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Items: 1 to 50 of 87

1.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

2.

Potential for stem cell treatment in manganism.

de Moura TC, Afadlal S, Hazell AS.

Neurochem Int. 2018 Jan;112:134-145. doi: 10.1016/j.neuint.2017.10.005. Epub 2017 Oct 12.

PMID:
29032009
3.

Acute liver failure is associated with altered cerebral expression profiles of long non-coding RNAs.

Silva VR, Secolin R, Vemuganti R, Lopes-Cendes I, Hazell AS.

Neurosci Lett. 2017 Aug 24;656:58-64. doi: 10.1016/j.neulet.2017.06.038. Epub 2017 Jun 23.

PMID:
28648459
4.

Treatment of rats with the JAK-2 inhibitor fedratinib does not lead to experimental Wernicke's encephalopathy.

Hazell AS, Afadlal S, Cheresh DA, Azar A.

Neurosci Lett. 2017 Mar 6;642:163-167. doi: 10.1016/j.neulet.2017.01.041. Epub 2017 Jan 18.

PMID:
28109775
5.

The Vegetative State and Stem Cells: Therapeutic Considerations.

Hazell AS.

Front Neurol. 2016 Aug 23;7:118. doi: 10.3389/fneur.2016.00118. eCollection 2016. Review.

6.

Erratum to: Acute liver failure-induced hepatic encephalopathy is associated with changes in microRNA expression profiles in cerebral cortex of the mouse.

Vemuganti R, Silva VR, Mehta SL, Hazell AS.

Metab Brain Dis. 2015 Feb;30(1):247. doi: 10.1007/s11011-014-9644-y. No abstract available.

PMID:
25537182
7.

Thiamine deficiency: an update of pathophysiologic mechanisms and future therapeutic considerations.

Abdou E, Hazell AS.

Neurochem Res. 2015 Feb;40(2):353-61. doi: 10.1007/s11064-014-1430-z. Epub 2014 Oct 9. Review.

PMID:
25297573
8.

The application of SHERPA (Systematic Human Error Reduction and Prediction Approach) in the development of compensatory cognitive rehabilitation strategies for stroke patients with left and right brain damage.

Hughes CM, Baber C, Bienkiewicz M, Worthington A, Hazell A, Hermsdörfer J.

Ergonomics. 2015;58(1):75-95. doi: 10.1080/00140139.2014.957735. Epub 2014 Sep 15.

PMID:
25222822
9.

Mechanisms of hepatic encephalopathy and thiamine deficiency.

Vemuganti R, Hazell AS.

Metab Brain Dis. 2014 Dec;29(4):889-90. doi: 10.1007/s11011-014-9579-3. No abstract available.

10.

Role of astrocytes in thiamine deficiency.

Afadlal S, Labetoulle R, Hazell AS.

Metab Brain Dis. 2014 Dec;29(4):1061-8. doi: 10.1007/s11011-014-9571-y. Epub 2014 Jun 15. Review.

PMID:
24929329
11.

Acute liver failure-induced hepatic encephalopathy s associated with changes in microRNA expression rofiles in cerebral cortex of the mouse [corrected].

Vemuganti R, Silva VR, Mehta SL, Hazell AS.

Metab Brain Dis. 2014 Dec;29(4):891-9. doi: 10.1007/s11011-014-9545-0. Epub 2014 May 27. Erratum in: Metab Brain Dis. 2015 Feb;30(1):247.

PMID:
24861182
12.

Thiamine deficiency results in release of soluble factors that disrupt mitochondrial membrane potential and downregulate the glutamate transporter splice-variant GLT-1b in cultured astrocytes.

Jhala SS, Wang D, Hazell AS.

Biochem Biophys Res Commun. 2014 Jun 6;448(3):335-41. doi: 10.1016/j.bbrc.2014.04.017. Epub 2014 Apr 13.

PMID:
24735535
13.

Pyrithiamine-induced thiamine deficiency alters proliferation and neurogenesis in both neurogenic and vulnerable areas of the rat brain.

