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New Paradigm of Live Surgical Education: Synchronized Deferred Live Surgery.

Knol J, Bonjer J, Houben B, Wexner SD, Hompes R, Atallah S, Heald RJ, Sietses C, Chadi SA.

J Am Coll Surg. 2018 Oct;227(4):467-473. doi: 10.1016/j.jamcollsurg.2018.07.660. Epub 2018 Aug 14. No abstract available.


Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos.

Willsey HR, Walentek P, Exner CRT, Xu Y, Lane AB, Harland RM, Heald R, Santama N.

Dev Biol. 2018 Oct 15;442(2):276-287. doi: 10.1016/j.ydbio.2018.08.002. Epub 2018 Aug 8.


A Surgical Plane: Now 'Holy' In 4 Specialties.

Heald RJ.

Dis Colon Rectum. 2018 Sep;61(9):1003-1009. doi: 10.1097/DCR.0000000000001179. No abstract available.


The Use of Cell-Free Xenopus Extracts to Investigate Cytoplasmic Events.

Gibeaux R, Heald R.

Cold Spring Harb Protoc. 2018 Jul 6. doi: 10.1101/pdb.top097048. [Epub ahead of print]


The Future of Rectal Cancer Surgery: A Narrative Review of an International Symposium.

de Lacy FB, Chadi SA, Berho M, Heald RJ, Khan J, Moran B, Panis Y, Perez R, Tekkis P, Mortensen NJ, Lacy AM, Wexner SD, Chand M.

Surg Innov. 2018 Oct;25(5):525-535. doi: 10.1177/1553350618781227. Epub 2018 Jun 14.


A personal perspective of the development of MRI for Total Mesorectal Excision surgery.

Heald RJ.

Colorectal Dis. 2018 May;20 Suppl 1:8-11. doi: 10.1111/codi.14069.


The Incredible Shrinking Spindle.

Brownlee C, Heald R.

Dev Cell. 2018 May 21;45(4):421-423. doi: 10.1016/j.devcel.2018.05.007.


Standardized approach to robotic right colectomy - a video vignette.

Vieira P, Tayyab M, Domingos H, Cunha J, Heald R, Figueiredo N, Parvaiz A.

Colorectal Dis. 2018 Sep;20(9):827-828. doi: 10.1111/codi.14263. Epub 2018 Jun 12. No abstract available.


Oncological and Survival Outcomes in Watch and Wait Patients With a Clinical Complete Response After Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Systematic Review and Pooled Analysis.

Dattani M, Heald RJ, Goussous G, Broadhurst J, São Julião GP, Habr-Gama A, Perez RO, Moran BJ.

Ann Surg. 2018 Dec;268(6):955-967. doi: 10.1097/SLA.0000000000002761.


A lab co-op helps young faculty members to thrive.

Heald R.

Nature. 2018 Apr;556(7702):409. doi: 10.1038/d41586-018-04923-6. No abstract available.


Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis.

Kitaoka M, Heald R, Gibeaux R.

Cytoskeleton (Hoboken). 2018 Jun;75(6):244-257. doi: 10.1002/cm.21444. Epub 2018 Apr 17.


Subcellular scaling: does size matter for cell division?

Heald R, Gibeaux R.

Curr Opin Cell Biol. 2018 Jun;52:88-95. doi: 10.1016/ Epub 2018 Feb 28. Review.


Preparation of Cellular Extracts from Xenopus Eggs and Embryos.

Good MC, Heald R.

Cold Spring Harb Protoc. 2018 Jun 1;2018(6):pdb.prot097055. doi: 10.1101/pdb.prot097055.


Delaying surgery after neoadjuvant chemoradiotherapy in rectal cancer has no influence in surgical approach or short-term clinical outcomes.

Figueiredo N, Panteleimonitis S, Popeskou S, Cunha JF, Qureshi T, Beets GL, Heald RJ, Parvaiz A.

Eur J Surg Oncol. 2018 Apr;44(4):484-489. doi: 10.1016/j.ejso.2018.01.088. Epub 2018 Feb 2.


Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R.

Nature. 2018 Jan 18;553(7688):337-341. doi: 10.1038/nature25188. Epub 2018 Jan 10.


The Perfect Total Mesorectal Excision Obviates the Need for Anything Else in the Management of Most Rectal Cancers.

Heald RJ, Santiago I, Pares O, Carvalho C, Figueiredo N.

Clin Colon Rectal Surg. 2017 Nov;30(5):324-332. doi: 10.1055/s-0037-1606109. Epub 2017 Nov 27. Review.


Regulatory remodeling in the allo-tetraploid frog Xenopus laevis.

Elurbe DM, Paranjpe SS, Georgiou G, van Kruijsbergen I, Bogdanovic O, Gibeaux R, Heald R, Lister R, Huynen MA, van Heeringen SJ, Veenstra GJC.

Genome Biol. 2017 Oct 24;18(1):198. doi: 10.1186/s13059-017-1335-7.


Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.

