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Items: 1 to 50 of 56


An Online Survey for Pharmacoepidemiological Investigation (Survey of Non-Medical Use of Prescription Drugs Program): Validation Study.

Black JC, Rockhill K, Forber A, Amioka E, May KP, Haynes CM, Dasgupta N, Dart RC.

J Med Internet Res. 2019 Oct 25;21(10):e15830. doi: 10.2196/15830.


Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection.

Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22322-22330. doi: 10.1073/pnas.1909666116. Epub 2019 Oct 14.


Cardioprotection by the mitochondrial unfolded protein response requires ATF5.

Wang YT, Lim Y, McCall MN, Huang KT, Haynes CM, Nehrke K, Brookes PS.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H472-H478. doi: 10.1152/ajpheart.00244.2019. Epub 2019 Jul 5.


Nonmedical use of alprazolam in the UK: Results from a nationally representative survey.

Hockenhull J, Amioka E, Black JC, Haynes CM, Dargan PI, Dart RC, Wood DM.

Br J Clin Pharmacol. 2019 Aug;85(8):1841-1845. doi: 10.1111/bcp.13959. Epub 2019 Jun 5.


Entosis Controls a Developmental Cell Clearance in C. elegans.

Lee Y, Hamann JC, Pellegrino M, Durgan J, Domart MC, Collinson LM, Haynes CM, Florey O, Overholtzer M.

Cell Rep. 2019 Mar 19;26(12):3212-3220.e4. doi: 10.1016/j.celrep.2019.02.073.


Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3.

Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6146-6151. doi: 10.1073/pnas.1817259116. Epub 2019 Mar 8.


The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans.

Peterson ND, Cheesman HK, Liu P, Anderson SM, Foster KJ, Chhaya R, Perrat P, Thekkiniath J, Yang Q, Haynes CM, Pukkila-Worley R.

PLoS Genet. 2019 Jan 22;15(1):e1007935. doi: 10.1371/journal.pgen.1007935. eCollection 2019 Jan.


Signaling and Regulation of the Mitochondrial Unfolded Protein Response.

Naresh NU, Haynes CM.

Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6). pii: a033944. doi: 10.1101/cshperspect.a033944. Review.


Mitochondrial Biogenesis: MitoCPR Resuscitates Import-Defective Mitochondria.

Pires J, Haynes CM.

Curr Biol. 2018 Jun 4;28(11):R669-R671. doi: 10.1016/j.cub.2018.04.094.


Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.

Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocaña A, Herman MA, Haynes CM, Chipuk JE, Scott DK.

Diabetes. 2018 Aug;67(8):1561-1575. doi: 10.2337/db17-0943. Epub 2018 May 15.


Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.

Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M.

Cell Rep. 2018 Mar 20;22(12):3115-3125. doi: 10.1016/j.celrep.2018.02.099.


UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication.

Melber A, Haynes CM.

Cell Res. 2018 Mar;28(3):281-295. doi: 10.1038/cr.2018.16. Epub 2018 Feb 9. Review.


The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.

Shpilka T, Haynes CM.

Nat Rev Mol Cell Biol. 2018 Feb;19(2):109-120. doi: 10.1038/nrm.2017.110. Epub 2017 Nov 22. Review.


Mitochondrial Sterol Oxidation Marks the Spot.

Lamech L, Haynes CM.

Mol Cell. 2017 Nov 16;68(4):641-642. doi: 10.1016/j.molcel.2017.11.003. Review.


Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging.

Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI.

Cell Rep. 2017 Nov 7;21(6):1481-1494. doi: 10.1016/j.celrep.2017.10.038.


Vms1 Relieves a Mitochondrial Import Chokehold.

Lamech L, Haynes CM.

Dev Cell. 2017 Nov 6;43(3):259-260. doi: 10.1016/j.devcel.2017.10.022. Review.


The mitochondrial unfolded protein response: Signaling from the powerhouse.

Qureshi MA, Haynes CM, Pellegrino MW.

J Biol Chem. 2017 Aug 18;292(33):13500-13506. doi: 10.1074/jbc.R117.791061. Epub 2017 Jul 7. Review.


Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.

Deng P, Haynes CM.

Semin Cancer Biol. 2017 Dec;47:43-49. doi: 10.1016/j.semcancer.2017.05.002. Epub 2017 May 10. Review.


Integrating the UPRmt into the mitochondrial maintenance network.

Fiorese CJ, Haynes CM.

Crit Rev Biochem Mol Biol. 2017 Jun;52(3):304-313. doi: 10.1080/10409238.2017.1291577. Epub 2017 Feb 22. Review.


The mitokine quest(ion).

Deng P, Haynes CM.

Cell Res. 2016 Dec;26(12):1265-1266. doi: 10.1038/cr.2016.138. Epub 2016 Nov 25.


The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR.

Fiorese CJ, Schulz AM, Lin YF, Rosin N, Pellegrino MW, Haynes CM.

Curr Biol. 2016 Aug 8;26(15):2037-2043. doi: 10.1016/j.cub.2016.06.002. Epub 2016 Jul 14.


Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.

Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM.

Nature. 2016 May 19;533(7603):416-9. doi: 10.1038/nature17989. Epub 2016 May 2.


Metabolism and the UPR(mt).

Lin YF, Haynes CM.

Mol Cell. 2016 Mar 3;61(5):677-682. doi: 10.1016/j.molcel.2016.02.004. Review.


The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.

Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER.

Cell Rep. 2016 Feb 23;14(7):1581-1589. doi: 10.1016/j.celrep.2016.01.055. Epub 2016 Feb 11.


Cell biology: Surviving import failure.

Haynes CM.

Nature. 2015 Aug 27;524(7566):419-20. doi: 10.1038/nature14644. Epub 2015 Aug 5. No abstract available.


The unpredictability of prolonged activation of stress response pathways.

Lamech LT, Haynes CM.

J Cell Biol. 2015 Jun 22;209(6):781-7. doi: 10.1083/jcb.201503107.


Alan Hall 1952-2015.

Giancotti FG, Haynes CM, Machesky LM, Olson MF, Overholtzer M.

Nat Cell Biol. 2015 Jul;17(7):839-40. doi: 10.1038/ncb3190. Epub 2015 May 25. No abstract available.


UPR(mt)-mediated cytoprotection and organismal aging.

Schulz AM, Haynes CM.

Biochim Biophys Acta. 2015 Nov;1847(11):1448-56. doi: 10.1016/j.bbabio.2015.03.008. Epub 2015 Apr 7. Review.


Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection.

Pellegrino MW, Haynes CM.

BMC Biol. 2015 Apr 3;13:22. doi: 10.1186/s12915-015-0129-1. Review.


Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.

Mohrin M, Shin J, Liu Y, Brown K, Luo H, Xi Y, Haynes CM, Chen D.

Science. 2015 Mar 20;347(6228):1374-7. doi: 10.1126/science.aaa2361.


Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).

Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM.

Mol Cell. 2015 Apr 2;58(1):123-33. doi: 10.1016/j.molcel.2015.02.008. Epub 2015 Mar 12.


Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.

Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM.

Nature. 2014 Dec 18;516(7531):414-7. doi: 10.1038/nature13818. Epub 2014 Sep 28.


Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond.

Haynes CM, Fiorese CJ, Lin YF.

Trends Cell Biol. 2013 Jul;23(7):311-8. doi: 10.1016/j.tcb.2013.02.002. Epub 2013 Mar 13. Review.


Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel.

Wojtovich AP, Smith CO, Haynes CM, Nehrke KW, Brookes PS.

Biochim Biophys Acta. 2013 May;1827(5):598-611. doi: 10.1016/j.bbabio.2012.12.007. Epub 2013 Jan 2. Review.


Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.

Baker BM, Nargund AM, Sun T, Haynes CM.

PLoS Genet. 2012;8(6):e1002760. doi: 10.1371/journal.pgen.1002760. Epub 2012 Jun 14.


Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.

Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM.

Science. 2012 Aug 3;337(6094):587-90. doi: 10.1126/science.1223560. Epub 2012 Jun 14.


Signaling the mitochondrial unfolded protein response.

Pellegrino MW, Nargund AM, Haynes CM.

Biochim Biophys Acta. 2013 Feb;1833(2):410-6. doi: 10.1016/j.bbamcr.2012.02.019. Epub 2012 Mar 14. Review.


Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.

Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M.

Nat Cell Biol. 2011 Oct 16;13(11):1335-43. doi: 10.1038/ncb2363.


Arachnoid ossificans containing metaplastic hematopoietic marrow resulting in diffuse thoracic intrathecal cysts and severe myelopathy.

Abrams J, Li G, Mindea SA, Haynes CM, Cheng I.

Eur Spine J. 2012 Jun;21 Suppl 4:S436-40. doi: 10.1007/s00586-011-2005-1. Epub 2011 Sep 4.


Mitochondrial protein quality control during biogenesis and aging.

Baker BM, Haynes CM.

Trends Biochem Sci. 2011 May;36(5):254-61. doi: 10.1016/j.tibs.2011.01.004. Epub 2011 Feb 25. Review.


The mitochondrial UPR - protecting organelle protein homeostasis.

Haynes CM, Ron D.

J Cell Sci. 2010 Nov 15;123(Pt 22):3849-55. doi: 10.1242/jcs.075119. Review.


Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.

Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D.

Mol Cell. 2010 Apr 23;38(2):291-304. doi: 10.1016/j.molcel.2010.04.001.


The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.

Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D.

Mol Cell. 2010 Feb 26;37(4):529-40. doi: 10.1016/j.molcel.2010.01.015.


SnapShot: The unfolded protein response.

Wiseman RL, Haynes CM, Ron D.

Cell. 2010 Feb 19;140(4):590-590.e2. doi: 10.1016/j.cell.2010.02.006. No abstract available.


Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

Wiseman RL, Chin KT, Haynes CM, Stanhill A, Xu CF, Roguev A, Krogan NJ, Neubert TA, Ron D.

J Biol Chem. 2009 May 29;284(22):15233-45. doi: 10.1074/jbc.M109.002121. Epub 2009 Apr 6.


Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans.

Yun C, Stanhill A, Yang Y, Zhang Y, Haynes CM, Xu CF, Neubert TA, Mor A, Philips MR, Ron D.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):7094-9. doi: 10.1073/pnas.0707025105. Epub 2008 May 8.


Reninoma: case report and literature review.

Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, Katznelson L.

J Hypertens. 2008 Feb;26(2):368-73. doi: 10.1097/HJH.0b013e3282f283f3. Review.


ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.

Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D.

Dev Cell. 2007 Oct;13(4):467-80.


An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.

Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D.

Mol Cell. 2006 Sep 15;23(6):875-85.

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