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Should spirometer quality control be treated like other laboratory devices?

Haynes JM, Ruppel GL.

ERJ Open Res. 2019 Feb 11;5(1). pii: 00249-2018. doi: 10.1183/23120541.00249-2018. eCollection 2019 Feb.


The impact of Babesia microti blood donation screening.

Tonnetti L, Townsend RL, Deisting BM, Haynes JM, Dodd RY, Stramer SL.

Transfusion. 2019 Feb;59(2):593-600. doi: 10.1111/trf.15043. Epub 2018 Nov 30.


The effect of nicotine and nicotine+monoamine oxidase inhibitor on the value of alcohol.

Frye CCJ, Galizio A, Haynes JM, DeHart WB, Odum AL.

Behav Pharmacol. 2019 Jun;30(4):363-369. doi: 10.1097/FBP.0000000000000438.


Continuous nicotine exposure does not affect resurgence of alcohol seeking in rats.

Frye CCJ, Rung JM, Nall RW, Galizio A, Haynes JM, Odum AL.

PLoS One. 2018 Aug 15;13(8):e0202230. doi: 10.1371/journal.pone.0202230. eCollection 2018.


Induced Pluripotent Stem Cell-Derived Podocyte-Like Cells as Models for Assessing Mechanisms Underlying Heritable Disease Phenotype: Initial Studies Using Two Alport Syndrome Patient Lines Indicate Impaired Potassium Channel Activity.

Haynes JM, Selby JN, Vandekolk TH, Abad IPL, Ho JK, Lieuw WL, Leach K, Savige J, Saini S, Fisher CL, Ricardo SD.

J Pharmacol Exp Ther. 2018 Nov;367(2):335-347. doi: 10.1124/jpet.118.250142. Epub 2018 Aug 13.


PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein.

Daniel PM, Filiz G, Brown DV, Christie M, Waring PM, Zhang Y, Haynes JM, Pouton C, Flanagan D, Vincan E, Johns TG, Montgomery K, Phillips WA, Mantamadiotis T.

Neuro Oncol. 2018 Sep 3;20(10):1344-1355. doi: 10.1093/neuonc/noy068.


NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA.

Nat Commun. 2018 Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x.


Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke.

Evans MA, Lim R, Kim HA, Chu HX, Gardiner-Mann CV, Taylor KWE, Chan CT, Brait VH, Lee S, Dinh QN, Vinh A, Phan TG, Srikanth VK, Ma H, Arumugam TV, Fann DY, Poh L, Hunt CPJ, Pouton CW, Haynes JM, Selemidis S, Kwan W, Teo L, Bourne JA, Neumann S, Young S, Gowing EK, Drummond GR, Clarkson AN, Wallace EM, Sobey CG, Broughton BRS.

Stroke. 2018 Mar;49(3):700-709. doi: 10.1161/STROKEAHA.117.019136. Epub 2018 Jan 30.


Persistence and relapse of reinforced behavioral variability.

Galizio A, Frye CCJ, Haynes JM, Friedel JE, Smith BM, Odum AL.

J Exp Anal Behav. 2018 Jan;109(1):210-237. doi: 10.1002/jeab.309.


Basic spirometry testing and interpretation for the primary care provider.

Haynes JM.

Can J Respir Ther. 2018 Winter;54(4). doi: 10.29390/cjrt-2018-017. Epub 2018 Feb 1.


The Impact of Using Non-Birth Sex on the Interpretation of Spirometry Data in Subjects With Air-Flow Obstruction.

Haynes JM, Stumbo RW.

Respir Care. 2018 Feb;63(2):215-218. doi: 10.4187/respcare.05586. Epub 2017 Nov 28.


A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells.

Niclis JC, Gantner CW, Hunt CPJ, Kauhausen JA, Durnall JC, Haynes JM, Pouton CW, Parish CL, Thompson LH.

Stem Cell Reports. 2017 Sep 12;9(3):868-882. doi: 10.1016/j.stemcr.2017.08.002. Epub 2017 Aug 31.


Patient-Ventilator Asynchrony and Standard Waveforms: Looks Can Be Deceiving.

Haynes JM.

Respir Care. 2017 Jul;62(7):1004. doi: 10.4187/respcare.05593. No abstract available.


The potential of stem cells for 21st century neuroscience, II.

Haynes JM, Halliwell RF.

