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Items: 14

1.

Morphogenetic competence of HNF4 alpha-deficient mouse hepatic cells.

Hayhurst GP, Strick-Marchand H, Mulet C, Richard AF, Morosan S, Kremsdorf D, Weiss MC.

J Hepatol. 2008 Sep;49(3):384-95. doi: 10.1016/j.jhep.2008.04.024. Epub 2008 Jun 5.

2.

Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.

Beaudry JB, Pierreux CE, Hayhurst GP, Plumb-Rudewiez N, Weiss MC, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2006 Aug;26(16):6037-46.

3.

Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors.

Zhang Y, Repa JJ, Inoue Y, Hayhurst GP, Gonzalez FJ, Mangelsdorf DJ.

Mol Endocrinol. 2004 Apr;18(4):851-62. Epub 2004 Jan 8.

PMID:
14715930
4.

Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.

Andreola F, Hayhurst GP, Luo G, Ferguson SS, Gonzalez FJ, Goldstein JA, De Luca LM.

J Biol Chem. 2004 Jan 30;279(5):3434-8. Epub 2003 Nov 17.

5.
6.

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

Corchero J, Granvil CP, Akiyama TE, Hayhurst GP, Pimprale S, Feigenbaum L, Idle JR, Gonzalez FJ.

Mol Pharmacol. 2001 Dec;60(6):1260-7. Erratum in: Mol Pharmacol 2002 Jan;61(1):248.

PMID:
11723233
7.

In-vitro analysis of the contribution of CYP2D6.35 to ultra-rapid metabolism.

Allorge D, Harlow J, Boulet O, Hayhurst GP, Chowdry J, Roth E, Crewe K, Lo-Guidice JM, Lhermitte M, Broly F, Tucker GT, Ellis SW.

Pharmacogenetics. 2001 Nov;11(8):739-41. Review.

PMID:
11692084
8.

Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6.

Hayhurst GP, Harlow J, Chowdry J, Gross E, Hilton E, Lennard MS, Tucker GT, Ellis SW.

Biochem J. 2001 Apr 15;355(Pt 2):373-9.

9.
10.

Evidence that serine 304 is not a key ligand-binding residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Lightfoot T, Smith G, Harlow J, Rowland-Yeo K, Larsson C, Mahling J, Lim CK, Wolf CR, Blackburn MG, Lennard MS, Tucker GT.

Biochem J. 2000 Feb 1;345 Pt 3:565-71.

11.

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Mackman R, Tschirret-Guth RA, Smith G, Hayhurst GP, Ellis SW, Lennard MS, Tucker GT, Wolf CR, Ortiz de Montellano PR.

Arch Biochem Biophys. 1996 Jul 1;331(1):134-40.

PMID:
8660692
12.

Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.

Ellis SW, Hayhurst GP, Smith G, Lightfoot T, Wong MM, Simula AP, Ackland MJ, Sternberg MJ, Lennard MS, Tucker GT, et al.

J Biol Chem. 1995 Dec 8;270(49):29055-8.

13.
14.

Polymorphonuclear cells are not sites of persistence of human cytomegalovirus in healthy individuals.

Taylor-Wiedeman J, Hayhurst GP, Sissons JG, Sinclair JH.

J Gen Virol. 1993 Feb;74 ( Pt 2):265-8.

PMID:
8381466

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