Hazell AS, Wang D, Oanea R, Sun S, Aghourian M, Yong JJ.

Metab Brain Dis. 2014 Mar;29(1):145-52.

PMID:
24078061
14.

The impact of oxidative stress in thiamine deficiency: a multifactorial targeting issue.

Hazell AS, Faim S, Wertheimer G, Silva VR, Marques CS.

Neurochem Int. 2013 Apr;62(5):796-802. doi: 10.1016/j.neuint.2013.01.009. Epub 2013 Jan 18. Review.

PMID:
23333339
15.

Loss of the glutamate transporter splice-variant GLT-1b in inferior colliculus and its prevention by ceftriaxone in thiamine deficiency.

Jhala SS, Wang D, Hazell AS.

Neurochem Int. 2011 Apr;58(5):558-63. doi: 10.1016/j.neuint.2011.01.014. Epub 2011 Jan 20.

PMID:
21256174
16.

Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism.

Jhala SS, Hazell AS.

Neurochem Int. 2011 Feb;58(3):248-60. doi: 10.1016/j.neuint.2010.11.019. Epub 2010 Dec 3. Review.

PMID:
21130821
17.

Identification of complexin II in astrocytes: a possible regulator of glutamate release in these cells.

Hazell AS, Wang D.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):228-32. doi: 10.1016/j.bbrc.2010.11.098. Epub 2010 Nov 24.

PMID:
21110949
18.

Microglial activation is a major contributor to neurologic dysfunction in thiamine deficiency.

Wang D, Hazell AS.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):123-8. doi: 10.1016/j.bbrc.2010.09.128. Epub 2010 Oct 12.

PMID:
20932820
19.

Up-regulation of caveolin-1 and blood-brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency.

Beauchesne E, Desjardins P, Butterworth RF, Hazell AS.

Neurochem Int. 2010 Dec;57(7):830-7. doi: 10.1016/j.neuint.2010.08.022. Epub 2010 Sep 21.

PMID:
20816907
20.

eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain.

Beauchesne E, Desjardins P, Hazell AS, Butterworth RF.

J Neurochem. 2009 Oct;111(2):452-9. doi: 10.1111/j.1471-4159.2009.06338.x. Epub 2009 Aug 17.

21.

Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain.

Beauchesne E, Desjardins P, Hazell AS, Butterworth RF.

Neurochem Int. 2009 Sep;55(5):275-81. doi: 10.1016/j.neuint.2009.03.014. Epub 2009 Apr 5.

PMID:
19576514
22.

Loss of astrocytic glutamate transporters in Wernicke encephalopathy.

Hazell AS, Sheedy D, Oanea R, Aghourian M, Sun S, Jung JY, Wang D, Wang C.

Glia. 2010 Jan 15;58(2):148-56. doi: 10.1002/glia.20908.

23.

Astrocytes are a major target in thiamine deficiency and Wernicke's encephalopathy.

Hazell AS.

Neurochem Int. 2009 Jul-Aug;55(1-3):129-35. doi: 10.1016/j.neuint.2009.02.020. Epub 2009 Mar 9. Review.

PMID:
19428817
24.

Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation.

Hazell AS, Butterworth RF.

Alcohol Alcohol. 2009 Mar-Apr;44(2):141-7. doi: 10.1093/alcalc/agn120. Epub 2009 Jan 16. Review.

PMID:
19151161
25.

Syntheses, structures, and properties of copper(II) complexes of bis(2-pyridylmethyl) derivatives of o-, m-, and p-phenylenediamine and aniline.

Turba S, Walter O, Schindler S, Nielsen LP, Hazell A, J McKenzie C, Lloret F, Cano J, Julve M.

Inorg Chem. 2008 Oct 20;47(20):9612-23. doi: 10.1021/ic800244g. Epub 2008 Sep 18.

PMID:
18798612
26.

Three overcrowded zinc(II) complexes with potentially hexadentate polypyridyl ligands.

Hazell A, Mønsted O, Rasmussen JC, Toftlund H.

