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APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

Mohamed NE, Hay T, Reed KR, Smalley MJ, Clarke AR.

BMC Cancer. 2019 Jul 10;19(1):677. doi: 10.1186/s12885-019-5867-y.


Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ.

Oncotarget. 2019 Apr 5;10(27):2586-2606. doi: 10.18632/oncotarget.26830. eCollection 2019 Apr 5.


The hospital-based evaluation of laxative prophylaxis in ICU (HELP-ICU): A pilot cluster-crossover randomized clinical trial.

Hay T, Deane AM, Rechnitzer T, Fetterplace K, Reilly R, Ankravs M, Bailey M, Fazio T, Anstey J, D'Costa R, Presneill JJ, MacIsaac CM, Bellomo R.

J Crit Care. 2019 Aug;52:86-91. doi: 10.1016/j.jcrc.2019.04.010. Epub 2019 Apr 8.


Constipation, diarrhea, and prophylactic laxative bowel regimens in the critically ill: A systematic review and meta-analysis.

Hay T, Bellomo R, Rechnitzer T, See E, Ali Abdelhamid Y, Deane AM.

J Crit Care. 2019 Aug;52:242-250. doi: 10.1016/j.jcrc.2019.01.004. Epub 2019 Jan 10. Review.


Correction: Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.

Johnson CE, Dunlop EA, Seifan S, McCann HD, Hay T, Parfitt GJ, Jones AT, Giles PJ, Shen MH, Sampson JR, Errington RJ, Davies DM, Tee AR.

Oncogene. 2019 Apr;38(16):3102. doi: 10.1038/s41388-018-0598-0.


John D. Strain, MD (1951-2018).

Fenton LZ, Hay TC.

Pediatr Radiol. 2018 Oct;48(11):1681-1682. doi: 10.1007/s00247-018-4231-8. Epub 2018 Aug 27. No abstract available.


Commentary: The Invention of Aboriginal Diabetes: The Role of the Thrifty Gene Hypothesis in Canadian Health Care Provision.

Hay T.

Ethn Dis. 2018 Aug 9;28(Suppl 1):247-252. doi: 10.18865/ed.28.S1.247. eCollection 2018.


TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230.


Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.

Johnson CE, Dunlop EA, Seifan S, McCann HD, Hay T, Parfitt GJ, Jones AT, Giles PJ, Shen MH, Sampson JR, Errington RJ, Davies DM, Tee AR.

Oncogene. 2018 Nov;37(45):5913-5925. doi: 10.1038/s41388-018-0381-2. Epub 2018 Jul 6. Erratum in: Oncogene. 2019 Jan 8;:.


Retail food environments, shopping experiences, First Nations and the provincial Norths.

Burnett K, Skinner K, Hay T, LeBlanc J, Chambers L.

Health Promot Chronic Dis Prev Can. 2017 Oct;37(10):333-341. doi: 10.24095/hpcdp.37.10.03. English, French.


The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding.

Sherry MR, Hay TJM, Gulak MA, Nassiri A, Finnen RL, Banfield BW.

Sci Rep. 2017 May 15;7(1):1882. doi: 10.1038/s41598-017-02109-0.


Integrated multisystem analysis in a mental health and criminal justice ecosystem.

Falconer E, El-Hay T, Alevras D, Docherty JP, Yanover C, Kalton A, Goldschmidt Y, Rosen-Zvi M.

Health Justice. 2017 Dec;5(1):4. doi: 10.1186/s40352-017-0049-y. Epub 2017 Mar 22.


The Product of the Herpes Simplex Virus 2 UL16 Gene Is Critical for the Egress of Capsids from the Nuclei of Infected Cells.

Gao J, Hay TJM, Banfield BW.

J Virol. 2017 Apr 28;91(10). pii: e00350-17. doi: 10.1128/JVI.00350-17. Print 2017 May 15.


Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics.

Cohen KA, El-Hay T, Wyres KL, Weissbrod O, Munsamy V, Yanover C, Aharonov R, Shaham O, Conway TC, Goldschmidt Y, Bishai WR, Pym AS.

EBioMedicine. 2016 Jul;9:170-179. doi: 10.1016/j.ebiom.2016.05.041. Epub 2016 Jun 1.


Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels.

Jones HM, Butt RP, Webster RW, Gurrell I, Dzygiel P, Flanagan N, Fraier D, Hay T, Iavarone LE, Luckwell J, Pearce H, Phipps A, Segelbacher J, Speed B, Beaumont K.

Clin Pharmacokinet. 2016 Jul;55(7):875-887. doi: 10.1007/s40262-015-0365-0.


Hepatic progenitor cells of biliary origin with liver repopulation capacity.

Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ.

Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20.


Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain.

Bagal SK, Bungay PJ, Denton SM, Gibson KR, Glossop MS, Hay TL, Kemp MI, Lane CA, Lewis ML, Maw GN, Million WA, Payne CE, Poinsard C, Rawson DJ, Stammen BL, Stevens EB, Thompson LR.

ACS Med Chem Lett. 2015 Apr 29;6(6):650-4. doi: 10.1021/acsmedchemlett.5b00059. eCollection 2015 Jun 11.


RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models.

Tangudu NK, Verma VK, Clemons TD, Beevi SS, Hay T, Mahidhara G, Raja M, Nair RA, Alexander LE, Patel AB, Jose J, Smith NM, Zdyrko B, Bourdoncle A, Luzinov I, Iyer KS, Clarke AR, Dinesh Kumar L.

Mol Cancer Ther. 2015 May;14(5):1259-69. doi: 10.1158/1535-7163.MCT-14-0970. Epub 2015 Feb 18.


The herpes simplex virus 2 virion-associated ribonuclease vhs interferes with stress granule formation.

Finnen RL, Hay TJ, Dauber B, Smiley JR, Banfield BW.

J Virol. 2014 Nov;88(21):12727-39. doi: 10.1128/JVI.01554-14. Epub 2014 Aug 20.


Integrated multisystem analysis in a mental health and criminal justice ecosystem.

Falconer E, El-Hay T, Alevras D, Docherty J, Yanover C, Kalton A, Goldschmidt Y, Rosen-Zvi M.

AMIA Annu Symp Proc. 2014 Nov 14;2014:526-33. eCollection 2014.


Modelling single- and tandem-bubble dynamics between two parallel plates for biomedical applications.

Hsiao CT, Choi JK, Singh S, Chahine GL, Hay TA, Ilinskii YA, Zabolotskaya EA, Hamilton MF, Sankin G, Yuan F, Zhong P.

J Fluid Mech. 2013 Feb 1;716. doi: 10.1017/jfm.2012.526.


Model for the dynamics of a spherical bubble undergoing small shape oscillations between parallel soft elastic layers.

Hay TA, Ilinskii YA, Zabolotskaya EA, Hamilton MF.

J Acoust Soc Am. 2013 Aug;134(2):1454-62. doi: 10.1121/1.4812864.


Predictive models for type 2 diabetes onset in middle-aged subjects with the metabolic syndrome.

Ozery-Flato M, Parush N, El-Hay T, Visockienė Z, Ryliškytė L, Badarienė J, Solovjova S, Kovaitė M, Navickas R, Laucevičius A.

Diabetol Metab Syndr. 2013 Jul 15;5(1):36. doi: 10.1186/1758-5996-5-36.


Use of CAP88 at Department of Energy sites.

Snyder S, Vázquez G, Hay T.

Health Phys. 2013 Aug;105(2 Suppl 2):S164-8. doi: 10.1097/HP.0b013e3182904d8f.


Antibiotic inducibility of the mexXY multidrug efflux operon of Pseudomonas aeruginosa: involvement of the MexZ anti-repressor ArmZ.

Hay T, Fraud S, Lau CH, Gilmour C, Poole K.

PLoS One. 2013;8(2):e56858. doi: 10.1371/journal.pone.0056858. Epub 2013 Feb 18.


Abnormal infant pulmonary function in young children with neuroendocrine cell hyperplasia of infancy.

Kerby GS, Wagner BD, Popler J, Hay TC, Kopecky C, Wilcox SL, Quinones RR, Giller RH, Accurso FJ, Deterding RR.

Pediatr Pulmonol. 2013 Oct;48(10):1008-15. doi: 10.1002/ppul.22718. Epub 2012 Nov 20.


Models of cylindrical bubble pulsation.

Ilinskii YA, Zabolotskaya EA, Hay TA, Hamilton MF.

J Acoust Soc Am. 2012 Sep;132(3):1346-57. doi: 10.1121/1.4730888.


Information-based sequential selection of clinical tests in risk assessment.

Parush N, El-Hay T, Ozery-Flato M, Ryliskyte L, Visockiene Z, Laucevicius A.

Stud Health Technol Inform. 2012;180:781-5.


Model for bubble pulsation in liquid between parallel viscoelastic layers.

Hay TA, Ilinskii YA, Zabolotskaya EA, Hamilton MF.

J Acoust Soc Am. 2012 Jul;132(1):124-37. doi: 10.1121/1.4707489.


Green's functions for a volume source in an elastic half-space.

Zabolotskaya EA, Ilinskii YA, Hay TA, Hamilton MF.