Neurochem Int. 2017 Jun;106:1-2. doi: 10.1016/j.neuint.2017.05.001. No abstract available.


Impact of Hemoglobin and Carboxyhemoglobin Adjustment on the Interpretation of Pulmonary Diffusing Capacity in a General Population.

Haynes JM, Ruppel GL, Kaminsky DA.

Chest. 2017 May;151(5):1188-1189. doi: 10.1016/j.chest.2016.12.019. No abstract available.


Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents.

Niclis JC, Gantner CW, Alsanie WF, McDougall SJ, Bye CR, Elefanty AG, Stanley EG, Haynes JM, Pouton CW, Thompson LH, Parish CL.

Stem Cells Transl Med. 2017 Mar;6(3):937-948. doi: 10.5966/sctm.2016-0073. Epub 2016 Oct 14.


Debunking myths in pulmonary function testing.

Haynes JM.

Can J Respir Ther. 2017 Winter;53(1):7-11. Epub 2017 Feb 1. No abstract available.


Pulse Oximetry in Acute Respiratory Failure: What Should Be Expected?

Haynes JM, Ruppel GL.

Respir Care. 2016 Aug;61(8):1135. doi: 10.4187/respcare.04965. No abstract available.


FEV1/FEV6 May Misdiagnose Patients With COPD.

Ruppel GL, Haynes JM, Kaminsky DA.

Respir Care. 2016 Jul;61(7):999-1001. doi: 10.4187/respcare.04650. No abstract available.


Facile One-step Micropatterning Using Photodegradable Methacrylated Gelatin Hydrogels for Improved Cardiomyocyte Organization and Alignment.

Tsang KM, Annabi N, Ercole F, Zhou K, Karst D, Li F, Haynes JM, Evans RA, Thissen H, Khademhosseini A, Forsythe JS.

Adv Funct Mater. 2015 Feb 11;25(6):977-986.


Comparing mouse and human pluripotent stem cell derived cardiac cells: Both systems have advantages for pharmacological and toxicological screening.

Lagerqvist EL, Finnin BA, Elliott DA, Anderson DJ, Wu SM, Pouton CW, Haynes JM.

J Pharmacol Toxicol Methods. 2015 Jul-Aug;74:17-25. doi: 10.1016/j.vascn.2015.04.009. Epub 2015 May 6.


The American Thoracic Society/European Respiratory Society acceptability criteria for spirometry: asking too much or not enough?

Haynes JM, Kaminsky DA.

Respir Care. 2015 May;60(5):e113-4. doi: 10.4187/respcare.04061. No abstract available.


Human pluripotent stem cell derived midbrain PITX3(eGFP/w) neurons: a versatile tool for pharmacological screening and neurodegenerative modeling.

Watmuff B, Hartley BJ, Hunt CP, Fabb SA, Pouton CW, Haynes JM.

Front Cell Neurosci. 2015 Mar 31;9:104. doi: 10.3389/fncel.2015.00104. eCollection 2015.


Bronchoconstriction in response to deep inhalation during spirometry testing.

Haynes JM.

Respir Care. 2015 May;60(5):e105-9. doi: 10.4187/respcare.03995. Epub 2015 Apr 7. No abstract available.


PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.

Chan LJ, Bulitta JB, Ascher DB, Haynes JM, McLeod VM, Porter CJ, Williams CC, Kaminskas LM.

Mol Pharm. 2015 Mar 2;12(3):794-809. doi: 10.1021/mp5006189. Epub 2015 Feb 18.


Randomized controlled trial of cryoanalgesia (ice bag) to reduce pain associated with arterial puncture.

Haynes JM.

Respir Care. 2015 Jan;60(1):1-5. doi: 10.4187/respcare.03312. Epub 2014 Dec 16.


Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.

Kaminskas LM, McLeod VM, Ascher DB, Ryan GM, Jones S, Haynes JM, Trevaskis NL, Chan LJ, Sloan EK, Finnin BA, Williamson M, Velkov T, Williams ED, Kelly BD, Owen DJ, Porter CJ.

Mol Pharm. 2015 Feb 2;12(2):432-43. doi: 10.1021/mp500531e. Epub 2015 Jan 20.


Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells.

Hartley BJ, Fabb SA, Finnin BA, Haynes JM, Pouton CW.

J Vis Exp. 2014 Aug 23;(90):e51764. doi: 10.3791/51764.


SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Skelton RJ, Costa M, Anderson DJ, Bruveris F, Finnin BW, Koutsis K, Arasaratnam D, White AJ, Rafii A, Ng ES, Elefanty AG, Stanley EG, Pouton CW, Haynes JM, Ardehali R, Davis RP, Mummery CL, Elliott DA.

Stem Cell Res. 2014 Jul;13(1):172-9. doi: 10.1016/j.scr.2014.04.016. Epub 2014 May 4.


Respiratory care year in review 2013: neonatal respiratory care, pulmonary function testing, and pulmonary rehabilitation.

Smallwood CD, Haynes JM, Carlin BW, Hess DR.

Respir Care. 2014 May;59(5):777-87. doi: 10.4187/respcare.03242.


Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.

Kaminskas LM, McLeod VM, Ryan GM, Kelly BD, Haynes JM, Williamson M, Thienthong N, Owen DJ, Porter CJ.

J Control Release. 2014 Jun 10;183:18-26. doi: 10.1016/j.jconrel.2014.03.012. Epub 2014 Mar 14.


DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.

Hunt CP, Fabb SA, Pouton CW, Haynes JM.

PLoS One. 2013 Oct 23;8(10):e78759. doi: 10.1371/journal.pone.0078759. eCollection 2013.


Pulmonary function test quality in the elderly: a comparison with younger adults.

Haynes JM.

Respir Care. 2014 Jan;59(1):16-21. doi: 10.4187/respcare.02331. Epub 2013 Jun 25.


Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines.

Niclis JC, Pinar A, Haynes JM, Alsanie W, Jenny R, Dottori M, Cram DS.

Front Cell Neurosci. 2013 Apr 5;7:37. doi: 10.3389/fncel.2013.00037. eCollection 2013.


A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa.

Reen FJ, Haynes JM, Mooij MJ, O'Gara F.

PLoS One. 2013;8(1):e54479. doi: 10.1371/journal.pone.0054479. Epub 2013 Jan 28.


Expiratory reserve volume maneuver may be the preferred method for some patients during spirometry testing.

Haynes JM.

Respir Care. 2013 Feb;58(2):e14-5. doi: 10.4187/respcare.02133. No abstract available.


Myths, misunderstandings, and dogma in respiratory care.

Rubin BK, Haynes JM.

Respir Care. 2012 Aug;57(8):1314-24. doi: 10.4187/respcare.01816. Review.


Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists.

Gosling JI, Baker SP, Haynes JM, Kassiou M, Pouton CW, Warfe L, White PJ, Scammells PJ.

ChemMedChem. 2012 Jul;7(7):1191-201. doi: 10.1002/cmdc.201200208. Epub 2012 Jun 8.


Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.

Nefzger CM, Su CT, Fabb SA, Hartley BJ, Beh SJ, Zeng WR, Haynes JM, Pouton CW.

Stem Cells. 2012 Jul;30(7):1349-61. doi: 10.1002/stem.1105.


Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.

Hausler NE, Devine SM, McRobb FM, Warfe L, Pouton CW, Haynes JM, Bottle SE, White PJ, Scammells PJ.

J Med Chem. 2012 Apr 12;55(7):3521-34. doi: 10.1021/jm300206u. Epub 2012 Mar 29.


In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

Watmuff B, Pouton CW, Haynes JM.

PLoS One. 2012;7(2):e31999. doi: 10.1371/journal.pone.0031999. Epub 2012 Feb 22.


Randomized controlled trial of a breath-activated nebulizer in patients with exacerbation of COPD.

Haynes JM.

Respir Care. 2012 Sep;57(9):1385-90. doi: 10.4187/respcare.01609. Epub 2012 Feb 17.


Quality assurance of the pulmonary function technologist.

Haynes JM.

Respir Care. 2012 Jan;57(1):114-22; discussion 122-6. doi: 10.4187/respcare.01401.


NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG.

Nat Methods. 2011 Oct 23;8(12):1037-40. doi: 10.1038/nmeth.1740.


Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors.

White CW, Short JL, Haynes JM, Matsui M, Ventura S.

J Pharmacol Exp Ther. 2011 Dec;339(3):870-7. doi: 10.1124/jpet.111.186841. Epub 2011 Sep 1.


Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential.

Zeng WR, Fabb SR, Haynes JM, Pouton CW.

Neurochem Int. 2011 Sep;59(3):394-403. doi: 10.1016/j.neuint.2011.04.002. Epub 2011 May 23.


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