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Items: 1 to 50 of 431

1.

Concussion BASICS III: Serum biomarker changes following sport-related concussion.

Asken BM, Bauer RM, DeKosky ST, Svingos AM, Hromas G, Boone JK, DuBose DN, Hayes RL, Clugston JR.

Neurology. 2018 Nov 7. pii: 10.1212/WNL.0000000000006617. doi: 10.1212/WNL.0000000000006617. [Epub ahead of print]

PMID:
30404786
2.

Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing.

Widom JR, Nedialkov YA, Rai V, Hayes RL, Brooks CL 3rd, Artsimovitch I, Walter NG.

Mol Cell. 2018 Nov 1;72(3):541-552.e6. doi: 10.1016/j.molcel.2018.08.046.

PMID:
30388413
3.

Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats.

Glushakov AO, Glushakova OY, Korol TY, Acosta SA, Borlongan CV, Valadka AB, Hayes RL, Glushakov AV.

Int J Mol Sci. 2018 Oct 13;19(10). pii: E3151. doi: 10.3390/ijms19103151.

4.

Approaching protein design with multisite λ dynamics: Accurate and scalable mutational folding free energies in T4 lysozyme.

Hayes RL, Vilseck JZ, Brooks CL 3rd.

Protein Sci. 2018 Nov;27(11):1910-1922. doi: 10.1002/pro.3500.

PMID:
30175503
5.

Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond.

Kochanek PM, Dixon CE, Mondello S, Wang KKK, Lafrenaye A, Bramlett HM, Dietrich WD, Hayes RL, Shear DA, Gilsdorf JS, Catania M, Poloyac SM, Empey PE, Jackson TC, Povlishock JT.

Front Neurol. 2018 Aug 7;9:640. doi: 10.3389/fneur.2018.00640. eCollection 2018. Review.

6.

Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.

Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf JS, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Wang KKW.

J Neurotrauma. 2018 Aug 30. doi: 10.1089/neu.2017.5586. [Epub ahead of print]

PMID:
29987972
7.

Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).

Magruder JT, Fraser CD 3rd, Grimm JC, Crawford TC, Beaty CA, Suarez-Pierre A, Hayes RL, Johnston MV, Baumgartner WA.

J Cardiothorac Vasc Anesth. 2018 Jun 11. pii: S1053-0770(18)30354-9. doi: 10.1053/j.jvca.2018.05.021. [Epub ahead of print]

PMID:
29903683
8.

Predicting Binding Free Energies in a Large Combinatorial Chemical Space Using Multisite λ Dynamics.

Vilseck JZ, Armacost KA, Hayes RL, Goh GB, Brooks CL 3rd.

J Phys Chem Lett. 2018 Jun 21;9(12):3328-3332. doi: 10.1021/acs.jpclett.8b01284. Epub 2018 Jun 6.

PMID:
29847134
9.

Pre-Clinical Testing of Therapies for Traumatic Brain Injury.

DeWitt DS, Hawkins BE, Dixon CE, Kochanek PM, Armstead W, Bass CR, Bramlett HM, Buki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds SR, LaPlaca MC, Long JB, Meaney DF, Mondello S, Noble-Haeusslein LJ, Poloyac SM, Prough DS, Robertson CS, Saatman KE, Shultz SR, Shear DA, Smith DH, Valadka AB, VandeVord P, Zhang L.

J Neurotrauma. 2018 Aug 30. doi: 10.1089/neu.2018.5778. [Epub ahead of print]

PMID:
29756522
10.

Operation Brain Trauma Therapy: 2016 Update.

Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.

Mil Med. 2018 Mar 1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184.

PMID:
29635589
11.

Metabolomics and Precision Medicine in Trauma: The State of the Field.

Jayaraman SP, Anand RJ, DeAntonio JH, Mangino M, Aboutanos MB, Kasirajan V, Ivatury RR, Valadka AB, Glushakova O, Hayes RL, Bachmann LM, Brophy GM, Contaifer D, Warncke UO, Brophy DF, Wijesinghe DS.