J Acoust Soc Am. 2012 Mar;131(3):1831-42. doi: 10.1121/1.3672652.


Model for the dynamics of two interacting axisymmetric spherical bubbles undergoing small shape oscillations.

Kurihara E, Hay TA, Ilinskii YA, Zabolotskaya EA, Hamilton MF.

J Acoust Soc Am. 2011 Nov;130(5):3357-69. doi: 10.1121/1.3626137.


Application of PBPK modelling in drug discovery and development at Pfizer.

Jones HM, Dickins M, Youdim K, Gosset JR, Attkins NJ, Hay TL, Gurrell IK, Logan YR, Bungay PJ, Jones BC, Gardner IB.

Xenobiotica. 2012 Jan;42(1):94-106. doi: 10.3109/00498254.2011.627477. Epub 2011 Oct 30.


Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms.

Harrison A, Gardner I, Hay T, Dickins M, Beaumont K, Phipps A, Purkins L, Allan G, Christian R, Duckworth J, Gurrell I, Kempshall S, Savage M, Seymour M, Simpson M, Taylor L, Turnpenny P.

Xenobiotica. 2012 Jan;42(1):57-74. doi: 10.3109/00498254.2011.622418. Epub 2011 Oct 12.


Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration.

Cole S, Bagal S, El-Kattan A, Fenner K, Hay T, Kempshall S, Lunn G, Varma M, Stupple P, Speed W.

Xenobiotica. 2012 Jan;42(1):11-27. doi: 10.3109/00498254.2011.617847. Epub 2011 Oct 4. Review.


Familial neuroendocrine cell hyperplasia of infancy.

Popler J, Gower WA, Mogayzel PJ Jr, Nogee LM, Langston C, Wilson AC, Hay TC, Deterding RR.

Pediatr Pulmonol. 2010 Aug;45(8):749-55. doi: 10.1002/ppul.21219.


Neuroendocrine cell hyperplasia of infancy: diagnosis with high-resolution CT.

Brody AS, Guillerman RP, Hay TC, Wagner BD, Young LR, Deutsch GH, Fan LL, Deterding RR.

AJR Am J Roentgenol. 2010 Jan;194(1):238-44. doi: 10.2214/AJR.09.2743.


Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR.

Cancer Res. 2009 May 1;69(9):3850-5. doi: 10.1158/0008-5472.CAN-08-2388. Epub 2009 Apr 21.


Model of coupled pulsation and translation of a gas bubble and rigid particle.

Hay TA, Hamilton MF, Ilinskii YA, Zabolotskaya EA.

J Acoust Soc Am. 2009 Mar;125(3):1331-9. doi: 10.1121/1.3077216.


Neuroimaging correlates of parent ratings of working memory in typically developing children.

Mahone EM, Martin R, Kates WR, Hay T, Horská A.

J Int Neuropsychol Soc. 2009 Jan;15(1):31-41. doi: 10.1017/S1355617708090164.


Relationship of temporal lobe volumes to neuropsychological test performance in healthy children.

Wells CT, Mahone EM, Matson MA, Kates WR, Hay T, Horska A.

Brain Cogn. 2008 Nov;68(2):171-9. doi: 10.1016/j.bandc.2008.04.004. Epub 2008 May 29.


Modelling the genetics and demography of step cline formation: gastropod populations preyed on by experimentally introduced crabs.

Boulding EG, Hay T, Holst M, Kamel S, Pakes D, Tie AD.

J Evol Biol. 2007 Sep;20(5):1976-87.


Flexible piezopolymer ultrasonic guided wave arrays.

Hay TR, Rose JL.

IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jun;53(6):1212-7.


Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.

Hay T, Jenkins H, Sansom OJ, Martin NM, Smith GC, Clarke AR.

Cancer Res. 2005 Nov 15;65(22):10145-8. Erratum in: Cancer Res. 2006 Jan 1;66(1):599.


DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data.

Hay T, Clarke AR.

Biochem Soc Trans. 2005 Aug;33(Pt 4):715-7. Review.


Mutations in Apc and p53 synergize to promote mammary neoplasia.

Méniel V, Hay T, Douglas-Jones A, Sansom OJ, Clarke AR.

Cancer Res. 2005 Jan 15;65(2):410-6.


Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

Gallagher RC, Hay T, Meniel V, Naughton C, Anderson TJ, Shibata H, Ito M, Clevers H, Noda T, Sansom OJ, Mason JO, Clarke AR.

Oncogene. 2002 Sep 19;21(42):6446-57.


Hypophosphorylation of Mdm2 augments p53 stability.

Blattner C, Hay T, Meek DW, Lane DP.

Mol Cell Biol. 2002 Sep;22(17):6170-82.

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