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African KhoeSan ancestry linked to high-risk prostate cancer.

Petersen DC, Jaratlerdsiri W, van Wyk A, Chan EKF, Fernandez P, Lyons RJ, Mutambirw SBA, van der Merwe A, Venter PA, Bates W, Bornman MSR, Hayes VM.

BMC Med Genomics. 2019 Jun 4;12(1):82. doi: 10.1186/s12920-019-0537-0.


TMPRSS2-ERG fusions linked to prostate cancer racial health disparities: A focus on Africa.

Blackburn J, Vecchiarelli S, Heyer EE, Patrick SM, Lyons RJ, Jaratlerdsiri W, van Zyl S, Bornman MSR, Mercer TR, Hayes VM.

Prostate. 2019 Jul;79(10):1191-1196. doi: 10.1002/pros.23823. Epub 2019 May 15.


Diagnosis of fusion genes using targeted RNA sequencing.

Heyer EE, Deveson IW, Wooi D, Selinger CI, Lyons RJ, Hayes VM, O'Toole SA, Ballinger ML, Gill D, Thomas DM, Mercer TR, Blackburn J.

Nat Commun. 2019 Mar 27;10(1):1388. doi: 10.1038/s41467-019-09374-9.


Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer.

Feng Y, Ramnarine VR, Bell R, Volik S, Davicioni E, Hayes VM, Ren S, Collins CC.

BMC Genomics. 2019 Feb 18;20(1):146. doi: 10.1186/s12864-019-5457-z.


Prostate cancer genomics and racial health disparity.

Hayes VM, Jaratlerdsiri W, Bornman MSR.

Oncotarget. 2018 Nov 30;9(94):36650-36651. doi: 10.18632/oncotarget.26399. eCollection 2018 Nov 30. No abstract available.


Prostate Cancer in Southern Africa: Does Africa Hold Untapped Potential to Add Value to the Current Understanding of a Common Disease?

Hayes VM, Bornman MSR.

J Glob Oncol. 2018 Sep;4:1-7. doi: 10.1200/JGO.2016.008862. Epub 2017 Mar 21. No abstract available.


Whole-Genome Sequencing Reveals Elevated Tumor Mutational Burden and Initiating Driver Mutations in African Men with Treatment-Naïve, High-Risk Prostate Cancer.

Jaratlerdsiri W, Chan EKF, Gong T, Petersen DC, Kalsbeek AMF, Venter PA, Stricker PD, Bornman MSR, Hayes VM.

Cancer Res. 2018 Dec 15;78(24):6736-6746. doi: 10.1158/0008-5472.CAN-18-0254. Epub 2018 Sep 14.


Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten.

Nair SS, Luu PL, Qu W, Maddugoda M, Huschtscha L, Reddel R, Chenevix-Trench G, Toso M, Kench JG, Horvath LG, Hayes VM, Stricker PD, Hughes TP, White DL, Rasko JEJ, Wong JJ, Clark SJ.

Epigenetics Chromatin. 2018 May 28;11(1):24. doi: 10.1186/s13072-018-0194-0.


Optical mapping reveals a higher level of genomic architecture of chained fusions in cancer.

Chan EKF, Cameron DL, Petersen DC, Lyons RJ, Baldi BF, Papenfuss AT, Thomas DM, Hayes VM.

Genome Res. 2018 May;28(5):726-738. doi: 10.1101/gr.227975.117. Epub 2018 Apr 4.


Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer.

Kalsbeek AMF, Chan EKF, Grogan J, Petersen DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG, Kench JG, Stricker PD, Hayes VM.

Prostate. 2018 Jan;78(1):25-31. doi: 10.1002/pros.23440. Epub 2017 Nov 14.


Mitochondrial genome variation and prostate cancer: a review of the mutational landscape and application to clinical management.

Kalsbeek AMF, Chan EKF, Corcoran NM, Hovens CM, Hayes VM.

Oncotarget. 2017 Aug 4;8(41):71342-71357. doi: 10.18632/oncotarget.19926. eCollection 2017 Sep 19. Review.


Reconstructing Prehistoric African Population Structure.

