wei G, Rose PS, Yaszemski MJ, Sim FH, Boland PJ, Healey JH, Hornicek FJ, Schwab JH.

Spine J. 2017 May;17(5):636-644. doi: 10.1016/j.spinee.2016.11.004. Epub 2016 Nov 14.


Regorafenib: efficacy in multiple refractory sarcoma types.

Healey JH.

Lancet Oncol. 2016 Dec;17(12):1633-1634. doi: 10.1016/S1470-2045(16)30509-5. Epub 2016 Oct 14. No abstract available.


Direct Repair of the Superior Band of Bigelow's Ligament After Hip Arthroplasty: a Surgical Technique.

Liu J, McLawhorn AS, Christ AB, Dzenis P, Healey JH.

HSS J. 2016 Jul;12(2):165-9. doi: 10.1007/s11420-015-9485-1. Epub 2016 Mar 3.


Local Control Modality and Outcome for Ewing Sarcoma of the Femur: A Report From the Children's Oncology Group.

Daw NC, Laack NN, McIlvaine EJ, Krailo M, Womer RB, Granowetter L, Grier HE, Marina NM, Bernstein ML, Gebhardt MC, Marcus KJ, Advani SM, Healey JH, Letson GD, Gorlick RG, Randall RL.

Ann Surg Oncol. 2016 Oct;23(11):3541-3547. doi: 10.1245/s10434-016-5269-1. Epub 2016 May 23.


Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia.

Maybody M, Grewal RK, Healey JH, Antonescu CR, Fanchon L, Hwang S, Carrasquillo JA, Kirov A, Farooki A.

Cardiovasc Intervent Radiol. 2016 Sep;39(9):1352-7. doi: 10.1007/s00270-016-1350-1. Epub 2016 May 5.


Patient-reported Symptoms of Tenosynovial Giant Cell Tumors.

Gelhorn HL, Tong S, McQuarrie K, Vernon C, Hanlon J, Maclaine G, Lenderking W, Ye X, Speck RM, Lackman RD, Bukata SV, Healey JH, Keedy VL, Anthony SP, Wagner AJ, Von Hoff DD, Singh AS, Becerra CR, Hsu HH, Lin PS, Tap WD.

Clin Ther. 2016 Apr;38(4):778-93. doi: 10.1016/j.clinthera.2016.03.008. Epub 2016 Apr 1.


Pedicled Latissimus Dorsi Flap for Shoulder Soft-Tissue Reconstruction After Excision of a Musculoskeletal Neoplasm.

Engdahl R, Disa J, Athanasian EA, Healey JH, Cordeiro PG, Fabbri N.

JBJS Essent Surg Tech. 2016 Apr-Jun;6(2). pii: e16. doi: 10.2106/JBJS.ST.16.00002. Epub 2016 Apr 27. No abstract available.


How Does the Level of Nerve Root Resection in En Bloc Sacrectomy Influence Patient-Reported Outcomes?

van Wulfften Palthe OD, Houdek MT, Rose PS, Yaszemski MJ, Sim FH, Boland PJ, Healey JH, Hornicek FJ, Schwab JH.

Clin Orthop Relat Res. 2017 Mar;475(3):607-616. doi: 10.1007/s11999-016-4794-3.


Has the Level of Evidence of Podium Presentations at the Musculoskeletal Tumor Society Annual Meeting Changed Over Time?

Lerman DM, Cable MG, Thornley P, Evaniew N, Slobogean GP, Bhandari M, Healey JH, Randall RL, Ghert M.

Clin Orthop Relat Res. 2017 Mar;475(3):853-860. doi: 10.1007/s11999-016-4763-x.


Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.

Sansone P, Ceccarelli C, Berishaj M, Chang Q, Rajasekhar VK, Perna F, Bowman RL, Vidone M, Daly L, Nnoli J, Santini D, Taffurelli M, Shih NN, Feldman M, Mao JJ, Colameco C, Chen J, DeMichele A, Fabbri N, Healey JH, Cricca M, Gasparre G, Lyden D, Bonafé M, Bromberg J.

Nat Commun. 2016 Feb 9;7:10442. doi: 10.1038/ncomms10442.


Prosthetic-Joint-Associated Bordetella holmesii Infection.

Humphrey JM, Lacaille SN, Patel K, Thompson E, Tulumba S, Healey JH, Gilhuley KA, Babady NE, Kamboj M, Mead PA.

Open Forum Infect Dis. 2015 Nov 13;2(4):ofv169. doi: 10.1093/ofid/ofv169. eCollection 2015 Dec.


Editorial Comment: 2014 Musculoskeletal Tumor Society.

Healey JH.

Clin Orthop Relat Res. 2016 Mar;474(3):640-2. doi: 10.1007/s11999-015-4622-1. No abstract available.


Tumour exosome integrins determine organotropic metastasis.

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D.

Nature. 2015 Nov 19;527(7578):329-35. doi: 10.1038/nature15756. Epub 2015 Oct 28.


Conservative surgery in the treatment of giant cell tumor of the sacrum: 35 years' experience.

Domovitov SV, Chandhanayingyong C, Boland PJ, McKeown DG, Healey JH.

J Neurosurg Spine. 2016 Feb;24(2):228-240. doi: 10.3171/2015.4.SPINE13215. Epub 2015 Oct 30.


Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma.

Yang R, Piperdi S, Zhang Y, Zhu Z, Neophytou N, Hoang BH, Mason G, Geller D, Dorfman H, Meyers PA, Healey JH, Phinney DG, Gorlick R.