Safina BS, Elliott RL, Forrest AK, Heald RA, Murray JM, Nonomiya J, Pang J, Salphati L, Seward EM, Staben ST, Ultsch M, Wei B, Yang W, Sutherlin DP.

ACS Med Chem Lett. 2017 Aug 25;8(9):936-940. doi: 10.1021/acsmedchemlett.7b00170. eCollection 2017 Sep 14.


A DNA Crosslinker Collects Mitotic Chromosomes.

Sun M, Heald R.

Dev Cell. 2017 Sep 11;42(5):440-442. doi: 10.1016/j.devcel.2017.08.010.


Tailored-made robotic abdominoperineal resection, using the da Vinci Xi, for a regrowth of rectal tumour after complete clinical response - a video vignette.

Panteleimonitis S, Ahmed J, Popeskou SG, Figueiredo N, Qureshi T, Heald RJ, Parvaiz A.

Colorectal Dis. 2017 Jul;19(7):696-697. doi: 10.1111/codi.13725. No abstract available.


Physician Courtesy and Patient Satisfaction in a Pediatric Plastic and Oral Surgery Department.

Daniels KM, Yorlets RR, Flath-Sporn SJ, Labow BI, Heald RR, Taghinia AH.

J Healthc Manag. 2017 May/Jun;62(3):211-219. doi: 10.1097/JHM-D-16-00002.


Assessing the Cost of Prophylactic Antibiotic Use After Cleft Lip and Lip Adhesion Procedures.

Daniels KM, Lappi MD, Sporn SF, Caillouette CN, Heald R, Meara JG.

J Healthc Manag. 2016 Jul/Aug;61(4):282-289.


Local Excision Techniques for Rectal Cancer After Neoadjuvant Chemoradiotherapy: What Are We Doing?

Smith FM, Ahad A, Perez RO, Marks J, Bujko K, Heald RJ.

Dis Colon Rectum. 2017 Feb;60(2):228-239. doi: 10.1097/DCR.0000000000000749. Review.


Total Mesorectal Irradiation: The "Next Step" in the Multidisciplinary Management of Rectal Adenocarcinoma?

Pares O, Santiago I, Greco C, Heald R.

Dis Colon Rectum. 2016 Dec;59(12):1222-1226. No abstract available.


Physician Assistants Improve Efficiency and Decrease Costs in Outpatient Oral and Maxillofacial Surgery.

Resnick CM, Daniels KM, Flath-Sporn SJ, Doyle M, Heald R, Padwa BL.

J Oral Maxillofac Surg. 2016 Nov;74(11):2128-2135. doi: 10.1016/j.joms.2016.06.195. Epub 2016 Jul 22.


The mesorectum and mesocolon - Making sense of words.

Dattani M, Santiago I, Mahadevan V, Heald RJ.

Int J Surg. 2016 Dec;36(Pt A):390-391. doi: 10.1016/j.ijsu.2016.09.097. Epub 2016 Oct 15. No abstract available.


Genome evolution in the allotetraploid frog Xenopus laevis.

Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS.

Nature. 2016 Oct 20;538(7625):336-343. doi: 10.1038/nature19840.


Transcription brings the complex(ity) to the centromere.

Grenfell AW, Strzelecka M, Heald R.

Cell Cycle. 2017 Feb;16(3):235-236. doi: 10.1080/15384101.2016.1242962. Epub 2016 Oct 13. No abstract available.


Adjuvant chemotherapy may improve disease-free survival in patients with rectal cancer positive for MRI-detected extramural venous invasion following chemoradiation.

Chand M, Rasheed S, Heald R, Swift I, West N, Rao S, Tekkis P, Brown G.

Colorectal Dis. 2017 Jun;19(6):537-543. doi: 10.1111/codi.13535.


A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery.

Vallance A, Wexner S, Berho M, Cahill R, Coleman M, Haboubi N, Heald RJ, Kennedy RH, Moran B, Mortensen N, Motson RW, Novell R, O'Connell PR, Ris F, Rockall T, Senapati A, Windsor A, Jayne DG.

Colorectal Dis. 2017 Jan;19(1):O1-O12. doi: 10.1111/codi.13534.


Correction: Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.

Grenfell AW, Heald R, Strzelecka M.

J Cell Biol. 2016 Sep 12;214(6):783. doi: 10.1083/jcb.20160402908222016c. Epub 2016 Sep 5. No abstract available.


Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Chan BK, Hanan EJ, Bowman KK, Bryan MC, Burdick D, Chan E, Chen Y, Clausen S, Dela Vega T, Dotson J, Eigenbrot C, Elliott RL, Heald RA, Jackson PS, Knight JD, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Shao L, Wang S, Yeap SK, Yen I, Yu C, Heffron TP.

J Med Chem. 2016 Oct 13;59(19):9080-9093. Epub 2016 Sep 12.


Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.

Grenfell AW, Heald R, Strzelecka M.

J Cell Biol. 2016 Jul 18;214(2):133-41. doi: 10.1083/jcb.201604029. Epub 2016 Jul 11. Erratum in: J Cell Biol. 2016 Sep 12;214(6):783.


