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Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression Without Virion Production.

Lee J, Kosowicz JG, Hayward SD, Desai P, Stone J, Lee JM, Liu JO, Ambinder RF.

J Virol. 2019 Jul 24. pii: JVI.00998-19. doi: 10.1128/JVI.00998-19. [Epub ahead of print]


Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation.

Kosowicz JG, Lee J, Peiffer B, Guo Z, Chen J, Liao G, Hayward SD, Liu JO, Ambinder RF.

J Virol. 2017 Jul 27;91(16). pii: e00747-17. doi: 10.1128/JVI.00747-17. Print 2017 Aug 15.


Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling.

Li R, Liao G, Nirujogi RS, Pinto SM, Shaw PG, Huang TC, Wan J, Qian J, Gowda H, Wu X, Lv DW, Zhang K, Manda SS, Pandey A, Hayward SD.

PLoS Pathog. 2015 Dec 29;11(12):e1005346. doi: 10.1371/journal.ppat.1005346. eCollection 2015 Dec.


Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation.

Lee HG, Kim H, Kim EJ, Park PG, Dong SM, Choi TH, Kim H, Chong CR, Liu JO, Chen J, Ambinder RF, Hayward SD, Park JH, Lee JM.

Oncotarget. 2015 Oct 13;6(31):31018-29. doi: 10.18632/oncotarget.5041.


A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.

Woodard C, Liao G, Goodwin CR, Hu J, Xie Z, Dos Reis TF, Newman R, Rho H, Qian J, Zhu H, Hayward SD.

J Virol. 2015 Sep;89(18):9232-41. doi: 10.1128/JVI.01072-15. Epub 2015 Jun 24.


Hypermethylation of the interferon regulatory factor 5 promoter in Epstein-Barr virus-associated gastric carcinoma.

Dong SM, Lee HG, Cho SG, Kwon SH, Yoon H, Kwon HJ, Lee JH, Kim H, Park PG, Kim H, Hayward SD, Park JH, Lee JM.

J Microbiol. 2015 Jan;53(1):70-6. doi: 10.1007/s12275-014-4654-3. Epub 2015 Jan 4.


Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.

Woodard CL, Goodwin CR, Wan J, Xia S, Newman R, Hu J, Zhang J, Hayward SD, Qian J, Laterra J, Zhu H.

PLoS One. 2013 Sep 2;8(9):e72671. doi: 10.1371/journal.pone.0072671. eCollection 2013.


Potential of protein kinase inhibitors for treating herpesvirus-associated disease.

Li R, Hayward SD.

Trends Microbiol. 2013 Jun;21(6):286-95. doi: 10.1016/j.tim.2013.03.005. Epub 2013 Apr 19. Review.


Phosphorylation of the chromatin binding domain of KSHV LANA.

Woodard C, Shamay M, Liao G, Zhu J, Ng AN, Li R, Newman R, Rho HS, Hu J, Wan J, Qian J, Zhu H, Hayward SD.

PLoS Pathog. 2012;8(10):e1002972. doi: 10.1371/journal.ppat.1002972. Epub 2012 Oct 18.


SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.

Li R, Wang L, Liao G, Guzzo CM, Matunis MJ, Zhu H, Hayward SD.

J Virol. 2012 May;86(10):5412-21. doi: 10.1128/JVI.00314-12. Epub 2012 Mar 7.


A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.

Shamay M, Liu J, Li R, Liao G, Shen L, Greenway M, Hu S, Zhu J, Xie Z, Ambinder RF, Qian J, Zhu H, Hayward SD.

J Virol. 2012 May;86(9):5179-91. doi: 10.1128/JVI.00169-12. Epub 2012 Feb 29.


Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.

Li R, Zhu J, Xie Z, Liao G, Liu J, Chen MR, Hu S, Woodard C, Lin J, Taverna SD, Desai P, Ambinder RF, Hayward GS, Qian J, Zhu H, Hayward SD.

Cell Host Microbe. 2011 Oct 20;10(4):390-400. doi: 10.1016/j.chom.2011.08.013.


Comparison of humoral immune responses to Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus using a viral proteome microarray.

Zheng D, Wan J, Cho YG, Wang L, Chiou CJ, Pai S, Woodard C, Zhu J, Liao G, Martinez-Maza O, Qian J, Zhu H, Hayward GS, Ambinder RF, Hayward SD.

J Infect Dis. 2011 Dec 1;204(11):1683-91. doi: 10.1093/infdis/jir645. Epub 2011 Oct 11.


The Ying-Yang of the virus-host interaction: control of the DNA damage response.

Li R, Hayward SD.

Future Microbiol. 2011 Apr;6(4):379-83. doi: 10.2217/fmb.11.16.


Bortezomib induction of C/EBPβ mediates Epstein-Barr virus lytic activation in Burkitt lymphoma.

Shirley CM, Chen J, Shamay M, Li H, Zahnow CA, Hayward SD, Ambinder RF.

Blood. 2011 Jun 9;117(23):6297-303. doi: 10.1182/blood-2011-01-332379. Epub 2011 Mar 29.


De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.

Shamay M, Greenway M, Liao G, Ambinder RF, Hayward SD.

