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Items: 1 to 50 of 52

1.

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.

Baron DM, Matheny T, Lin YC, Leszyk JD, Kenna K, Gall KV, Santos DP, Tischbein M, Funes S, Hayward LJ, Kiskinis E, Landers JE, Parker R, Shaffer SA, Bosco DA.

Hum Mol Genet. 2019 Jul 1;28(13):2143-2160. doi: 10.1093/hmg/ddz048.

PMID:
30806671
2.

Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

Didiot MC, Ferguson CM, Ly S, Coles AH, Smith AO, Bicknell AA, Hall LM, Sapp E, Echeverria D, Pai AA, DiFiglia M, Moore MJ, Hayward LJ, Aronin N, Khvorova A.

Cell Rep. 2018 Sep 4;24(10):2553-2560.e5. doi: 10.1016/j.celrep.2018.07.106.

3.

Correction: DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves.

Safra N, Hayward LJ, Aguilar M, Sacks BN, Westropp JL, Mohr FC, Mellersh CS, Bannasch DL.

PLoS One. 2018 Apr 10;13(4):e0195924. doi: 10.1371/journal.pone.0195924. eCollection 2018.

4.

ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics.

Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ, Zhu H.

Acta Neuropathol. 2016 Oct;132(4):563-76. doi: 10.1007/s00401-016-1601-x. Epub 2016 Aug 1.

5.

Physiological basis for muscle stiffness and weakness in a knock-in M1592V mouse model of hyperkalemic periodic paralysis.

Khogali S, Lucas B, Ammar T, Dejong D, Barbalinardo M, Hayward LJ, Renaud JM.

Physiol Rep. 2015 Dec;3(12). pii: e12656. doi: 10.14814/phy2.12656. Epub 2015 Dec 22.

6.

Understanding the physiology of the asymptomatic diaphragm of the M1592V hyperkalemic periodic paralysis mouse.

Ammar T, Lin W, Higgins A, Hayward LJ, Renaud JM.

J Gen Physiol. 2015 Dec;146(6):509-25. doi: 10.1085/jgp.201511476.

7.

DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves.

Safra N, Hayward LJ, Aguilar M, Sacks BN, Westropp JL, Mohr FC, Mellersh CS, Bannasch DL.

PLoS One. 2015 Aug 5;10(8):e0133127. doi: 10.1371/journal.pone.0133127. eCollection 2015. Erratum in: PLoS One. 2018 Apr 10;13(4):e0195924.

8.

Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.

Tibshirani M, Tradewell ML, Mattina KR, Minotti S, Yang W, Zhou H, Strong MJ, Hayward LJ, Durham HD.

Hum Mol Genet. 2015 Feb 1;24(3):773-86. doi: 10.1093/hmg/ddu494. Epub 2014 Sep 30.

9.

Contractile abnormalities of mouse muscles expressing hyperkalemic periodic paralysis mutant NaV1.4 channels do not correlate with Na+ influx or channel content.

Lucas B, Ammar T, Khogali S, DeJong D, Barbalinardo M, Nishi C, Hayward LJ, Renaud JM.

Physiol Genomics. 2014 Jun 1;46(11):385-97. doi: 10.1152/physiolgenomics.00166.2013. Epub 2014 Apr 8.

PMID:
24714718
10.

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase.

Morfini GA, Bosco DA, Brown H, Gatto R, Kaminska A, Song Y, Molla L, Baker L, Marangoni MN, Berth S, Tavassoli E, Bagnato C, Tiwari A, Hayward LJ, Pigino GF, Watterson DM, Huang CF, Banker G, Brown RH Jr, Brady ST.

PLoS One. 2013 Jun 12;8(6):e65235. doi: 10.1371/journal.pone.0065235. Print 2013.

11.

Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro.

Convertini P, Zhang J, de la Grange P, Hayward LJ, Zhu H, Stamm S.

Biochim Biophys Acta. 2013 Aug;1832(8):1129-35. doi: 10.1016/j.bbadis.2013.03.015. Epub 2013 Mar 29.

12.

Lessons learned from muscle fatigue: implications for treatment of patients with hyperkalemic periodic paralysis.

Renaud JM, Hayward LJ.

Recent Pat Biotechnol. 2012 Dec;6(3):184-91. Review.

PMID:
23092434
13.

Late-onset progressive retinal atrophy in the Gordon and Irish Setter breeds is associated with a frameshift mutation in C2orf71.

Downs LM, Bell JS, Freeman J, Hartley C, Hayward LJ, Mellersh CS.

Anim Genet. 2013 Apr;44(2):169-77. doi: 10.1111/j.1365-2052.2012.02379.x. Epub 2012 Jun 12.