Shock. 2018 Jul;50(1):5-13. doi: 10.1097/SHK.0000000000001093.

PMID:
29280924
12.

Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Kobeissy FH, Liu MC, Yang Z, Zhang Z, Zheng W, Glushakova O, Mondello S, Anagli J, Hayes RL, Wang KKW.

Mol Neurobiol. 2018 Jan;55(1):898-900. doi: 10.1007/s12035-017-0764-3. No abstract available.

PMID:
28975597
13.

Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma.

Papa L, Robicsek SA, Brophy GM, Wang KKW, Hannay HJ, Heaton S, Schmalfuss I, Gabrielli A, Hayes RL, Robertson CS.

J Neurotrauma. 2018 Jan 1;35(1):32-40. doi: 10.1089/neu.2017.4994. Epub 2017 Nov 3.

PMID:
28895474
14.

CDOCKER and λ-dynamics for prospective prediction in D₃R Grand Challenge 2.

Ding X, Hayes RL, Vilseck JZ, Charles MK, Brooks CL 3rd.

J Comput Aided Mol Des. 2018 Jan;32(1):89-102. doi: 10.1007/s10822-017-0050-5. Epub 2017 Sep 7.

PMID:
28884249
15.

Prospective Assessment of Acute Blood Markers of Brain Injury in Sport-Related Concussion.

Meier TB, Nelson LD, Huber DL, Bazarian JJ, Hayes RL, McCrea MA.

J Neurotrauma. 2017 Nov 15;34(22):3134-3142. doi: 10.1089/neu.2017.5046. Epub 2017 Aug 4.

PMID:
28699381
16.

Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats.

Glushakova OY, Glushakov AO, Borlongan CV, Valadka AB, Hayes RL, Glushakov AV.

J Neurotrauma. 2018 Jan 1;35(1):157-173. doi: 10.1089/neu.2017.4999. Epub 2017 Jul 21.

PMID:
28637381
17.

Gibbs Sampler-Based λ-Dynamics and Rao-Blackwell Estimator for Alchemical Free Energy Calculation.

Ding X, Vilseck JZ, Hayes RL, Brooks CL 3rd.

J Chem Theory Comput. 2017 Jun 13;13(6):2501-2510. doi: 10.1021/acs.jctc.7b00204. Epub 2017 May 26.

18.

Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: Implications for chronic neurodegeneration.

Glushakova OY, Glushakov AA, Wijesinghe DS, Valadka AB, Hayes RL, Glushakov AV.

Brain Circ. 2017 Apr-Jun;3(2):87-108. doi: 10.4103/bc.bc_27_16. Epub 2017 Jul 18. Review.

19.

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.

Yang Z, Bramlett HM, Moghieb A, Yu D, Wang P, Lin F, Bauer C, Selig TM, Jaalouk E, Weissman AS, Rathore DS, Romo P, Zhang Z, Hayes RL, Wang MY, Dietrich WD, Wang KKW.

Mol Neurobiol. 2018 Mar;55(3):2174-2184. doi: 10.1007/s12035-017-0424-7. Epub 2017 Mar 13.

PMID:
28290147
20.

A magnesium-induced triplex pre-organizes the SAM-II riboswitch.

Roy S, Lammert H, Hayes RL, Chen B, LeBlanc R, Dayie TK, Onuchic JN, Sanbonmatsu KY.

PLoS Comput Biol. 2017 Mar 1;13(3):e1005406. doi: 10.1371/journal.pcbi.1005406. eCollection 2017 Mar.

21.

Adaptive Landscape Flattening Accelerates Sampling of Alchemical Space in Multisite λ Dynamics.

Hayes RL, Armacost KA, Vilseck JZ, Brooks CL 3rd.

J Phys Chem B. 2017 Apr 20;121(15):3626-3635. doi: 10.1021/acs.jpcb.6b09656. Epub 2017 Feb 10.

22.

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.