Skoglund P, Thompson JC, Prendergast ME, Mittnik A, Sirak K, Hajdinjak M, Salie T, Rohland N, Mallick S, Peltzer A, Heinze A, Olalde I, Ferry M, Harney E, Michel M, Stewardson K, Cerezo-Román JI, Chiumia C, Crowther A, Gomani-Chindebvu E, Gidna AO, Grillo KM, Helenius IT, Hellenthal G, Helm R, Horton M, López S, Mabulla AZP, Parkington J, Shipton C, Thomas MG, Tibesasa R, Welling M, Hayes VM, Kennett DJ, Ramesar R, Meyer M, Pääbo S, Patterson N, Morris AG, Boivin N, Pinhasi R, Krause J, Reich D.

Cell. 2017 Sep 21;171(1):59-71.e21. doi: 10.1016/j.cell.2017.08.049.


The disulfide isomerase ERp72 supports arterial thrombosis in mice.

Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW.

Blood. 2017 Aug 10;130(6):817-828. doi: 10.1182/blood-2016-12-755587. Epub 2017 Jun 2.


Next generation mapping reveals novel large genomic rearrangements in prostate cancer.

Jaratlerdsiri W, Chan EKF, Petersen DC, Yang C, Croucher PI, Bornman MSR, Sheth P, Hayes VM.

Oncotarget. 2017 Apr 4;8(14):23588-23602. doi: 10.18632/oncotarget.15802.


Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer.

Kalsbeek AM, Chan EF, Grogan J, Petersen DC, Jaratlerdsiri W, Gupta R, Lyons RJ, Haynes AM, Horvath LG, Kench JG, Stricker PD, Hayes VM.

Aging (Albany NY). 2016 Oct 5;8(11):2702-2712. doi: 10.18632/aging.101044.


ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL.

Transfusion. 2016 Jul;56(7):1775-85. doi: 10.1111/trf.13583. Epub 2016 Apr 4.


Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men.

McCrow JP, Petersen DC, Louw M, Chan EK, Harmeyer K, Vecchiarelli S, Lyons RJ, Bornman MS, Hayes VM.

Prostate. 2016 Mar;76(4):349-58. doi: 10.1002/pros.23126. Epub 2015 Dec 10.


The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.

Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW.

J Clin Invest. 2015 Nov 3;125(12):4391-406. doi: 10.1172/JCI80319.


Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer.

Stuchbery R, Kurganovs NJ, McCoy PJ, Nelson CC, Hayes VM, Corcoran NM, Hovens CM.

Curr Cancer Drug Targets. 2015;15(5):394-405. Review.


Revised timeline and distribution of the earliest diverged human maternal lineages in southern Africa.

Chan EK, Hardie RA, Petersen DC, Beeson K, Bornman RM, Smith AB, Hayes VM.

PLoS One. 2015 Mar 25;10(3):e0121223. doi: 10.1371/journal.pone.0121223. eCollection 2015.


First ancient mitochondrial human genome from a prepastoralist southern African.

Morris AG, Heinze A, Chan EK, Smith AB, Hayes VM.

Genome Biol Evol. 2014 Sep 10;6(10):2647-53. doi: 10.1093/gbe/evu202.


The disulfide isomerase ERp57 is required for fibrin deposition in vivo.

Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, Essex DW.

J Thromb Haemost. 2014 Nov;12(11):1890-7. doi: 10.1111/jth.12709. Epub 2014 Sep 26.


Clinical presentation of prostate cancer in black South Africans.

Tindall EA, Monare LR, Petersen DC, van Zyl S, Hardie RA, Segone AM, Venter PA, Bornman MS, Hayes VM.

Prostate. 2014 Jun;74(8):880-91. doi: 10.1002/pros.22806. Epub 2014 Apr 9.


Physician shadowing by college students: what do patients think?

Bing-You RG, Hayes VM, Skolfield JL.

BMC Res Notes. 2014 Mar 14;7:146. doi: 10.1186/1756-0500-7-146.


Addressing the contribution of previously described genetic and epidemiological risk factors associated with increased prostate cancer risk and aggressive disease within men from South Africa.

Tindall EA, Bornman MS, van Zyl S, Segone AM, Monare LR, Venter PA, Hayes VM.

BMC Urol. 2013 Dec 29;13:74. doi: 10.1186/1471-2490-13-74.


Performance of high-throughput sequencing for the discovery of genetic variation across the complete size spectrum.

Pang AW, Macdonald JR, Yuen RK, Hayes VM, Scherer SW.