PMID:
22686255
14.

Parallel mapping and simultaneous sequencing reveals deletions in BCAN and FAM83H associated with discrete inherited disorders in a domestic dog breed.

Forman OP, Penderis J, Hartley C, Hayward LJ, Ricketts SL, Mellersh CS.

PLoS Genet. 2012 Jan;8(1):e1002462. doi: 10.1371/journal.pgen.1002462. Epub 2012 Jan 12.

15.

Na+,K+-pump stimulation improves contractility in isolated muscles of mice with hyperkalemic periodic paralysis.

Clausen T, Nielsen OB, Clausen JD, Pedersen TH, Hayward LJ.

J Gen Physiol. 2011 Jul;138(1):117-30. doi: 10.1085/jgp.201010586.

16.

A yeast model of FUS/TLS-dependent cytotoxicity.

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH Jr, Lindquist S, Ringe D, Petsko GA.

PLoS Biol. 2011 Apr;9(4):e1001052. doi: 10.1371/journal.pbio.1001052. Epub 2011 Apr 26.

17.

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.

Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ Jr, Sapp P, McKenna-Yasek D, Brown RH Jr, Hayward LJ.

Hum Mol Genet. 2010 Nov 1;19(21):4160-75. doi: 10.1093/hmg/ddq335. Epub 2010 Aug 10.

18.

Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis.

Tiwari A, Liba A, Sohn SH, Seetharaman SV, Bilsel O, Matthews CR, Hart PJ, Valentine JS, Hayward LJ.

J Biol Chem. 2009 Oct 2;284(40):27746-58. doi: 10.1074/jbc.M109.043729. Epub 2009 Aug 3.

19.

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop.

Molnar KS, Karabacak NM, Johnson JL, Wang Q, Tiwari A, Hayward LJ, Coales SJ, Hamuro Y, Agar JN.

J Biol Chem. 2009 Nov 6;284(45):30965-73. doi: 10.1074/jbc.M109.023945. Epub 2009 Jul 27.

20.

Sensitive and specific identification of wild type and variant proteins from 8 to 669 kDa using top-down mass spectrometry.

Karabacak NM, Li L, Tiwari A, Hayward LJ, Hong P, Easterling ML, Agar JN.

Mol Cell Proteomics. 2009 Apr;8(4):846-56. doi: 10.1074/mcp.M800099-MCP200. Epub 2008 Dec 15.

21.

Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation.

Ström AL, Shi P, Zhang F, Gal J, Kilty R, Hayward LJ, Zhu H.

J Biol Chem. 2008 Aug 15;283(33):22795-805. doi: 10.1074/jbc.M800276200. Epub 2008 May 30.

22.

Retrograde axonal transport and motor neuron disease.

Ström AL, Gal J, Shi P, Kasarskis EJ, Hayward LJ, Zhu H.

J Neurochem. 2008 Jul;106(2):495-505. doi: 10.1111/j.1471-4159.2008.05393.x. Epub 2008 Apr 1. Review.

23.

Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.

Cao X, Antonyuk SV, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, Hart PJ.

J Biol Chem. 2008 Jun 6;283(23):16169-77. doi: 10.1074/jbc.M801522200. Epub 2008 Mar 31.

24.

Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness.

Hayward LJ, Kim JS, Lee MY, Zhou H, Kim JW, Misra K, Salajegheh M, Wu FF, Matsuda C, Reid V, Cros D, Hoffman EP, Renaud JM, Cannon SC, Brown RH Jr.

J Clin Invest. 2008 Apr;118(4):1437-49. doi: 10.1172/JCI32638.

25.

Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1.

Shaw BF, Lelie HL, Durazo A, Nersissian AM, Xu G, Chan PK, Gralla EB, Tiwari A, Hayward LJ, Borchelt DR, Valentine JS, Whitelegge JP.

J Biol Chem. 2008 Mar 28;283(13):8340-50. doi: 10.1074/jbc.M707751200. Epub 2008 Jan 11.

26.

Increased affinity for copper mediated by cysteine 111 in forms of mutant superoxide dismutase 1 linked to amyotrophic lateral sclerosis.

Watanabe S, Nagano S, Duce J, Kiaei M, Li QX, Tucker SM, Tiwari A, Brown RH Jr, Beal MF, Hayward LJ, Culotta VC, Yoshihara S, Sakoda S, Bush AI.

Free Radic Biol Med. 2007 May 15;42(10):1534-42. Epub 2007 Feb 15.

PMID:
17448900
27.

Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.

Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H.

J Biol Chem. 2007 Jun 1;282(22):16691-9. Epub 2007 Apr 2.

28.

Mutant SOD1 instability: implications for toxicity in amyotrophic lateral sclerosis.