Kobeissy FH, Guingab-Cagmat JD, Zhang Z, Moghieb A, Glushakova OY, Mondello S, Boutté AM, Anagli J, Rubenstein R, Bahmad H, Wagner AK, Hayes RL, Wang KK.

Front Neurol. 2016 Nov 22;7:198. eCollection 2016.

23.

Animal Models of Posttraumatic Seizures and Epilepsy.

Glushakov AV, Glushakova OY, Doré S, Carney PR, Hayes RL.

Methods Mol Biol. 2016;1462:481-519. doi: 10.1007/978-1-4939-3816-2_27.

24.

Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.

Cheng RR, Nordesjö O, Hayes RL, Levine H, Flores SC, Onuchic JN, Morcos F.

Mol Biol Evol. 2016 Dec;33(12):3054-3064. Epub 2016 Sep 7.

25.

Finding effective biomarkers for pediatric traumatic brain injury.

Glushakova OY, Glushakov AV, Hayes RL.

Brain Circ. 2016 Jul-Sep;2(3):129-132. doi: 10.4103/2394-8108.192518. Epub 2016 Oct 18. Review.

26.

Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.

Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP.

Sci Rep. 2016 Jun 20;6:28203. doi: 10.1038/srep28203.

27.

Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients.

Ren C, Kobeissy F, Alawieh A, Li N, Li N, Zibara K, Zoltewicz S, Guingab-Cagmat J, Larner SF, Ding Y, Hayes RL, Ji X, Mondello S.

Sci Rep. 2016 Apr 14;6:24588. doi: 10.1038/srep24588.

28.

SMOG 2: A Versatile Software Package for Generating Structure-Based Models.

Noel JK, Levi M, Raghunathan M, Lammert H, Hayes RL, Onuchic JN, Whitford PC.

PLoS Comput Biol. 2016 Mar 10;12(3):e1004794. doi: 10.1371/journal.pcbi.1004794. eCollection 2016 Mar.

29.

Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.

Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Panigrahy A, Richichi R, Callaway CW, Bell MJ, Mondello S, Hayes RL, Kochanek PM.

Resuscitation. 2016 Apr;101:65-70. doi: 10.1016/j.resuscitation.2016.01.024. Epub 2016 Feb 6.

30.

Biomarkers for acute diagnosis and management of stroke in neurointensive care units.

Glushakova OY, Glushakov AV, Miller ER, Valadka AB, Hayes RL.

Brain Circ. 2016 Jan-Mar;2(1):28-47. doi: 10.4103/2394-8108.178546. Epub 2016 Mar 11. Review.

31.

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.

Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri SP, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):595-605. doi: 10.1089/neu.2015.4132.

PMID:
26671651
32.

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KK, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):581-94. doi: 10.1089/neu.2015.4131.

PMID:
26671550
33.

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey PE, Povlishock JT, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):606-14. doi: 10.1089/neu.2015.4133. Review.

PMID:
26671284
34.

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey PE, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):553-66. doi: 10.1089/neu.2015.4122.

PMID:
26671075
35.

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Shear DA, Dixon CE, Bramlett HM, Mondello S, Dietrich WD, Deng-Bryant Y, Schmid KE, Wang KK, Hayes RL, Povlishock JT, Kochanek PM, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):523-37. doi: 10.1089/neu.2015.4115.

PMID:
26670792
36.

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):538-52. doi: 10.1089/neu.2015.4116.

PMID:
26670694
37.

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD, Wang KK, Caudle K, Empey PE, Poloyac SM, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Shear DA.

J Neurotrauma. 2016 Mar 15;33(6):567-80. doi: 10.1089/neu.2015.4130. Epub 2016 Jan 20.

PMID:
26541177
38.

Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.

Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, Saville B, Tyndall JA, Nash M, Buki A, Barzo P, Hack D, Tortella FC, Schmid K, Hayes RL, Vossough A, Sweriduk ST, Bazarian JJ.

