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Methyltransferase CheR binds to its chemoreceptor substrates independent of their signaling conformation yet modifies them differentially.

Li M, Hazelbauer GL.

Protein Sci. 2020 Feb;29(2):443-454. doi: 10.1002/pro.3760. Epub 2019 Nov 11.


Spatial Restrictions in Chemotaxis Signaling Arrays: A Role for Chemoreceptor Flexible Hinges across Bacterial Diversity.

Stalla D, Akkaladevi N, White TA, Hazelbauer GL.

Int J Mol Sci. 2019 Jun 19;20(12). pii: E2989. doi: 10.3390/ijms20122989.


A dual regulation mechanism of histidine kinase CheA identified by combining network-dynamics modeling and system-level input-output data.

Mello BA, Pan W, Hazelbauer GL, Tu Y.

PLoS Comput Biol. 2018 Jul 2;14(7):e1006305. doi: 10.1371/journal.pcbi.1006305. eCollection 2018 Jul.


Flexible Hinges in Bacterial Chemoreceptors.

Akkaladevi N, Bunyak F, Stalla D, White TA, Hazelbauer GL.

J Bacteriol. 2018 Feb 7;200(5). pii: e00593-17. doi: 10.1128/JB.00593-17. Print 2018 Mar 1.


Signaling complexes control the chemotaxis kinase by altering its apparent rate constant of autophosphorylation.

Pan W, Dahlquist FW, Hazelbauer GL.

Protein Sci. 2017 Aug;26(8):1535-1546. doi: 10.1002/pro.3179. Epub 2017 May 8.


Bacterial Chemoreceptor Dynamics: Helical Stability in the Cytoplasmic Domain Varies with Functional Segment and Adaptational Modification.

Bartelli NL, Hazelbauer GL.

J Mol Biol. 2016 Sep 25;428(19):3789-804. doi: 10.1016/j.jmb.2016.06.005. Epub 2016 Jun 15.


Differential backbone dynamics of companion helices in the extended helical coiled-coil domain of a bacterial chemoreceptor.

Bartelli NL, Hazelbauer GL.

Protein Sci. 2015 Nov;24(11):1764-76. doi: 10.1002/pro.2767. Epub 2015 Aug 25.


Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.

Parkinson JS, Hazelbauer GL, Falke JJ.

Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub 2015 Mar 30. Review.


Selective allosteric coupling in core chemotaxis signaling complexes.

Li M, Hazelbauer GL.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15940-5. doi: 10.1073/pnas.1415184111. Epub 2014 Oct 27.


Influence of membrane lipid composition on a transmembrane bacterial chemoreceptor.

Amin DN, Hazelbauer GL.

J Biol Chem. 2012 Dec 7;287(50):41697-705. doi: 10.1074/jbc.M112.415588. Epub 2012 Oct 15.


Bacterial chemotaxis: the early years of molecular studies.

Hazelbauer GL.

Annu Rev Microbiol. 2012;66:285-303. doi: 10.1146/annurev-micro-092611-150120. Review.


Microbiology: Adaptation by target remodelling.

Hazelbauer GL.

Nature. 2012 Apr 11;484(7393):173-5. doi: 10.1038/484173a. No abstract available.


Direct evidence that the carboxyl-terminal sequence of a bacterial chemoreceptor is an unstructured linker and enzyme tether.

Bartelli NL, Hazelbauer GL.

Protein Sci. 2011 Nov;20(11):1856-66. doi: 10.1002/pro.719. Epub 2011 Sep 15.


Core unit of chemotaxis signaling complexes.

Li M, Hazelbauer GL.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9390-5. doi: 10.1073/pnas.1104824108. Epub 2011 May 23.


Chemotaxis kinase CheA is activated by three neighbouring chemoreceptor dimers as effectively as by receptor clusters.

Li M, Khursigara CM, Subramaniam S, Hazelbauer GL.

Mol Microbiol. 2011 Feb;79(3):677-85. doi: 10.1111/j.1365-2958.2010.07478.x. Epub 2010 Dec 13.


Chemoreceptors in signalling complexes: shifted conformation and asymmetric coupling.

Amin DN, Hazelbauer GL.

Mol Microbiol. 2010 Dec;78(5):1313-23. doi: 10.1111/j.1365-2958.2010.07408.x. Epub 2010 Oct 12.