Acta Crystallogr C. 2008 May;64(Pt 5):m185-9. doi: 10.1107/S0108270108007014. Epub 2008 Apr 9.

PMID:
18451470
27.

Nmr spectroscopic analysis of regional brain energy metabolism in manganese neurotoxicity.

Zwingmann C, Leibfritz D, Hazell AS.

Glia. 2007 Nov 15;55(15):1610-7.

PMID:
17823966
28.

Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies.

Hazell AS.

Neurochem Int. 2007 Jun;50(7-8):941-53. Epub 2007 May 10. Review.

PMID:
17576023
29.

Glutamate transporter EAAT4 is increased in hippocampal astrocytes following lateral fluid-percussion injury in the rat.

Yi JH, Herrero R, Chen G, Hazell AS.

Brain Res. 2007 Jun 18;1154:200-5. Epub 2007 Apr 10.

PMID:
17490622
30.

Manganese induces cell swelling in cultured astrocytes.

Rama Rao KV, Reddy PV, Hazell AS, Norenberg MD.

Neurotoxicology. 2007 Jul;28(4):807-12. Epub 2007 Mar 4.

PMID:
17408748
31.

Small outlays yield large benefits.

Hazell A.

Health Estate. 2006 Nov;60(10):70-1. No abstract available.

PMID:
17137163
32.
33.

Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury.

Yi JH, Hazell AS.

Neurochem Int. 2006 Apr;48(5):394-403. Epub 2006 Feb 13. Review.

PMID:
16473439
34.
35.

Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment.

Hazell AS, Normandin L, Norenberg MD, Kennedy G, Yi JH.

Neurosci Lett. 2006 Apr 3;396(3):167-71. Epub 2005 Dec 27.

PMID:
16384640
36.

Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

Bémeur C, Ste-Marie L, Desjardins P, Vachon L, Butterworth RF, Hazell AS, Montgomery J.

Neurochem Int. 2005 Apr;46(5):399-407.

PMID:
15737438
37.
38.

Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy.

Navarro D, Zwingmann C, Hazell AS, Butterworth RF.

J Neurosci Res. 2005 Jan 1-15;79(1-2):33-41.

PMID:
15573405
40.

Aggregation control by homologous tripodal tetradentate amino acid ligands in oxo-bridged diiron(III) aquo complexes.

Mortensen MN, Jensen B, Hazell A, Bond AD, McKenzie CJ.

Dalton Trans. 2004 Oct 21;(20):3396-402. Epub 2004 Sep 14.

PMID:
15483729
42.

Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

Bémeur C, Ste-Marie L, Desjardins P, Butterworth RF, Vachon L, Montgomery J, Hazell AS.

Neurochem Int. 2004 Dec;45(8):1167-74.

PMID:
15380626
43.
44.

Molecular structure and vibrational spectra of spin-crossover complexes in solution and colloidal media: resonance Raman and time-resolved resonance Raman studies.

Brady C, Callaghan PL, Ciunik Z, Coates CG, Døssing A, Hazell A, McGarvey JJ, Schenker S, Toftlund H, Trautwein AX, Winkler H, Wolny JA.

Inorg Chem. 2004 Jul 12;43(14):4289-99.

PMID:
15236542
45.
46.

Decreased beta-actin mRNA expression in hyperglycemic focal cerebral ischemia in the rat.

Bémeur C, Ste-Marie L, Desjardins P, Hazell AS, Vachon L, Butterworth R, Montgomery J.

Neurosci Lett. 2004 Mar 11;357(3):211-4.

PMID:
15003287
47.
48.

Thiamine deficiency results in downregulation of the GLAST glutamate transporter in cultured astrocytes.

Hazell AS, Pannunzio P, Rama Rao KV, Pow DV, Rambaldi A.

Glia. 2003 Aug;43(2):175-84.

PMID:
12838509
50.

Manganese neurotoxicity: an update of pathophysiologic mechanisms.

Normandin L, Hazell AS.

Metab Brain Dis. 2002 Dec;17(4):375-87. Review.

PMID:
12602514

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