J Biol Chem. 2010 Nov 19;285(47):36377-86. doi: 10.1074/jbc.M110.155721. Epub 2010 Sep 16.


Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4.

Zhu J, Liao G, Shan L, Zhang J, Chen MR, Hayward GS, Hayward SD, Desai P, Zhu H.

J Virol. 2009 May;83(10):5219-31. doi: 10.1128/JVI.02378-08. Epub 2009 Feb 25.


Modulation of LMP1 protein expression by EBV-encoded microRNAs.

Lo AK, To KF, Lo KW, Lung RW, Hui JW, Liao G, Hayward SD.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16164-9. Epub 2007 Oct 2.


Molecular piracy: manipulation of the ubiquitin system by Kaposi's sarcoma-associated herpesvirus.

Fujimuro M, Hayward SD, Yokosawa H.

Rev Med Virol. 2007 Nov-Dec;17(6):405-22. Review.


The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-Myc.

Liu J, Martin HJ, Liao G, Hayward SD.

J Virol. 2007 Oct;81(19):10451-9. Epub 2007 Jul 18.


Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus.

Martin HJ, Lee JM, Walls D, Hayward SD.

J Virol. 2007 Sep;81(18):9748-58. Epub 2007 Jul 3.


RNA-binding proteins that inhibit RNA virus infection.

Zhu J, Gopinath K, Murali A, Yi G, Hayward SD, Zhu H, Kao C.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3129-34. Epub 2007 Feb 20.


Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation.

Liu J, Martin H, Shamay M, Woodard C, Tang QQ, Hayward SD.

J Virol. 2007 May;81(9):4722-31. Epub 2007 Feb 21.


Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.

Shamay M, Krithivas A, Zhang J, Hayward SD.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14554-9. Epub 2006 Sep 18.


Notch and Wnt signaling: mimicry and manipulation by gamma herpesviruses.

Hayward SD, Liu J, Fujimuro M.

Sci STKE. 2006 May 16;2006(335):re4. Review.


Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells.

Huang J, Liao G, Chen H, Wu FY, Hutt-Fletcher L, Hayward GS, Hayward SD.

J Virol. 2006 Feb;80(3):1098-109.


Multiplex PCR-based DNA array for simultaneous detection of three human herpesviruses, EVB, CMV and KSHV.

Fujimuro M, Nakaso K, Nakashima K, Sadanari H, Hisanori I, Teishikata Y, Hayward SD, Yokosawa H.

Exp Mol Pathol. 2006 Apr;80(2):124-31. Epub 2005 Nov 18.


p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.

Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A.

Neuron. 2005 Jul 7;47(1):29-41.


S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding.

Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A.

Nat Cell Biol. 2005 Jul;7(7):665-74. Epub 2005 Jun 12.


Regulation of expression of the Epstein-Barr virus BamHI-A rightward transcripts.

Chen H, Huang J, Wu FY, Liao G, Hutt-Fletcher L, Hayward SD.

J Virol. 2005 Feb;79(3):1724-33.


EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli.

Lee JM, Lee KH, Farrell CJ, Ling PD, Kempkes B, Park JH, Hayward SD.

J Virol. 2004 Nov;78(22):12694-7.


MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.

Laduron S, Deplus R, Zhou S, Kholmanskikh O, Godelaine D, De Smet C, Hayward SD, Fuks F, Boon T, De Plaen E.

Nucleic Acids Res. 2004 Aug 17;32(14):4340-50. Print 2004.


Viral interactions with the Notch pathway.

Hayward SD.

Semin Cancer Biol. 2004 Oct;14(5):387-96. Review.


Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide.

Farrell CJ, Lee JM, Shin EC, Cebrat M, Cole PA, Hayward SD.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4625-30. Epub 2004 Mar 19. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13694.


Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.

Fujimuro M, Hayward SD.

J Mol Med (Berl). 2004 Apr;82(4):223-31. Epub 2004 Jan 9. Review.


Lytic viral replication as a contributor to the detection of Epstein-Barr virus in breast cancer.

Huang J, Chen H, Hutt-Fletcher L, Ambinder RF, Hayward SD.

J Virol. 2003 Dec;77(24):13267-74.


A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.

Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD.

Nat Med. 2003 Mar;9(3):300-6. Epub 2003 Feb 18.


CCAAT/enhancer binding protein alpha interacts with ZTA and mediates ZTA-induced p21(CIP-1) accumulation and G(1) cell cycle arrest during the Epstein-Barr virus lytic cycle.

Wu FY, Chen H, Wang SE, ApRhys CM, Liao G, Fujimuro M, Farrell CJ, Huang J, Hayward SD, Hayward GS.

J Virol. 2003 Jan;77(2):1481-500.


Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis.

Lee JM, Lee KH, Weidner M, Osborne BA, Hayward SD.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11878-83. Epub 2002 Aug 23.


A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling.

Hicks C, Ladi E, Lindsell C, Hsieh JJ, Hayward SD, Collazo A, Weinmaster G.

J Neurosci Res. 2002 Jun 15;68(6):655-67.


Properties of two EBV Mta nuclear export signal sequences.

Chen L, Liao G, Fujimuro M, Semmes OJ, Hayward SD.

Virology. 2001 Sep 15;288(1):119-28.


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