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γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance.

Hayday AC.

J Immunol. 2019 Jul 15;203(2):311-320. doi: 10.4049/jimmunol.1800934. Review.


The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness.

Melandri D, Zlatareva I, Chaleil RAG, Dart RJ, Chancellor A, Nussbaumer O, Polyakova O, Roberts NA, Wesch D, Kabelitz D, Irving PM, John S, Mansour S, Bates PA, Vantourout P, Hayday AC.

Nat Immunol. 2018 Dec;19(12):1352-1365. doi: 10.1038/s41590-018-0253-5. Epub 2018 Nov 12.


Pillars Article: Regulation of Cutaneous Malignancy by γδ T Cells. Science. 2001. 294: 605-609.

Girardi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar RE, Hayday AC.

J Immunol. 2018 May 1;200(9):3031-3035. No abstract available.


Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human Vγ9Vδ2 T Cells.

Rodrigues NV, Correia DV, Mensurado S, Nóbrega-Pereira S, deBarros A, Kyle-Cezar F, Tutt A, Hayday AC, Norell H, Silva-Santos B, Dias S.

Cancer Immunol Res. 2018 Apr;6(4):448-457. doi: 10.1158/2326-6066.CIR-17-0327. Epub 2018 Jan 22.


Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.

Vantourout P, Laing A, Woodward MJ, Zlatareva I, Apolonia L, Jones AW, Snijders AP, Malim MH, Hayday AC.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1039-1044. doi: 10.1073/pnas.1701237115. Epub 2018 Jan 16.


Adaptive from Innate: Human IFN-γ+CD4+ T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.

Das A, Rouault-Pierre K, Kamdar S, Gomez-Tourino I, Wood K, Donaldson I, Mein CA, Bonnet D, Hayday AC, Gibbons DL.

J Immunol. 2017 Sep 1;199(5):1696-1705. doi: 10.4049/jimmunol.1700551. Epub 2017 Jul 28.


Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression.

Salim M, Willcox CR, Mohammed F, Hayday AC, Overduin M, Willcox BE, Knowles TJ.

Biomol NMR Assign. 2016 Oct;10(2):357-60. doi: 10.1007/s12104-016-9700-0. Epub 2016 Aug 4.


Corrigendum: Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC.

Nat Immunol. 2016 Apr;17(4):469. doi: 10.1038/ni0416-469b. No abstract available.


Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.

Salim M, Knowles TJ, Hart R, Mohammed F, Woodward MJ, Willcox CR, Overduin M, Hayday AC, Willcox BE.

J Biol Chem. 2016 Apr 22;291(17):9310-21. doi: 10.1074/jbc.M116.722066. Epub 2016 Feb 25.


Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events.

Sobolev O, Binda E, O'Farrell S, Lorenc A, Pradines J, Huang Y, Duffner J, Schulz R, Cason J, Zambon M, Malim MH, Peakman M, Cope A, Capila I, Kaundinya GV, Hayday AC.

Nat Immunol. 2016 Feb;17(2):204-13. doi: 10.1038/ni.3328. Epub 2016 Jan 4. Erratum in: Nat Immunol. 2016 Apr;17(4):469.


Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.

Swamy M, Abeler-Dörner L, Chettle J, Mahlakõiv T, Goubau D, Chakravarty P, Ramsay G, Reis E Sousa C, Staeheli P, Blacklaws BA, Heeney JL, Hayday AC.

Nat Commun. 2015 May 19;6:7090. doi: 10.1038/ncomms8090.


Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space.

Schmolka N, Wencker M, Hayday AC, Silva-Santos B.

Semin Immunol. 2015 Feb;27(1):19-25. doi: 10.1016/j.smim.2015.01.001. Epub 2015 Feb 25. Review.


Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.

Wencker M, Turchinovich G, Di Marco Barros R, Deban L, Jandke A, Cope A, Hayday AC.

Nat Immunol. 2014 Jan;15(1):80-7. doi: 10.1038/ni.2773. Epub 2013 Nov 17.


An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, Nestle FO, Barker JN, Bell RJ, Capon F, Trembath RC.

PLoS One. 2013 Aug 19;8(8):e71690. doi: 10.1371/journal.pone.0071690. eCollection 2013.


Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.

Michel ML, Pang DJ, Haque SF, Potocnik AJ, Pennington DJ, Hayday AC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17549-54. doi: 10.1073/pnas.1204327109. Epub 2012 Oct 9.


Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor.

Willcox CR, Pitard V, Netzer S, Couzi L, Salim M, Silberzahn T, Moreau JF, Hayday AC, Willcox BE, Déchanet-Merville J.