Bacterial chemoreceptors: providing enhanced features to two-component signaling.

Hazelbauer GL, Lai WC.

Curr Opin Microbiol. 2010 Apr;13(2):124-32. doi: 10.1016/j.mib.2009.12.014. Epub 2010 Feb 1. Review.


The chemoreceptor dimer is the unit of conformational coupling and transmembrane signaling.

Amin DN, Hazelbauer GL.

J Bacteriol. 2010 Mar;192(5):1193-200. doi: 10.1128/JB.01391-09. Epub 2010 Jan 8.


Molecular modeling of flexible arm-mediated interactions between bacterial chemoreceptors and their modification enzyme.

Muppirala UK, Desensi S, Lybrand TP, Hazelbauer GL, Li Z.

Protein Sci. 2009 Aug;18(8):1702-14. doi: 10.1002/pro.170.


Bacterial chemoreceptors: high-performance signaling in networked arrays.

Hazelbauer GL, Falke JJ, Parkinson JS.

Trends Biochem Sci. 2008 Jan;33(1):9-19. doi: 10.1016/j.tibs.2007.09.014. Epub 2007 Dec 31. Review.


Using Nanodiscs to create water-soluble transmembrane chemoreceptors inserted in lipid bilayers.

Boldog T, Li M, Hazelbauer GL.

Methods Enzymol. 2007;423:317-35.


Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties.

Boldog T, Grimme S, Li M, Sligar SG, Hazelbauer GL.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11509-14. Epub 2006 Jul 24.


The carboxyl-terminal linker is important for chemoreceptor function.

Li M, Hazelbauer GL.

Mol Microbiol. 2006 Apr;60(2):469-79.


Adaptational assistance in clusters of bacterial chemoreceptors.

Li M, Hazelbauer GL.

Mol Microbiol. 2005 Jun;56(6):1617-26.


Clustering requires modified methyl-accepting sites in low-abundance but not high-abundance chemoreceptors of Escherichia coli.

Lybarger SR, Nair U, Lilly AA, Hazelbauer GL, Maddock JR.

Mol Microbiol. 2005 May;56(4):1078-86.


Cellular stoichiometry of the components of the chemotaxis signaling complex.

Li M, Hazelbauer GL.

J Bacteriol. 2004 Jun;186(12):3687-94.


Allosteric enhancement of adaptational demethylation by a carboxyl-terminal sequence on chemoreceptors.

Barnakov AN, Barnakova LA, Hazelbauer GL.

J Biol Chem. 2002 Nov 1;277(44):42151-6. Epub 2002 Aug 23.


Site-directed spin labeling of a bacterial chemoreceptor reveals a dynamic, loosely packed transmembrane domain.

Barnakov A, Altenbach C, Barnakova L, Hubbell WL, Hazelbauer GL.

Protein Sci. 2002 Jun;11(6):1472-81.


Modeling the transmembrane domain of bacterial chemoreceptors.

Peach ML, Hazelbauer GL, Lybrand TP.

Protein Sci. 2002 Apr;11(4):912-23.


Location of the receptor-interaction site on CheB, the methylesterase response regulator of bacterial chemotaxis.

Barnakov AN, Barnakova LA, Hazelbauer GL.

J Biol Chem. 2001 Aug 31;276(35):32984-9. Epub 2001 Jul 2.


Transmembrane signaling in bacterial chemoreceptors.

Falke JJ, Hazelbauer GL.

Trends Biochem Sci. 2001 Apr;26(4):257-65. Review.


Efficient adaptational demethylation of chemoreceptors requires the same enzyme-docking site as efficient methylation.

Barnakov AN, Barnakova LA, Hazelbauer GL.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10667-72.


Mutational analysis of a transmembrane segment in a bacterial chemoreceptor.

Baumgartner JW, Hazelbauer GL.

J Bacteriol. 1996 Aug;178(15):4651-60.


Identification of functionally important helical faces in transmembrane segments by scanning mutagenesis.

Lee GF, Dutton DP, Hazelbauer GL.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5416-20.


Transmembrane signaling characterized in bacterial chemoreceptors by using sulfhydryl cross-linking in vivo.

Lee GF, Lebert MR, Lilly AA, Hazelbauer GL.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3391-5.

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