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Items: 25


β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking.

Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H.

PLoS One. 2018 May 7;13(5):e0196946. doi: 10.1371/journal.pone.0196946. eCollection 2018.


Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism.

Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani Y, Shintani N, Hashimoto H.

EMBO Rep. 2018 Mar;19(3). pii: e44860. doi: 10.15252/embr.201744860. Epub 2018 Jan 25.


Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response.

Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1992-1997. doi: 10.1016/j.bbrc.2017.11.116. Epub 2017 Nov 24.


Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.

Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA.

Neurobiol Learn Mem. 2017 Nov;145:222-231. doi: 10.1016/j.nlm.2017.10.010. Epub 2017 Oct 10.


High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H.

Neuron. 2017 Jun 21;94(6):1085-1100.e6. doi: 10.1016/j.neuron.2017.05.017.


Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.

Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.

Schizophr Res. 2017 Mar;181:75-82. doi: 10.1016/j.schres.2016.10.012. Epub 2016 Oct 27.


Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues.

Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H.

Front Mol Neurosci. 2016 Nov 22;9:126. eCollection 2016.


Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction.

Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.

Behav Brain Res. 2016 Nov 1;314:77-86. doi: 10.1016/j.bbr.2016.07.050. Epub 2016 Jul 29.


De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ.

Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.

J Mol Psychiatry. 2016 Apr 21;4:1. doi: 10.1186/s40303-016-0016-x. eCollection 2016.


Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.

Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.

J Hum Genet. 2016 Mar;61(3):199-206. doi: 10.1038/jhg.2015.141. Epub 2015 Nov 19.


Comparative gene expression profiles in pancreatic islets associated with agouti yellow mutation and PACAP overexpression in mice.

Ikeda K, Tomimoto S, Tsuchiya S, Hamagami KI, Shintani N, Sugimoto Y, Ichikawa A, Kasai A, Nakazawa T, Nagayasu K, Hayata-Takano A, Baba A, Hashimoto H.

Biochem Biophys Rep. 2015 Jun 24;2:179-183. doi: 10.1016/j.bbrep.2015.06.006. eCollection 2015 Jul.


p13 overexpression in pancreatic β-cells ameliorates type 2 diabetes in high-fat-fed mice.

Higashi S, Katagi K, Shintani N, Ikeda K, Sugimoto Y, Tsuchiya S, Inoue N, Tanaka S, Koumoto M, Kasai A, Nakazawa T, Hayata-Takano A, Hamagami K, Tomimoto S, Yoshida T, Ohkubo T, Nagayasu K, Ago Y, Onaka Y, Hashimoto R, Ichikawa A, Baba A, Hashimoto H.

Biochem Biophys Res Commun. 2015 Jun 12;461(4):612-7. doi: 10.1016/j.bbrc.2015.04.074. Epub 2015 Apr 23.


Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide.

Shibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.

Neuroscience. 2015 Jun 25;297:95-104. doi: 10.1016/j.neuroscience.2015.03.062. Epub 2015 Apr 1.


PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF.

Ogata K, Shintani N, Hayata-Takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudry D, Vaudry H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H.

PLoS One. 2015 Mar 25;10(3):e0120526. doi: 10.1371/journal.pone.0120526. eCollection 2015.


Simultaneous neuron- and astrocyte-specific fluorescent marking.

Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H.

Biochem Biophys Res Commun. 2015 Mar 27;459(1):81-6. doi: 10.1016/j.bbrc.2015.02.073. Epub 2015 Feb 24.


CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice.

Onaka Y, Shintani N, Nakazawa T, Haba R, Ago Y, Wang H, Kanoh T, Hayata-Takano A, Hirai H, Nagata KY, Nakamura M, Hashimoto R, Matsuda T, Waschek JA, Kasai A, Nagayasu K, Baba A, Hashimoto H.

Behav Brain Res. 2015 May 1;284:131-7. doi: 10.1016/j.bbr.2015.02.013. Epub 2015 Feb 16.


Identification of the role of bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.

Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, Matsuda T, Baba A, Hashimoto H.

J Neurochem. 2015 Feb;132(4):418-28. doi: 10.1111/jnc.12999. Epub 2015 Jan 23.


Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism.

Takuma K, Hara Y, Kataoka S, Kawanai T, Maeda Y, Watanabe R, Takano E, Hayata-Takano A, Hashimoto H, Ago Y, Matsuda T.

Pharmacol Biochem Behav. 2014 Nov;126:43-9. doi: 10.1016/j.pbb.2014.08.013. Epub 2014 Sep 18.


Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice.

Hazama K, Hayata-Takano A, Uetsuki K, Kasai A, Encho N, Shintani N, Nagayasu K, Hashimoto R, Reglodi D, Miyakawa T, Nakazawa T, Baba A, Hashimoto H.

PLoS One. 2014 Feb 20;9(2):e89153. doi: 10.1371/journal.pone.0089153. eCollection 2014.


[Pituitary adenylate cyclase-activating polypeptide(PACAP) plays significant roles in mental function and neuronal development].

Hayata-Takano A, Seiriki K, Tajiri M, Ogata K, Shintani N, Baba A, Hashimoto H.

Nihon Shinkei Seishin Yakurigaku Zasshi. 2013 Apr;33(2):73-5. Japanese. No abstract available.


PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.

Inoue H, Shintani N, Sakurai Y, Higashi S, Hayata-Takano A, Baba A, Hashimoto H.

Front Endocrinol (Lausanne). 2013 Mar 11;4:27. doi: 10.3389/fendo.2013.00027. eCollection 2013.


The selective metabotropic glutamate 2/3 receptor agonist MGS0028 reverses psychomotor abnormalities and recognition memory deficits in mice lacking the pituitary adenylate cyclase-activating polypeptide.

Ago Y, Hiramatsu N, Ishihama T, Hazama K, Hayata-Takano A, Shibasaki Y, Shintani N, Hashimoto H, Kawasaki T, Onoe H, Chaki S, Nakazato A, Baba A, Takuma K, Matsuda T.

Behav Pharmacol. 2013 Feb;24(1):74-7. doi: 10.1097/FBP.0b013e32835cf3e5.


Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells.

Sakurai Y, Inoue H, Shintani N, Arimori A, Hamagami K, Hayata-Takano A, Baba A, Hashimoto H.

J Mol Neurosci. 2012 Nov;48(3):647-53. Epub 2012 Apr 3.


A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells.

Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H.

J Neurochem. 2012 Jul;122(1):81-93. doi: 10.1111/j.1471-4159.2012.07724.x. Epub 2012 Apr 4.

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