G3 (Bethesda). 2014 Jan 10;4(1):63-5. doi: 10.1534/g3.113.008797.


Complex patterns of genomic admixture within southern Africa.

Petersen DC, Libiger O, Tindall EA, Hardie RA, Hannick LI, Glashoff RH, Mukerji M; Indian Genome Variation Consortium, Fernandez P, Haacke W, Schork NJ, Hayes VM.

PLoS Genet. 2013;9(3):e1003309. doi: 10.1371/journal.pgen.1003309. Epub 2013 Mar 14.


A novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency.

Saunders DN, Tindall EA, Shearer RF, Roberson J, Decker A, Wilson JA, Hayes VM.

PLoS One. 2012;7(12):e51762. doi: 10.1371/journal.pone.0051762. Epub 2012 Dec 12.


Interleukin-6 promoter variants, prostate cancer risk, and survival.

Tindall EA, Severi G, Hoang HN, Southey MC, English DR, Hopper JL, Giles GG, Hayes VM; Australian Prostate Cancer BioResource.

Prostate. 2012 Dec 1;72(16):1701-7. doi: 10.1002/pros.22557. Epub 2012 Jul 10.


Helping hand for genomics in Africa.

Hayes VM, Venter PA, Mphahlele MJ.

Nature. 2011 Aug 10;476(7359):152. doi: 10.1038/476152c. No abstract available.


Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil).

Miller W, Hayes VM, Ratan A, Petersen DC, Wittekindt NE, Miller J, Walenz B, Knight J, Qi J, Zhao F, Wang Q, Bedoya-Reina OC, Katiyar N, Tomsho LP, Kasson LM, Hardie RA, Woodbridge P, Tindall EA, Bertelsen MF, Dixon D, Pyecroft S, Helgen KM, Lesk AM, Pringle TH, Patterson N, Zhang Y, Kreiss A, Woods GM, Jones ME, Schuster SC.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12348-53. doi: 10.1073/pnas.1102838108. Epub 2011 Jun 27. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625.


Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.

Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M.

Blood. 2010 Dec 2;116(23):5021-31. doi: 10.1182/blood-2010-03-276964. Epub 2010 Aug 19.


Comprehensive analysis of the cytokine-rich chromosome 5q31.1 region suggests a role for IL-4 gene variants in prostate cancer risk.

Tindall EA, Severi G, Hoang HN, Ma CS, Fernandez P, Southey MC, English DR, Hopper JL, Heyns CF, Tangye SG, Giles GG, Hayes VM; Australian Prostate Cancer BioResource.

Carcinogenesis. 2010 Oct;31(10):1748-54. doi: 10.1093/carcin/bgq081. Epub 2010 Apr 19.


Calling SNPs without a reference sequence.

Ratan A, Zhang Y, Hayes VM, Schuster SC, Miller W.

BMC Bioinformatics. 2010 Mar 15;11:130. doi: 10.1186/1471-2105-11-130.


The 4q27 locus and prostate cancer risk.

Tindall EA, Hoang HN, Southey MC, English DR, Hopper JL, Giles GG, Severi G, Hayes VM.

BMC Cancer. 2010 Feb 25;10:69. doi: 10.1186/1471-2407-10-69.


Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation.

Tindall EA, Petersen DC, Nikolaysen S, Miller W, Schuster SC, Hayes VM.

BMC Res Notes. 2010 Feb 22;3:39. doi: 10.1186/1756-0500-3-39.


Complete Khoisan and Bantu genomes from southern Africa.

Schuster SC, Miller W, Ratan A, Tomsho LP, Giardine B, Kasson LR, Harris RS, Petersen DC, Zhao F, Qi J, Alkan C, Kidd JM, Sun Y, Drautz DI, Bouffard P, Muzny DM, Reid JG, Nazareth LV, Wang Q, Burhans R, Riemer C, Wittekindt NE, Moorjani P, Tindall EA, Danko CG, Teo WS, Buboltz AM, Zhang Z, Ma Q, Oosthuysen A, Steenkamp AW, Oostuisen H, Venter P, Gajewski J, Zhang Y, Pugh BF, Makova KD, Nekrutenko A, Mardis ER, Patterson N, Pringle TH, Chiaromonte F, Mullikin JC, Eichler EE, Hardison RC, Gibbs RA, Harkins TT, Hayes VM.

