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Items: 32


Development, Characterization, and Standardization of a Nose-Only Inhalation Exposure System for Exposure of Rabbits to Small-Particle Aerosols Containing Francisella tularensis.

O'Malley KJ, Bowling JD, Barry EM, Hazlett KRO, Reed DS.

Infect Immun. 2019 Jul 23;87(8). pii: e00198-19. doi: 10.1128/IAI.00198-19. Print 2019 Aug.


Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.

Sunagar R, Kumar S, Namjoshi P, Rosa SJ, Hazlett KRO, Gosselin EJ.

PLoS One. 2018 Dec 11;13(12):e0207587. doi: 10.1371/journal.pone.0207587. eCollection 2018.


Aerosol prime-boost vaccination provides strong protection in outbred rabbits against virulent type A Francisella tularensis.

O'Malley KJ, Bowling JD, Stinson E, Cole KS, Mann BJ, Namjoshi P, Hazlett KRO, Barry EM, Reed DS.

PLoS One. 2018 Oct 22;13(10):e0205928. doi: 10.1371/journal.pone.0205928. eCollection 2018. Erratum in: PLoS One. 2018 Nov 15;13(11):e0207721.


Differential In Vitro Cultivation of Francisella tularensis Influences Live Vaccine Protective Efficacy by Altering the Immune Response.

Sunagar R, Kumar S, Rosa SJ, Hazlett KRO, Gosselin EJ.

Front Immunol. 2018 Jul 10;9:1594. doi: 10.3389/fimmu.2018.01594. eCollection 2018.


Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence of Ft SchuS4 to Immunized Animals.

Holland KM, Rosa SJ, Kristjansdottir K, Wolfgeher D, Franz BJ, Zarrella TM, Kumar S, Sunagar R, Singh A, Bakshi CS, Namjoshi P, Barry EM, Sellati TJ, Kron SJ, Gosselin EJ, Reed DS, Hazlett KRO.

Front Microbiol. 2017 Jun 22;8:1158. doi: 10.3389/fmicb.2017.01158. eCollection 2017.


Differential Cultivation of Francisella tularensis Induces Changes in the Immune Response to and Protective Efficacy of Whole Cell-Based Inactivated Vaccines.

Kumar S, Sunagar R, Pham G, Franz BJ, Rosa SJ, Hazlett KR, Gosselin EJ.

Front Immunol. 2017 Jan 10;7:677. doi: 10.3389/fimmu.2016.00677. eCollection 2016.


Francisella tularensis - Immune Cell Activator, Suppressor, or Stealthy Evader: The Evolving View from the Petri Dish.

Holland KM, Rosa SJ, Hazlett KR.

J Bioterror Biodef. 2016 Jun;7(2). pii: 144. Epub 2016 Apr 12.


The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.

He L, Nair MKM, Chen Y, Liu X, Zhang M, Hazlett KRO, Deng H, Zhang JR.

Infect Immun. 2016 Apr 22;84(5):1387-1402. doi: 10.1128/IAI.00076-16. Print 2016 May.


Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii.

Pelletier MR, Casella LG, Jones JW, Adams MD, Zurawski DV, Hazlett KR, Doi Y, Ernst RK.

Antimicrob Agents Chemother. 2013 Oct;57(10):4831-40. doi: 10.1128/AAC.00865-13. Epub 2013 Jul 22.


Discordant results obtained with Francisella tularensis during in vitro and in vivo immunological studies are attributable to compromised bacterial structural integrity.

Singh A, Rahman T, Malik M, Hickey AJ, Leifer CA, Hazlett KR, Sellati TJ.

PLoS One. 2013;8(3):e58513. doi: 10.1371/journal.pone.0058513. Epub 2013 Mar 12.


Multiple mechanisms mediate enhanced immunity generated by mAb-inactivated F. tularensis immunogen.

Iglesias BV, Bitsaktsis C, Pham G, Drake JR, Hazlett KR, Porter K, Gosselin EJ.

Immunol Cell Biol. 2013 Feb;91(2):139-48. doi: 10.1038/icb.2012.66. Epub 2012 Dec 18.


The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host.

Eggers CH, Caimano MJ, Malizia RA, Kariu T, Cusack B, Desrosiers DC, Hazlett KR, Claiborne A, Pal U, Radolf JD.

Mol Microbiol. 2011 Nov;82(3):679-97. doi: 10.1111/j.1365-2958.2011.07845.x. Epub 2011 Oct 12.


Identification of Francisella tularensis outer membrane protein A (FopA) as a protective antigen for tularemia.

Hickey AJ, Hazlett KR, Kirimanjeswara GS, Metzger DW.

Vaccine. 2011 Sep 16;29(40):6941-7. doi: 10.1016/j.vaccine.2011.07.075. Epub 2011 Jul 29.


Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity.

Zarrella TM, Singh A, Bitsaktsis C, Rahman T, Sahay B, Feustel PJ, Gosselin EJ, Sellati TJ, Hazlett KR.

PLoS One. 2011;6(7):e22335. doi: 10.1371/journal.pone.0022335. Epub 2011 Jul 22.


Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.

Parsonage D, Desrosiers DC, Hazlett KR, Sun Y, Nelson KJ, Cox DL, Radolf JD, Poole LB.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6240-5. doi: 10.1073/pnas.0910057107. Epub 2010 Mar 19.


Environmental adaptation of Francisella tularensis.

Hazlett KR, Cirillo KA.

Microbes Infect. 2009 Sep;11(10-11):828-34. doi: 10.1016/j.micinf.2009.06.001. Epub 2009 Jun 11. Review.


An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain.

Bakshi CS, Malik M, Mahawar M, Kirimanjeswara GS, Hazlett KR, Palmer LE, Furie MB, Singh R, Melendez JA, Sellati TJ, Metzger DW.

Vaccine. 2008 Sep 26;26(41):5276-88. doi: 10.1016/j.vaccine.2008.07.051. Epub 2008 Aug 8.


Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro.

Hazlett KR, Caldon SD, McArthur DG, Cirillo KA, Kirimanjeswara GS, Magguilli ML, Malik M, Shah A, Broderick S, Golovliov I, Metzger DW, Rajan K, Sellati TJ, Loegering DJ.

Infect Immun. 2008 Oct;76(10):4479-88. doi: 10.1128/IAI.00610-08. Epub 2008 Jul 21.


Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutation.

Banas JA, Miller JD, Fuschino ME, Hazlett KR, Toyofuku W, Porter KA, Reutzel SB, Florczyk MA, McDonough KA, Michalek SM.

Appl Environ Microbiol. 2007 Jan;73(1):357-61. Epub 2006 Nov 3.


TP0453, a concealed outer membrane protein of Treponema pallidum, enhances membrane permeability.

Hazlett KR, Cox DL, Decaffmeyer M, Bennett MP, Desrosiers DC, La Vake CJ, La Vake ME, Bourell KW, Robinson EJ, Brasseur R, Radolf JD.

J Bacteriol. 2005 Sep;187(18):6499-508.


The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase.

Hazlett KR, Rusnak F, Kehres DG, Bearden SW, La Vake CJ, La Vake ME, Maguire ME, Perry RD, Radolf JD.

J Biol Chem. 2003 Jun 6;278(23):20687-94. Epub 2003 Mar 31.


The immune response to infection with Treponema pallidum, the stealth pathogen.

Salazar JC, Hazlett KR, Radolf JD.

Microbes Infect. 2002 Sep;4(11):1133-40. Review.


Contribution of neelaredoxin to oxygen tolerance by Treponema pallidum.

Hazlett KR, Cox DL, Sikkink RA, Auch'ere F, Rusnak F, Radolf JD.

Methods Enzymol. 2002;353:140-56. No abstract available.


The crystal structure of Zn(II)-free Treponema pallidum TroA, a periplasmic metal-binding protein, reveals a closed conformation.

Lee YH, Dorwart MR, Hazlett KR, Deka RK, Norgard MV, Radolf JD, Hasemann CA.

J Bacteriol. 2002 Apr;184(8):2300-4.


The TprK protein of Treponema pallidum is periplasmic and is not a target of opsonic antibody or protective immunity.

Hazlett KR, Sellati TJ, Nguyen TT, Cox DL, Clawson ML, Caimano MJ, Radolf JD.

J Exp Med. 2001 May 7;193(9):1015-26.


Neelaredoxin, an iron-binding protein from the syphilis spirochete, Treponema pallidum, is a superoxide reductase.

Jovanović T, Ascenso C, Hazlett KR, Sikkink R, Krebs C, Litwiller R, Benson LM, Moura I, Moura JJ, Radolf JD, Huynh BH, Naylor S, Rusnak F.

J Biol Chem. 2000 Sep 15;275(37):28439-48.


27 three-dimensional analysis of streptococcus mutans biofilms. The relationship between biofilm structure and sensitivity to a biocide

Mazurkiewicz JE, Hazlett KR, Banas JA.

J Histochem Cytochem. 1999 Dec;47(12):1648D-1649. No abstract available.


Expression of HLA-DR (major histocompatibility complex class II) on neutrophils from patients treated with granulocyte-macrophage colony-stimulating factor for mobilization of stem cells.

Mudzinski SP, Christian TP, Guo TL, Cirenza E, Hazlett KR, Gosselin EJ.

Blood. 1995 Sep 15;86(6):2452-3. No abstract available.


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