Nat Immunol. 2012 Sep;13(9):872-9. doi: 10.1038/ni.2394. Epub 2012 Aug 12.


NK cells promote Th-17 mediated corneal barrier disruption in dry eye.

Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS.

PLoS One. 2012;7(5):e36822. doi: 10.1371/journal.pone.0036822. Epub 2012 May 8.


Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger JM, Simon AK, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G.

Immunity. 2012 Mar 23;36(3):427-37. doi: 10.1016/j.immuni.2012.01.016. Epub 2012 Mar 15.


Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis.

Hundhausen C, Bertoni A, Mak RK, Botti E, Di Meglio P, Clop A, Laggner U, Chimenti S, Hayday AC, Barker JN, Trembath RC, Capon F, Nestle FO.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):635-41. doi: 10.1038/jid.2011.378. Epub 2011 Nov 24.


Butyrophilins: an emerging family of immune regulators.

Abeler-Dörner L, Swamy M, Williams G, Hayday AC, Bas A.

Trends Immunol. 2012 Jan;33(1):34-41. doi: 10.1016/ Epub 2011 Oct 24. Review.


Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.

Laggner U, Di Meglio P, Perera GK, Hundhausen C, Lacy KE, Ali N, Smith CH, Hayday AC, Nickoloff BJ, Nestle FO.

J Immunol. 2011 Sep 1;187(5):2783-93. doi: 10.4049/jimmunol.1100804. Epub 2011 Aug 3.


Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.

Gibbons DL, Abeler-Dörner L, Raine T, Hwang IY, Jandke A, Wencker M, Deban L, Rudd CE, Irving PM, Kehrl JH, Hayday AC.

J Immunol. 2011 Sep 1;187(5):2067-71. doi: 10.4049/jimmunol.1100833. Epub 2011 Jul 27.


Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells.

Turchinovich G, Hayday AC.

Immunity. 2011 Jul 22;35(1):59-68. doi: 10.1016/j.immuni.2011.04.018. Epub 2011 Jul 7.


Butyrophilin-like 1 encodes an enterocyte protein that selectively regulates functional interactions with T lymphocytes.

Bas A, Swamy M, Abeler-Dörner L, Williams G, Pang DJ, Barbee SD, Hayday AC.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4376-81. doi: 10.1073/pnas.1010647108. Epub 2011 Feb 28.


Skint-1 is a highly specific, unique selecting component for epidermal T cells.

Barbee SD, Woodward MJ, Turchinovich G, Mention JJ, Lewis JM, Boyden LM, Lifton RP, Tigelaar R, Hayday AC.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3330-5. doi: 10.1073/pnas.1010890108. Epub 2011 Feb 7.


Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.

Ribot JC, Chaves-Ferreira M, d'Orey F, Wencker M, Gonçalves-Sousa N, Decalf J, Simas JP, Hayday AC, Silva-Santos B.

J Immunol. 2010 Dec 1;185(11):6421-6425. doi: 10.4049/jimmunol.1002283. Epub 2010 Oct 29.


In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

Meraviglia S, Eberl M, Vermijlen D, Todaro M, Buccheri S, Cicero G, La Mendola C, Guggino G, D'Asaro M, Orlando V, Scarpa F, Roberts A, Caccamo N, Stassi G, Dieli F, Hayday AC.

Clin Exp Immunol. 2010 Aug;161(2):290-7. doi: 10.1111/j.1365-2249.2010.04167.x. Epub 2010 May 10.


Molecular analysis of tumor-promoting CD8+ T cells in two-stage cutaneous chemical carcinogenesis.

Kwong BY, Roberts SJ, Silberzahn T, Filler RB, Neustadter JH, Galan A, Reddy S, Lin WM, Ellis PD, Langford CF, Hayday AC, Girardi M.

J Invest Dermatol. 2010 Jun;130(6):1726-36. doi: 10.1038/jid.2009.362. Epub 2009 Nov 19.


Gammadelta T cells and the lymphoid stress-surveillance response.

Hayday AC.

Immunity. 2009 Aug 21;31(2):184-96. doi: 10.1016/j.immuni.2009.08.006.


Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants.

Gibbons DL, Haque SF, Silberzahn T, Hamilton K, Langford C, Ellis P, Carr R, Hayday AC.

Eur J Immunol. 2009 Jul;39(7):1794-806. doi: 10.1002/eji.200939222.


Barrier immunity.

Hayday AC, Spencer J.

Semin Immunol. 2009 Jun;21(3):99-100. doi: 10.1016/j.smim.2009.04.003. Epub 2009 May 14. No abstract available.