Microtubules: 50 years on from the discovery of tubulin.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E.

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45. Review.


An ontogenetic approach to gynecologic malignancies.

Santiago IA, Gomes AP, Heald RJ.

Insights Imaging. 2016 Jun;7(3):329-39. doi: 10.1007/s13244-016-0480-y. Epub 2016 Apr 15. Review.


A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles.

Grenfell AW, Strzelecka M, Crowder ME, Helmke KJ, Schlaitz AL, Heald R.

J Cell Biol. 2016 Apr 11;213(1):127-36. doi: 10.1083/jcb.201509079. Epub 2016 Apr 4.


Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2016 Mar 24;59(6):2848. doi: 10.1021/acs.jmedchem.6b00301. Epub 2016 Mar 11. No abstract available.


Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

Bryan MC, Burdick DJ, Chan BK, Chen Y, Clausen S, Dotson J, Eigenbrot C, Elliott R, Hanan EJ, Heald R, Jackson P, La H, Lainchbury M, Malek S, Mann SE, Purkey HE, Schaefer G, Schmidt S, Seward E, Sideris S, Wang S, Yen I, Yu C, Heffron TP.

ACS Med Chem Lett. 2015 Dec 17;7(1):100-4. doi: 10.1021/acsmedchemlett.5b00428. eCollection 2016 Jan 14.


The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Heffron TP, Heald RA, Ndubaku C, Wei B, Augistin M, Do S, Edgar K, Eigenbrot C, Friedman L, Gancia E, Jackson PS, Jones G, Kolesnikov A, Lee LB, Lesnick JD, Lewis C, McLean N, Mörtl M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L, Sideris S, Staben ST, Steinbacher S, Tsui V, Wallin J, Sampath D, Olivero AG.

J Med Chem. 2016 Feb 11;59(3):985-1002. doi: 10.1021/acs.jmedchem.5b01483. Epub 2016 Jan 20.


Thirty years of search and capture: The complex simplicity of mitotic spindle assembly.

Heald R, Khodjakov A.

J Cell Biol. 2015 Dec 21;211(6):1103-11. doi: 10.1083/jcb.201510015. Epub 2015 Dec 14. Review.


Robotic total mesorectal excision - precision surgery with even more precise tools.

Chand M, Heald RJ, Parvaiz A.

J R Soc Med. 2016 Feb;109(2):78-9. doi: 10.1177/0141076815617695. Epub 2015 Nov 25. No abstract available.


Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2015 Nov 25;58(22):8877-95. doi: 10.1021/acs.jmedchem.5b01412. Epub 2015 Nov 12. Erratum in: J Med Chem. 2016 Mar 24;59(6):2848.


Biological Scaling Problems and Solutions in Amphibians.

Levy DL, Heald R.

Cold Spring Harb Perspect Biol. 2015 Aug 10;8(1):a019166. doi: 10.1101/cshperspect.a019166. Review.


Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening.

Lane AB, Strzelecka M, Ettinger A, Grenfell AW, Wittmann T, Heald R.

Dev Cell. 2015 Aug 10;34(3):373-8. doi: 10.1016/j.devcel.2015.06.003. Epub 2015 Jul 23.


Transanal Total Mesorectal Excision for Rectal Cancer: Outcomes after 140 Patients.

Lacy AM, Tasende MM, Delgado S, Fernandez-Hevia M, Jimenez M, De Lacy B, Castells A, Bravo R, Wexner SD, Heald RJ.

J Am Coll Surg. 2015 Aug;221(2):415-23. doi: 10.1016/j.jamcollsurg.2015.03.046. Epub 2015 Mar 30.


A comparative analysis of spindle morphometrics across metazoans.

Crowder ME, Strzelecka M, Wilbur JD, Good MC, von Dassow G, Heald R.

Curr Biol. 2015 Jun 1;25(11):1542-50. doi: 10.1016/j.cub.2015.04.036. Epub 2015 May 21.


Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.

Miller KE, Heald R.

J Cell Biol. 2015 Apr 27;209(2):211-20. doi: 10.1083/jcb.201412097. Epub 2015 Apr 20.


Structured training in robotic colorectal surgery.

Tou S, Bergamaschi R, Heald RJ, Parvaiz A.

Colorectal Dis. 2015 Mar;17(3):185. doi: 10.1111/codi.12898. No abstract available.


RUVs drive chromosome decondensation after mitosis.

Strzelecka M, Heald R.

Dev Cell. 2014 Nov 10;31(3):259-260. doi: 10.1016/j.devcel.2014.10.018. Epub 2014 Nov 10.


Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.

Hanan EJ, Eigenbrot C, Bryan MC, Burdick DJ, Chan BK, Chen Y, Dotson J, Heald RA, Jackson PS, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Tam C, Wang S, Yeap SK, Yen I, Yin J, Yu C, Zilberleyb I, Heffron TP.

J Med Chem. 2014 Dec 11;57(23):10176-91. doi: 10.1021/jm501578n. Epub 2014 Nov 20.

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