Tiwari A, Hayward LJ.

Neurodegener Dis. 2005;2(3-4):115-27. Review.

PMID:
16909016
29.

Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis.

Rodriguez JA, Shaw BF, Durazo A, Sohn SH, Doucette PA, Nersissian AM, Faull KF, Eggers DK, Tiwari A, Hayward LJ, Valentine JS.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10516-21. Epub 2005 Jul 14.

30.
31.

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

Antonyuk S, Elam JS, Hough MA, Strange RW, Doucette PA, Rodriguez JA, Hayward LJ, Valentine JS, Hart PJ, Hasnain SS.

Protein Sci. 2005 May;14(5):1201-13.

32.

Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis.

Tummala H, Jung C, Tiwari A, Higgins CM, Hayward LJ, Xu Z.

J Biol Chem. 2005 May 6;280(18):17725-31. Epub 2005 Mar 7.

33.

Structural basis of heteromeric smad protein assembly in TGF-beta signaling.

Chacko BM, Qin BY, Tiwari A, Shi G, Lam S, Hayward LJ, De Caestecker M, Lin K.

Mol Cell. 2004 Sep 10;15(5):813-23.

34.

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

Hough MA, Grossmann JG, Antonyuk SV, Strange RW, Doucette PA, Rodriguez JA, Whitson LJ, Hart PJ, Hayward LJ, Valentine JS, Hasnain SS.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5976-81. Epub 2004 Mar 31.

35.

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS.

Elam JS, Taylor AB, Strange R, Antonyuk S, Doucette PA, Rodriguez JA, Hasnain SS, Hayward LJ, Valentine JS, Yeates TO, Hart PJ.

Nat Struct Biol. 2003 Jun;10(6):461-7.

PMID:
12754496
36.

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.

Strange RW, Antonyuk S, Hough MA, Doucette PA, Rodriguez JA, Hart PJ, Hayward LJ, Valentine JS, Hasnain SS.

J Mol Biol. 2003 May 9;328(4):877-91.

PMID:
12729761
37.

An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate.

Elam JS, Malek K, Rodriguez JA, Doucette PA, Taylor AB, Hayward LJ, Cabelli DE, Valentine JS, Hart PJ.

J Biol Chem. 2003 Jun 6;278(23):21032-9. Epub 2003 Mar 20.

38.
39.

Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase.

Rodriguez JA, Valentine JS, Eggers DK, Roe JA, Tiwari A, Brown RH Jr, Hayward LJ.

J Biol Chem. 2002 May 3;277(18):15932-7. Epub 2002 Feb 19.

40.

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

Hayward LJ, Rodriguez JA, Kim JW, Tiwari A, Goto JJ, Cabelli DE, Valentine JS, Brown RH Jr.

J Biol Chem. 2002 May 3;277(18):15923-31. Epub 2002 Feb 19.

41.

Defective slow inactivation of sodium channels contributes to familial periodic paralysis.

Hayward LJ, Sandoval GM, Cannon SC.

Neurology. 1999 Apr 22;52(7):1447-53.

PMID:
10227633
42.
43.
44.

Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis.

Hosler BA, Nicholson GA, Sapp PC, Chin W, Orrell RW, de Belleroche JS, Esteban J, Hayward LJ, Mckenna-Yasek D, Yeung L, Cherryson AK, Dench JE, Wilton SD, Laing NG, Horvitz HR, Brown RH Jr.

Neuromuscul Disord. 1996 Oct;6(5):361-6.

PMID:
8938700
45.

Inactivation defects caused by myotonia-associated mutations in the sodium channel III-IV linker.

Hayward LJ, Brown RH Jr, Cannon SC.

J Gen Physiol. 1996 May;107(5):559-76.

46.

Adhesion of Aeromonas sp. to cell lines used as models for intestinal adhesion.

Kirov SM, Hayward LJ, Nerrie MA.

Epidemiol Infect. 1995 Dec;115(3):465-73.

47.

Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis.

Cannon SC, Hayward LJ, Beech J, Brown RH Jr.

J Neurophysiol. 1995 May;73(5):1892-9.

PMID:
7623088
49.

The growth and expression of virulence factors at refrigeration temperature by Aeromonas strains isolated from foods.

Kirov SM, Ardestani EK, Hayward LJ.

Int J Food Microbiol. 1993 Nov 26;20(3):159-68.

PMID:
7906137
50.

Milk as a Potential Source of Aeromonas Gastrointestinal Infection.

Kirov SM, Hui DS, Hayward LJ.

J Food Prot. 1993 Apr;56(4):306-312. doi: 10.4315/0362-028X-56.4.306.

PMID:
31091631

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