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Items: 32


Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction.

Bravo-Merodio L, Acharjee A, Hazeldine J, Bentley C, Foster M, Gkoutos GV, Lord JM.

Sci Data. 2019 Dec 19;6(1):328. doi: 10.1038/s41597-019-0337-6.


Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury.

Dinsdale RJ, Hazeldine J, Al Tarrah K, Hampson P, Devi A, Ermogenous C, Bamford AL, Bishop J, Watts S, Kirkman E, Dalle Lucca JJ, Midwinter M, Woolley T, Foster M, Lord JM, Moiemen N, Harrison P.

Br J Surg. 2019 Sep 10. doi: 10.1002/bjs.11310. [Epub ahead of print]


Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation.

Chimen M, Evryviadou A, Box CL, Harrison MJ, Hazeldine J, Dib LH, Kuravi SJ, Payne H, Price JMJ, Kavanagh D, Iqbal AJ, Lax S, Kalia N, Brill A, Thomas SG, Belli A, Crombie N, Adams RA, Evans SA, Deckmyn H, Lord JM, Harrison P, Watson SP, Nash GB, Rainger GE.

Haematologica. 2019 Aug 29. pii: haematol.2018.215145. doi: 10.3324/haematol.2018.215145. [Epub ahead of print]


Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient.

Bentley C, Hazeldine J, Greig C, Lord J, Foster M.

Burns Trauma. 2019 Aug 2;7:26. doi: 10.1186/s41038-019-0158-z. eCollection 2019. Review.


Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.

Sapey E, Patel JM, Greenwood H, Walton GM, Grudzinska F, Parekh D, Mahida RY, Dancer RCA, Lugg ST, Howells PA, Hazeldine J, Newby P, Scott A, Nightingale P, Hill AT, Thickett DR.

Am J Respir Crit Care Med. 2019 Nov 15;200(10):1282-1293. doi: 10.1164/rccm.201812-2328OC.


Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.

Hazeldine J, Dinsdale RJ, Harrison P, Lord JM.

Front Immunol. 2019 Apr 2;10:685. doi: 10.3389/fimmu.2019.00685. eCollection 2019.


Impact of plasma viscosity on microcirculatory flow after traumatic haemorrhagic shock: A prospective observational study.

Naumann DN, Hazeldine J, Bishop J, Midwinter MJ, Harrison P, Nash G, Hutchings SD.

Clin Hemorheol Microcirc. 2019;71(1):71-82. doi: 10.3233/CH-180397.


Author Correction: Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury.

Hill LJ, Di Pietro V, Hazeldine J, Davies D, Toman E, Logan A, Belli A.

Sci Rep. 2018 Mar 12;8(1):4572. doi: 10.1038/s41598-018-22951-0.


Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study.

Naumann DN, Hazeldine J, Dinsdale RJ, Bishop JR, Midwinter MJ, Harrison P, Hutchings SD, Lord JM.

PLoS One. 2017 Dec 19;12(12):e0189870. doi: 10.1371/journal.pone.0189870. eCollection 2017.


Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study.

Naumann DN, Hazeldine J, Davies DJ, Bishop J, Midwinter MJ, Belli A, Harrison P, Lord JM.

Shock. 2018 Apr;49(4):420-428. doi: 10.1097/SHK.0000000000000999.


Poor microcirculatory flow dynamics are associated with endothelial cell damage and glycocalyx shedding after traumatic hemorrhagic shock.

Naumann DN, Hazeldine J, Midwinter MJ, Hutchings SD, Harrison P.

J Trauma Acute Care Surg. 2018 Jan;84(1):81-88. doi: 10.1097/TA.0000000000001695.


Changes in the pattern of plasma extracellular vesicles after severe trauma.

Kuravi SJ, Yates CM, Foster M, Harrison P, Hazeldine J, Hampson P, Watson C, Belli A, Midwinter M, Nash GB.

PLoS One. 2017 Aug 24;12(8):e0183640. doi: 10.1371/journal.pone.0183640. eCollection 2017.


Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study.

Hazeldine J, Naumann DN, Toman E, Davies D, Bishop JRB, Su Z, Hampson P, Dinsdale RJ, Crombie N, Duggal NA, Harrison P, Belli A, Lord JM.

PLoS Med. 2017 Jul 18;14(7):e1002338. doi: 10.1371/journal.pmed.1002338. eCollection 2017 Jul.


Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury.

Hill LJ, Di Pietro V, Hazeldine J, Davies D, Toman E, Logan A, Belli A.

Sci Rep. 2017 Jul 10;7(1):5002. doi: 10.1038/s41598-017-04722-5. Erratum in: Sci Rep. 2018 Mar 12;8(1):4572.


Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.

Sapey E, Patel JM, Greenwood HL, Walton GM, Hazeldine J, Sadhra C, Parekh D, Dancer RCA, Nightingale P, Lord JM, Thickett DR.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1325-1336. doi: 10.1164/rccm.201704-0814OC.