Nature. 2010 Feb 18;463(7283):943-7. doi: 10.1038/nature08795.


Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.

Tindall EA, Hayes VM.

DNA Res. 2010 Apr;17(2):117-22. doi: 10.1093/dnares/dsq003. Epub 2010 Feb 12.


Inflammatory genetic markers of prostate cancer risk.

Tindall EA, Hayes VM, Petersen DC.

Cancers (Basel). 2010 Jun 8;2(2):1198-220. doi: 10.3390/cancers2021198.


Sibship analysis of associations between SNP haplotypes and a continuous trait with application to mammographic density.

Stone J, Gurrin LC, Hayes VM, Southey MC, Hopper JL, Byrnes GB.

Genet Epidemiol. 2010 May;34(4):309-18. doi: 10.1002/gepi.20462.


Optimization methods for selecting founder individuals for captive breeding or reintroduction of endangered species.

Miller W, Wright SJ, Zhang Y, Schuster SC, Hayes VM.

Pac Symp Biocomput. 2010:43-53.


Genetic structure of a unique admixed population: implications for medical research.

Patterson N, Petersen DC, van der Ross RE, Sudoyo H, Glashoff RH, Marzuki S, Reich D, Hayes VM.

Hum Mol Genet. 2010 Feb 1;19(3):411-9. doi: 10.1093/hmg/ddp505. Epub 2009 Nov 5.


Correlation between HIV-1 seropositivity and prevalence of a gamma-secretase polymorphism in two distinct ethnic populations.

van Loo KM, van Schijndel JE, van Zweeden M, van Manen D, Trip MD, Petersen DC, Schuitemaker H, Hayes VM, Martens GJ.

J Med Virol. 2009 Nov;81(11):1847-51. doi: 10.1002/jmv.21601.


Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer.

Comstock CE, Augello MA, Benito RP, Karch J, Tran TH, Utama FE, Tindall EA, Wang Y, Burd CJ, Groh EM, Hoang HN, Giles GG, Severi G, Hayes VM, Henderson BE, Le Marchand L, Kolonel LN, Haiman CA, Baffa R, Gomella LG, Knudsen ES, Rui H, Henshall SM, Sutherland RL, Knudsen KE.

Clin Cancer Res. 2009 Sep 1;15(17):5338-49. doi: 10.1158/1078-0432.CCR-08-2865. Epub 2009 Aug 25.


Assessing high-resolution melt curve analysis for accurate detection of gene variants in complex DNA fragments.

Tindall EA, Petersen DC, Woodbridge P, Schipany K, Hayes VM.

Hum Mutat. 2009 Jun;30(6):876-83. doi: 10.1002/humu.20919.


HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer.

Rasiah KK, Gardiner-Garden M, Padilla EJ, Möller G, Kench JG, Alles MC, Eggleton SA, Stricker PD, Adamski J, Sutherland RL, Henshall SM, Hayes VM.

Mol Cell Endocrinol. 2009 Mar 25;301(1-2):89-96. doi: 10.1016/j.mce.2008.11.021. Epub 2008 Nov 28.


No association between common chemokine and chemokine receptor gene variants and prostate cancer risk.

Petersen DC, Severi G, Hoang HN, Padilla EJ, Southey MC, English DR, Hopper JL, Giles GG, Hayes VM.

Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3615-7. doi: 10.1158/1055-9965.EPI-08-0896.


The rs743572 common variant in the promoter of CYP17A1 is not associated with prostate cancer risk or circulating hormonal levels.

Severi G, Hayes VM, Tesoriero AA, Southey MC, Hoang HN, Padilla EJ, Morris HA, English DR, Sutherland RL, Boyle P, Hopper JL, Giles GG.

BJU Int. 2008 Feb;101(4):492-6. Epub 2007 Nov 6.


Mammographic density and candidate gene variants: a twins and sisters study.

Stone J, Gurrin LC, Byrnes GB, Schroen CJ, Treloar SA, Padilla EJ, Dite GS, Southey MC, Hayes VM, Hopper JL.

Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1479-84.


Novel Plexor SNP genotyping technology: comparisons with TaqMan and homogenous MassEXTEND MALDI-TOF mass spectrometry.

Tindall EA, Speight G, Petersen DC, Padilla EJ, Hayes VM.

Hum Mutat. 2007 Sep;28(9):922-7.


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