J Neurotrauma. 2016 Jan 15;33(2):203-14. doi: 10.1089/neu.2015.4149. Epub 2015 Dec 18.

39.

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):513-22. doi: 10.1089/neu.2015.4113. Epub 2015 Dec 10. Review.

PMID:
26439468
40.

CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from Bench to Bedside: A Translational Perspective.

Mouhieddine TH, El Houjeiri L, Sabra M, Hayes RL, Mondello S.

In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 20.

41.

Potential Use of Calpain Inhibitors as Brain Injury Therapy.

Cagmat EB, Guingab-Cagmat JD, Vakulenko AV, Hayes RL, Anagli J.

In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 40.

42.

Generalized Manning Condensation Model Captures the RNA Ion Atmosphere.

Hayes RL, Noel JK, Mandic A, Whitford PC, Sanbonmatsu KY, Mohanty U, Onuchic JN.

Phys Rev Lett. 2015 Jun 26;114(25):258105. Epub 2015 Jun 26.

43.

Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.

Carman AJ, Ferguson R, Cantu R, Comstock RD, Dacks PA, DeKosky ST, Gandy S, Gilbert J, Gilliland C, Gioia G, Giza C, Greicius M, Hainline B, Hayes RL, Hendrix J, Jordan B, Kovach J, Lane RF, Mannix R, Murray T, Seifert T, Shineman DW, Warren E, Wilde E, Willard H, Fillit HM.

Nat Rev Neurol. 2015 Apr;11(4):230-44. doi: 10.1038/nrneurol.2015.30. Epub 2015 Mar 17. Review.

PMID:
25776822
44.

Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.

Huang XJ, Glushakova O, Mondello S, Van K, Hayes RL, Lyeth BG.

J Neurotrauma. 2015 Aug 15;32(16):1179-89. doi: 10.1089/neu.2015.3873. Epub 2015 May 14.

PMID:
25763798
45.

Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury.

Tóth A, Schmalfuss I, Heaton SC, Gabrielli A, Hannay HJ, Papa L, Brophy GM, Wang KK, Büki A, Schwarcz A, Hayes RL, Robertson CS, Robicsek SA.

J Neurotrauma. 2015 Sep 1;32(17):1307-11. doi: 10.1089/neu.2014.3696. Epub 2015 May 19.

46.

Biomarkers.

Mondello S, Hayes RL.

Handb Clin Neurol. 2015;127:245-65. doi: 10.1016/B978-0-444-52892-6.00016-7. Review.

PMID:
25702221
47.

UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A Single Center Pilot Study.

Douglas-Escobar MV, Heaton SC, Bennett J, Young LJ, Glushakova O, Xu X, Barbeau DY, Rossignol C, Miller C, Old Crow AM, Hayes RL, Weiss MD.

Front Neurol. 2014 Dec 19;5:273. doi: 10.3389/fneur.2014.00273. eCollection 2014.

48.

Minor and repetitive head injury.

Buki A, Kovacs N, Czeiter E, Schmid K, Berger RP, Kobeissy F, Italiano D, Hayes RL, Tortella FC, Mezosi E, Schwarcz A, Toth A, Nemes O, Mondello S.

Adv Tech Stand Neurosurg. 2015;42:147-92. doi: 10.1007/978-3-319-09066-5_8. Review.

PMID:
25411149
49.

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Kobeissy FH, Liu MC, Yang Z, Zhang Z, Zheng W, Glushakova O, Mondello S, Anagli J, Hayes RL, Wang KK.

Mol Neurobiol. 2015 Aug;52(1):696-709. doi: 10.1007/s12035-014-8898-z. Epub 2014 Oct 2. Erratum in: Mol Neurobiol. 2017 Sep 27;:.

50.

Intercellular stress reconstitution from traction force data.

Zimmermann J, Hayes RL, Basan M, Onuchic JN, Rappel WJ, Levine H.

Biophys J. 2014 Aug 5;107(3):548-554. doi: 10.1016/j.bpj.2014.06.036.

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