Skin immune surveillance by T cells--a new order?

Strid J, Tigelaar RE, Hayday AC.

Semin Immunol. 2009 Jun;21(3):110-20. doi: 10.1016/j.smim.2009.03.002. Epub 2009 Apr 14. Review.


CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ, Silva-Santos B.

Nat Immunol. 2009 Apr;10(4):427-36. doi: 10.1038/ni.1717. Epub 2009 Mar 8.


Suppression of airway inflammation by a natural acute infection of the intestinal epithelium.

Gibbons DL, Haque SF, Copestake SL, Wells JW, Noble A, Smith AL, Hayday AC.

Mucosal Immunol. 2009 Mar;2(2):144-55. doi: 10.1038/mi.2008.83. Epub 2008 Dec 24.


Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease.

Dodd J, Riffault S, Kodituwakku JS, Hayday AC, Openshaw PJ.

J Immunol. 2009 Jan 15;182(2):1174-81.


Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization.

Leggat JA, Gibbons DL, Haque SF, Smith AL, Wells JW, Choy K, Lloyd CM, Hayday AC, Noble A.

J Allergy Clin Immunol. 2008 Nov;122(5):1014-1021.e4. doi: 10.1016/j.jaci.2008.08.011. Epub 2008 Sep 19.


The habitual, diverse and surmountable obstacles to human immunology research.

Hayday AC, Peakman M.

Nat Immunol. 2008 Jun;9(6):575-80. doi: 10.1038/ni0608-575. No abstract available.


Establishing humanized mice using stem cells: maximizing the potential.

Bernard D, Peakman M, Hayday AC.

Clin Exp Immunol. 2008 Jun;152(3):406-14. doi: 10.1111/j.1365-2249.2008.03659.x. Epub 2008 Apr 24. Review.


Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells.

Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP.

Nat Genet. 2008 May;40(5):656-62. doi: 10.1038/ng.108. Epub 2008 Apr 13.


Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis.

Strid J, Roberts SJ, Filler RB, Lewis JM, Kwong BY, Schpero W, Kaplan DH, Hayday AC, Girardi M.

Nat Immunol. 2008 Feb;9(2):146-54. doi: 10.1038/ni1556. Epub 2008 Jan 6.


Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer.

Dieli F, Vermijlen D, Fulfaro F, Caccamo N, Meraviglia S, Cicero G, Roberts A, Buccheri S, D'Asaro M, Gebbia N, Salerno A, Eberl M, Hayday AC.

Cancer Res. 2007 Aug 1;67(15):7450-7.


Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis.

Roberts SJ, Ng BY, Filler RB, Lewis J, Glusac EJ, Hayday AC, Tigelaar RE, Girardi M.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6770-5. Epub 2007 Apr 5.


Characterization of a monoclonal antibody specific for human peripheral myelin protein 22 and its use in immunohistochemical studies of the fetal and adult nervous system.

Gregson NA, Zhang G, Pritchard J, Wang A, Sanvito L, Hayday AC, Hughes RA.

J Peripher Nerv Syst. 2007 Mar;12(1):2-10.


Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy.

Vermijlen D, Ellis P, Langford C, Klein A, Engel R, Willimann K, Jomaa H, Hayday AC, Eberl M.

J Immunol. 2007 Apr 1;178(7):4304-14.


CD8 Raft localization is induced by its assembly into CD8alpha beta heterodimers, Not CD8alpha alpha homodimers.

Pang DJ, Hayday AC, Bijlmakers MJ.

J Biol Chem. 2007 May 4;282(18):13884-94. Epub 2007 Mar 6.


Key factors in the organized chaos of early T cell development.

Hayday AC, Pennington DJ.

Nat Immunol. 2007 Feb;8(2):137-44. Review.


Reduced circulating CD4+CD25+ cell populations in Guillain-Barré syndrome.

Pritchard J, Makowska A, Gregson NA, Hayday AC, Hughes RA.

J Neuroimmunol. 2007 Feb;183(1-2):232-8. Epub 2007 Jan 18.


Early events in the thymus affect the balance of effector and regulatory T cells.

Pennington DJ, Silva-Santos B, Silberzahn T, Escórcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ, Hayday AC.

Nature. 2006 Dec 21;444(7122):1073-7.


Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant.

Lewis JM, Girardi M, Roberts SJ, Barbee SD, Hayday AC, Tigelaar RE.

Nat Immunol. 2006 Aug;7(8):843-50. Epub 2006 Jul 9.


Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells.

Girardi M, Lewis JM, Filler RB, Hayday AC, Tigelaar RE.

J Invest Dermatol. 2006 Apr;126(4):808-14.

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