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BMJ Case Rep. 2018 Oct 12;2018. pii: bcr-2018-225046. doi: 10.1136/bcr-2018-225046.

Disseminated nocardiosis with infective endocarditis of a transplanted heart.

Author information

1
School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
2
Department of Internal Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Abstract

Nocardiosis is caused by various species of Nocardia and typically occurs as an opportunistic infection. It frequently disseminates, most often involving the lungs, subcutaneous tissues and central nervous system. It has rarely been reported to affect native heart valves. We report the case of a 64-year-old man with disseminated nocardiosis involving the brain, lungs, muscle and tricuspid valve of a transplanted heart. Following antimicrobial therapy, the patient improved clinically and there was no evidence of residual infection on follow-up imaging. This case highlights the presentation of nocardiosis, current therapeutic guidelines and the question of prophylaxis against Nocardia in immunocompromised patients.

KEYWORDS:

TB and other respiratory ionfections; immunology; infection (neurology); transplantation; valvar diseases

PMID:
30317192
PMCID:
PMC6194394
DOI:
10.1136/bcr-2018-225046
[Indexed for MEDLINE]
Free PMC Article

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