Changes in novel haematological parameters following thermal injury: A prospective observational cohort study.

Dinsdale RJ, Devi A, Hampson P, Wearn CM, Bamford AL, Hazeldine J, Bishop J, Ahmed S, Watson C, Lord JM, Moiemen N, Harrison P.

Sci Rep. 2017 Jun 12;7(1):3211. doi: 10.1038/s41598-017-03222-w.


MicroRNAs as Novel Biomarkers for the Diagnosis and Prognosis of Mild and Severe Traumatic Brain Injury.

Di Pietro V, Ragusa M, Davies D, Su Z, Hazeldine J, Lazzarino G, Hill LJ, Crombie N, Foster M, Purrello M, Logan A, Belli A.

J Neurotrauma. 2017 Jun 1;34(11):1948-1956. doi: 10.1089/neu.2016.4857. Epub 2017 Apr 10.


Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality.

Bancos I, Hazeldine J, Chortis V, Hampson P, Taylor AE, Lord JM, Arlt W.

Eur J Endocrinol. 2017 Apr;176(4):471-480. doi: 10.1530/EJE-16-0969.


The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review.

Hazeldine J, Hampson P, Lord JM.

Burns Trauma. 2016 Sep 21;4:33. doi: 10.1186/s41038-016-0059-3. eCollection 2016. Review.


Male 11β-HSD1 Knockout Mice Fed Trans-Fats and Fructose Are Not Protected From Metabolic Syndrome or Nonalcoholic Fatty Liver Disease.

Larner DP, Morgan SA, Gathercole LL, Doig CL, Guest P, Weston C, Hazeldine J, Tomlinson JW, Stewart PM, Lavery GG.

Endocrinology. 2016 Sep;157(9):3493-504. doi: 10.1210/en.2016-1357. Epub 2016 Jul 6.


Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study.

Hampson P, Dinsdale RJ, Wearn CM, Bamford AL, Bishop JRB, Hazeldine J, Moiemen NS, Harrison P, Lord JM.

Ann Surg. 2017 Jun;265(6):1241-1249. doi: 10.1097/SLA.0000000000001807.


Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus.

Hazeldine J, Lord JM, Belli A.

Front Neurol. 2015 Nov 5;6:235. doi: 10.3389/fneur.2015.00235. eCollection 2015. Review.


Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient.

Hazeldine J, Lord JM, Hampson P.

Ageing Res Rev. 2015 Nov;24(Pt B):349-57. doi: 10.1016/j.arr.2015.10.003. Epub 2015 Oct 17. Review.


N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways.

Hazeldine J, Hampson P, Opoku FA, Foster M, Lord JM.

Injury. 2015;46(6):975-84. doi: 10.1016/j.injury.2015.03.028. Epub 2015 Mar 17.


The impact of trauma on neutrophil function.

Hazeldine J, Hampson P, Lord JM.

Injury. 2014 Dec;45(12):1824-33. doi: 10.1016/j.injury.2014.06.021. Epub 2014 Jul 1. Review.


Innate immunesenescence: underlying mechanisms and clinical relevance.

Hazeldine J, Lord JM.

Biogerontology. 2015 Apr;16(2):187-201. doi: 10.1007/s10522-014-9514-3. Epub 2014 Jul 10. Review.


Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.

Hazeldine J, Harris P, Chapple IL, Grant M, Greenwood H, Livesey A, Sapey E, Lord JM.

Aging Cell. 2014 Aug;13(4):690-8. doi: 10.1111/acel.12222. Epub 2014 Apr 30.


The impact of ageing on natural killer cell function and potential consequences for health in older adults.

Hazeldine J, Lord JM.

Ageing Res Rev. 2013 Sep;12(4):1069-78. doi: 10.1016/j.arr.2013.04.003. Epub 2013 May 6.


Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease.

Hampson P, Hazeldine J, Lord JM.

Curr Opin Hematol. 2013 Jan;20(1):10-5. doi: 10.1097/MOH.0b013e32835b06be. Review.


Reduced release and binding of perforin at the immunological synapse underlies the age-related decline in natural killer cell cytotoxicity.

Hazeldine J, Hampson P, Lord JM.

Aging Cell. 2012 Oct;11(5):751-9. doi: 10.1111/j.1474-9726.2012.00839.x. Epub 2012 Jun 19.


Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis.

Wang K, Hampson P, Hazeldine J, Krystof V, Strnad M, Pechan P, M J.

PLoS One. 2012;7(1):e30128. doi: 10.1371/journal.pone.0030128. Epub 2012 Jan 19.


Dehydroepiandrosterone as a regulator of immune cell function.

Hazeldine J, Arlt W, Lord JM.

J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):127-36. doi: 10.1016/j.jsbmb.2009.12.016. Epub 2010 Jan 12. Review.


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