Clin Orthop Relat Res. 2016 Jan;474(1):178-89.


A Phase Ib/II Study of Gemcitabine and Docetaxel in Combination With Pazopanib for the Neoadjuvant Treatment of Soft Tissue Sarcomas.

Munhoz RR, D'Angelo SP, Gounder MM, Keohan ML, Chi P, Carvajal RD, Singer S, Crago AM, Landa J, Healey JH, Qin LX, Hameed M, Ezeoke MO, Singh AS, Agulnik M, Chmielowski B, Luke JJ, Van Tine BA, Schwartz GK, Tap WD, Dickson MA.

Oncologist. 2015 Nov;20(11):1245-6. doi: 10.1634/theoncologist.2015-0245. Epub 2015 Oct 8.


Intensified Chemotherapy With Dexrazoxane Cardioprotection in Newly Diagnosed Nonmetastatic Osteosarcoma: A Report From the Children's Oncology Group.

Schwartz CL, Wexler LH, Krailo MD, Teot LA, Devidas M, Steinherz LJ, Goorin AM, Gebhardt MC, Healey JH, Sato JK, Meyers PA, Grier HE, Bernstein ML, Lipshultz SE.

Pediatr Blood Cancer. 2016 Jan;63(1):54-61. doi: 10.1002/pbc.25753. Epub 2015 Sep 23.


Revision Distal Femoral Arthroplasty With the Compress(®) Prosthesis Has a Low Rate of Mechanical Failure at 10 Years.

Zimel MN, Farfalli GL, Zindman AM, Riedel ER, Morris CD, Boland PJ, Healey JH.

Clin Orthop Relat Res. 2016 Feb;474(2):528-36. doi: 10.1007/s11999-015-4552-y. Epub 2015 Sep 22.


Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

Tap WD, Wainberg ZA, Anthony SP, Ibrahim PN, Zhang C, Healey JH, Chmielowski B, Staddon AP, Cohn AL, Shapiro GI, Keedy VL, Singh AS, Puzanov I, Kwak EL, Wagner AJ, Von Hoff DD, Weiss GJ, Ramanathan RK, Zhang J, Habets G, Zhang Y, Burton EA, Visor G, Sanftner L, Severson P, Nguyen H, Kim MJ, Marimuthu A, Tsang G, Shellooe R, Gee C, West BL, Hirth P, Nolop K, van de Rijn M, Hsu HH, Peterfy C, Lin PS, Tong-Starksen S, Bollag G.

N Engl J Med. 2015 Jul 30;373(5):428-37. doi: 10.1056/NEJMoa1411366.


Obituary: A Remembrance of Franklin Theodore Hoaglund MD (1930-2014).

Healey JH.

Clin Orthop Relat Res. 2015 Sep;473(9):3067-9. doi: 10.1007/s11999-015-4397-4. Epub 2015 Jun 16. No abstract available.


Editorial Comment: Symposium: Sex Differences in Musculoskeletal Disease and Science.

Jepsen KJ, Lane NE, Healey JH, Tosi LL.

Clin Orthop Relat Res. 2015 Aug;473(8):2474-8. doi: 10.1007/s11999-015-4368-9. No abstract available.


How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease-decision analysis and comparison of three international patient populations.

Piccioli A, Spinelli MS, Forsberg JA, Wedin R, Healey JH, Ippolito V, Daolio PA, Ruggieri P, Maccauro G, Gasbarrini A, Biagini R, Piana R, Fazioli F, Luzzati A, Di Martino A, Nicolosi F, Camnasio F, Rosa MA, Campanacci DA, Denaro V, Capanna R.

BMC Cancer. 2015 May 22;15:424. doi: 10.1186/s12885-015-1396-5.


Carbon fiber intramedullary nails reduce artifact in postoperative advanced imaging.

Zimel MN, Hwang S, Riedel ER, Healey JH.

Skeletal Radiol. 2015 Sep;44(9):1317-25. doi: 10.1007/s00256-015-2158-9. Epub 2015 May 17.


Ewing sarcoma in adults treated with modern radiotherapy techniques.

Casey DL, Meyers PA, Alektiar KM, Magnan H, Healey JH, Boland PJ, Wolden SL.

Radiother Oncol. 2014 Nov;113(2):248-53. doi: 10.1016/j.radonc.2014.11.023. Epub 2014 Nov 26.


Editorial comment: 2013 meetings of the Musculoskeletal Tumor Society and the International Society of Limb Salvage.

Healey JH.

Clin Orthop Relat Res. 2015 Mar;473(3):794-5. doi: 10.1007/s11999-014-4087-7. No abstract available.


Comparative evaluation of local control strategies in localized Ewing sarcoma of bone: a report from the Children's Oncology Group.

DuBois SG, Krailo MD, Gebhardt MC, Donaldson SS, Marcus KJ, Dormans J, Shamberger RC, Sailer S, Nicholas RW, Healey JH, Tarbell NJ, Randall RL, Devidas M, Meyer JS, Granowetter L, Womer RB, Bernstein M, Marina N, Grier HE.

Cancer. 2015 Feb 1;121(3):467-75. doi: 10.1002/cncr.29065. Epub 2014 Sep 23.


EWSR1-PBX3: a novel gene fusion in myoepithelial tumors.

Agaram NP, Chen HW, Zhang L, Sung YS, Panicek D, Healey JH, Nielsen GP, Fletcher CD, Antonescu CR.

Genes Chromosomes Cancer. 2015 Feb;54(2):63-71. doi: 10.1002/gcc.22216. Epub 2014 Sep 18.

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